BACH2 restrains activation of the fetal-haemoglobin-encoding γ-globin genes, while loss of BACH2 enhances NRF2 chromatin occupancy and promotes the formation of activation foci at the γ-globin genes.

Mechanisms by which primary tumor cells acquire metastatic capability through metabolic and signaling adaptations are currently poorly understood. We demonstrate that tumor-intrinsic ceramide metaboli...

BOSTON, MA [Sept. 23, 2026] — Our understanding of how cells interact with each other has been driven for decades by the central concept of receptor-mediated

Join the IFN lambda Satellite Workshop 2026 in Glasgow. Free registration, keynote speakers, and research collaborations.

TRAM is a regulator of myddosome assembly through dissociating MyD88 from the TLR–TIRAP complex to enable myddosome maturation and durable downstream signal transduction.

TRAM is a regulator of myddosome assembly through dissociating MyD88 from the TLR–TIRAP complex to enable myddosome maturation and durable downstream signal transduction.

How cumulative environmental allergen exposures are encoded by peripheral sensory neurons to shape immune responsiveness is unclear. Zhu et al. show that protease allergens induce an mTORC1-dependent,...

A multimodal analysis of patients with multiple myeloma who developed enterocolitis following BCMA CAR-T cell treatment shows that CAR-T cell-associated enterocolitis is not defined exclusively by pla...

A cancer cell glutamine transporter creates a metabolic barrier to antitumor immunity.

The metabolic state of NK cells affects their innate immune function, and although cell-intrinsic pathways are better known, their cellular environment could provide cues that are less studied. Here t...

Tissue mitochondrial activity controls macrophage abundance by regulating CSF1 availability, thereby enabling efficient waste removal.

Fagniez et al. identify new patients with inherited RORγT deficiency characterized by impaired TCRα rearrangement, depletion of MAIT and iNKT cells, reduce

In aging hosts, platelet serotonin fuels lung-damaging clots, leading to enhanced respiratory distress in the context of COVID-19.

Neutrophil extracellular traps (NETs) feature a branched chromatin architecture whose origin and function remain unknown. We found that NET branching is mediated by RAD51, a protein generating DNA jun...

Nature Reviews Immunology - Adaptive immunity is indispensable to vertebrates, yet most living organisms defend themselves perfectly well without it. Here, I ask why somatically diversified antigen...

Lipids generated by oxidative stress and their effects on immunity and cancer are reviewed.

Iron accumulation in tumors is well established, but how cancer cells tolerate its toxicity remains unclear. Jain et al. show that cancer cells adapt via a heme-SDH-CoQ axis that buffers iron-induced ...

Lipids generated by oxidative stress and their effects on immunity and cancer are reviewed.

What Have We Been Missing in the Proteome?

By selectively targeting peripheral 5-HT2AR without inducing psychedelic effects, a non-brain-penetrant agonist boosts antitumor CD8+ T cell immunity and improves immunotherapy responses in preclinica...

Ryan and Zanoni redefine TCA cycle metabolites as metabolic danger signals that shape immunity across infections, inflammation, and cancers. They introduce the concept of metabolic DAMPs (“metaDAMPs”) as a unifying framework for understanding immune activities of endogenous metabolites and outline emerging technologies positioning immunometabolism as a tractable axis for therapeutic intervention.

Mitochondrial tricarboxylic acid (TCA) cycle metabolites have emerged as critical regulators of immunity and inflammation beyond their canonical metab…

In senescent cells, mitochondria-derived acetyl-CoA promotes histone acetylation and increases chromatin accessibility at inflammatory gene loci. Inhibition of SLC25A1 attenuates these effects, unders...

How does the body recognize viral infection? How do viruses engage the immune system during replication? These seemingly simple questions led me to study pattern recognition, a concept first proposed ...

High endothelial venules (HEVs) facilitate lymphocyte entry into lymph nodes by displaying peripheral node addressin (PNAd), yet how PNAd is regulated remains poorly understood. Jacobs et al. reveal t...

Aging disrupts tissue homeostasis across organ systems. Here, we identify tissue-resident macrophages (TRMs) as central coordinators of age-related organ decline through impaired clearance of senescen...

The nasal mucosa is a key decision point during respiratory viral infection. Here, Kazer et al. review new understanding of how local host cell subsets respond during viral infection and how this knowledge may enable tissue-scale protection through mucosal vaccines.

Allergen exposure activates gasdermin D in lung epithelial cells through an iron-mediated, protease-independent mechanism requiring the PAR1-ferritinophagy-PCBP2 axis. This unconventional cleavage dri...