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Baptiste Lacoste

@blacoste.bsky.social
1.5K followers 343 following 507 posts

Senior Scientist, Professor & Program Director @ OHRI & uOttawa 🇨🇦. Fascinated by vascular & metabolic causes of neurodevelopmental disorders, SciArt and the night sky 🔬 🎨 🔭 Follow for 🧪 news and more! Look for #cerebrovascular

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Baptiste Lacoste @blacoste.bsky.social · 03/09/2026
Interesting new review #BBB #ATVBjournal www.ahajournals.org/doi/10.1161/...
ahajournals.org
Cell-to-Cell Signaling Networks at the Blood-Brain Barrier in Health and Disease | Arteriosclerosis, Thrombosis, and Vascular Biology
The blood-brain barrier (BBB) is a highly specialized interface between the central nervous system and the peripheral circulation, crucial for maintaining neuronal homeostasis and protecting the brain...
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Baptiste Lacoste @blacoste.bsky.social · 03/09/2026
Some cool stuff coming soon, stay tuned !
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Baptiste Lacoste @blacoste.bsky.social · 28/08/2026
Did you see it yesterday? from my backyard... #LunarEclipse
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Baptiste Lacoste @blacoste.bsky.social · 24/08/2026
🚨 Want to isolate astrocytes and study their function? With Nicole Blakeley, PhD Candidate in our lab, we are happy to present a new protocol, which hopefully will help labs dive into glial biology with less hurdles. Cheers ! #glia #astrocytes
cell.com
Protocol for assessing molecular signatures and metabolic function of primary murine cortical astrocytes
Astrocytes are the most numerous brain cells and are central to the regulation of brain metabolism. Here, we present a protocol for identifying molecular signatures and assessing the metabolic functio...
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Baptiste Lacoste @blacoste.bsky.social · 20/08/2026
Neurovascular coupling maturation finally assessed in humans (data from 40 newborns and 4 adults) 🤩 #cerebrovascular #CBF
researchsquare.com
Maturation of the neonatal cortical-depth-dependent BOLD response measured using ultra-high field fMRI
The human brain undergoes rapid and dramatic development across the perinatal period which is critical for lifelong brain function. In the mature brain, neuronal activity, metabolism, vasculature and ...
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Baptiste Lacoste @blacoste.bsky.social · 17/08/2026
Beautiful new paper by @dablab.bsky.social and team! "Pericyte KATP channel hyperactivity redistributes cortical blood flow in a CADASIL mouse model" #cerebrovascular
nature.com
Pericyte KATP channel hyperactivity redistributes cortical blood flow in a CADASIL mouse model - Nature Cardiovascular Research
By integrating spatial transcriptomics, advanced in vivo imaging, ex vivo myography, electrophysiology, in vitro functional assays and in silico modeling, Jeffrey et al. delineate a previously unrecog...
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Baptiste Lacoste @blacoste.bsky.social · 05/08/2026
Super useful!! #cerebrovascular
pnas.org
A reference protein atlas of the adult mouse brain vasculature | PNAS
Current methods for assessing low-abundance proteins in individual cells are limited. As a result, cell functions are often inferred from single-ce...
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Baptiste Lacoste @blacoste.bsky.social · 03/08/2026
#cerebrovascular #atlas #human
cell.com
Spatial atlas of the human brain vasculature reveals specialized cell ensembles
An integrative cell and spatial atlas defines the organizing logic of the adult human cerebrovasculature, providing a framework for studying how vascular cell states support brain function and shape n...
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Baptiste Lacoste @blacoste.bsky.social · 01/08/2026
I am delighted to welcome Dr. Aida Oryza Lopez-Ortiz in our lab ! Aida now joins our efforts to understand how astrocytes regulate cerebrovascular remodeling and repair. And to do so, she just received a prestigious Canada Impact+ Post-doctoral Training Award, what a great way to start !
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Baptiste Lacoste @blacoste.bsky.social · 26/07/2026
🚨We have a new star in Ottawa! Consider joining Erika Wang’s lab if you are passionate about bioengineering, therapeutics and nanomedicine! 👇👇 #newrecruit #ECR
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Baptiste Lacoste @blacoste.bsky.social · 21/07/2026
🚨 Now available on Nature Careers ! #Recruitment #Ottawa
nature.com
Tier 2 Canada Research Chair in Vascular Links to Neurodevelopment - Ottawa, Ontario (CA) job with University of Ottawa, Ontario CANADA | 12861923
uOttawa, in partnership with the OHRI, invites applications for a Tier 2 CRC in Vascular Links to Neurodevelopment and their impact on brain health.
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Reposted by Baptiste Lacoste
Wuhyun Koh @wuhyunkoh.bsky.social · 07/07/2026
Excited to share that one of the very first research projects initiated in our ABCD lab, "Astrocytic Ankyrin-2 Enables Memory Persistence in the Mouse Hippocampus," has now been published in Nature Communications (DOI: 10.1038/s41467-026-75009-5). www.drkohlab.com/post/our-art...
drkohlab.com
Astrocytic Ankyrin-2 Enables Memory Persistence in the Mouse Hippocampus
Why do some memories last for weeks, months, or even years, while others quickly fade away? Astrocytes may hold the key.
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Baptiste Lacoste @blacoste.bsky.social · 12/07/2026
New paper by @craigedbrown.bsky.social ! #stroke #cerebrovascular
nature.com
Knockdown of endothelial Serpine1 improves stroke recovery by attenuating peri-infarct blood flow and blood-brain barrier disruption - Cell Death & Disease
Cell Death & Disease - Knockdown of endothelial Serpine1 improves stroke recovery by attenuating peri-infarct blood flow and blood-brain barrier disruption
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Baptiste Lacoste @blacoste.bsky.social · 04/07/2026
🚨 We are recruiting at the Ottawa Hospital Research Institute, in the Regenerative Medicine Program ! If your are passionate about basic science, and dream to develop your own research program, please apply! #Ottawa #Canada #Recruitment #Scientist #Research Full description at the link below:
uottawa.wd3.myworkdayjobs.com
Tier 2 Canada Research Chair in Vascular Links to Neurodevelopment
Follow us on LinkedIn Posting Reason: New Position Job Type: Contingent Worker Anticipated Duration in Months (for contracts and temporary assignments): Job Family: Academic Leadership and Faculty # o...
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Baptiste Lacoste @blacoste.bsky.social · 17/06/2026
A really elegant study by @alexdubrac.bsky.social & team, published at @natureportfolio.nature.com ! #cerebrovascular
nature.com
Mapping neuro-vascular unit communications reveals distinct angiogenic programs across developing mouse brain regions - Nature Communications
Brain blood vessels interact with neural cells to shape brain development, yet how these communications differ across regions remains unclear. Here, the authors show that region-specific neurovascular...
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Reposted by Baptiste Lacoste
Tom Longden @talongden.bsky.social · 09/06/2026
Very happy to share our latest work out in PNAS this week, led by Amy Xiang. We show that capillary thin-strand pericytes express TMEM16A calcium-activated chloride channels, which set the operating point for capillary control of cerebral blood flow in vivo. www.pnas.org/doi/10.1073/...
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Baptiste Lacoste @blacoste.bsky.social · 05/06/2026
New paper by @caglaeroglu.bsky.social ! #astrocytes #development
doi.org
Neuroligin-2 is ubiquitinated by Nedd4l to control developmental astrocyte morphogenesis
Sakers et al. report that astrocytic NLs are functionally diverse proteins with unique intracellular protein–protein interactions. They show that Nedd4l bi
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Baptiste Lacoste @blacoste.bsky.social · 03/06/2026
Save the date 😎 #CSHL #BBB
meetings.cshl.edu
Brain Barriers
Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.
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Baptiste Lacoste @blacoste.bsky.social · 29/05/2026
Amazing paper by Andrew Yang's lab using a new, a non-invasive genetic system to trace neuron-derived protein clearance from the brain to cerebrospinal fluid and border tissues 🤩 #cerebrovascular www.sciencedirect.com/science/arti...
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Baptiste Lacoste @blacoste.bsky.social · 24/05/2026
Our cerebrovascular symposium @canacn.bsky.social in Montreal was a blast with full room! Thanks Aurélie, Grant, Ravi and Alex for your fantastic talks! May the vessels be with you 💪 #symposium #CanadianNeuroscience #cerebrovascular
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Baptiste Lacoste @blacoste.bsky.social · 15/04/2026
The absolute dream paper for any #cerebrovascular developmental biologist !! Congrats to @nicolasrenier.bsky.social, @alexdubrac.bsky.social and their teams !
cell.com
The spatiotemporal dynamics of postnatal vascularization in the mouse brain
Whole-brain tissue clearing and spatial transcriptomics were applied to map postnatal vascular development in the mouse brain, identifying three coordinated phases that link vascular growth to neurona...
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Baptiste Lacoste @blacoste.bsky.social · 12/04/2026
New study clarifies the role of Angiopoietin 2 in the brain vasculature #Cerebrovascular 👇
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Baptiste Lacoste @blacoste.bsky.social · 10/04/2026
Look at this beautiful preprint ! by Neil Dani & team #ChoroidPlexus #BrainBarrier www.biorxiv.org/content/10.6...
biorxiv.org
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Baptiste Lacoste @blacoste.bsky.social · 29/03/2026
New insights into brain imaging by @annadevor.bsky.social just dropped 🧠✨ This study shows that neuromodulators, especially norepinephrine, actively reshape how neural activity translates into blood flow signals across the cortex. A powerful step toward more accurate brain mapping! #cerebrovascular
nature.com
The neurovascular impulse response function differentially reflects intrinsic neuromodulation across cortical regions - Nature Neuroscience
A new optical imaging study demonstrates that norepinephrine and the state of arousal influence hemodynamic correlations across cerebral cortex, calling for a conceptual shift in interpreting function...
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Baptiste Lacoste @blacoste.bsky.social · 26/03/2026
New results show that, in addition to neural changes, sleep involves nonneural processes such as vasomotor-driven hydrodynamic waves 🤩 #Cerebrovascular #sleep
pnas.org
Sleep alters neurovascular and hydrodynamic coupling in the human brain | PNAS
Sleep is essential for maintaining brain tissue homeostasis, which is facilitated by enhanced cerebrospinal fluid (CSF) solute transport. Infraslow...
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Baptiste Lacoste @blacoste.bsky.social · 25/03/2026
🚨 For astrocyte lovers 👇👇
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Reposted by Baptiste Lacoste
Fabrice Dabertrand @dablab.bsky.social · 31/07/2025
🚨Our new paper in Circ Research on the cover + 📖 editorial by Dr. Jackson🔗https://tinyurl.com/2d6hxa83 👏 Danielle Jeffrey tinyurl.com/bdduwe43 collaboration with @osamaharraz.bsky.social Lab ♀️ Female mice show lower hippocampal tone 🌸 Estrogen-dependent⚡️ SK channels dominate 💡 Ludeman Family Center
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Baptiste Lacoste @blacoste.bsky.social · 06/02/2026
Wrapping up my visit to UVA, had a great time and learned about a lot of exciting stuff! Thanks @eyolab.bsky.social for hosting me!
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Baptiste Lacoste @blacoste.bsky.social · 02/02/2026
Professional advice: when celebrating your 10th year lab anniversary🍻, bring your trainees to an axe throwing club, so they can release all the anger accumulated. Let them imaging your face is on the wall 😂
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Baptiste Lacoste @blacoste.bsky.social · 30/01/2026
Cool neurovascular paper in #zebrafish #cerebrovascular #development
nature.com
NMDA receptors coordinate brain vascular development via neuron-to-endothelial tip cell crosstalk in zebrafish - Nature Communications
Neurovascular interaction is critical for normal brain vascular development. Here, the authors show that neuronal NMDARs regulate brain vascular development via VEGF-induced global Ca2+ activities of ...
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Baptiste Lacoste @blacoste.bsky.social · 28/01/2026
New findings suggesting that PROX1 compromises BBB integrity by negatively regulating BBB-associated Wnt signaling. #BBB #BloodBrainBarrier #cerebrovascular
insight.jci.org
JCI Insight - Endothelial PROX1 induces blood-brain barrier disruption in the central nervous system
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Reposted by Baptiste Lacoste
Osama Harraz @osamaharraz.bsky.social · 30/12/2025
🎉 New Publication in @pnas.org Excited to share our lab’s latest research article: PIP₂ Corrects an Endothelial Piezo1 Channelopathy pnas.org/doi/abs/10.1... (Open Access)
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Baptiste Lacoste @blacoste.bsky.social · 17/12/2025
New preprint from the lab! For those who love astrocytes 🤩. We welcome feedback! #preprint #openaccess #astrocytes #autism
biorxiv.org
Metabolic, epigenetic and transcriptomic alterations in postnatal 16p11.2 deficient murine astrocytes
Autism Spectrum Disorders (ASD) are associated with metabolic dysregulation. While astrocytes are integral to cerebral metabolism, their molecular and functional changes in ASD are poorly known. Using...
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Baptiste Lacoste @blacoste.bsky.social · 16/12/2025
Happy holidays and best wishes from our lab!
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Baptiste Lacoste @blacoste.bsky.social · 03/12/2025
A beautiful paper from my friend @naguibmechawar.bsky.social's team ! www.nature.com/articles/s41... #cerebrovascular
nature.com
Pervasive neurovascular dysfunction in the ventromedial prefrontal cortex of female depressed suicides with a history of childhood abuse - Molecular Psychiatry
Molecular Psychiatry - Pervasive neurovascular dysfunction in the ventromedial prefrontal cortex of female depressed suicides with a history of childhood abuse
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Baptiste Lacoste @blacoste.bsky.social · 20/11/2025
PDGFRα is required for postnatal cerebral perivascular fibroblast development. Congrats @siegenthalerlab.bsky.social ! #cerebrovascular #fibroblasts #development
sciencedirect.com
PDGFRα is required for postnatal cerebral perivascular fibroblast development
Perivascular fibroblasts (PVFs) are a cell type associated with large diameter blood vessels in the brain and spinal cord parenchyma and leptomeninges…
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Reposted by Baptiste Lacoste
Osama Harraz @osamaharraz.bsky.social · 19/11/2025
Excited to share the latest from our lab (final version, open access): Brain Capillary Ion Channels: Physiology and Channelopathies Physiology | @apspublications.bsky.social journals.physiology.org/doi/full/10.... @uvmlarnermed.bsky.social
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Baptiste Lacoste @blacoste.bsky.social · 18/11/2025
Hypertension-induced neurovascular and cognitive dysfunction at single-cell resolution @cp-neuron.bsky.social #cerebrovascular #hypertension
sciencedirect.com
Hypertension-induced neurovascular and cognitive dysfunction at single-cell resolution
Hypertension is a leading cause of cognitive impairment, attributed to cerebrovascular insufficiency, blood-brain barrier disruption, and white matter…
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Baptiste Lacoste @blacoste.bsky.social · 16/11/2025
Excellent new review on the blood-brain barrier, by Alon Friedman and colleague @natureportfolio.nature.com #Cerebrovascular #BloodBrainBarrier
nature.com
Dynamic modulation of the blood–brain barrier in the healthy brain - Nature Reviews Neuroscience
The blood–brain barrier was conventionally seen as a static protective structure, but a more complex, dynamic view of this barrier has now emerged. In this Review, Friedman et al. discuss the dynamic ...
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Baptiste Lacoste @blacoste.bsky.social · 12/11/2025
The brain neurovascular epigenome and its association with dementia. #cerebrovascular #epigenetics
cell.com
The brain neurovascular epigenome and its association with dementia
Ziegler et al. reveal distinct genetic and epigenetic mechanisms underlying Alzheimer’s disease and cerebral small vessel disease within neurovascular cells, identifying immune-related AD risk and bro...
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Baptiste Lacoste @blacoste.bsky.social · 08/11/2025
So happy I have been able to witness the incredible growth and success of (now Dr.) Sozerko Yiandiev, who defended his PhD thesis with brio in Lyon this week! It was a true pleasure to co-mentor Sozerko with @jcourchet.bsky.social during the past 5 years 🍻👨‍🎓 #Thesis #BrainMetabolism
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Baptiste Lacoste @blacoste.bsky.social · 08/11/2025
When the stars of glial scar borders and stroke recovery “have a baby”, it gives this 😅 #astrocytes #stroke #cerebrovascular
sciencedirect.com
Regionally mapped astrocytic responses to cortical and white matter stroke show differential roles in astrocyte-induced vascular remodeling
Stroke is a major cause of disability. Astrocytes respond to stroke in a gradated manner, but details of that response and its consequences for tissue…
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Baptiste Lacoste @blacoste.bsky.social · 07/11/2025
#astrocytes #endothelium #cerebrovascular 😱🤩🤩
nature.com
Molecular profiling of brain endothelial cell to astrocyte endfoot communication in mouse and human - Nature Communications
Deciphering body-brain communication pathways is key to a deeper understanding of brain physiology and pathology. Here, the authors define the astrocyte endfoot proteome and show dynamic vascular-to-a...
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Baptiste Lacoste @blacoste.bsky.social · 20/10/2025
The best Sunday of the year 🤩 #peaceful #fall
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María R. Aburto @maburto.bsky.social · 14/10/2025
A privilege to chair symposium ‘Vascular function and cognitive health across the lifespan’ symposium today at @ecnp.eu Thanks to speakers @vcoelhosantoslab.bsky.social Amanda Kiliaan, @mariangelesmoro.bsky.social and @blacoste.bsky.social for their fantastic presentations. #ECNP2025
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Baptiste Lacoste @blacoste.bsky.social · 06/10/2025
An important advance in vascular biology!! #endothelium #vascular
pnas.org
Soluble guanylyl cyclase, the NO receptor, drives vasorelaxation via endothelial S-nitrosation | PNAS
We previously demonstrated that the NO-stimulated soluble guanylyl cyclase (GC1), which produces cGMP, also has the ability to transfer S-nitrosoth...
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Baptiste Lacoste @blacoste.bsky.social · 06/10/2025
Thanks again Yao Yao for the kind invite to USF! Super fun visit, I learned a lot from you and your colleagues 🙏🙏
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Baptiste Lacoste @blacoste.bsky.social · 28/09/2025
Interested in assessing #BBB integrity at high resolution in 3D by electron tomography without spending $$$$$ on cryo-EM? I think we can help with this detailed method 😇 #cerebrovascular #microscopy #EM
onlinelibrary.wiley.com
Volumetric Analysis of the Blood–Brain Barrier After Ischemic Stroke by Electron Tomography in Mice
Objective Transmission electron microscopy (TEM) enables ultrastructural investigation of both organic and nonorganic samples. However, conventional TEM is limited by the acquisition of two-dimensio...
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Baptiste Lacoste @blacoste.bsky.social · 12/09/2025
Very cool new paper from @caglaeroglu.bsky.social's lab showing the mitochondria dynamics regulate astroglial morphogenesis! doi.org/10.1083/jcb.... #Astrocytes #Development
doi.org
Mitochondrial fission controls astrocyte morphogenesis and organization in the cortex | Journal of Cell Biology | Rockefeller University Press
During cortical astrocyte morphogenesis, mitochondria fragment and decrease in size to populate distal astrocyte processes. Drp1-mediated mitochondrial fis
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Baptiste Lacoste @blacoste.bsky.social · 07/09/2025
New work establishing a key role for FOXQ1 in the regulation of brain endothelial metabolism. #Cerebrovascular
doi.org
FOXQ1 Regulates Brain Endothelial Mitochondrial Function by Orchestrating Calcium Signaling and Cristae Morphology
FOXQ1 emerges as a master transcriptional regulator of brain endothelial metabolism, orchestrating mitochondrial function through dual control of calcium signaling and cristae organization. This stud...
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