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Ottawa Institute of Systems Biology

@oisb-ibso.bsky.social
126 followers 486 following 42 posts

Collaboration to address Canada's emerging health challenges www.uottawa.ca/research-innovation/…

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Michelle Momany @mcmomany.bsky.social · 08/10/2026
Join us in UGA Fungal Group! Dept of Microbiology is hiring tenure track Associate or Full prof in Medical Mycology pursuing translational and/or fundamental understanding of human fungal pathogens using any experimental or computational system. www.ugajobsearch.com/postings/508...
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Friedrich Förster @fridof.bsky.social · 07/10/2026
Can RNA itself drive toxicity in Huntington’s disease? Join the Kaiser lab (Bijvoet Centre, Utrecht University) to tackle this question using cutting-edge single-molecule biophysics, optical tweezers & fluorescence microscopy. www.uu.nl/en/organisat...
uu.nl
PhD Position on Biophysical Origins of RNA Toxicity in Huntington’s Disease
Exciting Opportunity for a PhD Researcher: Join our team to investigate molecular mechanisms in Huntington’s Disease!
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Tung Le @tunglejic.bsky.social · 08/10/2026
🚨PhD opportunity alert!!! Come work with us on this new cool NERC DTP PhD project Investigate How Bacterial Hosts Control Domesticated Viral Machines to Drive Horizontal Gene Transfer in Marine Environments. Retweet = nice. Thank you!!! aries-dtp.ac.uk/studentships...
aries-dtp.ac.uk
Investigate How Bacterial Hosts Control Domesticated Viral Machines to Drive Horizontal Gene Transfer in Marine Environments? | Aries
Professor Tung Le, John Innes Centre – contact me Professor Jonathan Todd, Quadram Institute & UEA Dr Ngat Tran, John Innes Centre Horizontal gene transfer (HGT) is a major driver of bacterial…
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Science Magazine @science.org · 08/10/2026
Mammalian cells produce and store a sulfur compound for antioxidant protection. Learn more in a new #SciencePerspective: scim.ag/46FAqIx
scim.ag
King sulfur
Mammalian cells produce and store a sulfur compound for antioxidant protection
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Science Magazine @science.org · 07/10/2026
This year’s Nobel Prize in Chemistry honors Henri Kagan of the Université Paris-Sud and Kenso Soai of Tokyo University of Science for providing clues to how life’s one-handed chemistry might have emerged. Learn more: scim.ag/3Vobwe7
Nobel Prize honors researchers who solved chemistry's asymmetry mystery
Henri Kagan and Kenso Soai win award for reactions leading to one-handed molecules
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Baptiste Lacoste @blacoste.bsky.social · 07/10/2026
Some local news 🤩 #Autism #BasicScience
ottawacitizen.com
Ottawa study reverses autism symptoms in mice, first step to developing drug treatment
Researchers fixed a problem in blood brain vessels, a first step to developing a drug treatment for humans.
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Epigenome Technologies @epigenometech.bsky.social · 05/10/2026
New Epigenome Technologies Blog! epigenometech.com/blog/posts/2... "Replication Stress Induces Genome Organization via G9a and CTCF" Links between chromatin changes and higher-order genome organization maintain genome integrity in response to replication stress #Blog #Chromatin #Epigenetics
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Anthony Hessel, PhD @hesselanthony.bsky.social · 05/10/2026
What a fantastic visit to Prof. Charles Chung lab at the Department of Physiology, School of Medicine, Wayne State University Wayne State University School of Medicine.
Giving a department lecture. Back slides show muscle Xray diffraction patterns. Charles Chung and Anthony Hessel on the Wayne State Medical School campus.Downtown Detroit Skyline
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Science Magazine @science.org · 05/10/2026
A recent analysis in Science of more than 116,000 bird songs has revealed that the astonishing variety of passerine birdsong is built from just eight basic acoustic motifs, like trills, whistles, and harmonic notes. Learn more on #WorldAnimalDay: scim.ag/3SziyeL
A phylogenetic distribution and trait correlates of acoustic motifs in passerine birds. Hedline reads: The global biogeography of passerine songs
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Benoit Bruneau @benoitbruneau.bsky.social · 04/10/2026
Happy Pluripotency Day! #Oct4
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Takashi Akera Lab @takashiakeralab.bsky.social · 04/10/2026
I want to thank my entire lab for organizing an amazing tenure celebration party!🎊 We will continue pursuing crazy biology in chromosomes and reproduction 🧬
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George O'Toole (he/him/his) @geiselbiofilm.bsky.social · 02/10/2026
Excited to be part of another collaboration with my colleague Mark Sundrud exploring the impact of bile on immune regulation. This study is lead by Mark's postdoc, Zhiping Xiao. pubmed.ncbi.nlm.nih.gov/42779649/
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Nacho Molina @molinalab.bsky.social · 03/10/2026
It was a pleasure to collaborate on this beautiful piece of work led by Susan Mango: nature.com/articles/s41...
nature.com
Single-molecule chromatin tracing reveals a diversity of megabase heterochromatin domains - Nature Structural & Molecular Biology
Single-molecule imaging reveals diverse, megabase-scale heterochromatin domains in C. elegans. Some resemble TADs and depend on condensin I; others are independent of condensin and histone H3K9me, inc...
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Sheila Teves @sheilateves.bsky.social · 02/10/2026
Welcome to the Teves lab's newest Masters student Jordan Lam! teveslab.wordpress.com
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Andrew Santiago-Frangos @asantiagofrangos.bsky.social · 01/10/2026
Our lab's first preprint! The antiphage protein Tiamat is an ATPase and DNase with homologs across the tree of life. What started as undergrad Shirley Yuan's summer project grew into a paper and a collaboration with @jpkbravo.bsky.social's group. Link: www.biorxiv.org/content/10.6...
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GIIN @genomeiinetwork.bsky.social · 01/10/2026
Our next seminar is on Tuesday, October 6 from 5-6PM (Rome), 11-12AM (NYC). We are excited to host two fantastic speakers Jo Morris and @garinis.bsky.social, who will share their latest research with us. Don't miss it! Zoom link: uzh.zoom.us/j/6598481621...
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Kelly Dawe @corncolors.bsky.social · 01/10/2026
The UGA Genetics Department is hiring! Please help spread the word. We have an opening for an Associate Professor/Professor in Genetics, Synthetic Biology, and Biological Engineering. See ad for details – and join us here in Athens, GA!
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FragileNucleosome @fnucleosome.bsky.social · 02/10/2026
📢🧬Join us on Wednesday, Oct 7th for the next #FragileNucleosome seminar to hear exciting chromatin stories from Moonmoon and Paul! If you still haven't registered for our series: us06web.zoom.us/webinar/regi...
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Ellen Leffler @ellenleffler.bsky.social · 30/09/2026
My department at University of Utah is recruiting new faculty, with "Human" and "Genetics" broadly defined. It is a fantastic place to start a lab, with collaboration, creativity and conviviality encouraged. Applications due Oct 16. Please share and apply! utah.peopleadmin.com/postings/208...
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Whitehead Institute @whiteheadinstitute.bsky.social · 01/10/2026
Two Whitehead Institute Members have received Bose Research Grants: @iaincheeseman.bsky.social will study overlooked versions of known proteins to understand their contribution to disease. Siniša Hrvatin will explore how some animals survive freezing to advance cryopreservation tinyurl.com/5csd3ejj
tinyurl.com
Whitehead Institute Members Iain Cheeseman and Siniša Hrvatin receive Bose Research Grants | Whitehead Institute
Whitehead Institute Members Iain Cheeseman and Siniša Hrvatin have each received a Professor Amar G. Bose Research Grant, which supports ambitious MIT faculty research that may be too early, explorato...
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Reposted by Ottawa Institute of Systems Biology
Mathilda Lennartz @mathilda95.bsky.social · 30/09/2026
UPDATE!: I am absolutely stoked that the second paper of my PhD is now out in @natcellbio.nature.com :D. We combined lipid imaging, STED microscopy, and mathematical modelling in a super cool team effort to quantify lipid partitioning inside clathrin-coated pits. www.nature.com/articles/s41....
nature.com
Quantification of lipid sorting during clathrin-mediated endocytosis - Nature Cell Biology
Lennartz et al. evaluate lipid enrichment in clathrin-coated pits and observe that the differential lipid partitioning into clathrin-coated pits is largely driven by the lipid asymmetry of the plasma ...
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W. Brent Derry @wbderry.bsky.social · 30/09/2026
Faculty position at the University of Toronto 👇 jobs.utoronto.ca/job/Toronto-...
jobs.utoronto.ca
Assistant Professor - Systems Neurophysiology
Assistant Professor - Systems Neurophysiology
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Baptiste Lacoste @blacoste.bsky.social · 30/09/2026
🚨 Excited to share that our new paper is published today in Neuron ! We show that P2Y2 receptor activation restores cerebrovascular function and reverses behavioural impairments in mice carrying a 16p11.2 deletion. #Autism #Publication #BasicScience www.cell.com/neuron/fullt...
cell.com
Purinergic receptor activation rectifies autism-associated endothelial dysfunction
Ouellette et al. report that a 16p11.2 deletion induces a bioenergetic failure in brain endothelial cells. Activation of purinergic signaling via P2Y2 receptors restored endothelial function and impro...
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George O'Toole (he/him/his) @geiselbiofilm.bsky.social · 28/09/2026
The newest issue of JB is out! A swarm is featured on the cover. Check out the newest minireviews, research articles and this month a special historical piece. journals.asm.org/toc/jb/208/9 @asm.org #JBacteriol @microsky.bsky.social
journals.asm.org
JB Table of Contents Volume 208, Issue 9
Journal of Bacteriology: Table of Contents Volume 208, Issue 9
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Miguel Ramalho-Santos @mrsantos.bsky.social · 28/09/2026
We are recruiting at the Lunenfeld-Tanenbaum Research Institute (LTRI) and the University of Toronto! In the areas of Reproduction, Pregnancy and Developmental Biology, at Assistant or Associate Professor level. Deadline: Nov 29, 2026 Find more and apply👇: 🔗 apply.interfolio.com/192324
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Saccharomyces Genome Database @yeastgenome.bsky.social · 28/09/2026
🗑️ #Yeast nuclear ubiquitin ligase Uls2 has surprising side job: tagging cytosolic proteins for degradation. Orphaned/ oxidatively damaged proteins aggregate in nucleus & become SUMO-dependent substrate ➡️ = compartment-spanning QC pathway 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...
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Kimberly Beatty @beattylab.bsky.social · 28/09/2026
Please share: OHSU is hiring an Assistant Prof. in the Dept. of Chemical Physiology & Biochemistry. We are looking for a chemical biologist who will apply novel chemical tools in physiological systems. Apply online: www.ohsu.edu/human-resour... (Job # 2026-41667).
ohsu.edu
OHSU Faculty, Physician and Academic Jobs in Oregon
Find higher education faculty, physician and research jobs and build your academic health career at OHSU in Portland, Oregon.
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Kacy Gordon @kacylynn.bsky.social · 28/09/2026
JOB ALERT: UNC Bio is hiring 2 tenure track assistant profs doing molecular, cell, and dev bio. The search is intentionally broad, so please share widely and spread the word! Find more information and apply here: unc.peopleadmin.com/postings/325... Application review begins Nov 1.
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Alejandro Manzano Marín @amanzanom.bsky.social · 28/09/2026
A #transcriptionFactor regulates development of a bacteria-housing eukaryotic cell through DNA damage mitigation by the Luan lab (not in here...) doi.org/10.1073/pnas... #SymbioSky
doi.org
A transcription factor regulates development of a bacteria-housing eukaryotic cell through DNA damage mitigation | PNAS
Intracellular microorganisms are widespread and housed within specialized host cells called bacteriocytes in many invertebrates. Although increasin...
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Michel Cayouette @michelcayouette.bsky.social · 28/09/2026
If you are a postdoc looking for opportunities to present your latest results, apply to our Early-Career Scientists Seminar Series (ECS3) to get invited to our Institute, all expenses paid. A unique opportunity! Apply here: www.ircm.qc.ca/en/ecs3
ircm.qc.ca
ECS3
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Vivek Mutalik @vivekmutalik.bsky.social · 03/04/2026
📣Huge preprint 🔔 Today we share something our group has been working toward for a long time, led by @lucasmoriniere.bsky.social We asked can we predict which receptor a phage targets from its genome sequence alone? For most phages, we couldn’t. So Lucas set out to do something I had only dreamed of.
Phage receptor prediction from genome sequencing alone. Bacterial receptor (blue) interacting with phage proteins (purple) is shown here
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Igor Brodsky @brodskyigorlab.bsky.social · 27/09/2026
The power of funding fundamental discovery in driving unexpected benefits for humankind are unmatched. We should be funding more basic research not less
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erzbergerlab.bsky.social @erzbergerlab.bsky.social · 28/09/2026
www.nature.com/articles/s41...
nature.com
Cotranslational membrane protein biogenesis by an EMC-bound translocon - Nature Structural & Molecular Biology
The authors use selective ribosome profiling, cryo-ET and site-specific photocrosslinking to show how the ER membrane protein complex (EMC) cooperates with ribosome-bound translocons to facilitate mul...
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Holly Moeller @mixotrophe.bsky.social · 27/09/2026
🚨We're hiring!🚨 Join us as a laboratory technician to work on acquired metabolism, from tree-fungal mutualisms to the evolution of protistan photosynthesis. Apply by Oct. 7 at careerspub.universityofcalifornia.edu/psp/ucsb/EMP...
careerspub.universityofcalifornia.edu
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Joshua Weitz @joshuasweitz.bsky.social · 28/09/2026
Wonderful profile of our new colleague in the Dept. of Biology in Maryland, @couchmicroscopy.bsky.social with secrets yet to be uncovered into a major evolutionary transition hanging out in murky waters. www.nytimes.com/2026/09/26/s...
nytimes.com
In an $80 Motel Room, a Discovery to Shed Light on the Origins of Life (Gift Article)
A scrappy science project led to a significant discovery: two new species of a rare organism that could elucidate a fundamental transition in the history of life on our planet.
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Lawrence Rudy Cadena @rudycadenabioevo.bsky.social · 27/09/2026
Our paper on the subcellular proteome of Paulinella is finally out! A possible oxygen-scavenging mechanism to enhance RuBisCO carboxylation highlights how protists can reveal unexpected solutions to challenges in photosynthesis. Big kudos to everyone involved! @evanowack.bsky.social
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Prof Jenny Rohn @jennyrohn.bsky.social · 28/09/2026
"P. aeruginosa subverts mucosal immunity and establishes a self-sustaining immunopathological loop, offering potential targets for #CF precision therapies." really interesting - may have analogies in other infections too #MicroSky #ImmunoSky #IDSky
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Leah Smith @leahmsmith.bsky.social · 28/09/2026
Adapting the power of transposon sequencing to phages! Our final paper is out now👇 Our plasmids 🧬 are available on @addgene.bsky.social – try phage Tn-seq on your favorite phage!
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Alejandro Montenegro @aemonten.bsky.social · 27/09/2026
I'm sorry, what now? www.cell.com/cell/fulltex...
cell.com
Direct cell-to-cell transmission of retrotransposons
Retrotransposons can infect neighboring cells using a mechanism that relies on a small fusogen-like protein rather than on the envelope protein that is typically required for infection.
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joe dobbs @joedobbs.bsky.social · 25/09/2026
Our work investigating the cooperation between gene expression machines is now online @cellpress.bsky.social. Check it out if you're interested in high-throughput #cryoET, transcription and translation, or using structural biology to quantify gene expression in cells! 🔬 www.cell.com/cell/fulltex...
cell.com
Single-cell visual proteomics of a minimal bacterium reveals structural coordination of gene expression machineries
Cryo-electron tomography (cryo-ET) resolves and quantifies an almost complete view of bacterial translation, revealing how gene expression machineries coordinate across the processes of transcription,...
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bioRxivpreprint @biorxivpreprint.bsky.social · 25/09/2026
Regulation of polyphosphate homeostasis in S. cerevisiae by the Sky1 protein kinase www.biorxiv.org/content/10.64898/20…
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Ákos T Kovács @evolvedbiofilm.bsky.social · 25/09/2026
Here it is online, a week after the teaser talk at #EMBOBacNet... @natmicrobiol.nature.com by @humollidorentina.bsky.social et al from @aharms485.bsky.social with @veeninglab.com Systematic mapping of bacteriophage gene essentiality with HIDEN-SEQ www.nature.com/articles/s41...
nature.com
Systematic mapping of bacteriophage gene essentiality with HIDEN-SEQ - Nature Microbiology
HIDEN-SEQ (hidden Acr-enabled transposon-insertion sequencing) is a transposon-insertion sequencing method for phages that systematically links their genes to selectable phenotypes.
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Ottawa Institute of Systems Biology @oisb-ibso.bsky.social · 25/09/2026
New polyphosphate work from the Downey Lab @oisb-ibso.bsky.social : www.biorxiv.org/content/10.6...
biorxiv.org
Regulation of polyphosphate homeostasis in S. cerevisiae by the Sky1 protein kinase
Eukaryotic cells store inorganic phosphate in the form of long chains called polyphosphates (polyP) that can reach many hundreds of residues in length. In the budding yeast Saccharomyces cerevisiae, p...
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George O'Toole (he/him/his) @geiselbiofilm.bsky.social · 24/09/2026
Pls ahre: Open recruitment in the new Department of Systems Biology at UC Irvine. Assistant Professor in Systems Biology, experimental or theoretical, who will complement existing strengths in the department (systems.bio.uci.edu). Application link: recruit.ap.uci.edu/JPF10377
systems.bio.uci.edu
Systems Biology | UC Irvine Charlie Dunlop School of Biological Sciences
Welcome to the Department of Systems Biology at UC Irvine Leading the way to Discovery, Explanation, and Prediction Department of […]
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Jan-Ulrik Dahl (Dahl lab, ISU) @janulrikdahl.bsky.social · 25/09/2026
Join us and become my colleague! The School of Biological Sciences is opening the search for an Assistant Professor in the field of Host-Microbe Interactions with the targeted start date of Fall 2027. Please reach out to me with any questions you have: jobsearch.illinoisstate.edu/jobs/assista...
jobsearch.illinoisstate.edu
ASSISTANT PROFESSOR IN HOST-MICROBE INTERACTIONS (IMMUNOLOGY, MICROBIOLOGY) - Normal, Illinois, Illinois, United States
Title: ASSISTANT PROFESSOR IN HOST-MICROBE INTERACTIONS (IMMUNOLOGY, MICROBIOLOGY)Employee Classification: Asst ProfessorDivision Name: Academic AffairsCollege/Unit: College of Arts and SciencesDepart...
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Gautam Dey @gautamdey.bsky.social · 24/09/2026
Proud to contribute the World’s Hottest Mitotic Spindle™️ to this incredible study @fmikus.bsky.social @dudinlab.bsky.social #ProtistsOnSky
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Ottawa Institute of Systems Biology @oisb-ibso.bsky.social · 25/09/2026
New polyphosphate work from the Downey Lab @oisb-ibso.bsky.social : www.biorxiv.org/content/10.6...
biorxiv.org
Regulation of polyphosphate homeostasis in S. cerevisiae by the Sky1 protein kinase
Eukaryotic cells store inorganic phosphate in the form of long chains called polyphosphates (polyP) that can reach many hundreds of residues in length. In the budding yeast Saccharomyces cerevisiae, p...
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Reposted by Ottawa Institute of Systems Biology
Maitreya Dunham @maitreya.bsky.social · 24/09/2026
Exciting news: @uwgenome.bsky.social will be hiring for two tenure-track faculty positions this year, one open rank and one assistant professor. Both are “Genome Sciences” interpreted broadly so we welcome applicants working in a variety of fields and methods. Ad will be out shortly.
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Duerkop Lab @duerkoplab.bsky.social · 23/09/2026
Better late than never. Congrats to former PhD trainee Shelby Andersen on the publication of RADS. RADS identifies antiphage defense systems connected to small serine recombinases. The question remains, why are defense systems often placed in this context? 🤔 journals.plos.org/plosbiology/...
journals.plos.org
Small serine recombinases are markers for antiphage defense system discovery
Identifying antiphage defense systems is challenging for bacterial species where such systems are understudied. This study describes a bioinformatic pipeline that uses a small serine recombinase as a ...
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John Rubinstein @johnrubinstein.bsky.social · 24/09/2026
The @structurabio.bsky.social @sickkidsto.bsky.social CryoSPARC workshop is underway!
Instructor Rich Waldo presents slides on advanced topics in cryo-EM image analysis to an attentive class.
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