A key requirement to address fundamental questions in developmental biology is the ability to visualise and manipulate endogenous signalling proteins in vivo. Here we generate such an enabling experim...

This article discusses the preprinted work of Lokshtanov and colleagues (Lokshtanov et al., 2026 preprint) as well as that of Xu and team (Xu et al., 2026 preprint). As preprints, these works have…

Join us in Lausanne to connect with the global community shaping the future of cell understanding and engineering.

Summary: A guide to mechanics in development: unlock how forces, material properties and geometry shape the forms of life.

Cavanaugh et al. show that embryos from aged mice have increased contractility and tissue viscosity on embryonic day 4.5, which leads to poor spreading and attachment. Similar age-associated mechanica...

Cellular processes often exhibit irreversible state transitions even after external signals responsible for a transition are withdrawn. Long-standi...

Animals capable of whole-body regeneration can heal virtually any wound. Here they show that Hofstenia miamia accomplishes this feat through variable morphogenetic strategies that depend on which epit...

The differentiation variability of human pluripotent stem cell lines is diagnosed and corrected.

Gastrulation is the morphogenetic process by which the single-layered pluripotent epiblast is reorganised into the three germ layers and the basic bod…

The Department of Biology at ETH Zurich invites applications for the above-mentioned tenured professorship at the Institute of Biochemistry

Cell intercalation is an exchange of cell neighbours. Now it is shown in a minimal system of four cells that intercalation is driven by junction tension and migratory forces.

Assistant Professor in Biophysics of Living Systems

Mani, Tardif, Rossier et al. show that mechanical stress triggers caveolin-1 release from caveolae, enabling its diffusion in the plasma membrane and interaction with signalling effectors to regulate ...

During regeneration, tissues must translate transient cellular variability into stable spatial organization. Tissue architecture generates a density-dependent window of heterogeneity in the mechanosen...