Reposted by Anthony Hessel, PhDJournal of Biomechanics @jbiomech.bsky.social · 07/05/2026😃 In a new article published in J Biomech, Zero et al. show initial pre‑activation muscle length doesn’t significantly change the stretch–shortening cycle in permeabilized single fibres; non–cross‑bridge elements like titin were unlikely altered by starting length. 👀 buff.ly/eFwJbQe 022
Reposted by Anthony Hessel, PhDJournal of Experimental Biology @jexpbiol.bsky.social · 09/04/2026Check out the new articles posted in our special issue, The Integrative Biology of Exercise, drawing on work in vertebrates and invertebrates to illustrate the plasticity or evolutionary changes necessary for exercise or sustained locomotion journals.biologists.com/jeb/issue/22... 056
Reposted by Anthony Hessel, PhDKonow lab at UMass Lowell @konowlab.bsky.social · 27/01/2026We are hiring a POSTDOC on an NIH award to measure inertial effects of (in)active muscle. Please share and re-post widely! Please send expressions of interest to my UML email. 1610
Reposted by Anthony Hessel, PhDAurora Scientific @aurorascientific.bsky.social · 18/03/2026In honor of #BioVault, watch the full interview with Accelerated Muscle Biotechnologies as Anthony Hessel, PhD and Khoi Nguyen, PhD share benefits to muscle research, directions in x-ray diffraction, and more! Post: bit.ly/asi-amb-collab-840A-biovault 840A: bit.ly/840A-BioVault 024
Anthony Hessel, PhD @hesselanthony.bsky.social · 18/03/2026👏Thank you for your service. There is nothing more direct then meeting with those with power of the purse. We all need to stay engaged with these people, letting them know how important the science infratructure and training pipelines are to the economic superiority of the States. 010
Reposted by Anthony Hessel, PhDAurora Scientific @aurorascientific.bsky.social · 11/03/2026Aurora Scientific is proud to introduce our much-anticipated new product, built in partnership with @ambiotech.us: 840A BioVault! aurorascientific.com/products/mus... A portable chamber that takes your experiments from bench to beamline. 1102
Reposted by Anthony Hessel, PhDChris Rand @crand22.bsky.social · 11/03/2026Ecstatic to see this launched! Thanks to our amazing partners @ambiotech.us, @hesselanthony.bsky.social and Khoi for their support throughout. 021
Reposted by Anthony Hessel, PhDJournal of General Physiology @jgp.org · 03/03/2026Greenman et al. review the role of cMyBP-C post-translational modifications in health & disease. During cardiovascular disease, oxidative stress may drive the inverse relationship btwn. phosphorylation & S-glutathionylation of cMyBP-C, identifying new therapeutic targets rupress.org/jgp/article/... 011
Reposted by Anthony Hessel, PhDIntegrative Movement Science Institute @movementscience.bsky.social · 27/02/2026We are proud to share that IMSI Co-Director Kiisa Nishikawa has been named the recipient of the 2026 SEB Bidder Lecture Award by the Society for Experimental Biology. Please join us in congratulating her on this outstanding achievement. #SEB2026 #ExperimentalBiology #ScientificAchievement #STEM 062
Reposted by Anthony Hessel, PhDJulien Ochala @droch.bsky.social · 17/02/2026Our new project unveiling an integrative single-fiber framework that connect multi-omic cellular heterogeneity to molecular function in ICU-related muscle wasting! Congratulations to all authors especially Alexandra who led the whole project! Thank you to @lundbeckfonden.bsky.social for the supportbiorxiv.org 062
Reposted by Anthony Hessel, PhDBen Collins @bencollins.bsky.social · 06/02/2026There's exactly one normal man left on planet Earth. 194170082080
Reposted by Anthony Hessel, PhDJournal of General Physiology @jgp.org · 04/02/2026A primer on the methods of skeletal and cardiac muscle mechanics using permeabilized preparations. New review from Anthony Hessel @hesselanthony.bsky.social, Christopher Rand @crand22.bsky.social, Khoi Nguyen and colleagues: rupress.org/jgp/article/... #Myofilaments #SkeletalMuscle #CardiacMuscle 022
Reposted by Anthony Hessel, PhDAurora Scientific @aurorascientific.bsky.social · 02/02/2026New review from our partners Accelerated Muscle Biotechnologies (Anthony Hessel, PhD, Katelyn Manross, Khoi Nguyen), co-authored with our Chris Rand & Matthew Borkowski. #MusclePhysiology #CardiacResearch Check it out: bit.ly/a-primer-on-the-methods-of-s… 023
Reposted by Anthony Hessel, PhDClockwork @watchclockwork.com · 31/01/2026💪 NEW VIDEO: Flying over the A-band of an atomic-scale model of a vertebrate muscle sarcomere. Let's explore the molecular mechanics that make your muscles work. Rendered using @bradyajohnston.bsky.social 's molecular nodes Model based on the incredible work of the @raunser-lab.bsky.social lab 32712
Anthony Hessel, PhD @hesselanthony.bsky.social · 29/01/2026Accelerated Muscle Biotechnologies is looking for a subcontractor (muscle physiologist) for a 5 day project at Brookhaven National Laboratory, conducting muscle mechanics / small-angle X-ray diffraction experiments. See LinkedIn post for details. www.linkedin.com/posts/anthon...linkedin.comAccelerated Muscle Biotechnologies is looking for a subcontractor (muscle physiologist) for a 5 day project at Brookhaven National Laboratory, conducting muscle mechanics / small-angle X-ray… | Anthon...Accelerated Muscle Biotechnologies is looking for a subcontractor (muscle physiologist) for a 5 day project at Brookhaven National Laboratory, conducting muscle mechanics / small-angle X-ray diffracti... 103
Anthony Hessel, PhD @hesselanthony.bsky.social · 28/01/2026Really happy about this paper getting published, where we muse on some of the finer aspects of the permeablized fiber mechanics technique. Have things you wished were covered? Go write one of these up to! Science is better when we all share our "institutional knowledge"! 022
Anthony Hessel, PhD @hesselanthony.bsky.social · 28/01/2026Anothee run at the P03 beamline PETRAIII complete. It was a exhausting run but we checked off all goals. 010
Anthony Hessel, PhD @hesselanthony.bsky.social · 26/01/2026Americans are supposed to be the good guys. It makes applying/enforcing laws harder but that is the burden of being the good guys. We rarely reach that ideal in practice but I will do all I can to support those who fight the good fight to bring us towards it. Protests comes in many ways. #NoKings 030
Reposted by Anthony Hessel, PhDScience Magazine @science.org · 06/01/2026The National Institutes of Health has agreed to settle lawsuits over its handling of grant applications that conflicted with President Donald Trump’s directives. scim.ag/4jsQ7scscim.agAfter legal deal, NIH to review grant proposals frozen, denied, or withdrawn because of Trump directivesAgreement requires agency to evaluate hundreds of applications “in good faith” using its standard process 02517
Reposted by Anthony Hessel, PhDJulien Ochala @droch.bsky.social · 18/12/2025Our team at Københavns Universitet - University of Copenhagen will soon be looking for a postdoc with experience in AI-driven vHTS and cardiac sarcomere modeling. If interested please send me an email. Spread the word :-)bmi.ku.dkOchala Group – University of Copenhagen 043
Reposted by Anthony Hessel, PhDdanielzkruse.bsky.social @danielzkruse.bsky.social · 27/11/2025First preprint from my PhD! www.biorxiv.org/content/10.1... We show that piperine: 1️⃣ increases ON myosin in resting skeletal muscle. 2️⃣ enhances dynamic contractility 3️⃣ in a muscle-type-dependent manner @hesselanthony.bsky.socialbiorxiv.orgPiperine activates the thick filament of resting rat skeletal muscle, enhancing dynamic contractility in a fiber-type-dependent mannerThick-filament activation, whereby myosin heads transition from an OFF to an ON state, is a key regulatory step in muscle contraction and a promising therapeutic target. The availability of ON-state m... 011
Reposted by Anthony Hessel, PhDAurora Scientific @aurorascientific.bsky.social · 26/11/2025In February 2025, Aurora Scientific formed a strategic partnership with Accelerated Muscle Biotechnologies (AMB). Watch this video interview with Anthony Hessel, PhD and Khoi Nguyen, PhD from AMB, and our own Chris Rand to learn about our partnership! bit.ly/asi-amb-partnership-interview 044
Reposted by Anthony Hessel, PhDMatthew Alexander, PhD @mattmuscleguy.bsky.social · 25/11/2025New #PNASNews paper: Exercise suppresses DEAF1 to normalize mTORC1 activity and reverse muscle aging. #Myoblue tinyurl.com/y5rayxmztinyurl.comExercise suppresses DEAF1 to normalize mTORC1 activity and reverse muscle aging | PNASSkeletal muscle is essential for movement, respiration, and metabolism, with mTORC1 acting as a key regulator of protein synthesis and degradation.... 041
Reposted by Anthony Hessel, PhDJulien Ochala @droch.bsky.social · 22/11/2025Our collaborative effort unravelled puzzling results warranted more research on the topic of myosin and cardiac chamber specificities @ucph.bsky.socialfaseb.onlinelibrary.wiley.comCardiac Chamber‐Specific Regulation of Myosin Biochemical Super‐Relaxation and Auto‐InhibitionThe combination of Mant-ATP (2′-(or-3′)-O-(N-Methylanthraniloyl) Adenosine 5′-Triphosphate) chase experiments and all-atomistic molecular dynamics simulations, revealed that myosin auto-inhibition an... 001
Anthony Hessel, PhD @hesselanthony.bsky.social · 22/11/2025Top recommendation for this post doc opportunity from my PhD lab group. Great mentor, lab, place to live. Amazing projects and an unusual amount of funding. 010
Reposted by Anthony Hessel, PhDGlen Pyle | Womens Heart Health ❤️🩹🖇️ @glenpyle.bsky.social · 06/11/2025How great is the HPV vaccine? It can even ⬇️ the risk of cervical cancer when given after precancerous cells are found. I wonder why RFK Jr isn't talking about this study.🤔 www.thelancet.com/journals/lan...thelancet.comEarly and long-term effects of prophylactic and post-excision human papillomavirus vaccination on recurrent high-grade cervical intraepithelial neoplasia relative to margin status: a retrospective coh...Regardless of timing, HPV vaccination has a beneficial long-term effect in lowering the risk of CIN2+ recurrence. Despite the greater reduction in relapse achieved by post-excision vaccination, the di... 1106
Reposted by Anthony Hessel, PhDCameron Hill @cameronhill13.bsky.social · 15/10/2025Excited to share our preprint using time-resolved small-angle X-ray diffraction to study myosin motor conformations during isometric twitch and tetanus contractions in the slow-twitch rat soleus skeletal muscle #myoblue 073
Reposted by Anthony Hessel, PhDJulien Ochala @droch.bsky.social · 29/09/2025We are looking for an enthusiastic MD or PhD to work on a postdoc project on the molecular mechanisms underlying human hibernating myocardium and ischemic cardiomyopathy. If interested send me an email! #heart #cardiomyopathy #sarcomereemployment.ku.dk14 postdoctoral fellowships to the BRIDGE – Translational Excellence Programme 044
Reposted by Anthony Hessel, PhDJonathan Huie, PhD @jmhuie.bsky.social · 28/08/2025Excited to share the first paper from my PhD! We looked at what traits help Aneides salamanders excel at climbing using museum specimens, CT scans, SEM, and more! No claws or toe pads, so how do they do it? In short, with long limbs, big feet and grippy toes! 🦎🧪 DM for PDF doi.org/10.1098/rspb... 114648
Reposted by Anthony Hessel, PhDPhysiological Reports @physrep.bsky.social · 16/09/2025This new #Methods article evaluates #freeze-drying to #RNAlater and three RNAlater-ICE-based protocols for #skeletal #muscle #biopsy tissue preservation for subsequent manual isolation of #fibers and other downstream applications. doi.org/10.14814/phy... #Physiology #MyoBluedoi.org 001
Anthony Hessel, PhD @hesselanthony.bsky.social · 21/08/2025Calling all BPS member / interested muscle people!!! Sam Harris is spearheading a push towards make a new muscle subgroup at the Biophysical Society. *Signatures from active members are needed*, but anyone with an interest can sign. Please help the cause! www.change.org/p/establish-...change.orgSign the PetitionEstablish a Dedicated Cardiac and Skeletal Muscle Research Subgroup Within The Biophysical Society 030
Reposted by Anthony Hessel, PhDKen Campbell @cardiaccampbell.bsky.social · 20/08/2025Congrats to Brent Scott from the Greenberg lab for this new paper on danicamtiv's mechanism of action. www.pnas.org/doi/10.1073/... Excited to see our FiberSim code being put to such good use. campbell-muscle-lab.github.io/FiberSim/pnas.orgDanicamtiv reduces myosin’s working stroke but activates the thin filament by accelerating actomyosin attachment | PNASHeart failure is a leading cause of death worldwide, and even with current treatments, the 5-y transplant-free survival rate is only ~50 to 70%. As... 041
Reposted by Anthony Hessel, PhDGlen Pyle | Womens Heart Health ❤️🩹🖇️ @glenpyle.bsky.social · 20/08/2025Can you really repair an engine while it's running? 👩🏽🔧 The heart can. 💪🏼🫀 Our latest @faseborg.bsky.social paper shows how the protein 'CapZ' helps heart muscle to keep running during exercise. ⛹🏼♀️🏊♂️ #Exercise #Heart #Muscle #BasicScience #Cardiology faseb.onlinelibrary.wiley.com/doi/10.1096/...faseb.onlinelibrary.wiley.comCardiac CapZ Regulation During Acute Exercise in Female MiceCapZ regulates actin addition at the barbed ends of sarcomeric actin. At rest, phosphorylated CapZIP slows addition, and dephosphorylated CapZIP promotes a wobble state to allow actin cycling. During... 1105
Reposted by Anthony Hessel, PhDShicheng Guo @shihcheng.bsky.social · 16/08/2025Global study: 2.08M people, 133 cohorts, 39 countries, 6 continents. 5 risk factors influence 50% of lifetime cardiovascular disease risk. PMID:40162648, N Engl J Med 2025, @NEJM doi.org/10.1056/NEJMoa2415879 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪doi.orghttps://doi.org/10.1056/NEJMoa2415879No description available 132
Anthony Hessel, PhD @hesselanthony.bsky.social · 05/08/2025This may be a bit strongly worded. Some people took initiative to write grants even when in a secure post doc. Some wrote grants that were tailored-made to be impactful/career boosting. IMHO, no problem with career strategy in an ultra competitive funding landscape. Wayyy more deserve than spots. 110
Reposted by Anthony Hessel, PhDLisa Whitenack, PhD @whitenacklab.bsky.social · 31/07/2025Y’all!!! Our comparative anatomy textbook is out!!! Free, open access, and just in time for the fall semester! 410637
Reposted by Anthony Hessel, PhDGeoff Power @geoffpower.bsky.social · 30/07/2025"The successful candidate will have expertise in area(s) related to cardiovascular physiology, metabolic regulation and dysregulation, and/or hormonal mechanisms that maintain homeostasis, with a focus on aging." 132
Anthony Hessel, PhD @hesselanthony.bsky.social · 18/07/2025All scientists need to be doing more of this and posting on all types of social media platforms (not just on the echo chamber communities). We must get better at communicating our science in a fun and effective way to a broad audience or tax payers/ voters. 120
Reposted by Anthony Hessel, PhDJoseph Gordon @josephwgordon.bsky.social · 15/07/2025www.nature.com/articles/s41...nature.comMuscle mass loss during GLP1 receptor agonist therapy prevented with GDF8 and activin A blockade - Nature Reviews EndocrinologyNature Reviews Endocrinology - Muscle mass loss during GLP1 receptor agonist therapy prevented with GDF8 and activin A blockade 122
Reposted by Anthony Hessel, PhDGrace Lindsay @neurograce.bsky.social · 15/07/2025Day of Action planned for July 21 to protect science protectscienceandinnovation.orgprotectscienceandinnovation.orgProtect Science and Innovation 15118
Anthony Hessel, PhD @hesselanthony.bsky.social · 13/07/2025NIH moves towards alternatives to animal models, in line with the shift in the EU. This is not bad policy in principal but not yet always feasible on technical grounds. It's important to continue searching for "muscles in a dish" that are of quality for Xray diffraction. Who wants to collab? 020
Reposted by Anthony Hessel, PhDPrasad Jallepalli, MD, PhD @prasad.bsky.social · 12/07/2025nothing would make me happier than US science returning to the amazing and transformational legacy of success and dominance but if that's not possible, we need other places with the vision to take over as the pacesetter humanity's long term success demands no less 23412
Reposted by Anthony Hessel, PhDGlen Pyle | Womens Heart Health ❤️🩹🖇️ @glenpyle.bsky.social · 10/07/2025I was delighted to accept the King Charles III Coronation Medal for my lab's research & advocacy for women's heart health.🫀💃🏻 We appreciate the support of IMPART at @dalhousie.bsky.social & @womensresearch.bsky.social, & were grateful to be nominated by the Heart & Stroke Foundation of Canada. 2225
Reposted by Anthony Hessel, PhDThe Journal of Physiology @jphysiol.bsky.social · 02/07/2025Damien M. Callahan presents this #TranslationalPerspective on the work of Laitila et al. linking altered structure and post-translational modification of Troponin T to dystonia in nemaline myopathies💭 ✍️ 🔗 physoc.onlinelibrary.wiley.com/doi/10.1113/... 033
Anthony Hessel, PhD @hesselanthony.bsky.social · 27/06/2025I am honored to announce that I was awarded the Du Bois-Reymond Prize of the German Physiological Society! “The German Physiological Society recognizes an outstanding and independent scientific work in a current field of physiology.”lnkd.inLinkedInThis link will take you to a page that’s not on LinkedIn 490
Anthony Hessel, PhD @hesselanthony.bsky.social · 25/06/2025At NSLS II, @brookhavenlab.bsky.social for another big muscle Xray research run. The science gods are telling me that this run will be 💯 000
Reposted by Anthony Hessel, PhDJournal of Molecular and Cellular Cardiology @jmccardiology.bsky.social · 10/06/2025🚨 Editor's Choice! 🚨 Research from University of Arizona shows L348P point mutation in cardiac myosin binding protein-C alters transient responses to stretch, slows cardiac relaxation & is embryonic lethal in homozygous CRISPR gene-edited mice Read: doi.org/10.1016/j.yj... 063
Anthony Hessel, PhD @hesselanthony.bsky.social · 24/06/2025US Judge reinstated 848 NIH grants illegally canceled by th admin. The ruling, below, lays out all the grants. Read through them. See all the good that is being put back in place and then double your efforts to resist the destruction of the US science enterprise. acrobat.adobe.com/id/urn:aaid:...acrobat.adobe.comAdobe Acrobat 010