For nearly 150 years, textbooks have described dendritic morphology as optimized for efficient synaptic voltage transfer from spines to the soma, implemented as a tubular design respecting Rall’s 3/2…

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Two-photon calcium imaging is a standard tool for measuring neuronal population activity in vivo , yet how axial resolution, sensor expression strategy, and analysis pipeline jointly affect data accur...

Luminos LLC provides instrumentation for bidirectional microscopy and all-optical electrophysiology.

Simultaneous voltage imaging of soma and dendrites in layer 2/3 cortical neurons in live mice reveals rich dynamics of spike back-propagation, with amplitude shaped by spiking history, dendrite locati...

Flexible learning relies on integrating sensory and contextual information to adjust behavioral output in different environments. The anterolateral motor cortex (ALM) is a frontal area critical for ac...

Engrams, ensembles of neurons that store memories, exist along a continuum of retrievability. Normally, sensory cues can reactivate a latent engram to…

Voltage-gated ion channels are found in many membrane-enclosed structures, including synaptic vesicles, endosomes, mitochondria, chloroplasts, viruses and bacteria. In small compartments, assumptions ...

Adam Ezra Cohen explains the real-world consequences of canceling federal research grants in the name of fighting antisemitism.

ALI is an approach for analyzing voltage imaging data that is inspired by algorithms used in super-resolution microscopy. It allows resolving the activity of single neurons in densely labeled populati...

Several fluorescent proteins, when expressed in E. coli, are sensitive to weak magnetic fields. We found that mScarlet3 fluorescence in E. coli reversibly decreased by 21% in the presence of a 60 mT m...

Scientists have created a broadly effective antivenom using the blood of a Wisconsin man who has spent years exposing himself to deadly snakebites from black mambas, taipans, cobras and many others.

Researchers developed DELTA, a method for brain-wide measurement of synaptic protein turnover with single-synapse resolution, providing a powerful tool to localize and study mechanisms underlying syna...

Kim and coworkers describe a technique, EPSILON, to map AMPA receptor exocytosis, a proxy for synaptic plasticity, in mice. The authors demonstrated a correlation between AMPA receptor exocytosis and ...

Bidirectional microscopy (BDM) combines simultaneous targeted optical perturbation and imaging of biophysical or biochemical signals (e.g. membrane voltage, Ca2+, or signaling molecules). A core chall...