Background Ultra-endurance sports are increasingly popular, yet the long-term physiological consequences of sustained extreme training loads remain poorly understood. In particular, the effects of p...

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This Review defines seven hallmarks of skeletal muscle homeostasis, providing a unifying framework for understanding, measuring and preserving muscle health.

Mitochondrial quality control is essential for cellular homeostasis, particularly in neurons, where mitochondrial dysfunction is implicated in the pathogenesis of neurodegenerative diseases. Mitoph...

Growth differentiation factor 15 (GDF15) suppresses liver inflammation and fibrosis in metabolic dysfunction-associated steatohepatitis (MASH), which is independent of reduced food intake, body weight...

Mitochondrial function is central to embryonic development, yet its assessment in the embryonic heart is hampered by limited tissue availability. Here, we present a protocol to measure mitochondrial o...

Background The serine/threonine kinase AKT is a key regulator of glucose and energy metabolism. Prevailing dogma suggests that AKT is an obligate intermediate for glucose uptake in all metabolic tis.....

Cell Death Discovery - Molecular diversity of mitochondrial autophagy receptors: context-dependent effects in human health and disease

Diabetic cardiomyopathy (DbCM) is commonly defined as ventricular dysfunction in a person living with diabetes in the absence of hypertension and/or corona

The natural process of aging in humans often increases one’s risk for a number of chronic diseases, including type 2 diabetes (T2D), dyslipidemia, hypertension, and cardiovascular disease (CVD). It is...

Cell Death & Differentiation - Mitochondrial calcium uptake drives organelle remodeling to promote inflammasome-dependent cytokine release

Taskin, Shankar, Peselj, et al. demonstrate that mitochondria possess an intrinsic surveillance system that senses mild oxidative stress and activates the UPRmt before damage signals reach the cytosol...

“Quality weight loss” can be distinguished from regular weight loss in that the skeletal muscle is preserved. This can be achieved pharmacologically, by inducing mechanisms that preserve or increase ....

This study demonstrates that overexpression of irisin, an exercise-induced myokine, ameliorates obesity and insulin resistance in high-fat-diet-fed mice by increasing local IL-33 production and preser...

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The study showed in a placebo-controlled crossover design that 4-week treatment with β2-adrenergic agonist clenbuterol enhances insulin-stimulated glucose uptake in skeletal muscle but not brown adipo...

The study showed in a placebo-controlled crossover design that 4-week treatment with β2-adrenergic agonist clenbuterol enhances insulin-stimulated glucose uptake in skeletal muscle but not brown adipo...

Skeletal muscle accounts for approximately 40% of total body mass and is essential for locomotion, metabolic regulation and systemic homeostasis. Adipose tissue is increasingly recognized as an activ...

Rational drug design seeks small molecules, aptamers, or peptides to disrupt key cellular targets. Autophagy, crucial in tumor formation, dormancy, an…

GLP-1 medicines are used to treat people with type 2 diabetes, obesity, and metabolic dysfunction-associated steatohepatitis (MASH). Here, Gonzalez-Rellan et al. demonstrate that semaglutide activates...

Spinal muscular atrophy (SMA) is a neurodegenerative disorder caused by mutations in the SMN1 gene. Although classically viewed as a neurogenic dis...

While life expectancy has increased, the prevalence of lifestyle diseases has increased. Here, Febbraio and Pedersen discuss the concept of “exercise as medicine” for the treatment of lifestyle diseas...

Abstract. Heart failure (HF) with preserved ejection fraction (HFpEF) is the most rapidly growing cardiovascular disease worldwide, affecting up to 30 mill

In this Review, Kotani and Nakatogawa discuss recent advances in our understanding of the molecular basis of autophagy induction and delineate how diverse mechanisms converge on core principles to ens...

In this Review, Khoury and colleagues examine the growing body of evidence demonstrating the benefits of screening for cardiovascular risk factors, including dyslipidaemia and high blood pressure, sta...

Heinen et al. show that the mitochondrial import complex recruits lipid droplets to the mitochondrial outer membrane. The mitochondrial import complex binds to the lipid metabolism enzyme Ayr1 and con...

In this review, the authors discuss and contextualize the cellular responses launched after mitochondrial stress and note the importance of the emerging understanding in applying this new knowledge in...

Nature Reviews Cardiology, Published online: 17 March 2026; doi:10.1038/s41569-026-01278-8Elevated plasma concentrations of lipoprotein(a) (Lp(a)) are an important risk factor for several cardiovascular diseases. However, to date, elevated Lp(a) levels have not been directly targeted by clinicians because Lp(a) levels are almost entirely genetically determined and are comparatively resistant to standard lipid-lowering therapies. This unmet medical need might soon be addressed with the advent of potent Lp(a)-lowering therapies.

Heinen et al. show that the mitochondrial import complex recruits lipid droplets to the mitochondrial outer membrane. The mitochondrial import complex binds to the lipid metabolism enzyme Ayr1 and con...

Metabolic dysfunction-associated steatotic liver disease (MASLD) arises from dysregulated interactions between nutrient delivery, adipose tissue lipid handling and liver lipid metabolism, which collectively coalesce to drive inflammatory signalling leading to metabolic dysfunction-associated steatoh …

Aims/hypothesis People with type 1 diabetes are recommended to modify insulin dosing and/or carbohydrate intake before, during and after exercise to manage blood glucose levels and prevent hypoglycaem...

This multi-cohort study reports genetic variants in myostatin associated with increased muscle mass, strength, and reduced adiposity. These findings support long-term myostatin blockade for muscle pre...

Bimagrumab is a monoclonal antibody targeting type II activin receptors. In a randomized trial, bimagrumab combined with semaglutide led to up to 17.8 kg weight reduction, surpassing the effects of se...

STIM1 is a transmembrane protein localized in the endoplasmic reticulum (ER), where it acts as a calcium ion sensor, activating store-operated Ca2+ entry upon ER Ca2+ depletion. Via cellular calcium i...

Muscle stem cells (MuSCs) are essential for skeletal muscle repair. Following injury, MuSCs reside in low oxygen environments until muscle fibers and vascularization are restablished. The dynamics of ...

Mitophagy maintains mitochondrial homeostasis through the selective degradation of damaged or excess mitochondria. Recently, we identified mitofissin/Atg44, a mitochondrial intermembrane space-residen...

Our recent collaborative studies (Robichaux et al., bioRxiv [Preprint] 2025 doi: 10.1101/2025.06.13.658955) identify ATAD3a as a critical component of the mitochondrial permeability transition pore (m...

Intermittent fasting (IF) can lower body mass during obesity, but it is unknown why certain individuals lose less fat and more lean mass during IF. We…

BACKGROUND: The prevalence of heart failure is increasing globally, with poor prognosis, highlighting the need for novel therapeutic strategies. PKCα (protein kinase C alpha), encoded by PRKCA, plays ...

Read the latest articles of Cell Death at ScienceDirect.com, Elsevier’s leading platform of peer-reviewed scholarly literature

Read the latest articles of Cell Death at ScienceDirect.com, Elsevier’s leading platform of peer-reviewed scholarly literature

In this Review, Porrello and colleagues describe the origins of the fetal gene hypothesis and discuss the evolution of this hypothesis by considering more recent evidence from genome-wide sequencing s...

Chivite et al. show that the genetic inactivation of the mitochondrial fusion protein MFN2 in the endothelium triggers a protective stress response that boosts fat burning, increases secretion of the ...

Das et al. show that the death mechanism ferroptosis is regulated in cell populations by the parallel induction of necrotic and apoptotic modes of execution. Death propagation, a unique feature of nec...

There is growing recognition of the metabolic links between metabolic dysfunction-associated steatotic liver disease (MASLD) and sarcopenia and the need to take these links into account when diagnosin...