A scalable blueprint for postdoctoral training embeds entrepreneurial venture mechanics and industry mobility directly into academic infrastructure to cultivate ‘T-shaped’ scientific leaders.

Stem cell differentiation is controlled by manipulating RNA condensates.

Recent moves of note in and around the biotech and pharma industries.

Nature Biotechnology - On-demand glycemic control by engineered bacteria

DIAL designs synthetic promoters for generation of heritable setpoints of gene expression across a range of cell types.

Scientists uncover thousands of previously missed proteins, many of which appear to be relevant to human health — including promising new targets for cancer immunotherapies.

Lipid nanoparticles are improved by including RNA cargo size in the design process.

The thermostability of RNA vaccines is improved with AI.

A photolabile oligonucleotide system enables spatially resolved single-cell measurements to show how the epigenome regulates gene expression.

Recent patents relating to systems, methods and compositions for use in synthetic biology.

Nature Biotechnology - New model for industry PhDs

Sustained epigenetic silencing in monkeys is made more efficient with optimized regulators.

A breast cancer drug linked with a test to detect ESR1 mutations in circulating tumor DNA is one of a wave of new drugs developed to tackle resistance to estrogen-receptor-targeted therapies.

Guidance for optimizing lipid nanoparticle formulations is derived using sophisticated biophysical techniques.

Nature Biotechnology - Biomimetic cells for studying T cell mechanotransduction

Interpreting transcript diversity requires moving beyond ‘known’ versus ‘novel’ and towards a multidimensional framework based on technical credibility, contextual prevalence, reproducibility, molecul...

Nature Biotechnology - FDA approves oncolytic virus

The FDA cannot approve generic drugs for marketing until brand-name drug patents on its list expire or are successfully challenged, but courts have recently found that certain device-only patents are ...

A new generation of RNA therapies delivered by lipid nanoparticles takes aim at extrahepatic tissues.

While technologies for smaller gene edits, such as base editing, have already entered clinical trials, larger gene cargoes face different challenges, including low editing efficiencies, delivery vehic...

Mutation of conserved prolines enhances correct pairing of light and heavy chains for bispecific IgG-like antibody production.

Nature Biotechnology - AI-guided design of complete bacteriophage genomes

A breast cancer drug linked with a test to detect ESR1 mutations in circulating tumor DNA is one of a wave of new drugs developed to tackle resistance to estrogen-receptor-targeted therapies.

A method to label cultured human embryos finds chromosome segregation errors in placenta-fated cells.

China’s Decree 818 aims to bring hospital-based cell, gene and individualized therapies into the clinic safely. Its success will depend on whether it is consistently applied and whether adverse outcom...

Multiplexed editing in primary human T cells generates enhanced immune cell therapies.

A new generation of RNA therapies delivered by lipid nanoparticles takes aim at extrahepatic tissues.

CIRI3 speeds up circRNA detection with low memory requirements.

A scalable blueprint for postdoctoral training embeds entrepreneurial venture mechanics and industry mobility directly into academic infrastructure to cultivate ‘T-shaped’ scientific leaders.

Nature Biotechnology - Moderna flu vaccine wins FDA approval

Modified nanopore simultaneously identifies diverse biomolecules and their modifications.

Six proteomic clocks are applied in a clinical trial to assess anti-aging effects.

Scientists uncover thousands of previously missed proteins, many of which appear to be relevant to human health — including promising new targets for cancer immunotherapies.

Six proteomic clocks are applied in a clinical trial to assess anti-aging effects.

By Benjamin Boettner (BOSTON) — Rock weathering, the breakdown and dissolving of rocks and minerals caused by their exposure to water, air, and biological life, is a major regulator of Earth’s atmosph...

Obvious chemical substitutions could be used to generate powerful new composition-of-matter patents, highlighting the need for patent and antitrust policy reforms that better separate strategic pursui...

From circulating microRNAs to menstrual-fluid transcriptomics, biotech companies are betting on radically different biomarkers to detect a disease that still lacks a clear molecular definition.

Recent moves of note in and around the biotech and pharma industries.

Reference materials should be adopted as a common calibrator for multiomics measurement and co‑profiled with study samples. Multiomics results should be reported as sample‑to‑reference ratios so that ...

DNA recombination in rice is optimized by engineering genomic attachment sites.

This multidisciplinary biomedical engineer hopes to bridge data-driven discovery and mechanistic understanding, advancing precision oncology through interpretable, biologically grounded machine learni...