The MacCoss Lab used Claude to build and validate an open-source DIA search tool – an experiment that could change how scientists and software developers work together

Abstract. One critical step in any targeted mass spectrometry experiment is selecting, from each protein of interest, a small number of peptides that respo

In 2024, we introduced you to Sydney “Syd” Sattler, then a PhD candidate in the Abitua Lab in UW’s Department of Genome Sciences, as the first UW recipient of the Shurl and Kay Curci Foundation PhD Fe...

Integrative 3D epigenomic profiling of four glial cell types from the mid-gestation human cortex reveals cell-type-specific regulatory elements and chromatin interactions that illuminate the roles of ...

Background G6PD deficiency is one of the most common enzyme deficiencies worldwide, and increases the likelihood of adverse reactions to certain drugs and foods. As availability of routine sequencing ...

Antibody affinity maturation results from a somatic evolutionary process that takes place in the germinal center. A “parallel replay” experiment on germinal center B cells reveals the evolutionary for...

Genetic introgression from Neanderthals and Denisovans shaped modern human genomes; however, introgressed structural variants (SVs ≥ 50 base pairs) remain challenging to discover. We integrated high-q...

After initially work on population genetics theory of recombination, of migration, and of speciation, his main focus has been on phylogenetic inference. He s...

Congratulations to this year’s winners and all of the finalists for sharing their work and representing the breadth and brilliance of graduate research at the University of Washington! First Place |…

Variant in situ sequencing (VIS-seq) links genetic variants to cell images, revealing how variants affect molecules, subcellular structures, and cells at scale. Applied to thousands of LMNA and PTEN v...

YouTube video by Fred Hutch Biostatistics Program

The UW is delighted to announce the recipients of the 56th annual University of Washington Awards of Excellence! The awards honor outstanding alumni, faculty, staff, students and retirees who...

WASHINGTON — The National Academy of Sciences announced today the election of 120 members and 25 international members in recognition of their distinguished and continuing achievements in original res...

The Husky 100 recognizes 100 UW undergraduate and graduate students who are making the most of their time at the UW.

Broadly neutralizing antibodies (bNAbs) show promise for HIV treatment and prevention, but are vulnerable to resistance evolution. Comprehensively ...

BBI

NOTCH2NL (NOTCH2-N-terminus-like) genes arose from ape-specific chromosome 1 segmental duplications implicated in human brain cortical expansion, including an incomplete NOTCH2 gene. Genetic character...

YouTube video by UW Medicine

NeMO Analytics is a compendium of public transcriptomic data focused on the neocortex, enabling biologists without coding expertise to explore hundreds of datasets. Joint decomposition of these data y...

Four University of Washington researchers have been named AAAS Fellows, according to an announcement by the American Association for the Advancement of Science. They are among 449 newly elected...

Amyotrophic lateral sclerosis (ALS) is a fatal progressive neurodegenerative disease with no known cure. As a Schmidt Science Fellow, Lauren will use advanced mass spectrometry and protein analysis of...

How he made a research breakthrough.

The ability to predict rapid evolutionary processes within our bodies would advance both medical science and evolutionary biology. We discuss technologies that move us towards intrahost evolutionary p...

Short‑read sequencing misses many early and repeat‑driven mutations. Here, the authors show that long‑read sequencing in autism families increases detection of germline and postzygotic mutations and r...

Large-effect variants in autism remain elusive. Here, the authors use long-read sequencing to assemble phased genomes for 189 individuals, identifying pathogenic variants in TBL1XR1, MECP2, and SYNGAP...

A look at the 12 recipients of the first AI for Science fund.

A model of intrahost poliovirus replication shows that, after several rounds of replication, pocapavir, a poliovirus capsid inhibitor, collapses viral density, preventing intracellular interactions th...

Single-molecule chromatin fiber sequencing exposes single-cell-level heterogeneity in the chromatin architecture of individual regulatory elements.

The Mendel Medal 2026 has been awarded to Professor Joe Felsenstein. Professor Joe Felsenstein was born in 1942, grew up in Philadelphia and studied as an

Freeman Hrabowski Scholars are outstanding early career faculty who have the potential to become leaders in their research fields.

Author summary We investigated factors influencing the success of oral mucosal gene therapy for Fanconi Anemia (FA), a genetic syndrome marked by DNA repair defects in conjunction with a heightened ri...

Mutational Scanning Symposium 2026, 25-27 March, Melbourne