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Brandon Chen, PhD

@brandontwchen.bsky.social
830 followers 709 following 30 posts

NCI K99 postdoc with Kivanç Birsoy | Inter-organellar metabolic communication, cancer metabolism

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Reposted by Brandon Chen, PhD
Artem Khan @artemakhan.bsky.social · 06/11/2025
The link to our paper: dlvr.it/TP5gK5
dlvr.it
Machine-learning-guided discovery of SLC25A45 as a mediator of mitochondrial methylated amino acid import and carnitine synthesis
Khan et al. apply machine learning to identify substrates of UNC93A, SLC45A4, and SLC25A45. Biochemical assays and in vivo metabolite tracing establish SLC25A45 as a key mediator of mitochondrial impo...
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Reposted by Brandon Chen, PhD
Artem Khan @artemakhan.bsky.social · 06/11/2025
Also thanks to Zachary Sebo and Navdeep Chandel for writing a preview to our work as well as a complementary study from Thomas MacVicar's lab www.cell.com/molecular-ce...
cell.com
An orphan no more: SLC25A45 controls mitochondrial import of methylated amino acids
Solute carrier (SLC) genes encode the largest membrane transporter superfamily, with many orphan members of unknown function. In recent Cell Metabolism and Molecular Cell articles, Khan et al. and Dia...
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Reposted by Brandon Chen, PhD
Artem Khan @artemakhan.bsky.social · 06/11/2025
The cover depicts a GWAS Manhattan plot as a city skyline reflected onto a New York City-style subway metabolic map: organelles as boroughs, metabolites as stations, transporters as trains.
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Reposted by Brandon Chen, PhD
Artem Khan @artemakhan.bsky.social · 06/11/2025
Happy to see our recent work on SLC25A45 featured on the cover of @cp-cellmetabolism.bsky.social . Huge thanks to @yuyangliu.bsky.social for the design! @KivancBirsoy @rockefeller.edu
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Reposted by Brandon Chen, PhD
Artem Khan @artemakhan.bsky.social · 11/10/2025
Excited to share our work on discovery of SLC25A45 as a mediator of mitochondrial methylated amino acid import and carnitine biosynthesis. @cp-cellmetabolism.bsky.social www.cell.com/cell-metabol...
cell.com
Machine-learning-guided discovery of SLC25A45 as a mediator of mitochondrial methylated amino acid import and carnitine synthesis
Khan et al. apply machine learning to identify substrates of UNC93A, SLC45A4, and SLC25A45. Biochemical assays and in vivo metabolite tracing establish SLC25A45 as a key mediator of mitochondrial impo...
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Reposted by Brandon Chen, PhD
Eddie Rashan @edreesrashan.bsky.social · 23/06/2025
AND IT'S DONE! A 🧵 on our recent article now out in @natsmb.nature.com! Co-led with @abbybartlett.bsky.social, Pagliarini Lab, @judisimcox.bsky.social, we find ACAD10/11 are NOT like other acyl-CoA dehydrogenases and instead catabolize atypical lipids called 4-hydroxy acids 🤯 doi.org/10.1038/s415...
doi.org
ACAD10 and ACAD11 enable mammalian 4-hydroxy acid lipid catabolism - Nature Structural & Molecular Biology
Rashan, Bartlett and colleagues show that mammalian 4-hydroxy fatty acids are primarily catabolized by ACAD10 and ACAD11 (atypical mitochondrial and peroxisomal acyl-CoA dehydrogenases, respectively) ...
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Reposted by Brandon Chen, PhD
Caleb Cheng @djcalebc.bsky.social · 24/04/2025
Beyond grateful to share that my main PhD thesis project, Targeting PIKfyve-driven lipid metabolism in pancreatic cancer (@lyssiotislab.bsky.social + Arul Chinnaiyan lab), has just been published in @nature.com!
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Brandon Chen, PhD @brandontwchen.bsky.social · 17/04/2025
Happy to share our most recent review on mitochondria-organelle metabolic communication with Yatrik Shah and Costas Lyssiotis now online at Molecular Cell! We explored aspect of lipid transfer, organelle membrane contacts, ROS, metabolites, and metals! www.sciencedirect.com/science/arti...
sciencedirect.com
Mitochondria-organelle crosstalk in establishing compartmentalized metabolic homeostasis
Mitochondria serve as central hubs in cellular metabolism by sensing, integrating, and responding to metabolic demands. This integrative function is a…
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Reposted by Brandon Chen, PhD
Zen Faulkes @doctorzen.net · 08/02/2025
Worst week for science EVER. Sunday: ASM scrubs DEI mentions from website. Tue: NASA scrubs DEI from website; ICE arrests a student on campus; NSF plans to cut staff; USAID halted. Wed: HHMI kills diversity program; NIH trashes applications for diversity F grants. Fri: NIH cuts indirects.
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Reposted by Brandon Chen, PhD
E John Wherry @ejohnwherry.bsky.social · 08/02/2025
This will kill science in the US. This is how China wins. Why is this not on the news? Why are people not more upset about this? grants.nih.gov/grants/guide...
grants.nih.gov
NOT-OD-25-068: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD
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Reposted by Brandon Chen, PhD
Jeremy Berg @jeremymberg.bsky.social · 08/02/2025
A Primer on Indirect Cost Rates
media.tenor.com
a cartoon says hey everybody an old man 's talking while bart simpson looks on
ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on
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Reposted by Brandon Chen, PhD
Lyssiotis Lab @lyssiotislab.bsky.social · 05/02/2025
We are soliciting poster and short talk abstracts for the NYASciences Cancer Metabolism meeting. Just around the corner - join us for awesome metabolism in the Big Apple 🍎 Speakers: Kivanc Birsoy, Christine Chio, Marcia Haigis, Andy Intlekofer, Thales PapaG, Jared Rutter, Dan Wahl, Eileen White
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Reposted by Brandon Chen, PhD
André Nadler @nadlerlab.bsky.social · 31/01/2025
It’s incredibly hard to study lipids in biological membranes on the nanoscale. You need near-perfect information on both membrane ultrastructure and lipid density, which usually isn’t attainable. Lipid-CLEM brought to you by @mathilda95.bsky.social changes that. www.biorxiv.org/content/10.1...
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Reposted by Brandon Chen, PhD
Peter Mullen @petemullen.bsky.social · 03/02/2025
Registration and abstract submissions are open for the Third Annual SoCal Metabolism Symposium at USC. Go to gero.usc.edu/event/third-... The abstract and early bird price deadlines are Feb 28th
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Reposted by Brandon Chen, PhD
Juan C. Landoni @jclandoni.bsky.social · 30/01/2025
Fresh new paper alert 🚨 by @marcellharhai.bsky.social @jourdainlab.bsky.social et al. expanding the inventory of potential #mitodisease genes and a herculean deep-dive into FAM136A across models and human disease! 🧪🧫🐭👂 Really happy to see it out and to have played a small part 🔬 #mito #sciencesky
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Brandon Chen, PhD @brandontwchen.bsky.social · 29/01/2025
Really enjoyed writing this spotlight highlighting recent works from @keunwooryu.bsky.social at al in the Thompson lab along with @lyssiotislab.bsky.social and Yatrik Shah! Mitochondria heterogeneity FTW! --- Link below to the spotlight and the original @nature.com articles in the reference👇
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Reposted by Brandon Chen, PhD
Trends in Endocrinology and Metabolism @cp-trendsendomet.bsky.social · 29/01/2025
ONLINE NOW! Subcellular mitochondrial heterogeneity enables opposing metabolic demands, by @brandontwchen.bsky.social, Yatrik Shah and @lyssiotislab.bsky.social, discussing the recent work by @keunwooryu.bsky.social et al. Read it for free until March 19th at: authors.elsevier.com/a/1kWLq3jDgW...
(A) Oxidative mitochondria, in red, retain cristae to house the electron transport chain, comprising complexes CI, CII, CIII, CIV, and CV. Glutamine metabolism in the oxidative tricarboxylic acid (TCA) cycle fuels ATP synthesis. Oxidative mitochondria can be identified by the retention of CV expression. Reductive mitochondria, in blue, lose cristae and use reducing potential to drive reductive ornithine and proline biosynthesis from glutamine. Reductive mitochondria distinctly present with pyrroline-5-carboxylase synthase (P5CS) filaments. (B) Reductive mitochondria in which P5CS has been oligomerized into filaments are sequestered via mitochondrial fission, a process that can be mediated by dynamin-like protein 1 (DRP1). Mitochondrial fusion sequesters oxidative mitochondria. This process can be driven by mitofusin 1 and 2 (MFN1/2).
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Reposted by Brandon Chen, PhD
Danielle L. Schmitt 🔬 @schmittwitt.bsky.social · 28/01/2025
I got home from lab and immediately called and wrote to my representative and senators. I urge you to do the same.
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Reposted by Brandon Chen, PhD
Susanne Ahmari @ahmarilab.bsky.social · 27/01/2025
I decided to be more efficient in my doomscrolling & made my first starter-pack!😅 These are folks that IMO have been great sources of reliable info during the federal communication ban. Please 1) tell me if you want to be taken off, and 2) give suggestions for others to add go.bsky.app/KZnq7Qe
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Katie Mack @astrokatie.com · 28/01/2025
I think some people hear “grants” and think that without them, scientists and government workers just have less stuff to play with at work. But grants fund salaries for students, academics, researchers, and people who work in all areas of public service. “Pausing” grants means people don’t eat.
washingtonpost.com
White House pauses all federal grants, sparking confusion
The Trump administration has put a hold on all federal financial grants and loans, affecting tens of billions of dollars in payments.
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Reposted by Brandon Chen, PhD
Roland Dunbrack 🏳️‍🌈 @rolanddunbrack.bsky.social · 28/01/2025
All NIH/NSF awards may be paused as of today. Money is disbursed annually, so if you have your money, you're OK for a while. My next R35 grant year starts Apr 1. I hope Trump doesn't read my X/bsky feeds that say he's a racist, a rapist, a cheat, & a traitor. www.washingtonpost.com/business/202...
washingtonpost.com
White House pauses all federal grants, sparking confusion
The Trump administration has put a hold on all federal financial grants and loans, affecting tens of billions of dollars in payments.
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Reposted by Brandon Chen, PhD
Dave Levitan @davelevitan.bsky.social · 27/01/2025
From a source inside the National Cancer Institute: “Everyone is scrambling to figure out how we’re supposed to work to serve the public when we can’t engage at all.”
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Reposted by Brandon Chen, PhD
Nancy Kanwisher @nancykanwisher.bsky.social · 28/01/2025
Academic workers across the country are organizing to call on our congressional representatives on Thursday, 1/30, at 3pm ET / 12pm PT to demand these restrictions be lifted immediately. There will be a training over zoom at the beginning of the event. Join us! form.jotform.com/250226137228...
form.jotform.com
Join researchers across the country in fighting restrictions on the NIH
Please click the link to complete this form.
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Reposted by Brandon Chen, PhD
Jeremy Yoder says no war @jbyoder.org · 28/01/2025
Reiterating my call to fellow federally-funded scientists: Call your reps, tell them how this hurts science and everything good that comes from science (Also non-scientists, and scientists without federal funding! But the more of us who can directly speak to the impacts of these freezes the better)
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Reposted by Brandon Chen, PhD
Megan Killian @megankillian.bsky.social · 26/01/2025
I'm one of these 11,965, and with funding from the NIH and NSF, I've been able to recruit several more full-time employees to MI (many coming from other states!) since 2023. @repdingell.bsky.social, please advocate for us in science, health, and research to continue supporting the michigan economy
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Brandon Chen, PhD @brandontwchen.bsky.social · 20/01/2025
Crazy that I defended on Friday! Really appreciate everything I learned from Yatrik and @lyssiotislab.bsky.social over the years! Can't ask for better mentors, labs, colleagues, friends, and support over the years! Next step, postdoc with Kivanc Birsoy at Rockefeller University !🧿🗽
lab picturedefense picturedefense picture
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Reposted by Brandon Chen, PhD
Lyssiotis Lab @lyssiotislab.bsky.social · 03/01/2025
The end of an era. @brandontwchen.bsky.social brought us kicking & screaming into cell biology, and what an exciting journey it’s been. We are so very proud of everything he’s accomplished! Join us 1/17 for his defense. Thereafter… watch out NYC, here he comes!!
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Brandon Chen, PhD @brandontwchen.bsky.social · 03/01/2025
hahahahahahaha
I am defending in 2 weeks
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Reposted by Brandon Chen, PhD
Juan C. Landoni @jclandoni.bsky.social · 23/12/2024
Stoked to share TWO preprints on mitochondrial pearling! 🎉 We uncover how spontaneous #mitochondria pearling drives #mtDNA nucleoid distribution (doi.org/10.1101/2024...), and @gavsturm.bsky.social et al. dissect the biophysics behind it (doi.org/10.1101/2024...). Details below! 🔬🧵🧪
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Reposted by Brandon Chen, PhD
Sebastian S. Cocioba @atinygreencell.bsky.social · 11/12/2024
Come with me as I troubleshoot this very high GC PCR toward clonable homology arms in an actinobacteria. Testing DMSO, Betaine 1M, and Propylene Glycol to see if we get amplification. Arms are 1000bp. Full length with arms and gene is 2800bp. Let's go! 🧵 1/n
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Reposted by Brandon Chen, PhD
Aakriti Jain @aakritijain.bsky.social · 09/12/2024
Excited for some cool science at #CellBio2024 this year! Come by my poster (Sun. Dec 15, 1.30-3pm Board B136) and stay for my talk (Sun. Dec 15, 4 pm Rm 33B) where I'll tell you about our work on a lysosomal mechanism for membrane protein degradation!
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Reposted by Brandon Chen, PhD
Lyssiotis Lab @lyssiotislab.bsky.social · 09/12/2024
If you are attending #ASCB2024, check out this suite of Shah/Lyssiotis Lab presentations! @brandontwchen.bsky.social
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Reposted by Brandon Chen, PhD
Natalie Niemi @nieminm.bsky.social · 09/12/2024
Are you going to #ASCB2024 @ascbiology.bsky.social? Excited to be co-chairing a session on Organelle Biogenesis, Turnover, & Quality Control with @labfriedman.bsky.social on Monday, 12/16. We have a fantastic line up of speakers - see you there!
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Brandon Chen, PhD @brandontwchen.bsky.social · 08/12/2024
Looking forward to returning to #CellBio2024 and present our updated work on metabolic regulation of ER-mito contact sites! Excited to meet new fiends and re-connect with my fav colleagues! link to preprint: www.biorxiv.org/content/10.1...
Title: Metabolic and epigenetic control of endoplasmic reticulum-mitochondrial contact sties
Session: Toward Building In Vitro Organelle Interaction Systems
Location: Room 33B
Date: Saturday, Dec 14 9:35 AM
Duration: 10 minutes
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Brandon Chen, PhD @brandontwchen.bsky.social · 02/12/2024
Amazing course for someone who really wants to dive into the fascinating world of quantitative light imaging 🤩
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Jennifer Waters @jencwaters.bsky.social · 02/12/2024
We are so excited that @janfunkey.bsky.social has agreed to give the keynote seminar for @qiatcshl.bsky.social 2025 @cshlnews.bsky.social! 🔬🖥️ 🛤️ Applications due 1/31/2025. t.co/x87ngy34UC
t.co
https://meetings.cshl.edu/courses.aspx?course=C-QICM
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Lyssiotis Lab @lyssiotislab.bsky.social · 02/12/2024
Is BluSky ready for this much Mo? This group of Dudes is serious about Mo’s and about raising awareness for men’s mental health and cancer research 👨🏻💪🏼 #Movember @ja-nietocarrion.bsky.social
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Reposted by Brandon Chen, PhD
Micah G. Allen @micahgallen.com · 02/12/2024
Would you like to see @biorxivpreprint.bsky.social add a share to blue sky button?! I know I would! Share this post to let @richardsever.bsky.social @erictopol.bsky.social and others at bioarxiv know!
A screenshot of a paper on bioarxiv illustrating the lack of blue sky share button!
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Constantin Pape @cppape.bsky.social · 30/11/2024
You can now watch the I2K video tutorial on #micro-sam by @anwaiarchit.bsky.social on YouTube: www.youtube.com/watch?v=dxjU... Check it out for an in-depth explanation for how to use our tool to segment your microscopy images.
youtube.com
Segment Anything for Microscopy
YouTube video by I2K Conference
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Danielle L. Schmitt 🔬 @schmittwitt.bsky.social · 30/11/2024
Are you going to #CellBio2024? Be sure to check out my session Sunday morning about the future of metabolism, featuring talks from trainees (grad & postdoc) and early career faculty!
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Reposted by Brandon Chen, PhD
Mara Duncan @mcduncanlab.bsky.social · 29/11/2024
🧪Dear Grad student, Are you overdue for a thesis committee meeting but feel like you have nothing to show since your last meeting? I'm begging you to schedule that meeting now! 1/🧵
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Juan C. Landoni @jclandoni.bsky.social · 29/11/2024
A tragically failed staining for #FluorescenceFriday, but a fun opportunity to play with @kwolbachia.bsky.social awesome LUTs! Can anyone recognize the structures in this bouquet? 💐 #SciSky #AcademicSky #FluorescentFriday 🔬 🧪 🐡 🦑
Fluorescent image (failed)
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Reposted by Brandon Chen, PhD
Avezov lab @avezovlab.bsky.social · 26/11/2024
🚨For the lucky colleagues attending #CellBio2024 in San Diego, check out our session on 'ER structure and function across cell types' Room28C- Dec18th 09:00am! A fantastic lineup covering the latest across the field. See you there! **Please RT** 🥳 t.co/6eq3cyGlVZ
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Brandon Chen, PhD @brandontwchen.bsky.social · 26/11/2024
The amount of concurrent science writing (grants, articles, reviews, dissertation) I'm doing right now at the end of grad school is kind of insane, but I'm kinda loving it. WEIRDDD
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Reposted by Brandon Chen, PhD
Rich Possemato @richpossemato.bsky.social · 26/11/2024
I’m excited to share new work out of the lab in Nature Metabolism today on the impact of tumor-relevant glucose concentrations on the response to pyrimidine synthesis inhibitors. t.co/9hOGW4x97T. PDF: rdcu.be/d1vkV
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https://www.nature.com/articles/s42255-024-01166-w
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Julia Ugras @juliaugras.bsky.social · 26/11/2024
Getting some pretty IF images done with @mruckert.bsky.social on the @leicamicrosystems.bsky.social Stellaris before Thanksgiving break 🤩🍂
Image of multiplex immunofluoresence staining
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Sonya Neal @neal-lab.bsky.social · 25/11/2024
Hello, BlueSky Universe! I'm Sonya Neal, an Associate professor at UC San Diego and HHMI Freeman Hrabowski Scholar. Proudly First-Gen, Black in STEM and passionate about paying it forward. In my people-first lab, we are driven to explore the most understudied membrane proteins
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Itai Yanai @itaiyanai.bsky.social · 24/11/2024
How to write a grant? 1. The application is for the reviewer, not you, the applicant. 2. Communicate in stories. 3. Make your story cohesive—leave no puzzling gaps. 4. Make your story resonate to keep the reviewer reading. 5. Accept chance and noise in peer-review. www.pnas.org/doi/epub/10....
https://www.pnas.org/doi/epub/10.1073/pnas.2315735121
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Walter W. Chen, MD, PhD @walterwchen.bsky.social · 23/11/2024
Hello Bluesky community! Since I’m new here, I wanted to introduce myself! I am a neonatologist and scientist studying mitochondria, peroxisomes, and metabolism (currently a postdoc in @rjdlab.bsky.social). A short thread of some work I have done:
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Kevin C Klatt, PhD, RD @kcklatt.bsky.social · 18/11/2024
Building out an eclectic mix of #nutrition, food and #metabolism folks here ⬇️ bsky.app/profile/did:...
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