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Saccharomyces Genome Database @yeastgenome.bsky.social · 03/10/2026

🧘 #Yeast RPL22 pre-mRNA acts as its own regulator. The intron toggles between 2 competing structures: one blocks splicing, one permits it. Rising Rpl22 levels shift the balance toward inhibition, creating a protein-responsive RNA switch 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

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Saccharomyces Genome Database @yeastgenome.bsky.social · 03/10/2026

♻️ #Yeast Acs2 generates acetyl-CoA locally at chromatin, while its mammalian ortholog ACSS2 also recaptures acetate from histone deacetylation at promoters. This acetate recycling loop couples metabolism ↔️ chromatin state across species 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

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Saccharomyces Genome Database @yeastgenome.bsky.social · 01/10/2026

New on SGD gene pages: #EC numbers for enzymes, #AlphaFold structure thumbnails for all in the Protein section! Click through to Protein Details for interactive AlphaFold viewer, domains, modification sites, more! #yeast HOG1: www.yeastgenome.org/locus/hog1#p... www.yeastgenome.org/blog/enzyme-...

SGD gene pages include EC numbers (where assigned) and AlphaFold structure thumbnails in the Protein section.

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Saccharomyces Genome Database @yeastgenome.bsky.social · 30/09/2026

New on SGD gene pages: #Regulation summary graphic! See how many putative Regulators and Targets a gene has, based on experimental evidence. Click for all regulation annotations and a regulator/target diagram. Try #HOG1: www.yeastgenome.org/locus/S00000... #yeast www.yeastgenome.org/blog/new-reg...

Horizontal bar graph showing 83 Targets and 22 Regulators for HOG1 on its SGD Regulation page.

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Saccharomyces Genome Database @yeastgenome.bsky.social · 30/09/2026

🏋️ Not all #Yeast strains handle acetic acid equally. Respiratory capacity and carbon flux determine survival under acid stress, and two S. cerevisiae strains show strikingly different responses with implications for strain engineering 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

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Saccharomyces Genome Database @yeastgenome.bsky.social · 29/09/2026

🧲 How does #Yeast CAF-1 find the replication fork to deposit histones? Via PCNA, using not 1 but 2 PIP motifs. The newly found PIP1β makes atypical extended contacts w/second PCNA subunit; disrupting both motifs abolishes CAF-1 function 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

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Saccharomyces Genome Database @yeastgenome.bsky.social · 28/09/2026

🗑️ #Yeast nuclear ubiquitin ligase Uls2 has surprising side job: tagging cytosolic proteins for degradation. Orphaned/ oxidatively damaged proteins aggregate in nucleus & become SUMO-dependent substrate ➡️ = compartment-spanning QC pathway 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

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Saccharomyces Genome Database @yeastgenome.bsky.social · 26/09/2026

🫧 Autophagosome membranes don't just grow by lipid transfer. #Yeast cryo-ET shows vesicles clustering around and fusing with the phagophore rim during expansion, a contribution that was previously attributed only to the nucleation stage 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

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Saccharomyces Genome Database @yeastgenome.bsky.social · 24/09/2026

⛓️‍💥 In #Yeast a broken helicase can be worse than no helicase. Inactive Hrq1 binds DNA but can't unwind it= 🙅 inter-strand crosslink repair. ➡️ Sheds light on how partial LoF mutations in human RECQL4 may similarly disrupt genome stability. 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

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Saccharomyces Genome Database @yeastgenome.bsky.social · 24/09/2026

✂️ The spliceosome has to shed Dib1 before it can start cutting RNA. New #Yeast research shows Dib1's C-terminal tail is what keeps it docked near the catalytic core via Prp8 and Prp31, and losing that tail is enough to kill the cell. 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

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Saccharomyces Genome Database @yeastgenome.bsky.social · 23/09/2026

🍷🧬 Save the date! #ICYGMB2027 the 33rd Int'l Conference on Yeast Genetics & Molecular Biology comes to Porto, Portugal, July 19-22, 2027! A stellar international lineup of speakers + 16 workshops across yeast biology. Full details 👉 www.i3s.up.pt/ICYGMB2027 #YeastGenetics

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Saccharomyces Genome Database @yeastgenome.bsky.social · 23/09/2026

🛟 When DNA breaks in #Yeast, Tel1 phosphorylates Rad9, driving its self-assembly to hold broken ends together & steer repair toward homologous recombination. A Tel1 FAT-domain variant reveals this axis by rescuing end-tethering defects 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

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Saccharomyces Genome Database @yeastgenome.bsky.social · 22/09/2026

📈 #Yeast Dhh1 (human DDX6) bridges deadenylation and decapping in mRNA decay, but how it's activated was unclear. Edc3 and Not1 tune its ATPase activity through distinct mechanisms, cooperating for a 200-fold boost 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

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Saccharomyces Genome Database @yeastgenome.bsky.social · 15/09/2026

🕳️ #Yeast CCP isn't just an H₂O₂ scavenger, it's a sensor. When H₂O₂ spikes in respiring mitochondria, hole hopping oxidizes H175, releasing the heme to activate catalase A and keep the ETC running efficiently. Also, oxene≠ox...or does it? 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

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Saccharomyces Genome Database @yeastgenome.bsky.social · 14/09/2026

🔬 Single #Yeast cells trapped in alginate microspheres ➡️ every division is traceable. Confocal microscopy + a mathematical formula reconstructs the full replicative history of a founder cell, revealing age of every cell in the microcolony 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

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Saccharomyces Genome Database @yeastgenome.bsky.social · 12/09/2026

🔄 A single amino acid change in histone H2A causes transcription chaperone yFACT to pile up at the wrong end of genes. H2A's docking domain is essential for yFACT to release properly after transcription @micropub7n.bsky.social 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

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Saccharomyces Genome Database @yeastgenome.bsky.social · 11/09/2026

🥝🍷 Spontaneous fermentation makes complex wines but risks spoilage. High #Yeast inoculum in semi-spontaneous kiwifruit fermentation cuts acetic acid while retaining indigenous microbiota that boost fruity esters and floral terpenoids 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

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Saccharomyces Genome Database @yeastgenome.bsky.social · 09/09/2026

⚗️ Getting proteins out of #Yeast efficiently isn't just a downstream problem. Cultivation pH, growth phase, culture mode & glucose availability all reshape the cell wall, directly affecting how much protein mild disruption can recover 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

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Saccharomyces Genome Database @yeastgenome.bsky.social · 09/09/2026

A plug-n-play platform for evolving yeast rDNA identifies variants that improve noncanonical amino acid incorporation across tRNA synthetase/tRNA pairs, establishing ribosome engineering as a route to eukaryotic genetic code expansion 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

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Saccharomyces Genome Database @yeastgenome.bsky.social · 05/09/2026

🔬 How does #Yeast build a kinetochore on DNA that resists nucleosome formation? Cryo-EM reveals 4 complexes, 2 never seen before. Ndc10 trimerization stabilizes the inner kinetochore. Without it, assembly & chromosome segregation fail 🧬 #YeastResearch 🧪 #SGD 🔬 yeastgenome.org/reference/S1...

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Saccharomyces Genome Database @yeastgenome.bsky.social · 03/09/2026

🛠️ Bacteria have long had plasmids w/tunable copy numbers. Eukaryotes haven't, until now: new #Yeast platform =stable, programmable gene dosage control across a 109-copy range. Applications from #MetabolicEngineering ➡️ strain preservation 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

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Saccharomyces Genome Database @yeastgenome.bsky.social · 03/09/2026

⚗️ L-tartaric acid is essential for food and pharmaceuticals but typically extracted from grapes. #Yeast can now make it from scratch via a de novo pathway combining computational enzyme mining, cofactor engineering, & protein design 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

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Saccharomyces Genome Database @yeastgenome.bsky.social · 02/09/2026

🌳 @bloomingtonindiana.bsky.social grad students isolated wild #Yeast from a 230-year-old campus oak & partnered with local breweries to produce a fruity-funky ale for the US 250th anniversary🍻 🔥 Place-based, community-embedded CUREs 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

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Saccharomyces Genome Database @yeastgenome.bsky.social · 31/08/2026

🧠 #Yeast cells remember where they divided. Bud neck septin double ring acts as a selective spatial memory, concentrating proteins that mark cytokinetic remnants & preserving molecular record of division to subsequent cell generations 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

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Saccharomyces Genome Database @yeastgenome.bsky.social · 29/08/2026

🔋 Mitochondrial cristae house the machinery of cellular respiration & their shape is inseparable from their function. A new review across animals, yeast, & protists reveals shared & divergent mechanisms for building these subcompartments 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

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Saccharomyces Genome Database @yeastgenome.bsky.social · 28/08/2026

💡 Looking for a publication in SGD? Quick tip: 🧬 The Locus Summary shows footnotes for that specific page 📚 The Literature tab has the COMPLETE reference list organized by topic. Find all curated publications for any gene there! Read more: www.yeastgenome.org/blog/finding... #YeastResearch 🧪 #SGD 🔬

static.klipy.com

Belle in Beauty and the Beast Library

ALT: Belle in Beauty and the Beast Library

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Saccharomyces Genome Database @yeastgenome.bsky.social · 27/08/2026

🥊 Before Rps2 even reaches the nucleus, chaperone Tsr4 & importin Pse1 compete for same region. Tsr4 wins on affinity, but Pse1 compensates by contacting additional sites on full-length Rps2, enabling nuclear import for ribosome assembly 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

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Saccharomyces Genome Database @yeastgenome.bsky.social · 26/08/2026

🎛️ Pah1 controls whether yeast cells store fat or build membranes, and its activity depends on where it sits in the cell. Pho85-Pho80 primes Rim11, keeping Pah1 in the cytosol and tuning expression of the phospholipid enzyme Cho1 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

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Saccharomyces Genome Database @yeastgenome.bsky.social · 25/08/2026

🔢 Mer2 has 4 binding sites for the chromatin reader Spp1, but only 2 ever get filled, always opposite sides of complex. Allostery likely explains the pattern, with one Spp1 subunit blocking adjacent sites while activating opposite one 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

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Saccharomyces Genome Database @yeastgenome.bsky.social · 22/08/2026

🍷 Wine yeast domestication story: Despite bottleneck during domestication, #Yeast developed striking genome dynamism - varying heterozygosity, aneuploidy & gene content create adaptive potential for harsh winemaking environments 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

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Saccharomyces Genome Database @yeastgenome.bsky.social · 20/08/2026

The August SGD Newsletter is out! 🎉 Celebrating 30 years since the first eukaryotic genome, plus new Pathway Pages, redesigned Chemical & Complex Pages, Functional Networks, how-to guides, & more 🍺🔬🧬 Check your email or read the whole version here: yeastgenome.org/blog/sgd-newsletter-august-2026

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Reposted by Saccharomyces Genome Database

PomBase: The S. pombe knowledgebase @pombase.bsky.social · 20/08/2026

Treat biological databases as infrastructure, not projects www.nature.com/articles/d41... We're quietly defunding the infrastructure modern biology runs on. PomBase, FlyBase, HGNC. have faced, or facing, existential funding crises since 2024. Curation expertise, once lost, is difficult to rebuild.

nature.com

Treat biological databases as infrastructure, not projects

Letter to the Editor

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Saccharomyces Genome Database @yeastgenome.bsky.social · 20/08/2026

⏰ Cellular stress timer: #Yeast stress granules gradually solidify during starvation via PKA phosphorylation, acting as molecular timer for recovery. Maturation controls orderly growth restart, may illuminate neurodegeneration mechanisms 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

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Saccharomyces Genome Database @yeastgenome.bsky.social · 18/08/2026

This year marks 30 years since the S. cerevisiae genome was published-the first complete eukaryotic genome! "Life with 6000 Genes" meeting Aug 31-Sep 1 celebrates this milestone. SGD's 32-year retrospective coming in FEMS Yeast Research. #yeast #genomics #30years www.yeastgenome.org/blog/celebra...

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Saccharomyces Genome Database @yeastgenome.bsky.social · 18/08/2026

🌡️ Extreme stress tolerance: Native #Yeast from Atacama Desert vineyard outperforms commercial strains in heat & high salt conditions. Genomic variants in osmotic sensing genes explain enhanced stress resistance 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

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Saccharomyces Genome Database @yeastgenome.bsky.social · 15/08/2026

🆕 The New #Yeast Papers page got an upgrade! Filter latest literature by author, journal, year, gene, allele, complex, or pathway. Zero in on papers most relevant to your research! Updated daily with the past 30 days of publications added to #SGD 👉 yeastgenome.org/reference/recent #yeastgenome

Screenshot of the SGD "Literature Recently Added to SGD" page, showing a list of 444 references added between 2026-07-15 and 2026-08-14. A filter panel on the left side of the page includes options to filter by author, journal, year, and associated genes, with checkboxes and reference counts shown for each filter value.

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Saccharomyces Genome Database @yeastgenome.bsky.social · 12/08/2026

🧈 Fat production controller: #Yeast Nem1 phosphatase activates Pah1 enzyme to make fats (triacylglycerols) from phosphatidate. Active site mutations break this lipid synthesis pathway despite normal protein structure & interactions 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

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Saccharomyces Genome Database @yeastgenome.bsky.social · 12/08/2026

🍶 Flavor genetics decoded: Commercial Korean makgeolli #Yeast strains produce enhanced levels of flavor compounds like acetoin & diacetyl. Missing clove flavor traced to broken FDC1 genes - restored by genetic complementation 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

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Saccharomyces Genome Database @yeastgenome.bsky.social · 12/08/2026

www.yeastgenome.org/blog/new-pat... New Pathway Pages at SGD! Genes, chemicals, networks, GO-CAMs #yeast #pathways #GO-CAM #ChEBI Check it out! www.yeastgenome.org/pathway/GLYO...

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Saccharomyces Genome Database @yeastgenome.bsky.social · 11/08/2026

🎵 From rhythm to rescue: #Yeast YGP1 shows rhythmic cell cycle expression via Puf5 during normal growth, then shifts to high-level stress response via Msn2/Msn4 during glucose depletion. Different needs, different controls 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

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Saccharomyces Genome Database @yeastgenome.bsky.social · 06/08/2026

🧑‍🤝‍🧑 Cellular mutual support system: #Yeast Cbf1 transcription factor helps build kinetochore machinery, while kinetochore stabilizes Cbf1 on DNA. This feedback loop ensures proper chromosome segregation & genome stability 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

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Saccharomyces Genome Database @yeastgenome.bsky.social · 06/08/2026

🫀 Mitochondrial coordination system: #Yeast Coa6 coordinates copper delivery to Cox2 & cytochrome c maturation. When Coa6 is lost, reducing cytochrome c levels rescues Complex IV assembly 👉 insights for treating human heart disease 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

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Saccharomyces Genome Database @yeastgenome.bsky.social · 05/08/2026

🧪 New at SGD: Redesigned chemical pages! ✨ Interactive 2D structures at top 📊 Phenotype & GO annotations on one page 🔗 Links to ChEBI, PubChem, Rhea 🔬 Shared Chemicals network for related compounds Example (cisplatin): www.yeastgenome.org/chemical/CHE... Browse: www.yeastgenome.org/search?categ...

molecular structure of anticancer drug cisplatin

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Saccharomyces Genome Database @yeastgenome.bsky.social · 05/08/2026

😰 When the going gets tough: Review shows #yeast don't just survive stress; they strategically switch to sexual reproduction & sporulation. Multiple sensing pathways coordinate this shift from growth ➡︎ reproduction under harsh conditions 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

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Saccharomyces Genome Database @yeastgenome.bsky.social · 04/08/2026

☕ Caffeine sensitivity reveals function: #Yeast ILM1 deletion causes caffeine hypersensitivity & G1 cell cycle delays- uncharacterized gene linked to TORC1 signaling pathway that controls cell growth & division 🧬 #YeastResearch 🧪 #SGD 🔬 @micropub7n.bsky.social www.yeastgenome.org/reference/S1...

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Saccharomyces Genome Database @yeastgenome.bsky.social · 03/08/2026

🎉 SGD's protein complex pages just got a major upgrade! ✨ GO annotations now on main page (no more tab-switching!) 🧬 New Composition section with stoichiometry & PDB links 🔗 Shared Biology networks show related complexes Check it out: www.yeastgenome.org/complex/CPX-...

Relationships the m-AAA protease complex shares with other yeast complexes. The "Network" shows Gene Ontology terms and subunits shared between this complex and other complexes as an interactive graph.

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Saccharomyces Genome Database @yeastgenome.bsky.social · 03/08/2026

🔬 New at SGD: Functional Networks section on gene & complex pages! ✨ Shared Annotations networks show related genes 🧬 GO-CAM pathway models reveal causal relationships 📊 470 genes now have GO-CAM models Explore: www.yeastgenome.org/locus/MET2#f...

Network diagram showing genes connected to a central query gene by lines, representing shared GO annotations. Genes are displayed as nodes with their names, connected by edges indicating functional similarity based on overlapping Molecular Function, Biological Process, or Cellular Component annotations.

GO-CAM pathway model diagram showing gene products (displayed as colored boxes) connected by arrows representing causal relationships between molecular activities. The diagram illustrates how genes work together in a biological pathway with directional flow showing activation, regulatory interactions, and dependencies between molecular functions.

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Saccharomyces Genome Database @yeastgenome.bsky.social · 31/07/2026

🔍 Check out SGD's redesigned search landing page! Improved autocomplete, quick category browsing, and highlights of newly added literature & recent annotations. 🔴 Click the big red "Explore SGD" button on the SGD homepage or just hit return in an empty search box 👉 www.yeastgenome.org/search

Screenshot of SGD's search landing page showing a search box at the top, category buttons for browsing genes, complexes, pathways and chemicals, and sidebar panels displaying newly added literature and recent annotations.

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Saccharomyces Genome Database @yeastgenome.bsky.social · 30/07/2026

🌙 Moonlighting protein review: #Yeast Hxk2p doesn't just process glucose - it's a metabolic hub controlling gene expression, energy homeostasis & cellular physiology. Loss triggers system-wide shift toward respiratory metabolism 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

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Saccharomyces Genome Database @yeastgenome.bsky.social · 30/07/2026

☣️ Toxin engineering advance: #Yeast killer toxin K2 analyzed through systematic alanine scanning, showing enhanced toxicity variants & altered target specificity through single mutations, providing platform for protein engineering 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

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