iiinova — where your digital self keeps evolving

Miguel Ramalho-Santos @mrsantos.bsky.social · 28/09/2026

We are recruiting at the Lunenfeld-Tanenbaum Research Institute (LTRI) and the University of Toronto! In the areas of Reproduction, Pregnancy and Developmental Biology, at Assistant or Associate Professor level. Deadline: Nov 29, 2026 Find more and apply👇: 🔗 apply.interfolio.com/192324

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Miguel Ramalho-Santos @mrsantos.bsky.social · 25/09/2026

Our PhD student Bryn Martin received the Dr. Louis Siminovitch Catalyst Award from the Dep. of Molecular Genetics at U. Toronto! For excellence in research and mentoring. Note: Louis Siminovitch was a founder of both the Department and the LTRI. Congratulations, Bryn! @sinaihealth.bsky.social

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Miguel Ramalho-Santos @mrsantos.bsky.social · 17/08/2026

Congratulations Giacomo Furlan + Evelyne Collignon for the paper out now in Dec Cell! Mouse embryos don't go to sleep unless told to do so by Nodal/Smad2. Thank you, Liz Robertson! @cp-devcell.bsky.social @sinaihealth.bsky.social 2month full-text access here: www.sciencedirect.com/science/arti...

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Miguel Ramalho-Santos @mrsantos.bsky.social · 27/07/2026

Lab artists go the Art Gallery of Ontario! - Jul 2026

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Miguel Ramalho-Santos @mrsantos.bsky.social · 07/07/2026

Congratulations to our Lab PhD student on successfully passing the PhD defense on June 22, 2026! Your dedication, perseverance, and commitment have culminated in this remarkable achievement. Wishing you continued success in the next chapter of your career. Congratulations, Dr.Andrew!

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Miguel Ramalho-Santos @mrsantos.bsky.social · 15/06/2026

Love the smell of "accepted in principle" in the (Monday) morning...

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Miguel Ramalho-Santos @mrsantos.bsky.social · 08/05/2026

In our latest anti-bias lab meeting, we discussed the global impacts for societies and scientific research of the blockade of the Strait of Hormuz arising from the war of US and Israel with Iran.

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Miguel Ramalho-Santos @mrsantos.bsky.social · 24/03/2026

Great work by Brandon Cho, our fantastic student-turned-postdoc, out now in Oncogene. Great collaboration w Linda Penn (Toronto). We put the chromatin remodeller CHD1 in an "epistasis battle" with overexpression of THE oncogene MYC in a breast cancer model. 1/2 www.nature.com/articles/s41...

nature.com

CHD1 is a synthetic lethal vulnerability in MYC-driven breast cancer - Oncogene

Oncogene - CHD1 is a synthetic lethal vulnerability in MYC-driven breast cancer

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Miguel Ramalho-Santos @mrsantos.bsky.social · 12/03/2026

Really proud of our stellar lab manager, Kirti Mittal! 1st author in a paper out in @genesdev.bsky.social. From chromatin-bound RNA to functional studies in human ESCs, she discovered a new role for alpha-satellite repeats in nuclear compartmentalization. Congrats! pubmed.ncbi.nlm.nih.gov/41730687/

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Miguel Ramalho-Santos @mrsantos.bsky.social · 09/10/2025

(1/4) New Pre-print! 🌟 Embryonic development is usually seen as a continuous process, yet some embryos can pause their development to survive harsh conditions, a phenomenon known as diapause. How this pausing is actively maintained has remained a mystery.

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Reposted by Miguel Ramalho-Santos

ISSCR @isscr.org · 08/10/2025

The ISSCR is seeking nominations for Vice President and three Director positions. This is an opportunity to help shape the future of stem cell research and contribute to a global scientific community. Nominations are due 22 October 2025. Learn more 👉 www.isscr.org/nominations

isscr.org

2026 Election Nominations — International Society for Stem Cell Research

Elections and nominations for the International Society for Stem Cell Research board of directors and officers.

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Miguel Ramalho-Santos @mrsantos.bsky.social · 07/10/2025

John Gurdon was a true giant: - founder of cell reprogramming; - founder of molecular embryology; - unabashed advocate for basic research; - advisor to numerous successful trainees/PIs; - gentle human that touched so many. In dark times with science under attack, let his vision be a guiding light.

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Miguel Ramalho-Santos @mrsantos.bsky.social · 24/09/2025

🚨 JOB ALERT 🚨 We are hiring TWO principal investigators in systems, cellular, chemical or molecular biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto. Apply now or repost!

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Miguel Ramalho-Santos @mrsantos.bsky.social · 09/09/2025

Thank you for this honor and the continued trust in our group's research! We hope that our work will honor the memory and legacy of Anne and Max Tanenbaum. It is truly a privilege to be part of the amazing communities of @uoftmedicine.bsky.social and @sinaihealth.bsky.social.

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Miguel Ramalho-Santos @mrsantos.bsky.social · 04/09/2025

(1/4) New preprint from the lab! The MYC transcription factor is a potent cancer driver when its expression is dysregulated, but efforts to target MYC directly have not been fruitful. We identify CHD1 as a synthetic lethal vulnerability in MYC-driven breast cancer. www.biorxiv.org/content/10.1...

biorxiv.org

CHD1 is a synthetic lethal vulnerability in MYC-driven breast cancer

The MYC transcription factor is a key regulator of growth during development and a potent cancer driver when its expression is dysregulated. Strategies to inhibit MYC oncogenic activity would mark a s...

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Miguel Ramalho-Santos @mrsantos.bsky.social · 25/07/2025

🌞 Let's enjoy the summer time in Toronto! 🏖️

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Reposted by Miguel Ramalho-Santos

Maria Alcolea @mariapalcolea.bsky.social · 04/07/2025

⏳Only 1 week left to submit your talk for the Fusion Stem Cells & Cancer Conference! 🧪Share your exciting discoveries with us!! 📍Malta 🗓️Talk Deadline: July 10 🔗http://bit.ly/49sCfJp @joneslabucsf.bsky.social, Kathrin Plath, @katemiro.bsky.social at @fusionconf.bsky.social

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Miguel Ramalho-Santos @mrsantos.bsky.social · 12/06/2025

Congrats to Dr. Cho on the successful PhD defense!

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Miguel Ramalho-Santos @mrsantos.bsky.social · 13/03/2025

Thank you @isscr.org Stem Cell Reports for selecting our work for the March cover! Caption: (1/3) In this issue, Kim and Ramalho-Santos provide a perspective on the history of stem cell transcriptomics. They show that a stemness signature from the early 2000’s foreshadowed hypertranscription.

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Reposted by Miguel Ramalho-Santos

Research at Sinai Health @sinaihealth.bsky.social · 13/02/2025

Read the recent review by @mrsantos.bsky.social that marks two decades of stem cell breakthroughs 🔬 🙌 🎉 Discover how a serendipitous discovery of a stem cell gene signature has led to understanding hypertranscription, with implications for health and disease. www.cell.com/stem-cell-re...

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Miguel Ramalho-Santos @mrsantos.bsky.social · 07/02/2025

Out now at Stem Cell Reports @isscr.org: a Perspective on the history of stem cell transcriptomics. We show that a stemness signature from the early 2000’s (Miguel's PhD work) foreshadowed stem cell hypertranscription. Thanks @pairedbox.bsky.social for this adventure! www.cell.com/stem-cell-re...

cell.com

20 years of stemness: From stem cells to hypertranscription and back

Kim and Ramalho-Santos provide a historical perspective starting from the first studies in stem cell transcriptomics in the early 2000s to our present day understanding of hypertranscription in stem c...

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Miguel Ramalho-Santos @mrsantos.bsky.social · 29/01/2025

🗞️Breaking News: our team was just awarded a new, 5-year CIHR Project Grant for our studies of the regulation of hypertranscription! We are very grateful to the Canadian Institutes of Health Research for their continued support of our research in developmental epigenetics. @sinaihealth.bsky.social

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Miguel Ramalho-Santos @mrsantos.bsky.social · 02/01/2025

We found that copies of the LINE1 transposon are key “architects” of the nucleolar genome in human embryonic stem cells. This work brings together two facets of Barbara McClintock’s pioneering research: nucleolar organizer regions and transposable elements. www.genesdev.org/cgi/doi/10.1...

genesdev.org

LINE1 elements at distal junctions of rDNA repeats regulate nucleolar organization in human embryonic stem cells

A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields

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