Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

LIMD1 helps AGO2 silence microRNA targets more effectively, revealing an additional layer of control beyond RNA sequence alone.

Translational regulation is a critical component of the cellular response to environmental stress. Ionizing radiation (IR) exists naturally at low doses (e.g., cosmic rays and radioactive materials) b...

Different RNA modifications elicit different translation elongation rates for in vitro transcribed mRNAs that result in disparate translation outputs and fidelity, as shown here for N4-acetylcytidine ...

Harris Snell et al. report that ZC3H7A and ZC3H7B, two chordate-specific RNA-binding proteins, directly bind and coordinate the decay and translational regulation of A/U3-rich non-optimal mRNAs. By re...

Kretov et al. introduce RBPscan, an RNA-editing-based platform that measures how RNA-binding proteins engage their targets in living cells. This approach quantifies the binding strength of protein-RNA...

LARP6 is an EMT-associated RNA-binding protein with diverse RNA targets. Here, the authors show that the N-terminal disordered region of LARP6 promotes RNA-binding selectivity by modulating the adjace...

Stress responses enable cells to detect, adapt to, and survive challenges. The benefit of these signaling pathways depends on their reversibility. The integrated stress response (ISR) is elicited by p...

The eukaryotic translation initiation factor 3 (eIF3) is the largest and most complex initiation factor in eukaryotes, functioning as a central hub that integrates signals from cellular stress, metabo...

RNA-binding proteins (RBPs) considerably expand the information content of the genome and can determine the lifespan, localization and function of RNA, thereby controlling when, where and how much pro...

Rather than adapting to the codon usage of their host, viruses use viral 5′ untranslated regions to initiate translation, which allows them to produce viral proteins in host cells efficiently despite ...

Despite a growing interest in the ribotoxic stress response (RSR), it remains unknown how the upstream p38 and JNK-activating MAP3 kinase ZAKα senses translational impairment. Combining Alphafold3 pre...

Abstract. RNA–protein complexes have emerged as central players in numerous key cellular processes with significant relevance in health and disease. To fur

The kinase ZAK is activated at collided ribosomes to mediate the ribotoxic stress response.

Translation can be initiated from a specific start codon using trans-RNA.

Germinal center B cells rely on ZFP36L1 and ZFP36L2 to control cell division and avoid replication stress that leads to apoptosis.

Selenocysteine, incorporated into polypeptides at recoded termination codons, plays an essential role in redox biology. Using GPX1 and GPX4, selenoenzymes that mitigate oxidative stress, as reporters,...

The RNA-binding proteins DND1 and NANOS3 are essential for primordial germ cell survival. Their co-immunoprecipitation and overlapping loss-of-function phenotypes suggest joint function, yet how they ...

Postdoc with a primary duty consisting research-related work. Required to meet FLSA threshold to be paid on a salaried basis, otherwise employment record will convert to hourly.

Fragile X syndrome (FXS) results from a deficiency of the ubiquitously expressed RNA-binding protein fragile X protein (FMRP). While FMRP-mediated tra…

A position as Postdoctoral Research Associate is available at the Department of Cellular and Molecular Medicine, in the group headed by Dr. Andrew Blackford. Th

GIGYF2 (growth factor receptor–bound protein 10 [GRB10]-interacting GYF [glycine–tyrosine–phenylalanine] protein 2) reduces mRNA stability and translation via microRNAs, ribosome quality control, and ...

MSCA Postdoctoral Fellowships enhance the creative and innovative potential of researchers holding a PhD and who wish to acquire new skills through advanced training, international, interdisciplinary ...

Abstract. Translational regulation at the stage of initiation can impact the number of ribosomes translating each mRNA molecule. However, the translational

Eukaryotic ribosome assembly is an intricate process that involves four ribosomal RNAs, 80 ribosomal proteins, and over 200 biogenesis factors that pa…

PhD Project - Improving AML treatment efficacy by targeting mRNA and protein quality control mechanisms at Queen’s University Belfast, listed on FindAPhD.com