Baptiste Lacoste @blacoste.bsky.social · 03/09/2026Interesting new review #BBB #ATVBjournal www.ahajournals.org/doi/10.1161/...ahajournals.orgCell-to-Cell Signaling Networks at the Blood-Brain Barrier in Health and Disease | Arteriosclerosis, Thrombosis, and Vascular BiologyThe blood-brain barrier (BBB) is a highly specialized interface between the central nervous system and the peripheral circulation, crucial for maintaining neuronal homeostasis and protecting the brain... 040
Baptiste Lacoste @blacoste.bsky.social · 28/08/2026Did you see it yesterday? from my backyard... #LunarEclipse 040
Baptiste Lacoste @blacoste.bsky.social · 24/08/2026🚨 Want to isolate astrocytes and study their function? With Nicole Blakeley, PhD Candidate in our lab, we are happy to present a new protocol, which hopefully will help labs dive into glial biology with less hurdles. Cheers ! #glia #astrocytescell.comProtocol for assessing molecular signatures and metabolic function of primary murine cortical astrocytesAstrocytes are the most numerous brain cells and are central to the regulation of brain metabolism. Here, we present a protocol for identifying molecular signatures and assessing the metabolic functio... 0136
Baptiste Lacoste @blacoste.bsky.social · 20/08/2026Neurovascular coupling maturation finally assessed in humans (data from 40 newborns and 4 adults) 🤩 #cerebrovascular #CBFresearchsquare.comMaturation of the neonatal cortical-depth-dependent BOLD response measured using ultra-high field fMRIThe human brain undergoes rapid and dramatic development across the perinatal period which is critical for lifelong brain function. In the mature brain, neuronal activity, metabolism, vasculature and ... 020
Baptiste Lacoste @blacoste.bsky.social · 17/08/2026Beautiful new paper by @dablab.bsky.social and team! "Pericyte KATP channel hyperactivity redistributes cortical blood flow in a CADASIL mouse model" #cerebrovascularnature.comPericyte KATP channel hyperactivity redistributes cortical blood flow in a CADASIL mouse model - Nature Cardiovascular ResearchBy integrating spatial transcriptomics, advanced in vivo imaging, ex vivo myography, electrophysiology, in vitro functional assays and in silico modeling, Jeffrey et al. delineate a previously unrecog... 083
Baptiste Lacoste @blacoste.bsky.social · 05/08/2026Super useful!! #cerebrovascularpnas.orgA reference protein atlas of the adult mouse brain vasculature | PNASCurrent methods for assessing low-abundance proteins in individual cells are limited. As a result, cell functions are often inferred from single-ce... 020
Baptiste Lacoste @blacoste.bsky.social · 03/08/2026#cerebrovascular #atlas #humancell.comSpatial atlas of the human brain vasculature reveals specialized cell ensemblesAn integrative cell and spatial atlas defines the organizing logic of the adult human cerebrovasculature, providing a framework for studying how vascular cell states support brain function and shape n... 060
Baptiste Lacoste @blacoste.bsky.social · 01/08/2026I am delighted to welcome Dr. Aida Oryza Lopez-Ortiz in our lab ! Aida now joins our efforts to understand how astrocytes regulate cerebrovascular remodeling and repair. And to do so, she just received a prestigious Canada Impact+ Post-doctoral Training Award, what a great way to start ! 040
Baptiste Lacoste @blacoste.bsky.social · 26/07/2026🚨We have a new star in Ottawa! Consider joining Erika Wang’s lab if you are passionate about bioengineering, therapeutics and nanomedicine! 👇👇 #newrecruit #ECR 031
Baptiste Lacoste @blacoste.bsky.social · 21/07/2026🚨 Now available on Nature Careers ! #Recruitment #Ottawanature.comTier 2 Canada Research Chair in Vascular Links to Neurodevelopment - Ottawa, Ontario (CA) job with University of Ottawa, Ontario CANADA | 12861923uOttawa, in partnership with the OHRI, invites applications for a Tier 2 CRC in Vascular Links to Neurodevelopment and their impact on brain health. 11014
Reposted by Baptiste LacosteWuhyun Koh @wuhyunkoh.bsky.social · 07/07/2026Excited to share that one of the very first research projects initiated in our ABCD lab, "Astrocytic Ankyrin-2 Enables Memory Persistence in the Mouse Hippocampus," has now been published in Nature Communications (DOI: 10.1038/s41467-026-75009-5). www.drkohlab.com/post/our-art...drkohlab.comAstrocytic Ankyrin-2 Enables Memory Persistence in the Mouse HippocampusWhy do some memories last for weeks, months, or even years, while others quickly fade away? Astrocytes may hold the key. 173
Baptiste Lacoste @blacoste.bsky.social · 12/07/2026New paper by @craigedbrown.bsky.social ! #stroke #cerebrovascularnature.comKnockdown of endothelial Serpine1 improves stroke recovery by attenuating peri-infarct blood flow and blood-brain barrier disruption - Cell Death & DiseaseCell Death & Disease - Knockdown of endothelial Serpine1 improves stroke recovery by attenuating peri-infarct blood flow and blood-brain barrier disruption 070
Baptiste Lacoste @blacoste.bsky.social · 04/07/2026🚨 We are recruiting at the Ottawa Hospital Research Institute, in the Regenerative Medicine Program ! If your are passionate about basic science, and dream to develop your own research program, please apply! #Ottawa #Canada #Recruitment #Scientist #Research Full description at the link below:uottawa.wd3.myworkdayjobs.comTier 2 Canada Research Chair in Vascular Links to NeurodevelopmentFollow us on LinkedIn Posting Reason: New Position Job Type: Contingent Worker Anticipated Duration in Months (for contracts and temporary assignments): Job Family: Academic Leadership and Faculty # o... 01314
Baptiste Lacoste @blacoste.bsky.social · 17/06/2026A really elegant study by @alexdubrac.bsky.social & team, published at @natureportfolio.nature.com ! #cerebrovascularnature.comMapping neuro-vascular unit communications reveals distinct angiogenic programs across developing mouse brain regions - Nature CommunicationsBrain blood vessels interact with neural cells to shape brain development, yet how these communications differ across regions remains unclear. Here, the authors show that region-specific neurovascular... 061
Reposted by Baptiste LacosteTom Longden @talongden.bsky.social · 09/06/2026Very happy to share our latest work out in PNAS this week, led by Amy Xiang. We show that capillary thin-strand pericytes express TMEM16A calcium-activated chloride channels, which set the operating point for capillary control of cerebral blood flow in vivo. www.pnas.org/doi/10.1073/... 293
Baptiste Lacoste @blacoste.bsky.social · 05/06/2026New paper by @caglaeroglu.bsky.social ! #astrocytes #developmentdoi.orgNeuroligin-2 is ubiquitinated by Nedd4l to control developmental astrocyte morphogenesisSakers et al. report that astrocytic NLs are functionally diverse proteins with unique intracellular protein–protein interactions. They show that Nedd4l bi 032
Baptiste Lacoste @blacoste.bsky.social · 03/06/2026Save the date 😎 #CSHL #BBBmeetings.cshl.eduBrain BarriersCold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics. 0134
Baptiste Lacoste @blacoste.bsky.social · 29/05/2026Amazing paper by Andrew Yang's lab using a new, a non-invasive genetic system to trace neuron-derived protein clearance from the brain to cerebrospinal fluid and border tissues 🤩 #cerebrovascular www.sciencedirect.com/science/arti... 0215
Baptiste Lacoste @blacoste.bsky.social · 24/05/2026Our cerebrovascular symposium @canacn.bsky.social in Montreal was a blast with full room! Thanks Aurélie, Grant, Ravi and Alex for your fantastic talks! May the vessels be with you 💪 #symposium #CanadianNeuroscience #cerebrovascular 0111
Baptiste Lacoste @blacoste.bsky.social · 15/04/2026The absolute dream paper for any #cerebrovascular developmental biologist !! Congrats to @nicolasrenier.bsky.social, @alexdubrac.bsky.social and their teams !cell.comThe spatiotemporal dynamics of postnatal vascularization in the mouse brainWhole-brain tissue clearing and spatial transcriptomics were applied to map postnatal vascular development in the mouse brain, identifying three coordinated phases that link vascular growth to neurona... 1146
Baptiste Lacoste @blacoste.bsky.social · 12/04/2026New study clarifies the role of Angiopoietin 2 in the brain vasculature #Cerebrovascular 👇 031
Baptiste Lacoste @blacoste.bsky.social · 10/04/2026Look at this beautiful preprint ! by Neil Dani & team #ChoroidPlexus #BrainBarrier www.biorxiv.org/content/10.6...biorxiv.org 051
Baptiste Lacoste @blacoste.bsky.social · 29/03/2026New insights into brain imaging by @annadevor.bsky.social just dropped 🧠✨ This study shows that neuromodulators, especially norepinephrine, actively reshape how neural activity translates into blood flow signals across the cortex. A powerful step toward more accurate brain mapping! #cerebrovascularnature.comThe neurovascular impulse response function differentially reflects intrinsic neuromodulation across cortical regions - Nature NeuroscienceA new optical imaging study demonstrates that norepinephrine and the state of arousal influence hemodynamic correlations across cerebral cortex, calling for a conceptual shift in interpreting function... 0101
Baptiste Lacoste @blacoste.bsky.social · 26/03/2026New results show that, in addition to neural changes, sleep involves nonneural processes such as vasomotor-driven hydrodynamic waves 🤩 #Cerebrovascular #sleeppnas.orgSleep alters neurovascular and hydrodynamic coupling in the human brain | PNASSleep is essential for maintaining brain tissue homeostasis, which is facilitated by enhanced cerebrospinal fluid (CSF) solute transport. Infraslow... 040
Reposted by Baptiste LacosteFabrice Dabertrand @dablab.bsky.social · 31/07/2025🚨Our new paper in Circ Research on the cover + 📖 editorial by Dr. Jackson🔗https://tinyurl.com/2d6hxa83 👏 Danielle Jeffrey tinyurl.com/bdduwe43 collaboration with @osamaharraz.bsky.social Lab ♀️ Female mice show lower hippocampal tone 🌸 Estrogen-dependent⚡️ SK channels dominate 💡 Ludeman Family Center 0111
Baptiste Lacoste @blacoste.bsky.social · 06/02/2026Wrapping up my visit to UVA, had a great time and learned about a lot of exciting stuff! Thanks @eyolab.bsky.social for hosting me! 040
Baptiste Lacoste @blacoste.bsky.social · 02/02/2026Professional advice: when celebrating your 10th year lab anniversary🍻, bring your trainees to an axe throwing club, so they can release all the anger accumulated. Let them imaging your face is on the wall 😂 080
Baptiste Lacoste @blacoste.bsky.social · 30/01/2026Cool neurovascular paper in #zebrafish #cerebrovascular #developmentnature.comNMDA receptors coordinate brain vascular development via neuron-to-endothelial tip cell crosstalk in zebrafish - Nature CommunicationsNeurovascular interaction is critical for normal brain vascular development. Here, the authors show that neuronal NMDARs regulate brain vascular development via VEGF-induced global Ca2+ activities of ... 060
Baptiste Lacoste @blacoste.bsky.social · 28/01/2026New findings suggesting that PROX1 compromises BBB integrity by negatively regulating BBB-associated Wnt signaling. #BBB #BloodBrainBarrier #cerebrovascularinsight.jci.org JCI Insight - Endothelial PROX1 induces blood-brain barrier disruption in the central nervous system 050
Reposted by Baptiste LacosteOsama Harraz @osamaharraz.bsky.social · 30/12/2025🎉 New Publication in @pnas.org Excited to share our lab’s latest research article: PIP₂ Corrects an Endothelial Piezo1 Channelopathy pnas.org/doi/abs/10.1... (Open Access) 1166
Baptiste Lacoste @blacoste.bsky.social · 17/12/2025New preprint from the lab! For those who love astrocytes 🤩. We welcome feedback! #preprint #openaccess #astrocytes #autismbiorxiv.orgMetabolic, epigenetic and transcriptomic alterations in postnatal 16p11.2 deficient murine astrocytesAutism Spectrum Disorders (ASD) are associated with metabolic dysregulation. While astrocytes are integral to cerebral metabolism, their molecular and functional changes in ASD are poorly known. Using... 3279
Baptiste Lacoste @blacoste.bsky.social · 03/12/2025A beautiful paper from my friend @naguibmechawar.bsky.social's team ! www.nature.com/articles/s41... #cerebrovascularnature.comPervasive neurovascular dysfunction in the ventromedial prefrontal cortex of female depressed suicides with a history of childhood abuse - Molecular PsychiatryMolecular Psychiatry - Pervasive neurovascular dysfunction in the ventromedial prefrontal cortex of female depressed suicides with a history of childhood abuse 060
Baptiste Lacoste @blacoste.bsky.social · 20/11/2025PDGFRα is required for postnatal cerebral perivascular fibroblast development. Congrats @siegenthalerlab.bsky.social ! #cerebrovascular #fibroblasts #developmentsciencedirect.comPDGFRα is required for postnatal cerebral perivascular fibroblast developmentPerivascular fibroblasts (PVFs) are a cell type associated with large diameter blood vessels in the brain and spinal cord parenchyma and leptomeninges… 1196
Reposted by Baptiste LacosteOsama Harraz @osamaharraz.bsky.social · 19/11/2025Excited to share the latest from our lab (final version, open access): Brain Capillary Ion Channels: Physiology and Channelopathies Physiology | @apspublications.bsky.social journals.physiology.org/doi/full/10.... @uvmlarnermed.bsky.social 1123
Baptiste Lacoste @blacoste.bsky.social · 18/11/2025Hypertension-induced neurovascular and cognitive dysfunction at single-cell resolution @cp-neuron.bsky.social #cerebrovascular #hypertensionsciencedirect.comHypertension-induced neurovascular and cognitive dysfunction at single-cell resolutionHypertension is a leading cause of cognitive impairment, attributed to cerebrovascular insufficiency, blood-brain barrier disruption, and white matter… 031
Baptiste Lacoste @blacoste.bsky.social · 16/11/2025Excellent new review on the blood-brain barrier, by Alon Friedman and colleague @natureportfolio.nature.com #Cerebrovascular #BloodBrainBarriernature.comDynamic modulation of the blood–brain barrier in the healthy brain - Nature Reviews NeuroscienceThe blood–brain barrier was conventionally seen as a static protective structure, but a more complex, dynamic view of this barrier has now emerged. In this Review, Friedman et al. discuss the dynamic ... 084
Baptiste Lacoste @blacoste.bsky.social · 12/11/2025The brain neurovascular epigenome and its association with dementia. #cerebrovascular #epigeneticscell.comThe brain neurovascular epigenome and its association with dementiaZiegler et al. reveal distinct genetic and epigenetic mechanisms underlying Alzheimer’s disease and cerebral small vessel disease within neurovascular cells, identifying immune-related AD risk and bro... 052
Baptiste Lacoste @blacoste.bsky.social · 08/11/2025So happy I have been able to witness the incredible growth and success of (now Dr.) Sozerko Yiandiev, who defended his PhD thesis with brio in Lyon this week! It was a true pleasure to co-mentor Sozerko with @jcourchet.bsky.social during the past 5 years 🍻👨🎓 #Thesis #BrainMetabolism 192
Baptiste Lacoste @blacoste.bsky.social · 08/11/2025When the stars of glial scar borders and stroke recovery “have a baby”, it gives this 😅 #astrocytes #stroke #cerebrovascularsciencedirect.comRegionally mapped astrocytic responses to cortical and white matter stroke show differential roles in astrocyte-induced vascular remodelingStroke is a major cause of disability. Astrocytes respond to stroke in a gradated manner, but details of that response and its consequences for tissue… 082
Baptiste Lacoste @blacoste.bsky.social · 07/11/2025#astrocytes #endothelium #cerebrovascular 😱🤩🤩nature.comMolecular profiling of brain endothelial cell to astrocyte endfoot communication in mouse and human - Nature CommunicationsDeciphering body-brain communication pathways is key to a deeper understanding of brain physiology and pathology. Here, the authors define the astrocyte endfoot proteome and show dynamic vascular-to-a... 15915
Baptiste Lacoste @blacoste.bsky.social · 20/10/2025The best Sunday of the year 🤩 #peaceful #fall 1220
Reposted by Baptiste LacosteMaría R. Aburto @maburto.bsky.social · 14/10/2025A privilege to chair symposium ‘Vascular function and cognitive health across the lifespan’ symposium today at @ecnp.eu Thanks to speakers @vcoelhosantoslab.bsky.social Amanda Kiliaan, @mariangelesmoro.bsky.social and @blacoste.bsky.social for their fantastic presentations. #ECNP2025 0103
Baptiste Lacoste @blacoste.bsky.social · 06/10/2025An important advance in vascular biology!! #endothelium #vascularpnas.orgSoluble guanylyl cyclase, the NO receptor, drives vasorelaxation via endothelial S-nitrosation | PNASWe previously demonstrated that the NO-stimulated soluble guanylyl cyclase (GC1), which produces cGMP, also has the ability to transfer S-nitrosoth... 021
Baptiste Lacoste @blacoste.bsky.social · 06/10/2025Thanks again Yao Yao for the kind invite to USF! Super fun visit, I learned a lot from you and your colleagues 🙏🙏 070
Baptiste Lacoste @blacoste.bsky.social · 28/09/2025Interested in assessing #BBB integrity at high resolution in 3D by electron tomography without spending $$$$$ on cryo-EM? I think we can help with this detailed method 😇 #cerebrovascular #microscopy #EMonlinelibrary.wiley.comVolumetric Analysis of the Blood–Brain Barrier After Ischemic Stroke by Electron Tomography in MiceObjective Transmission electron microscopy (TEM) enables ultrastructural investigation of both organic and nonorganic samples. However, conventional TEM is limited by the acquisition of two-dimensio... 2144
Baptiste Lacoste @blacoste.bsky.social · 12/09/2025Very cool new paper from @caglaeroglu.bsky.social's lab showing the mitochondria dynamics regulate astroglial morphogenesis! doi.org/10.1083/jcb.... #Astrocytes #Developmentdoi.orgMitochondrial fission controls astrocyte morphogenesis and organization in the cortex | Journal of Cell Biology | Rockefeller University PressDuring cortical astrocyte morphogenesis, mitochondria fragment and decrease in size to populate distal astrocyte processes. Drp1-mediated mitochondrial fis 141
Baptiste Lacoste @blacoste.bsky.social · 07/09/2025New work establishing a key role for FOXQ1 in the regulation of brain endothelial metabolism. #Cerebrovasculardoi.orgFOXQ1 Regulates Brain Endothelial Mitochondrial Function by Orchestrating Calcium Signaling and Cristae MorphologyFOXQ1 emerges as a master transcriptional regulator of brain endothelial metabolism, orchestrating mitochondrial function through dual control of calcium signaling and cristae organization. This stud... 030