Over the last three decades, dogma-breaking studies have refuted the brain’s assumed immune isolation. Echoing Ramón y Cajal metaphor of neurons as “butterflies,” Schwartz proposes viewing the brain a...

ALS/FTD-linked mutations in UBQLN2, a protein quality control factor, impair degradation of enzymes essential for mitochondrial lipid catabolism, leading to metabolic dysfunction and neurodegeneration...

Chronic pain often evolves into depression and anxiety, yet mechanisms linking sensory distress to affective dysfunction remain unclear. Integrating human neuroimaging from the UK Biobank with a roden...

Psychological stress is believed to exacerbate dermatitis, yet the neurobiological mechanisms linking stress to immune processes remain elusive. We identified a subset of prodynorphin-positive (Pdyn+)...

Damage to the blood-brain barrier is linked to immune changes and cognitive decline.

Damage to the blood-brain barrier is linked to immune changes and cognitive decline.

The country is facing a coming wave of dementia for its ageing population, and is investing in research into drugs, diagnostics and even surgery to prepare itself.

Microglia are key drivers of synapse refinement during development. Ramirez et al. show that astrocytes instruct this process through the secreted synaptogenic protein Hevin/Sparcl1. The proteolytical...

Liver exercise factor GPLD1 rejuvenates blood-brain barrier integrity and reverses cognitive impairments in aging and Alzheimer’s disease models by targeting GPI-anchored proteins on brain endothelial...

Myelin damage is a hallmark of several neurological disorders, but how it occurs remains to be fully understood. In this study, we found that early damage in zebrafish and rodent demyelination models ...

Amyloid β (Aβ) accumulation is a hallmark of Alzheimer’s disease (AD). Emerging evidence suggests that impaired microglial Aβ phagocytosis is a key...

INTRODUCTION Microglia are macrophage-like brain resident immune cells known to express numerous Alzheimer's disease risk genes. Here we generated a human induced pluripotent stem cell (iPSC) derive...