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Sam Lewis, Ph.D.

@samlewis.bsky.social
2.7K followers 833 following 154 posts

Assistant Professor, UC Berkeley Dept of Molecular and Cell Biology, she/her, personal account, views do not reflect those of my employer. Studying the flow of genetic information through mitochondrial networks. www.thelewislab.org

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Reposted by Sam Lewis, Ph.D.
American Society for Cell Biology @ascbiology.bsky.social · 29/09/2026
Congratulations to Samantha Lewis of UC Berkeley, recipient of the 2026 WICB Junior Award for Excellence in Research recognizing outstanding early-career scientific achievement. www.ascb.org/society-news/ascb-anno…
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Drug Monkey @drugmonkey.bsky.social · 08/09/2026
And there it is. As rumored, and as predicted by YHN from the gitgo, enhanced triage of NIH grants will continue. grants.nih.gov/grants/guide...
grants.nih.gov
NOT-OD-26-114: Continuation of Modifications to Peer Review Practices
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Continuation of Modifications to Peer Review Practices NOT-OD-26-114. NIH
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Jim Hurley @jimhurley.bsky.social · 06/09/2026
The ULK1 complex triggers autophagy on membranes, but with no typical membrane binding domains, how does it get there? See the answer in a brilliant collective effort out now in Science Advances: www.science.org/doi/10.1126/....
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P. Djéli Clark | The Disgruntled Haradrim @pdjeliclark.bsky.social · 22/07/2026
Forgot to mention… my short story “If the Martians Have Magic” was narrated by Wil Wheaton in June on his It’s Storytime podcast. This is my 2nd story narrated by one of the TNG crew (legendary LeVar Burton narrated “The Angel of Khan el-Khalili”) and now I feel like I gotta collect the set.
podcasts.apple.com
"If the Martians Have Magic" by P. Djèlí Clark
Podcast Episode · It's Storytime with Wil Wheaton · June 17 · 1h 4m
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Reposted by Sam Lewis, Ph.D.
Christina Wolbrecht @cwolbrecht.bsky.social · 13/08/2026
Folks, who is telling high school students -- who I am sure are smart and talented and ambitious -- to cold email college professors and volunteer to do research or collaborate with them? This is not a good idea. Please stop this.
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Sam Lewis, Ph.D. @samlewis.bsky.social · 04/08/2026
I'm honored to receive the @ascbiology.bsky.social WICB Junior Award for Excellence in Research! Thank you to my lab team, my @berkeleymcb.bsky.social mentors and nominators, and my family for their support.
ASCB WICB Junior Award for Excellence in Research, presented to: Samantha Lewis, UC Berkeley.
Presented to a woman or non-binary person in an early stage of their career (within seven years of appointment to an independent position at the nomination deadline) who is making exceptional scientific contributions to cell biology, is developing a strong independent research program, and exhibits the potential for continuing at a high level of scientific endeavor and leadership.
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UC Berkeley MCB @berkeleymcb.bsky.social · 03/08/2026
Congrats to MCB's Diana Bautista, Samantha Lewis & Matt Welch for being ASCB Honorific Award Winners! 👏🎉@ascbbiology.bsky.social, @dianambautista.bsky.social, @samlewis.bsky.social, @mattwelchlab.bsky.social
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Jonas Blomme @handle.invalid · 17/07/2026
Excited to share our latest preprint on #PhycologyFriday. We map out the carbon fixation pathway for the first time in a multicellular alga, the green seaweed Ulva, and reveal a unique Rubisco-Linker interaction in the pyrenoid, a chloroplast condensate. Below I summarize some key points. #seaweeds
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Jeeyun Chung @jeeyunc.bsky.social · 29/06/2026
What do lipid droplets do in neurons? Thrilled to share the 🌟1st preprint from my lab, led by Eleni Katafygiotou, showing activity-dependent formation of neuronal LDs in vitro and in vivo, and the impact of LD modulation on neuronal function and behavior. #lipidtime www.biorxiv.org/content/10.6...
biorxiv.org
Activity-dependent lipid droplet biogenesis and turnover regulate synaptic integrity
Lipid droplets (LDs) are conserved organelles that buffer lipid storage and stress, yet their dynamics and functions in neurons remain largely unknown. Here, we report activity-dependent dynamics of n...
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Reposted by Sam Lewis, Ph.D.
bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · 10/06/2026
Structural Mechanism and Cellular Restriction of Tau Seeding from Endolysosomes www.biorxiv.org/content/10.64898/20…
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Elizabeth Jacobs, PhD @elizabethjacobs.bsky.social · 08/06/2026
The Trump Administration’s racist science policies have achieved some of their goals. The number of Black Principal Investigators has dropped by 10% between 2024 and 2025; while the number of Hispanic PIs has fallen by 7%. For research trainees, the numbers are far worse.
jamanetwork.com
Trends in NIH Investigators by Sex, Race, Ethnicity, and Disability Status
This cross-sectional study assesses National Institutes of Health (NIH) data from fiscal years 2016-2025 comprising annual counts of principal investigators funded through research grants and fellowsh...
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Sam Lewis, Ph.D. @samlewis.bsky.social · 08/06/2026
🚨 This proposal to cap total NIH RPGs per PI includes R00, R03, R35, and DP2. grants.nih.gov/grants/guide...
grants.nih.gov
NOT-OD-26-086: Request for Information: Proposal to Cap the Number of Simultaneous Research Project Grants per Principal Investigator to Support More Researchers and Maximize Scientific Productivity a...
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Request for Information: Proposal to Cap the Number of Simultaneous Research Project Grants per Principal Investigator ...
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Michael Ward @michael-e-ward.bsky.social · 13/05/2026
On July 1st, I'll be joining the faculty at UC Berkeley, with a joint appointment in the Division of Molecular Therapeutics within MCB and the Helen Wills Neuroscience Institute.
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Sam Lewis, Ph.D. @samlewis.bsky.social · 06/05/2026
academic.oup.com/nar/article/...
academic.oup.com
Mitochondrial DNA replication is regulated by endoplasmic reticulum-mitochondrial contact sites, the mitochondrial calcium uniporter, and manganese
Abstract. Mitochondrial DNA replication occurs at contact sites between the endoplasmic reticulum (ER) and mitochondria (ERMCS). Beyond the known role of t
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Reposted by Sam Lewis, Ph.D.
ZD Dochterman @zddochterman.bsky.social · 05/05/2026
A must read for all weirdos
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Kelly Robson @kellyrobson.com · 22/04/2026
My Nebula and Hugo finalist novella is on super Kindle deal $1.49 right now! Meet Minh, cranky 83 year-old ecologist who gives no f*cks, and earnest young Kiki who only wants to learn everything Minh knows. Together, they time travel and get into big trouble.
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Jake @waveturtlejake.bsky.social · 18/04/2026
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Michael Baym @baym.lol · 17/04/2026
I’m looking for an automated way to read others’s scientific data without giving credit or acknowledgement, and also claim full credit for insights from it. And I want it to have a fitting name OAI: say no more
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Reposted by Sam Lewis, Ph.D.
Nick Fleisher @nickfleisher.bsky.social · 17/04/2026
There's also a kind of intentional myopia in focusing just on higher ed when diagnosing "declining trust." Only one of these explanations also has something to say about why there's simultaneously declining trust in elections, public health authorities, etc, in the same spaces over the same period
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Reposted by Sam Lewis, Ph.D.
Needhi Bhalla 💅🏽 @needhibhalla.bsky.social · 15/04/2026
I'm excited to tell you about the most recent preprint in my lab, demonstrating that a conserved spindle matrix protein, NPP-21/TPR, is required for the stronger checkpoint in germline cells during embryogenesis in C. elegans
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Sam Lewis, Ph.D. @samlewis.bsky.social · 13/04/2026
Excited to share a new collaborative paper with Lena Koslover's team, fueled by @chanzuckerberg.bsky.social Metabolism Across Scales Program 🧪 1/ www.pnas.org/doi/10.1073/...
pnas.org
Diffusive spreading across dynamic mitochondrial network architectures | PNAS
In eukaryotic cells, mitochondria form networks that range from highly fused interconnected structures to fragmented populations of individual orga...
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Sam Lewis, Ph.D. @samlewis.bsky.social · 24/03/2026
I had a wonderful time connecting with the research community at the Buck last week! Special thanks to Saam Doroodian, Malene Hansen, and Ashley Webb!
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Reposted by Sam Lewis, Ph.D.
I-75 Scientist @flscitriguy.bsky.social · 19/03/2026
NIGMS is signed onto the F31 NOFO. grants.nih.gov/grants/guide...
grants.nih.gov
NOT-GM-26-002: Notice of NIGMS Participation in PA-25-422 "Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship (Parent F31)"
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Notice of NIGMS Participation in PA-25-422
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Devine lab @devinelab.bsky.social · 13/03/2026
⚡️We are excited to share a new paper from the lab by @drkhole.bsky.social in @cp-cellrepmethods.bsky.social - suggesting MitoTracker dyes are not a reliable tool for detecting intercellular mitochondrial transfer❗️ www.cell.com/cell-reports...
cell.com
MitoTracker transfers from astrocytes to neurons independently of mitochondria
The mitochondrial dye MitoTracker is commonly used to investigate intercellular mitochondrial transfer (IMT), particularly between astrocytes and neurons. Hole et al. compare MitoTracker with a geneti...
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Sam Lewis, Ph.D. @samlewis.bsky.social · 11/03/2026
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Reposted by Sam Lewis, Ph.D.
Jordy F. Botello @jbotello.bsky.social · 10/03/2026
Some molecular machines, like ribosomes, can persist for long periods of time in cells. Could molecular aging of ribosomes shape how proteins are made? In our new preprint we track ribosomes as they age in cells and uncover unexpected effects on translation (1/10) www.biorxiv.org/content/10.6...
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Sam Lewis, Ph.D. @samlewis.bsky.social · 06/03/2026
On my way to DC and looking forward to this exciting mini-symposium! #ASBMB26
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Robert Hill @bobalhill.bsky.social · 06/03/2026
Megan Doty et al discovered that myelin remains for weeks after cortical axons degenerate. We call the sheaths without an axon de-axoned myelin. During the slow, asynchronous, degeneration, microglia don't play a major role in clearing the axon or de-axoned myelin. www.science.org/doi/10.1126/...
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mechanical twerk @ruhee.ca · 08/02/2026
No Kings includes Draft Kings
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Meghna Gupta @meghnag27.bsky.social · 07/02/2026
We are organizing a mini-symposium on "Membrane and Organelle Dynamics" at ASBMB 2026! #ASBMB @asbmb.bsky.social @aydinlab.bsky.social and I have put together a fantastic lineup of speakers for Day 1 morning. Come learn about some cutting-edge research in the field.
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Lorena Oli @olifiersl.bsky.social · 06/02/2026
Check out my first @prelights.bsky.social article, based on some great work done by Dr. Tejashree Waingankar & @samlewis.bsky.social at UC Berkeley 🔬🧬🧠 prelights.biologists.com/highlights/s...
prelights.biologists.com
Self-renewal of neuronal mitochondria through asymmetric division - preLights
Neurons contain “hotspots” for mitochondrial biogenesis at distal branch points
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Reposted by Sam Lewis, Ph.D.
James Barrett @james-r-barrett.bsky.social · 30/01/2026
How does molecular valency shape condensate assembly and function? We used the CO2-fixing organelle in algae—the pyrenoid—to find out… 🧵 Preprint here!: www.biorxiv.org/content/10.6... @cellarchlab.com @phaips.vd.st @biologyatyork.bsky.social #Rubisco #PhaseSeparation #Condensates #Pyrenoid
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Sam Lewis, Ph.D. @samlewis.bsky.social · 15/01/2026
I found me!
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Sam Lewis, Ph.D. @samlewis.bsky.social · 14/01/2026
I taught my grad-level cell bio seminar using the Socratic method in the fall, and shockingly (to me), students loved it. No slides, just yapping. I assigned two research articles per week as the starting point, but we were mostly led by their questions
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Sam Lewis, Ph.D. @samlewis.bsky.social · 09/01/2026
I love this video of mitochondrial trafficking and POLG2-GFP in pLL neurons of live zebrafish larvae - from our awesome collaborator Katie Drerup @kdrerup.bsky.social at UW-Madison. She and her team are so talented!
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Reposted by Sam Lewis, Ph.D.
Reto Fiolka @retof.bsky.social · 02/01/2026
The cryo cyclical multiplexing expansion microscopy (Cy-ExM) preprint from @seweryn-galecki.bsky.social , @kevin-dean.bsky.social et al is online. 20 targets across an entire cell. Mr. Snouty also joined the fun. www.biorxiv.org/content/10.6...
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Sam Lewis, Ph.D. @samlewis.bsky.social · 29/12/2025
The Raven Scholar, by Antonia Hodgson The Devils, by Joe Abercrombie The Angel of the Crows, by Katherine Addison
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Sam Lewis, Ph.D. @samlewis.bsky.social · 18/12/2025
⚡️Mitochondria make ATP, the energy that powers life. But in neurons, with axons up to a meter long, how do these tiny power plants stay functional in the right places? We went looking. 1/n www.biorxiv.org/content/10.6...
biorxiv.org
Self-renewal of neuronal mitochondria through asymmetric division
Mitochondrial ATP production is essential for life. Mitochondrial function depends on the spatio-temporal coordination of nuclear and mitochondrial genome expression, yet how this coordination occurs ...
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Reposted by Sam Lewis, Ph.D.
bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · 18/12/2025
Self-renewal of neuronal mitochondria through asymmetric division www.biorxiv.org/content/10.64898/20…
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Reposted by Sam Lewis, Ph.D.
Mike Feigin 🥯 @mikefeigin.bsky.social · 18/12/2025
How are people dealing with AI use in their grad programs, specifically for thesis proposal, qualifying exam, dissertation? Banned completely? Allowed, but have to recognize its use? No guardrails at all? We have to develop a policy and I’m totally at a loss.
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Sam Lewis, Ph.D. @samlewis.bsky.social · 17/12/2025
I just submitted some work that we're really excited about - preprint loading! Here's a sneak peek 👀
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Riker Googling @rikergoogling.bsky.social · 16/12/2025
why can’t replicators make pumpkin spice raktajino all year long
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I-75 Scientist @flscitriguy.bsky.social · 11/12/2025
I think some folks might be happy to see this. NIGMS MIRA R35 for EI/NI has been published. PAR-26-121 files.simpler.grants.gov/opportunitie...
files.simpler.grants.gov
PAR-26-121: Maximizing Investigators' Research Award (MIRA) (R35 - Clinical Trial Optional)
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Sam Lewis, Ph.D. @samlewis.bsky.social · 09/12/2025
www.ahajournals.org/doi/10.1161/...
ahajournals.org
Mitochondrial Genetics in Cardiovascular Health and Disease: A Scientific Statement From the American Heart Association | Circulation
Metabolic and genetic abnormalities have long been noted in cardiovascular diseases, but the contribution of mitochondrial genetic (mitochondrial DNA [mtDNA]) variation is understudied. Mitochondrial ...
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Reposted by Sam Lewis, Ph.D.
Mike Drucker @mikedrucker.bsky.social · 04/12/2025
I wrote a bit for McSweeney's about Isaac Chotiner interviewing Santa Claus. Just a little something for the holiday season. Enjoy!
mcsweeneys.net
The New Yorker’s Isaac Chotiner Interviews Santa Claus
For several centuries, Santa Claus has been one of the most prolific mythical gift-givers in the world. Formerly known as Saint Nicholas of Myra, a...
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Miriam Posner @miriamposner.com · 18/11/2025
WE JUST KEEP WINNING. (UC President's Postdoctoral Fellowship Program RESTORED!!!!)
On official UC letterhead: 
UNIVERSITY
OF
CALIFORNIA
James B. Milliken President
Office of the President
1111 Franklin Street Oakland, CA 94607
universityofcalifornia.edu
CAMPUSES Berkeley
Davis
Irvine
UCLA
Merced
Riverside San Diego San Francisco
Santa Barbara Santa Cruz
MEDICAL CENTERS
Davis
Irvine
UCLA
San Diego
San Francisco
NATIONAL LABORATORIES Lawrence Berkeley Lawrence Livermore Los Alamos
DIVISION OF AGRICULTURE AND NATURAL RESOURCES
November 18, 2025
Dear Chancellors:
I'm writing with regard to the President's Postdoctoral Fellowship Program (PPFP) and the program's associated faculty hiring incentive.
As you know, for more than 40 years, PPFP has provided postdoctoral research fellowships, professional development, and faculty mentoring to scholars in all fields whose research, teaching, and service advance the academic and research missions of the University of California.
Since 2003, UC campuses that hire current and former PPFP fellows into ladder-rank positions have been eligible for a hiring incentive funded by the University that provides support for newly hired fellows for five years. Since the creation of the incentive, more than $162 million has been invested by the University to support PPFP faculty hires. This commitment has enabled our campuses to successfully recruit and retain outstanding faculty across a range of disciplines.
Given the myriad challenges currently facing UC - including disruptions to billions of dollars in annual federal support, as well as uncertainty around the state budget- reasonable questions were raised in recent months about whether the University could maintain the commitment to current levels of incentive funding. After considering a recommendation to sunset the incentive program due to these significant fiscal constraints, I consulted with all of you as well as faculty and campus academic administrators and systemwide Academic Senate leadership.
[continued on next image]After learning more about the history and success of the program and weighing the thoughtful perspectives that have been shared, I have concluded that barring extraordinary financial setbacks, the PPFP faculty hiring incentive program will continue while the University continues to assess the program's structure as well as its long-term financial sustainability. As a result of our continuing consultation and review, there may be consideration of some changes to elements of the program including the total number of incentives supported, a number that has fluctuated significantly over the years, and how the awards are distributed among campuses. In the meantime, the University will continue to fund the PPFP faculty hiring incentive program and campuses may continue to take advantage of these incentives. We will have an opportunity to discuss any potential changes prior to adoption.
As we look to the future, I will continue to engage with faculty leaders, program stakeholders, and UC community members about this important program. I especially appreciate the thoughtful perspectives shared in recent weeks by Academic Council Chair Palazoglu and Vice Chair Scott, the Council of Graduate Deans, UC faculty members, and you as our campus leaders.

Sincerely,
James B. Milliken
President
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Butlerian Jihadist of House Slytherin @shimminykricket.blacksky.app · 07/10/2025
I learned how to read well because I was doing it all the time. A Goosebumps book and an encyclopedia volume hated to see me coming. I dont even know how you develop proper reading skills if you only read books at school.
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Erica D. Pratt @pratted.bsky.social · 26/09/2025
Announcing such a major change to NSF GRFP this late in the cycle is incredibly cruel. 2nd yr students (mine included) have been working so hard on their proposals despite ongoing uncertainty. They are driven and passionate about being outstanding scientists and helping those coming up behind them.
This means individuals in the following statuses at the time of application are eligible:

    Undergraduate in the final (senior) year of a bachelor’s degree program
    Bachelor’s degree-holder with NO enrollment in a graduate degree program (non-degree graduate coursework allowed)
    Individual enrolled in a joint bachelor’s-master’s degree program with at least three undergraduate years completed  
    First-year graduate student in their first graduate degree program with less than one academic year completed in the degree program (according to institution’s academic calendar)
        Individuals enrolled in joint bachelor’s-master’s degree programs are considered graduate students. For GRFP, joint bachelor’s-master’s degrees are defined as degrees concurrently pursued and awarded.
        Not be a current NSF employee.

Applications that do not meet eligibility requirements will be returned without review as being ineligible for a fellowship.
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Jim Hurley @jimhurley.bsky.social · 20/09/2025
Position available! Team @mito911.bsky.social needs a new scientific program manager to take over from legendary super-PM @doroteaartscience.bsky.social, who is moving on to bigger things. This is a Berkeley-based position. Apply at aprecruit.berkeley.edu/JPF05103.
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Anna Gifty @itsafronomics.blacksky.app · 11/09/2025
mood today #blacksky:
Black woman sitting in a wheel chair
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