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Anthony Hessel, PhD

@hesselanthony.bsky.social
398 followers 183 following 243 posts

Muscle physiologist at Uni of Muenster. Founder, Accelerated Muscle Biotechnologies. Dog foster / diva boston terrier parent. My wife tolerates me well. He/him.🥼🧪🔬💪♥️ #MyoBlue #NoKing

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Reposted by Anthony Hessel, PhD
Journal of Biomechanics @jbiomech.bsky.social · 07/05/2026
😃 In a new article published in J Biomech, Zero et al. show initial pre‑activation muscle length doesn’t significantly change the stretch–shortening cycle in permeabilized single fibres; non–cross‑bridge elements like titin were unlikely altered by starting length. 👀 buff.ly/eFwJbQe
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Reposted by Anthony Hessel, PhD
Journal of Experimental Biology @jexpbiol.bsky.social · 09/04/2026
Check out the new articles posted in our special issue, The Integrative Biology of Exercise, drawing on work in vertebrates and invertebrates to illustrate the plasticity or evolutionary changes necessary for exercise or sustained locomotion journals.biologists.com/jeb/issue/22...
Social media card advertising the JEB Integrative Biology of Exercise Special issue. The card as a black background. The text (left justified) reads: 
Special Issue
the Integrative Biology of Exercise
Guest Editors: Erika Eliason, Christopher Guglielmo, Natalie Holt and Monica Daley
Beneath the text is the JEB logo. 
On the right of the card is the 'Integrative Biology of Exercise' logo, including a flying goose, a trout making a turn and a dumbbell weight.
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Anthony Hessel, PhD @hesselanthony.bsky.social · 28/03/2026
#NoKings
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Reposted by Anthony Hessel, PhD
Konow lab at UMass Lowell @konowlab.bsky.social · 27/01/2026
We are hiring a POSTDOC on an NIH award to measure inertial effects of (in)active muscle. Please share and re-post widely! Please send expressions of interest to my UML email.
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Reposted by Anthony Hessel, PhD
Aurora Scientific @aurorascientific.bsky.social · 18/03/2026
In honor of #BioVault, watch the full interview with Accelerated Muscle Biotechnologies as Anthony Hessel, PhD and Khoi Nguyen, PhD share benefits to muscle research, directions in x-ray diffraction, and more! Post: bit.ly/asi-amb-collab-840A-biovault 840A: bit.ly/840A-BioVault
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Anthony Hessel, PhD @hesselanthony.bsky.social · 18/03/2026
👏Thank you for your service. There is nothing more direct then meeting with those with power of the purse. We all need to stay engaged with these people, letting them know how important the science infratructure and training pipelines are to the economic superiority of the States.
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Reposted by Anthony Hessel, PhD
Aurora Scientific @aurorascientific.bsky.social · 11/03/2026
Aurora Scientific is proud to introduce our much-anticipated new product, built in partnership with @ambiotech.us: 840A BioVault! aurorascientific.com/products/mus... A portable chamber that takes your experiments from bench to beamline.
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Reposted by Anthony Hessel, PhD
Chris Rand @crand22.bsky.social · 11/03/2026
Ecstatic to see this launched! Thanks to our amazing partners @ambiotech.us, @hesselanthony.bsky.social and Khoi for their support throughout.
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Reposted by Anthony Hessel, PhD
Journal of General Physiology @jgp.org · 03/03/2026
Greenman et al. review the role of cMyBP-C post-translational modifications in health & disease. During cardiovascular disease, oxidative stress may drive the inverse relationship btwn. phosphorylation & S-glutathionylation of cMyBP-C, identifying new therapeutic targets rupress.org/jgp/article/...
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Reposted by Anthony Hessel, PhD
Integrative Movement Science Institute @movementscience.bsky.social · 27/02/2026
We are proud to share that IMSI Co-Director Kiisa Nishikawa has been named the recipient of the 2026 SEB Bidder Lecture Award by the Society for Experimental Biology. Please join us in congratulating her on this outstanding achievement. #SEB2026 #ExperimentalBiology #ScientificAchievement #STEM
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Reposted by Anthony Hessel, PhD
Julien Ochala @droch.bsky.social · 17/02/2026
Our new project unveiling an integrative single-fiber framework that connect multi-omic cellular heterogeneity to molecular function in ICU-related muscle wasting! Congratulations to all authors especially Alexandra who led the whole project! Thank you to @lundbeckfonden.bsky.social for the support
biorxiv.org
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Reposted by Anthony Hessel, PhD
Ben Collins @bencollins.bsky.social · 06/02/2026
There's exactly one normal man left on planet Earth.
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Reposted by Anthony Hessel, PhD
Journal of General Physiology @jgp.org · 04/02/2026
A primer on the methods of skeletal and cardiac muscle mechanics using permeabilized preparations. New review from Anthony Hessel @hesselanthony.bsky.social, Christopher Rand @crand22.bsky.social, Khoi Nguyen and colleagues: rupress.org/jgp/article/... #Myofilaments #SkeletalMuscle #CardiacMuscle
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Reposted by Anthony Hessel, PhD
Aurora Scientific @aurorascientific.bsky.social · 02/02/2026
New review from our partners Accelerated Muscle Biotechnologies (Anthony Hessel, PhD, Katelyn Manross, Khoi Nguyen), co-authored with our Chris Rand & Matthew Borkowski. #MusclePhysiology #CardiacResearch Check it out: bit.ly/a-primer-on-the-methods-of-s…
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Reposted by Anthony Hessel, PhD
Clockwork @watchclockwork.com · 31/01/2026
💪 NEW VIDEO: Flying over the A-band of an atomic-scale model of a vertebrate muscle sarcomere. Let's explore the molecular mechanics that make your muscles work. Rendered using @bradyajohnston.bsky.social 's molecular nodes Model based on the incredible work of the @raunser-lab.bsky.social lab
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Anthony Hessel, PhD @hesselanthony.bsky.social · 29/01/2026
Accelerated Muscle Biotechnologies is looking for a subcontractor (muscle physiologist) for a 5 day project at Brookhaven National Laboratory, conducting muscle mechanics / small-angle X-ray diffraction experiments. See LinkedIn post for details. www.linkedin.com/posts/anthon...
linkedin.com
Accelerated Muscle Biotechnologies is looking for a subcontractor (muscle physiologist) for a 5 day project at Brookhaven National Laboratory, conducting muscle mechanics / small-angle X-ray… | Anthon...
Accelerated Muscle Biotechnologies is looking for a subcontractor (muscle physiologist) for a 5 day project at Brookhaven National Laboratory, conducting muscle mechanics / small-angle X-ray diffracti...
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Anthony Hessel, PhD @hesselanthony.bsky.social · 28/01/2026
Really happy about this paper getting published, where we muse on some of the finer aspects of the permeablized fiber mechanics technique. Have things you wished were covered? Go write one of these up to! Science is better when we all share our "institutional knowledge"!
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Anthony Hessel, PhD @hesselanthony.bsky.social · 28/01/2026
Anothee run at the P03 beamline PETRAIII complete. It was a exhausting run but we checked off all goals.
Team members smiling at a bar. P03 beamline imageTeam picture at the lab
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Anthony Hessel, PhD @hesselanthony.bsky.social · 26/01/2026
Americans are supposed to be the good guys. It makes applying/enforcing laws harder but that is the burden of being the good guys. We rarely reach that ideal in practice but I will do all I can to support those who fight the good fight to bring us towards it. Protests comes in many ways. #NoKings
Immigration law center of Minnisota donation page screenshot. Go donate! Anything helps!
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Reposted by Anthony Hessel, PhD
Science Magazine @science.org · 06/01/2026
The National Institutes of Health has agreed to settle lawsuits over its handling of grant applications that conflicted with President Donald Trump’s directives. scim.ag/4jsQ7sc
scim.ag
After legal deal, NIH to review grant proposals frozen, denied, or withdrawn because of Trump directives
Agreement requires agency to evaluate hundreds of applications “in good faith” using its standard process
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Reposted by Anthony Hessel, PhD
Julien Ochala @droch.bsky.social · 18/12/2025
Our team at Københavns Universitet - University of Copenhagen will soon be looking for a postdoc with experience in AI-driven vHTS and cardiac sarcomere modeling. If interested please send me an email. Spread the word :-)
bmi.ku.dk
Ochala Group – University of Copenhagen
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Reposted by Anthony Hessel, PhD
danielzkruse.bsky.social @danielzkruse.bsky.social · 27/11/2025
First preprint from my PhD! www.biorxiv.org/content/10.1... We show that piperine: 1️⃣ increases ON myosin in resting skeletal muscle. 2️⃣ enhances dynamic contractility 3️⃣ in a muscle-type-dependent manner @hesselanthony.bsky.social
biorxiv.org
Piperine activates the thick filament of resting rat skeletal muscle, enhancing dynamic contractility in a fiber-type-dependent manner
Thick-filament activation, whereby myosin heads transition from an OFF to an ON state, is a key regulatory step in muscle contraction and a promising therapeutic target. The availability of ON-state m...
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Reposted by Anthony Hessel, PhD
Aurora Scientific @aurorascientific.bsky.social · 26/11/2025
In February 2025, Aurora Scientific formed a strategic partnership with Accelerated Muscle Biotechnologies (AMB). Watch this video interview with Anthony Hessel, PhD and Khoi Nguyen, PhD from AMB, and our own Chris Rand to learn about our partnership! bit.ly/asi-amb-partnership-interview
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Reposted by Anthony Hessel, PhD
Matthew Alexander, PhD @mattmuscleguy.bsky.social · 25/11/2025
New #PNASNews paper: Exercise suppresses DEAF1 to normalize mTORC1 activity and reverse muscle aging. #Myoblue tinyurl.com/y5rayxmz
tinyurl.com
Exercise suppresses DEAF1 to normalize mTORC1 activity and reverse muscle aging | PNAS
Skeletal muscle is essential for movement, respiration, and metabolism, with mTORC1 acting as a key regulator of protein synthesis and degradation....
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Reposted by Anthony Hessel, PhD
Julien Ochala @droch.bsky.social · 22/11/2025
Our collaborative effort unravelled puzzling results warranted more research on the topic of myosin and cardiac chamber specificities @ucph.bsky.social
faseb.onlinelibrary.wiley.com
Cardiac Chamber‐Specific Regulation of Myosin Biochemical Super‐Relaxation and Auto‐Inhibition
The combination of Mant-ATP (2′-(or-3′)-O-(N-Methylanthraniloyl) Adenosine 5′-Triphosphate) chase experiments and all-atomistic molecular dynamics simulations, revealed that myosin auto-inhibition an...
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Anthony Hessel, PhD @hesselanthony.bsky.social · 22/11/2025
Top recommendation for this post doc opportunity from my PhD lab group. Great mentor, lab, place to live. Amazing projects and an unusual amount of funding.
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Reposted by Anthony Hessel, PhD
Glen Pyle | Womens Heart Health ❤️‍🩹🖇️ @glenpyle.bsky.social · 06/11/2025
How great is the HPV vaccine? It can even ⬇️ the risk of cervical cancer when given after precancerous cells are found. I wonder why RFK Jr isn't talking about this study.🤔 www.thelancet.com/journals/lan...
thelancet.com
Early and long-term effects of prophylactic and post-excision human papillomavirus vaccination on recurrent high-grade cervical intraepithelial neoplasia relative to margin status: a retrospective coh...
Regardless of timing, HPV vaccination has a beneficial long-term effect in lowering the risk of CIN2+ recurrence. Despite the greater reduction in relapse achieved by post-excision vaccination, the di...
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Reposted by Anthony Hessel, PhD
Cameron Hill @cameronhill13.bsky.social · 15/10/2025
Excited to share our preprint using time-resolved small-angle X-ray diffraction to study myosin motor conformations during isometric twitch and tetanus contractions in the slow-twitch rat soleus skeletal muscle #myoblue
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Reposted by Anthony Hessel, PhD
Julien Ochala @droch.bsky.social · 29/09/2025
We are looking for an enthusiastic MD or PhD to work on a postdoc project on the molecular mechanisms underlying human hibernating myocardium and ischemic cardiomyopathy. If interested send me an email! #heart #cardiomyopathy #sarcomere
employment.ku.dk
14 postdoctoral fellowships to the BRIDGE – Translational Excellence Programme
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Reposted by Anthony Hessel, PhD
Jonathan Huie, PhD @jmhuie.bsky.social · 28/08/2025
Excited to share the first paper from my PhD! We looked at what traits help Aneides salamanders excel at climbing using museum specimens, CT scans, SEM, and more! No claws or toe pads, so how do they do it? In short, with long limbs, big feet and grippy toes! 🦎🧪 DM for PDF doi.org/10.1098/rspb...
Phylogeny of Aneides and Plethodon with animal photosPhylomorphospace showing body shape variationMorphospace of toe bones and box lots showing estimated gripping forceRepresentative SEM images of salamander feet
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Reposted by Anthony Hessel, PhD
Physiological Reports @physrep.bsky.social · 16/09/2025
This new #Methods article evaluates #freeze-drying to #RNAlater and three RNAlater-ICE-based protocols for #skeletal #muscle #biopsy tissue preservation for subsequent manual isolation of #fibers and other downstream applications. doi.org/10.14814/phy... #Physiology #MyoBlue
doi.org
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Anthony Hessel, PhD @hesselanthony.bsky.social · 21/08/2025
Calling all BPS member / interested muscle people!!! Sam Harris is spearheading a push towards make a new muscle subgroup at the Biophysical Society. *Signatures from active members are needed*, but anyone with an interest can sign. Please help the cause! www.change.org/p/establish-...
change.org
Sign the Petition
Establish a Dedicated Cardiac and Skeletal Muscle Research Subgroup Within The Biophysical Society
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Reposted by Anthony Hessel, PhD
Ken Campbell @cardiaccampbell.bsky.social · 20/08/2025
Congrats to Brent Scott from the Greenberg lab for this new paper on danicamtiv's mechanism of action. www.pnas.org/doi/10.1073/... Excited to see our FiberSim code being put to such good use. campbell-muscle-lab.github.io/FiberSim/
pnas.org
Danicamtiv reduces myosin’s working stroke but activates the thin filament by accelerating actomyosin attachment | PNAS
Heart failure is a leading cause of death worldwide, and even with current treatments, the 5-y transplant-free survival rate is only ~50 to 70%. As...
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Reposted by Anthony Hessel, PhD
Glen Pyle | Womens Heart Health ❤️‍🩹🖇️ @glenpyle.bsky.social · 20/08/2025
Can you really repair an engine while it's running? 👩🏽‍🔧 The heart can. 💪🏼🫀 Our latest @faseborg.bsky.social paper shows how the protein 'CapZ' helps heart muscle to keep running during exercise. ⛹🏼‍♀️🏊‍♂️ #Exercise #Heart #Muscle #BasicScience #Cardiology faseb.onlinelibrary.wiley.com/doi/10.1096/...
faseb.onlinelibrary.wiley.com
Cardiac CapZ Regulation During Acute Exercise in Female Mice
CapZ regulates actin addition at the barbed ends of sarcomeric actin. At rest, phosphorylated CapZIP slows addition, and dephosphorylated CapZIP promotes a wobble state to allow actin cycling. During...
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Reposted by Anthony Hessel, PhD
Shicheng Guo @shihcheng.bsky.social · 16/08/2025
Global study: 2.08M people, 133 cohorts, 39 countries, 6 continents. 5 risk factors influence 50% of lifetime cardiovascular disease risk. PMID:40162648, N Engl J Med 2025, @NEJM doi.org/10.1056/NEJMoa2415879 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
doi.org
https://doi.org/10.1056/NEJMoa2415879
No description available
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Anthony Hessel, PhD @hesselanthony.bsky.social · 05/08/2025
This may be a bit strongly worded. Some people took initiative to write grants even when in a secure post doc. Some wrote grants that were tailored-made to be impactful/career boosting. IMHO, no problem with career strategy in an ultra competitive funding landscape. Wayyy more deserve than spots.
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Anthony Hessel, PhD @hesselanthony.bsky.social · 05/08/2025
Yes! NIAMS and NHLBI as well!
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Reposted by Anthony Hessel, PhD
Lisa Whitenack, PhD @whitenacklab.bsky.social · 31/07/2025
Y’all!!! Our comparative anatomy textbook is out!!! Free, open access, and just in time for the fall semester!
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Geoff Power @geoffpower.bsky.social · 30/07/2025
"The successful candidate will have expertise in area(s) related to cardiovascular physiology, metabolic regulation and dysregulation, and/or hormonal mechanisms that maintain homeostasis, with a focus on aging."
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Anthony Hessel, PhD @hesselanthony.bsky.social · 18/07/2025
All scientists need to be doing more of this and posting on all types of social media platforms (not just on the echo chamber communities). We must get better at communicating our science in a fun and effective way to a broad audience or tax payers/ voters.
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Reposted by Anthony Hessel, PhD
Joseph Gordon @josephwgordon.bsky.social · 15/07/2025
www.nature.com/articles/s41...
nature.com
Muscle mass loss during GLP1 receptor agonist therapy prevented with GDF8 and activin A blockade - Nature Reviews Endocrinology
Nature Reviews Endocrinology - Muscle mass loss during GLP1 receptor agonist therapy prevented with GDF8 and activin A blockade
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Grace Lindsay @neurograce.bsky.social · 15/07/2025
Day of Action planned for July 21 to protect science protectscienceandinnovation.org
protectscienceandinnovation.org
Protect Science and Innovation
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Anthony Hessel, PhD @hesselanthony.bsky.social · 13/07/2025
NIH moves towards alternatives to animal models, in line with the shift in the EU. This is not bad policy in principal but not yet always feasible on technical grounds. It's important to continue searching for "muscles in a dish" that are of quality for Xray diffraction. Who wants to collab?
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Prasad Jallepalli, MD, PhD @prasad.bsky.social · 12/07/2025
nothing would make me happier than US science returning to the amazing and transformational legacy of success and dominance but if that's not possible, we need other places with the vision to take over as the pacesetter humanity's long term success demands no less
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Glen Pyle | Womens Heart Health ❤️‍🩹🖇️ @glenpyle.bsky.social · 10/07/2025
I was delighted to accept the King Charles III Coronation Medal for my lab's research & advocacy for women's heart health.🫀💃🏻 We appreciate the support of IMPART at @dalhousie.bsky.social & @womensresearch.bsky.social, & were grateful to be nominated by the Heart & Stroke Foundation of Canada.
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Reposted by Anthony Hessel, PhD
The Journal of Physiology @jphysiol.bsky.social · 02/07/2025
Damien M. Callahan presents this #TranslationalPerspective on the work of Laitila et al. linking altered structure and post-translational modification of Troponin T to dystonia in nemaline myopathies💭 ✍️ 🔗 physoc.onlinelibrary.wiley.com/doi/10.1113/...
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Anthony Hessel, PhD @hesselanthony.bsky.social · 27/06/2025
I am honored to announce that I was awarded the Du Bois-Reymond Prize of the German Physiological Society! “The German Physiological Society recognizes an outstanding and independent scientific work in a current field of physiology.”
lnkd.in
LinkedIn
This link will take you to a page that’s not on LinkedIn
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Anthony Hessel, PhD @hesselanthony.bsky.social · 25/06/2025
At NSLS II, @brookhavenlab.bsky.social for another big muscle Xray research run. The science gods are telling me that this run will be 💯
Car tells me the temperature is 100F
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Reposted by Anthony Hessel, PhD
Journal of Molecular and Cellular Cardiology @jmccardiology.bsky.social · 10/06/2025
🚨 Editor's Choice! 🚨 Research from University of Arizona shows L348P point mutation in cardiac myosin binding protein-C alters transient responses to stretch, slows cardiac relaxation & is embryonic lethal in homozygous CRISPR gene-edited mice Read: doi.org/10.1016/j.yj...
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Anthony Hessel, PhD @hesselanthony.bsky.social · 24/06/2025
US Judge reinstated 848 NIH grants illegally canceled by th admin. The ruling, below, lays out all the grants. Read through them. See all the good that is being put back in place and then double your efforts to resist the destruction of the US science enterprise. acrobat.adobe.com/id/urn:aaid:...
acrobat.adobe.com
Adobe Acrobat
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