Using LOPIT-DC-based spatial proteomics, Cadena et al. map the sub-organellar protein landscape of Paulinella chromatophora, a cercozoan with evolutionary-early-stage photosynthetic organelles. They f...

Summary: The placenta is the only mammalian organ that harbors a cancer-like genome while remaining functional and healthy. This Review highlights its high mutational load, structural variants, aneupl...

Transposable elements mobilize within and occasionally between genomes, including from host to virus. We identified two insertions of the human BC200 noncoding RNA gene in the poxvirus molluscum conta...

The Department of Earth and Planetary Sciences (www.eaps.ethz.ch) at ETH Zurich invites applications for the above-mentioned position.

Theory can help address cell and molecular biology’s major challenges, particularly those arising from large omics datasets.

Cells must access resources to survive, and the anatomy of multicellular structures influences this access. This study shows that bacteria in biofilms divide along oxygen gradients; their end-to-end…

Invisibles à l’œil nu, ces micro-organismes d’une incommensurable diversité sont essentiels à nos écosystèmes. Pendant longtemps, il a été difficile de les étudier, mais l’essor de nouvelles technique...

ExÂME is the Expansion Microscopy Atlas of Microbial Eukaryotes, a community-driven project uncovering the hidden cellular architectures of protists and microbial eukaryotes. Supported by the Moore Fo...

Apple will announce the new Apple Watch lineup later today, and Mark Gurman at Bloomberg has the early scoop. He...

Animal cells extensively remodel their cytoskeleton during differentiation and can notably switch between two major motility modes: flagellum-based swimming and actin-based crawling. We previously sho...

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Cellularization as a mechanism to build cells

Fischer et al. uncover a fundamental mechanism of membrane fusion during nuclear pore complex (NPC) assembly. Brl1 and Brr6 form ring-shaped, membrane-remodeling complexes that interact and bridge the...

Maslennikova et al. identify the ER membrane protein CLCC1 as an interaction partner of the dystonia-linked AAA+ ATPase Torsin1A. Torsin1A sustains the function of CLCC1, which is proposed to facilitate fusion of the nuclear envelope during NPC biogenesis by forming an oligomer that promotes lipid bilayer approach and remodeling.

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Basement membranes are scaffolds of proteins, like collagen, that give organs shape. During development, basement membranes must adapt to the growing organ. We infer how fast the basement membrane ada...

Jeffrey Farrell is an Earl Stadtman Investigator at the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), USA, where he heads the Unit on Cell Specification and ...