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MitoMavericks

@mitoscientists.bsky.social
145 followers 111 following 21 posts

A platform for scientists and physicians to share and discuss important discoveries related to the role of mitochondria in health and to advance mitochondrial science as a cornerstone of improving human health. Please tag us to amplify your contributions.

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Catalina Vasilescu, PhD @cvasilescu.bsky.social · 27/09/2026
Happy Sunday with a new edition of Mitochondria in Health and Disease! Full edition online: biomed.news/bims-mitdis/... See below for highlights 👇 @biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social @mito-news.bsky.social @mitoworld.bsky.social
Mitochondria in Health and Disease Issue 27 Sept 2026
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Keshav K Singh, PhD @mitoscientist.bsky.social · 22/09/2026
Deeply honored to receive the Lifetime Achievement Award from BioClues at #INBIX2026 in Ahmedabad. I am grateful to all the colleagues, collaborators, postdocs, and students who have shaped this journey. #BioClues #INBIX2026 #Bioinformatics #Science
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Catalina Vasilescu, PhD @cvasilescu.bsky.social · 20/09/2026
Celebrating Mitochondrial Disease Awareness Week with a new format for our @biomednews.bsky.social selection of papers on #Mitochondria in #Health and #Disease! 💚 biomed.news/bims-mitdis/... @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social @mitoworld.bsky.social
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Catalina Vasilescu, PhD @cvasilescu.bsky.social · 13/09/2026
Happy Sunday and a new edition of #Mitochondria in #Health & #Disease! biomed.news/bims-mitdis/... 💚 Highlights 👇 4D spatiotemporal landscape of mitochondrial phenotypes [..] @biomednews.bsky.social @mitoscientist.bsky.social @gavinmcstay.bsky.social @mito-news.bsky.social @mitoworld.bsky.social
4D spatiotemporal landscape of mitochondrial phenotypes across cellular states unlocked through representation learning
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Catalina Vasilescu, PhD @cvasilescu.bsky.social · 23/08/2026
A new collection of papers summarizing the research published last week on #Mitochondria in #Health & #Disease! 📚 biomed.news/bims-mitdis/... ➡️ A genetic switch involving EGR1 and EZH2 links aging and development [..] @biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social
A genetic switch involving EGR1 and EZH2 links aging and development across human tissues
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Catalina Vasilescu, PhD @cvasilescu.bsky.social · 16/08/2026
Last week of research on #Mitochondria in #Health and #Disease! biomed.news/bims-mitdis/... Key findings The pseudouridine synthase PUSL1 modifies U39 of mito[..] tRNAs and is linked to human neurological phenotypes @biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social
The pseudouridine synthase PUSL1 modifies U39 of mitochondrial tRNAs and is linked to human neurological phenotypes
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Catalina Vasilescu, PhD @cvasilescu.bsky.social · 09/08/2026
A new issue of #Mitochondria in #Health & #Disease! 📚 biomed.news/bims-mitdis/... 👉 Tau-induced mitochondrial reverse electron transport drives neurodegeneration @biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social @mito-news.bsky.social
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Keshav K Singh, PhD @mitoscientist.bsky.social · 10/08/2026
Marie Curie was the first woman to win a Nobel Prize and the only person to have won Nobel Prizes in two different scientific fields—Physics and Chemistry.
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Catalina Vasilescu, PhD @cvasilescu.bsky.social · 26/07/2026
A new week and a new selection of papers on #Mitochondria in #Health & #Disease! biomed.news/bims-mitdis/... Among highlights 👇 @biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social @mito-news.bsky.social
Epigenetic and 3D genome reprogramming during the aging of the human hippocampus
https://www.science.org/doi/10.1126/science.adt8307
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Keshav K Singh, PhD @mitoscientist.bsky.social · 30/07/2026
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Keshav K Singh, PhD @mitoscientist.bsky.social · 02/07/2026
NorthStrive Biosciences Announces Positive Results from Phase III of AI-Driven Drug Discovery Program with Yuva Biosciences share.google/bZNVVs4opDQf...
share.google
NorthStrive Biosciences Announces Positive Results from Phase III of AI-Driven Drug Discovery Program with Yuva Biosciences
Yuva Biosciences' proprietary MitoNova™ AI platform identified small-molecule candidates that were biologically validated in primary human skeletal muscle cells, with multiple candidates increasing AN...
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Catalina Vasilescu, PhD @cvasilescu.bsky.social · 28/06/2026
A new issue of #Mitochondria in #Health & #Disease! 📚 biomed.news/bims-mitdis/... A few highlights in the comments 👇 @biomednews.bsky.social @mitoscientist.bsky.social @gavinmcstay.bsky.social @mito-news.bsky.social @mitoscientists.bsky.social Subscribe here biomed.news/bims-mitdis
Mitochondrial DNA heteroplasmy drives cortical neuronal disturbances in human organoids harbouring the common m.3243A>G mutation
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Keshav K Singh, PhD @mitoscientist.bsky.social · 28/06/2026
Excited to speak at the Mitochondrial Health and Healthspan: Brain Metabolism and Bioenergetics symposium hosted by the New York Academy of Sciences. 📅 November 11, 2026 📍 New York City Learn more: events.nyas.org/mitochondria26 #Mitochondria #Healthspan #BrainHealth #Longevity #NYAS
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Catalina Vasilescu, PhD @cvasilescu.bsky.social · 21/06/2026
Here it is! 😉 A new collection of papers on #Mitochondria in #Health & #Disease! 📚 biomed.news/bims-mitdis/... 👉 SLC25A3 exports mitochondrial copper to metalate cytochrome c oxidase and prevent cuproptosis @biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social
SLC25A3 exports mitochondrial copper to metalate cytochrome c oxidase and prevent cuproptosis
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MitoMavericks @mitoscientists.bsky.social · 21/06/2026
www.npr.org/2023/06/18/1...?
npr.org
'There is always a way.' 8 pieces of wise life advice from dads
To honor the dads in our lives for Father's Day, we're sharing some of the best life advice our listeners ever got from their dads.
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Keshav K Singh, PhD @mitoscientist.bsky.social · 21/06/2026
It was fun to speak at the Mitochondrial Medicine Conference in Orlando! While it was exciting to discuss the latest developments in mitochondrial medicine, the true highlight was also reconnecting with so many friends and colleagues I’ve known for more than 30 years.
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MitoMavericks @mitoscientists.bsky.social · 20/06/2026
Congratulations to Yijen Wu, Brandon Pham, and Katie Mostoller on receiving the Mitochondria Research and Medicine Society Poster Award at the Mitochondrial Medicine meeting in Orlando! This recognition reflects their hard work, scientific curiosity, and dedication
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Catalina Vasilescu, PhD @cvasilescu.bsky.social · 14/06/2026
A new collection of papers on #Mitochondria in #Health & #Disease! 📚 biomed.news/bims-mitdis/... Highlights 👉 Mitochondria directly interact with the nuclear pore complex @biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mito-news.bsky.social @mitoscientists.bsky.social
Mitochondria-ER contacts function as an iron supply hub
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Keshav K Singh, PhD @mitoscientist.bsky.social · 09/06/2026
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Keshav K Singh, PhD @mitoscientist.bsky.social · 08/06/2026
I'm delighted to be a keynote speaker at the Skin Longevity meeting @ Bath University, UK. I look forward to discussions, new insights, and connecting with colleagues in this exciting field.
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Catalina Vasilescu, PhD @cvasilescu.bsky.social · 07/06/2026
A great new collection on #Mitochondria in #Health & #Disease with papers published last week! 📚 biomed.news/bims-mitdis/... Among highlights: 👉 TDP-43 oxidation and PP1 crosstalk at RNA granule-mitochondria contact sites @biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social
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MitoMavericks @mitoscientists.bsky.social · 06/06/2026
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Catalina Vasilescu, PhD @cvasilescu.bsky.social · 31/05/2026
Absolutely great collection of papers from last week on #Mitochondria in #Health & #Disease! 📚 biomed.news/bims-mitdis/... A few highlighted topics in the comments 👇 @biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mito-news.bsky.social @mitoscientists.bsky.social
Image generated with AI depicting 'mitochondria in blood cells' in watercolor style.
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Catalina Vasilescu, PhD @cvasilescu.bsky.social · 24/05/2026
New selection of papers on #Mitochondria in #Health & #Disease! 📚 biomed.news/bims-mitdis/... Mitochondrial l-2-hydroxyglutarate is a physiological [..] metabolite www.nature.com/articles/s41... @biomednews.bsky.social @mitoscientist.bsky.social @gavinmcstay.bsky.social @mito-news.bsky.social
nature.com
Mitochondrial l-2-hydroxyglutarate is a physiological signalling metabolite - Nature
l-2-Hydroxyglutarate is identified as a legitimate physiological signalling metabolite, and control of its levels is essential for postnatal growth and survival and correct renal development and funct...
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Keshav K Singh, PhD @mitoscientist.bsky.social · 21/05/2026
BREAKING NEWS: Scientists confirmed... "Mitochondria are still the powerhouse of the cell." Humans might forget passwords, anniversaries, and why they headed to the kitchen... but this fact? Stored permanently in the brain 😂😂
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Catalina Vasilescu, PhD @cvasilescu.bsky.social · 17/05/2026
New selection of papers on #Mitochondria in #Health & #Disease! 📚 biomed.news/bims-mitdis/... New tool Universal conditional knockout approach to multiple species.. pubmed.ncbi.nlm.nih.gov/42132111/ @biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mito-news.bsky.social
Universal conditional knockout approach to multiple species, from fish to human induced pluripotent stem cells
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Keshav K Singh, PhD @mitoscientist.bsky.social · 14/05/2026
Honored to speak at the upcoming “Mitochondrial Health and Health Span” symposium hosted by the New York Academy of Sciences on Nov. 11, 2026. Looking forward to engaging with leading researchers and physician-scientists on evolving function of mitochindria. www.nyas.org/shaping-scie...
nyas.org
Mitochondrial Health and Healthspan: Brain Metabolism and Bioenergetics - NYAS
Mitochondrial Health and Healthspan: Brain Metabolism and Bioenergetics will bring together leading researchers and clinician-scientists to explore the central role of mitochondria in brain function, ...
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Catalina Vasilescu, PhD @cvasilescu.bsky.social · 03/05/2026
Latest research collection on #Mitochondria in #Health and #Disease! biomed.news/bims-mitdis/... Nitrogen metabolism profiling reveals cell state-specific pyrimidine synthesis pathway choice www.nature.com/articles/s42... @biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social
Nitrogen metabolism profiling reveals cell state-specific pyrimidine synthesis pathway choice
https://www.nature.com/articles/s42255-026-01520-0
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Catalina Vasilescu, PhD @cvasilescu.bsky.social · 26/04/2026
Last week's selection of papers on #Mitochondria in #Health and #Disease biomed.news/bims-mitdis/... Accelerating Leigh syndrome drug discovery [...] in brain organoids www.nature.com/articles/s41... @gavinmcstay.bsky.social @biomednews.bsky.social @mitoscientist.bsky.social @mito-news.bsky.social
Accelerating Leigh syndrome drug discovery through deep learning screening in brain organoids
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Catalina Vasilescu, PhD @cvasilescu.bsky.social · 19/04/2026
Last 2 weeks of research on #Mitochondria in #Health and #Disease! 📚 biomed.news/bims-mitdis/... biomed.news/bims-mitdis/... Among highlights 👇 www.nature.com/articles/s41... @biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social
nature.com
Cell-type-targeted mitochondrial transplantation rescues cell degeneration - Nature
MitoCatch is a cell-type-specific mitochondrion-targeting system that links mitochondria and the cell surface by protein binders and delivers mitochondria into the target cell.
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MitoMavericks @mitoscientists.bsky.social · 06/04/2026
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Catalina Vasilescu, PhD @cvasilescu.bsky.social · 05/04/2026
Easter edition of #Mitochondria in #Health and #Disease! 🐰🐣 biomed.news/bims-mitdis/... @gavinmcstay.bsky.social @mitoscientist.bsky.social @biomednews.bsky.social @mitoscientists.bsky.social Perling drives mtDNA nucleoid distribution www.science.org/doi/10.1126/...
science.org
Pearling drives mitochondrial DNA nucleoid distribution
The distribution of mitochondrial DNA–containing nucleoids is essential for mitochondrial function and genome inheritance; however, no known mechanisms can explain nucleoid segregation or their regula...
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Catalina Vasilescu, PhD @cvasilescu.bsky.social · 29/03/2026
Latest published research on #Mitochondria in #Health and #Disease! 📚 #week13 biomed.news/bims-mitdis/... @biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social PLIN5 phosphorylation orchestrates mitochondria lipid-droplet coupling to control hepatic lipid flux and steatosis
https://www.nature.com/articles/s42255-026-01476-1
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Catalina Vasilescu, PhD @cvasilescu.bsky.social · 22/03/2026
#Mitochondria in #Health and #Disease - last 2 weeks of published research 📚: biomed.news/bims-mitdis/... biomed.news/bims-mitdis/... @biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social Mito control of glycerolipid synthesis by a PEP shuttle www.cell.com/cell/abstrac...
Mitochondrial control of glycerolipid synthesis by a PEP shuttle
https://www.cell.com/cell/abstract/S0092-8674(26)00224-2?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867426002242%3Fshowall%3Dtrue
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Catalina Vasilescu, PhD @cvasilescu.bsky.social · 08/03/2026
Last 2 weeks of literature on #Mitochondria in #Health & #Disease! 🤍 💚 biomed.news/bims-mitdis/... biomed.news/bims-mitdis/... @biomednews.bsky.social @mitoscientist.bsky.social @gavinmcstay.bsky.social Vit B2 and B3 nutrigenomics reveals a therapy for NAXD disease www.cell.com/cell/fulltex...
cell.com
Vitamin B2 and B3 nutrigenomics reveals a therapy for NAXD disease
A nutrigenomics framework identifies genetic diseases amenable to vitamin B2 and B3 therapies. This approach nominates vitamin B3 as a therapy for NAXD deficiency, a lethal neurodevelopmental disorder...
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Keshav K Singh, PhD @mitoscientist.bsky.social · 28/02/2026
Rare Disease Day – 28 February 2026 Let’s unite to improve diagnosis and understanding of mitochondrial disease. These rare conditions can affect any organ, at any age, impacting at least 1 in 4,000 people. Greater awareness and research are vital. #RareDiseaseDay #MitochondrialDisease
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Catalina Vasilescu, PhD @cvasilescu.bsky.social · 22/02/2026
A wonderful collection of literature from #week8 on #Mitochondria in #Health & #Disease! 📚 biomed.news/bims-mitdis/... @biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social A [...] bifunctional enzyme mitigates redox imbalance and lipotoxicity www.nature.com/articles/s42...
nature.com
A genetically encoded bifunctional enzyme mitigates redox imbalance and lipotoxicity - Nature Metabolism
The authors present a genetically encoded tool based on a bifunctional enzyme that can regenerate NAD+ while executing an engineered glycerol shunt. The tool successfully restored redox imbalance and ...
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Keshav K Singh, PhD @mitoscientist.bsky.social · 12/02/2026
The next big thing in wellness is mitochondrial health. www.vox.com/advice/47803...
vox.com
The next big thing in wellness is…mitochondria?
People are suddenly very concerned about the powerhouse of the cell.
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Catalina Vasilescu, PhD @cvasilescu.bsky.social · 08/02/2026
A new collection of papers on #Mitochondria in #Health and #Disease! #MitochondrialDisease 📚 biomed.news/bims-mitdis/... @biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social Mt superoxide regulates nuclear integrity and ageing via lipid metab www.nature.com/articles/s42...
nature.com
Mitochondrial superoxide regulates nuclear envelope integrity and ageing via redox-mediated lipid metabolism - Nature Metabolism
Mitochondrial superoxide production is shown to preserve nuclear envelope integrity by controlling lipid peroxidation, with impact on nuclear and organismal ageing in C. elegans.
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Keshav K Singh, PhD @mitoscientist.bsky.social · 06/02/2026
Mitochondria painting - without the pain(t). Unvarnished mitochondrial biology, live, and at scale.
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Catalina Vasilescu, PhD @cvasilescu.bsky.social · 01/02/2026
A new collection of papers from #week5 on Mitochondria in Health & Disease! #MitochondrialDisease biomed.news/bims-mitdis/... @biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social Among highlights www.nature.com/articles/s41...
nature.com
ALKB-1-dependent tRNA methylation is required for efficient paternal mitochondrial elimination - Nature Communications
For proper mitochondrial inheritance, paternal sperm mitochondria must be eliminated. Here, authors identify ALKB-1 mediated tRNA demethylation as essential for this clearance in Caenorhabditis elegan...
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Catalina Vasilescu, PhD @cvasilescu.bsky.social · 25/01/2026
A new collection of papers on Mitochondria in Health and Disease! #week3 #MitochondrialDisorders biomed.news/bims-mitdis/... @biomednews.bsky.social @mitoscientist.bsky.social @gavinmcstay.bsky.social Human mitochondrial helicase Twinkle has RNA binding, annealing, and strand-exchange activities
https://academic.oup.com/nar/article/54/2/gkag008/8433879?login=false
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Catalina Vasilescu, PhD @cvasilescu.bsky.social · 18/01/2026
Latest collection of papers on mitochondria in health and disease! #MitochondrialDisease #week3 biomed.news/bims-mitdis/... @biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social www.nature.com/articles/s42...
nature.com
Hexokinase detachment from mitochondria drives the Warburg effect to support compartmentalized ATP production - Nature Metabolism
Hexokinase detachment from the outer mitochondrial membrane is shown to support aerobic glycolysis in cancer cells. Differential localization of the HK1 isoform to the outer mitochondrial membrane, co...
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Keshav K Singh, PhD @mitoscientist.bsky.social · 16/01/2026
I asked AI to describe my contribution to the mitochondrial field. Received this. It's quite impressive and pretty accurate.
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Keshav K Singh, PhD @mitoscientist.bsky.social · 12/01/2026
Excited to speak at the symposium “Artificial Intelligence in Mitochondrial Medicine” 🧬 Exploring how AI is transforming mitochondrial medicine 📍 Pisa, Italy | 🏨 Hotel Galilei 📅 Jan 23, 2026 #AIinMedicine #MitochondrialMedicine #DigitalHealth #PrecisionMedicine
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Catalina Vasilescu, PhD @cvasilescu.bsky.social · 11/01/2026
Last 2 weeks of research papers relevant to #MitochondrialDisease! biomed.news/bims-mitdis/... biomed.news/bims-mitdis/... @biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social Mitochondrial control of fuel switching via carnitine biosynthesis www.science.org/doi/10.1126/...
science.org
Mitochondrial control of fuel switching via carnitine biosynthesis
Environmental adaptation often involves a shift in energy utilization toward mitochondrial fatty acid oxidation, which requires carnitine. Besides dietary sources of animal origin, carnitine biosynthe...
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Nature Metabolism @natmetabolism.nature.com · 31/12/2025
Reviews/Perspectives Top #Citations 2025: 🥇🧪 Jonathan Brestoff (Washington U Dept Med), Keshav Singh (@mitoscientist.bsky.social, U Alabama) et al. Recommendations for mitochondria transfer and transplantation nomenclature and characterization
nature.com
Recommendations for mitochondria transfer and transplantation nomenclature and characterization - Nature Metabolism
This Consensus Statement provides a nomenclature framework and experimental recommendations for studying mitochondrial transfer and transplantation.
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Nature Metabolism @natmetabolism.nature.com · 31/12/2025
Reviews/Perspectives Top #Altmetric 2025: 🥇🧪 Jonathan Brestoff (Washington U Dept Med), Keshav Singh (@mitoscientist.bsky.social, U Alabama) et al. Recommendations for mitochondria transfer and transplantation nomenclature and characterization
nature.com
Recommendations for mitochondria transfer and transplantation nomenclature and characterization - Nature Metabolism
This Consensus Statement provides a nomenclature framework and experimental recommendations for studying mitochondrial transfer and transplantation.
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Keshav K Singh, PhD @mitoscientist.bsky.social · 31/12/2025
🌹🌹May all that is beautiful and meaningful and brings you and your family joy be yours throughout the coming year! Wish you a very happy new year!🌹🌹
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Catalina Vasilescu, PhD @cvasilescu.bsky.social · 28/12/2025
End-of-year selection of papers on #MitochondrialDisease! 📚 biomed.news/bims-mitdis/... @biomednews.bsky.social @mitoscientist.bsky.social @gavinmcstay.bsky.social @mitoscientists.bsky.social Have a great 2026! ✨
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