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Babraham Institute

@babrahaminst.bsky.social
1.6K followers 253 following 171 posts

We make discoveries that help us understand human biology and improve lifelong health. Leaders in #AgeingResearch and cell biology. Research themes in #Epigenetics, #Immunology and #Signalling 📌 Cambridge, UK Funded by UKRI-BBSRC

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Teresa Rayon @trayon.bsky.social · 12/09/2026
‼️ Postdoc position open. We study how protein metabolism controls time. If you’re excited by this question, we’d love to hear from you! We’re looking for a motivated & collaborative researcher with a strong track record. 📅 30 September 2026 📢 Please share Apply here 👇👇
babraham.current-vacancies.com
Postdoctoral Research Scientist - Babraham
The lab investigates the molecular mechanisms that control biological timing in mouse and human stem cells (Azzi & Rayon, Curr Opinions 2024; Nakanoh et al., Dev Cell 2026). The central aim of this ex...
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Babraham Institute @babrahaminst.bsky.social · 10/09/2026
Congrats, Helena! onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
Expression and Role of the RNA‐Binding Protein, ZFP36L1, in Mouse T Follicular Helper Cell Differentiation and Function
T follicular helper (Tfh) cells support germinal center (GC) B cells, generating long-lived antibody-secreting and memory B cells. RNA-binding proteins likely fine-tune Tfh function, but selective de...
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Martin Turner @martint-babraham.bsky.social · 19/08/2026
Congratulations to Helena for getting her first 1st-author paper in this highly-reputable, long-established journal. onlinelibrary.wiley.com/page/journal...
onlinelibrary.wiley.com
European Journal of Immunology 1st Time Authors
Expression and Role of the RNA-Binding Protein, ZFP36L1, in Mouse T Follicular Helper Cell Differentiation and Function DOI 10.1002/eji.70260 First published: 18 August 2026 Full text | PDF
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Babraham Institute @babrahaminst.bsky.social · 10/09/2026
Congratulations to @trayon.bsky.social and colleagues for this exciting new cover story in Dev Cell!
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Teresa Rayon @trayon.bsky.social · 15/08/2026
Our work on the role of the proteasome in developmental tempo is out!!!! 🐭⌛️👤⏳ Six years after identifying an association between protein stability and developmental tempo, we now demonstrate a causal link between protein turnover and developmental tempo through proteasomal degradation
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Stefan Schoenfelder @stefanschoenfelder.bsky.social · 07/08/2026
Very happy to see this story finally out in @natbiotech.nature.com: www.nature.com/articles/s41... Fantastic collaboration with @lancasterlab.bsky.social on how to identify and ‘fix’ differentiation-compromised human pluripotent stem cells. @babrahaminst.bsky.social @mrclmb.ac.uk 🧵 below
nature.com
Reversible epiblast regionalization determines differentiation potential of human pluripotent stem cells - Nature Biotechnology
The differentiation variability of human pluripotent stem cell lines is diagnosed and corrected.
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Houseley Lab @houseleylab.bsky.social · 03/08/2026
Is healthy ageing possible on a normal diet? Our new eLIFE paper describes metabolic re-engineering of yeast to avoid senescence The A2A mutant we created is super-fit late in life even on a rich high glucose diet… these cells stay healthy until they die! elifesciences.org/articles/111...
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BioTrain @biotrain-tv.bsky.social · 24/06/2026
It's finally here! Registration for the 2026 joint international biohackathon is live! 📅 9-11 Sep #Cambridge or #Antwerp 2026.biohack.live #Hackathon #ComputationalBiology #Bioinformatics @uantwerpen.be @vibai.bsky.social @cmn-vib.bsky.social @babrahaminst.bsky.social @babraham-bioinf.bsky.social
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Babraham Institute @babrahaminst.bsky.social · 23/06/2026
Check out the latest pre-print from the Houseley lab 👇
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Babraham Institute @babrahaminst.bsky.social · 04/06/2026
Join our BioSCaPe PhD programme! You'll join an interdisciplinary, collaborative research environment and tackle fundamental biological questions with cutting-edge tools and expert supervision. Deadline 30th July. View the projects: buff.ly/Ex0o7rE
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Biomedical Picture of the Day BPoD @bpodaily.bsky.social · 12/05/2026
How RAB5C enzyme regulates the microbicidal phagosome in macrophages 📷 Edismauro Garcia Freitas-Filho et al, @uspoficial.bsky.social in @science.org Advances ➡️ bpod.org.uk/archive/2026/5/12
bpod.org.uk
BPoD | Eating In
Eating In - Biomedical pictures for May 2026.
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Simon Cook @drsimoncook.bsky.social · 01/05/2026
I am pleased to share a link to the latest paper from the Cook lab. www.biorxiv.org/content/10.6... The DYRK protein kinases, near neighbours to the MAPKs in the CMGC arm of the human kinome, control critical cell fate decisions and are deregulated in disease, much like the MAPKs and CDKs.
biorxiv.org
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BioTrain @biotrain-tv.bsky.social · 14/04/2026
It's #TestimonialTuesday Find out what our hashtag#Bioinformatics course attendees think of our training 👇 biotrain.tv #ScientificTraining #ComputationalBiology #Stats #Statistics #BigData #DataAnalysis #TrainingTuesday #TestimonialTuesday @babraham-bioinf.bsky.social @babrahaminst.bsky.social
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BioTrain @biotrain-tv.bsky.social · 07/04/2026
It's #TestimonialTuesday Find out what our hashtag#Bioinformatics course attendees think of our training 👇 biotrain.tv #ScientificTraining #ComputationalBiology #Stats #Statistics #BigData #DataAnalysis @babrahaminst.bsky.social #TrainingTuesday #TuesdayTestimonial
Dark blue background with quote about how fab the training is
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Teresa Rayon @trayon.bsky.social · 13/03/2026
What a great conference! Thanks to the German, Dutch and Spanish dev bio societies for arranging such an inspiring and inclusive meeting. Happy to have met new colleagues and good old friends from my PhD times.
meeting.gf
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Houseley Lab @houseleylab.bsky.social · 12/03/2026
Exciting new project in our lab @babrahaminst.bsky.social! We are working with @alesdantas.bsky.social at @newcastleuni.bsky.social to understand how extrachromosomal circular DNA mediates drug resistance in fungal pathogens Funded by @wellcometrust.bsky.social #ecDNA #eccDNA #Candida #Zymoseptoria
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Houseley Lab @houseleylab.bsky.social · 19/01/2026
Post-doc job alert! We have an exciting opportunity for a post doc to join our team at the Babraham Institute, exploring ageing metabolism and epigenetics. babrahaminstitute.livevacancies.co.uk#/job/details...
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Babraham Institute @babrahaminst.bsky.social · 26/01/2026
We are pleased to welcome Prof Sir Jim Smith as the Institute's Interim Director. Read more 👇
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Biomedical Picture of the Day BPoD @bpodaily.bsky.social · 10/01/2026
3D lab-grown model of implantation reveals cell types & molecular interactions between embryo & endometrium 📹 Matteo A. Molè, Sarah Elderkin & Irene Zorzan et al @babrahaminst.bsky.social in Cell @cellpress.bsky.social ➡️ bpod.org.uk/archive/2026...
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Babraham Institute @babrahaminst.bsky.social · 15/01/2026
There is just one day left to register for our upcoming Frontiers in Stem Cell Innovation Conference! Join leading academics and industry professionals exploring cutting-edge stem cell technologies and disease modelling for drug discovery. View the full agenda and register now: buff.ly/ZiURhGV
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Babraham Institute @babrahaminst.bsky.social · 24/12/2025
Happy holidays from all of us at the Babraham Institute!✨Our card includes an image of a mouse intestine that has been stained for DNA (blue), e-cadherin (green) and muc2 (red). 📸 Petrina Tan, Christophorou lab
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M. Molè Lab @matteomolelab.bsky.social · 24/12/2025
Our team has successfully achieved human embryo implantation in the lab using a 3D endometrial scaffold. The Goal: Implantation is of the biggest hurdle in pregnancy. By understanding this process in the lab, we can develop new therapeutics to improve clinical outcomes and IVF success rates.
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Simon Cook @drsimoncook.bsky.social · 23/12/2025
Christmas has come early. Fantastic to see this beautiful study from Peter Rugg-Gunn's lab at The Babraham Institute published today. Congratulations to Matteo Mole, Sarah Elderkin, Irene Zorzan and all other authors! www.cell.com/cell/fulltex...
cell.com
Modeling human embryo implantation in vitro
Building an in vitro model of receptive endometrium allows investigation of human embryo implantation and early post-implantation development and recapitulates the earliest stages in establishing the ...
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Babraham Institute @babrahaminst.bsky.social · 23/12/2025
NEWS | Researchers ‘listen in’ to embryo-mother interactions during implantation using a culture system replicating the womb lining www.babraham.ac.uk/news/2025/12...
Microscopy image of a day 14 human embryo that has implanted in the new endometrial model.
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Babraham Institute @babrahaminst.bsky.social · 15/12/2025
Christmas special: buy one ticket, bring a colleague for free! Join leading academics, industry experts, and biotech innovators and explore next-generation stem cell technology, disease modelling, and translational breakthroughs at the Frontiers in Stem Cell Innovation Conference! buff.ly/oMmTmYd
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Babraham Institute @babrahaminst.bsky.social · 05/12/2025
Earlybird deadline extended 🚨Join us at the Frontiers in Stem Cell Innovation (FISCI) Conference on the 5th –6th February 2026 in Cambridge. Up to 50% off ends 16th January: www.eventbrite.co.uk/e/frontiers-...
eventbrite.co.uk
Frontiers in Stem Cell Innovation 2026
Join leading academics and industry professionals exploring cutting-edge stem cell technologies and disease modelling for drug discovery
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Simon Cook @drsimoncook.bsky.social · 21/11/2025
www.embopress.org/doi/full/10.... Congratulations to Suzan Ber and @aesposito1975.bsky.social on their lovely study of KRAS alleles on glutamine and nitrogen metablism and signalling - just out in EMBO Reports. Such a pleasure to collaborate on this fascinating project! 👏
embopress.org
FOXO1 links KRAS G12D and G12V alleles to glutamine and nitrogen metabolism in colorectal cancer | EMBO reports
imageimageKRAS mutations at codon 12 induce profound metabolic changes in colorectal cancer cells. These oncogenic mutations promote FOXO1-dependent glutamine and nitrogen recycling, uncovering a vuln...
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Simon Cook @drsimoncook.bsky.social · 17/11/2025
I’m really pleased to share the link to a new Cook Lab paper published today in Nature Communications. www.nature.com/articles/s41...
nature.com
RAF inhibitors activate the integrated stress response by direct activation of GCN2 - Nature Communications
Three BRAF inhibitors are used to treat melanoma and colorectal cancer. Here, the authors demonstrate that these drugs bind and activate the protein kinase GCN2, a previously unappreciated off-target ...
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British Society for Research on Ageing @bsrageing.bsky.social · 17/11/2025
🚨UK Ageing Research League Table update @babrahaminst.bsky.social claims 1st 🥇 @unibirmingham.bsky.social in 2nd 🥈 @ox.ac.uk in 3rd 🥉 @ucl.ac.uk & (bluesky shy?) Univeristy of Westmisnter narroly miss the podium & are tied for 4th. How did your institution rank? bsra.org.uk/uk-ageing-re...
bsra.org.uk
UK Ageing Research League Table update Sept 2025 - BSRA
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Babraham Institute @babrahaminst.bsky.social · 14/11/2025
The countdown is on! One week left for early birds to get their tickets to the Frontiers in Stem Cell Innovation conference 🎟️ 📅 5–6 February 2026 📍 Cambridge, UK Hosted by The Babraham Institute and Newcastle University. Register now www.eventbrite.co.uk/e/frontiers-...
eventbrite.co.uk
Frontiers in Stem Cell Innovation 2026
Join leading academics and industry professionals exploring cutting-edge stem cell technologies and disease modelling for drug discovery
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Babraham Institute @babrahaminst.bsky.social · 23/10/2025
It’s #AnimalStats day in the UK today. You can see our animal stats at any time on our website, as well as finding out how and why we use mice in our research. www.babraham.ac.uk/our-research...
The graph title is: 2020-2024 Animal Use Statistics: Procedures & Severity
The graphic shows a horizontal bar chart showing the breakdown of severity numbers for each year from 2020 to 2024. 

In 2024, a total of 30,389 procedures were carried out, with 23,257 being sub-threshold, 6,581 being mild, 516 being moderate and 35 being severe.
For previous years the data is as follows:
In 2023, a total of 33,364 procedures were carried out, with 25,585 being sub-threshold, 7,349 being mild, 375 being moderate and 55 being severe.
In 2022, a total of 39,157 procedures were carried out, with 4,069 being sub-threshold, 34,651 being mild, 389 being moderate and 48 being severe.
In 2021, a total of 40,750 procedures were carried out, with 4,008 being sub-threshold, 36,093 being mild, 514 being moderate and 135 being severe.
In 2020, a total of 48,599 procedures were carried out, with 7,613 being sub-threshold, 40,223 being mild, 664 being moderate and 99 being severe.
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Florey Lab @floreylab.bsky.social · 21/10/2025
Check out the line up of amazing speakers at the 2026 GRC Autophagy meeting in Ventura, California, 15-20 March. Register now and share your latest findings. www.grc.org/autophagy-in...
grc.org
2026 Autophagy in Stress, Development and Disease Conference GRC
The 2026 Gordon Research Conference on Autophagy in Stress, Development and Disease will be held in Ventura, California. Apply today to reserve your spot.
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Babraham Institute @babrahaminst.bsky.social · 16/10/2025
Interested in #StemCell research and technologies? Then hopefully this pairing of events is already marked in your calendar for February 2026. If not, take a longer look! www.eventbrite.co.uk/e/frontiers-...
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Frontiers in stem cell innovations, 5 & 6 February 2026
Wellcome Genome Campus and Babraham Research Campus, Cambridge, UK
Partnered with the Annual World Organoid and Organ-on-a-chip Research Day+ (WORD+)

Speakers
Lyle Armstrong - Newcastle University,
Bilada Bilican - AstraZeneca, 
Adriana Buskin - Newcastle University, 
Maria Christophorou - Babraham Institute,
Davide Danovi - Migration Biotherapeutics,
Fiona Ducotterd - Alzheimers Research UK & UCL,
Mark Kotter - Cambridge Stem Cell Institute & bit.bio,
Nick Ktistakis - Babraham Institute,
Marzena Kurzawa-Akanbi - Newcastle University,
Majlinda Lako - Newcastle University,
Rick Livesey - Talisman Therapeutics & UCL,
Matteo Martufi - GSK,
Fiona Menzies - Eli Lilly & Co,
Peter Rugg-Gunn - Babraham Institute,
Stefan Schoenfelder - Babraham Institute,
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John Innes Centre @johninnescentre.bsky.social · 06/10/2025
VACANCY - We have an opportunity for a Postdoctoral Researcher to join the Howard Group, working to develop computational models of epigenetic dynamics in the Polycomb system. www.jic.ac.uk/vacancies/po... Closing date - 9 November 2025 Salary - £37,500 - £45,350 Contract - 36 months, full-time
jic.ac.uk
Postdoctoral Researcher (Howard Group) | John Innes Centre
An exciting opportunity has arisen for a Postdoctoral Researcher to join the Howard Group at the John Innes Centre, working on cutting-edge science in the field of Computational and Systems Biology.
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Babraham Institute @babrahaminst.bsky.social · 06/10/2025
ICYM our announcement from last week: Two incredible events unite to make one unmissable opportunity! www.eventbrite.co.uk/e/frontiers-...
eventbrite.co.uk
Frontiers in Stem Cell Innovation 2026
Join leading academics and industry professionals exploring cutting-edge stem cell technologies and disease modelling for drug discovery
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Babraham Institute @babrahaminst.bsky.social · 06/10/2025
NEW PUBLICATION | A research collaboration between the Rugg-Gunn lab and Lonza is moving researchers towards the ability to drive transgene expression (in CHO cells) at higher levels to improve biopharmaceuticals yields. analyticalsciencejournals.onlinelibrary.wiley.com/doi/epdf/10....
analyticalsciencejournals.onlinelibrary.wiley.com
Comprehensive Mapping of Functional Enhancers in Chinese Hamster Ovary Cells
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Milner Therapeutics Institute 🧪 @milnerinst.bsky.social · 29/09/2025
🚀 Applications are open for the Bio-spark Entrepreneurial Programme! Are you an early career researcher hoping to consider options outside the academic world? Are you looking for advice, experience or mentorship? 🗓️ Apply by 13 Oct 🔗 www.gravity.cam.ac.u...
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Babraham Institute @babrahaminst.bsky.social · 30/09/2025
3 days - 2 events - 1 amazing opportunity! Get set for two events showcasing bioscience innovation. 4-5 Feb - WORD+ 2026 event 5-6 Feb - our Frontiers in Stem Cell Innovation (FISCI) conference 📍Cambridge Registration for FISCI is open now: www.eventbrite.co.uk/e/frontiers-...
eventbrite.co.uk
Frontiers in Stem Cell Innovation 2026
Join leading academics and industry professionals exploring cutting-edge stem cell technologies and disease modelling for drug discovery
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Babraham Institute @babrahaminst.bsky.social · 30/09/2025
NEWS | A new multi-omics method enabling the profiling of multiple histone modifications and gene expression in single cells, and the researchers behind it, have been recognised with two awards. Congrats to the Rugg-Gunn lab and everyone involved! www.babraham.ac.uk/news/2025/09... #epigenetics
Text reads: News - Prizes for team behind game-changing multi-omics method to decode gene regulation. Image shows Dr Yang Wang (left) and Dr Peter Rugg-Gunn (right) shown over a data analysis plot from the scMTR-seq technique.
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Community Rehabilitation Research Network @communityrrn.bsky.social · 29/09/2025
Publishing Your Research? Resource for early career researchers from Alzheimer's Society Retreat Dr Johanna Jackson @imperialcollegeldn.bsky.social Dr Simon Andrews @babrahaminst.bsky.social Dr Christian Schnell @plosbiology.org Cherie Nyota @alzheimerssoc.bsky.social youtu.be/ACqKndCoM3Q?...
youtu.be
Advise on Publishing Your Research
YouTube video by Dementia Researcher
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Teresa Rayon @trayon.bsky.social · 28/09/2025
We've updated our first #preprint from the lab! A collaboration with @jamesbriscoe.bsky.social 🔥 now including in vivo 🐭&👤 embryo data www.biorxiv.org/content/10.1...
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Max Planck Institute for Molecular Genetics @molgen.mpg.de · 26/09/2025
2nd Meeting on Early Embryogenesis and Epigenetics 16 - 18 Feb 2026 at MPI for Molecular Genetics, Berlin with support by the Weizmann Institute for Science. Early bird registration until 30 Sep - register now👇 www.molgen.mpg.de/embryo2026
Save-the-date information:
New approaches to Early embryogenesis & epigenetics
February 16 - 18 2026
Max Planck Institute for Molecular Genetics, Berlin, Germany
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Michelle Linterman @linterman.bsky.social · 25/09/2025
Great to have this out, and such a pleasure to work together. @smguillaume.bsky.social @cristianbeccaria.bsky.social @iannaconelab.bsky.social
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delladavid-lab.bsky.social @delladavid-lab.bsky.social · 19/09/2025
🔬We have a fully funded Cambridge Biosciences DTP PhD postion to study #Proteostasis and #Aging in colloboration with @jrkumita.bsky.social @Pharmacology. Details on the project ▶️https://tinyurl.com/2zhkjjhs + bbsrcdtp.lifesci.cam.ac.uk/how-apply . Please RT.
tinyurl.com
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Babraham Bioinformatics @babraham-bioinf.bsky.social · 23/09/2025
This #TrainingTuesday why not check out our recently scheduled dates for the autumn term #Bioinformatics #ComputationalBiology #ECRchat www.bioinformatics.babraham.ac.uk/cgi-bin/publ... @babrahaminst.bsky.social
media.tenor.com
a man with a mustache wearing a black hat and a blue shirt
ALT: a man with a mustache wearing a black hat and a blue shirt
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Research Adjacent / Sarah McLusky @researchadjacent.bsky.social · 23/09/2025
NEW EPISODE: Reflections from last weeks International Research Culture Conference #IRCC25 at University of Warwick organised by the National Centre for Research Culture featuring guests Chandrika Nair, Alys Kay, and Dolly Coates. Find it in your podcast app or here buff.ly/tBStCUO
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Anne Corcoran @annecorcoran.bsky.social · 10/09/2025
Delighted to share that our paper solving the age-old mystery of whether and how VH-replacement shapes the antibody repertoire is in @embojournal.org www.embopress.org/doi/full/10.... Fantastic work from Harry White, @peterch405.bsky.social @babraham-bioinf.bsky.social @babrahaminst.bsky.social
This shows an antibody heavy chain successfully pairing with a surrogate light chain and signalling B cell progression. In contrast a non-pairing heavy chain fails to signal, the B cell stalls, and the suboptimal V gene is replaced by an upstream V to make a pairing heavy chain and rescue the B cell.
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Babraham Institute @babrahaminst.bsky.social · 08/09/2025
NEWS | Work just published by the Corcoran lab has described a mechanism estimated to be responsible for shaping the generation of up to half of all antibodies. www.babraham.ac.uk/news/2025/09/institute-immunologists-new-process-antibody-diversity @annecorcoran.bsky.social
Text reads: News - Institute immunologists uncover new process important for antibody diversity. Image shows a computer illustration of antibodies, showing the heavy chain (red) and the light chain (blue).
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delladavid-lab.bsky.social @delladavid-lab.bsky.social · 02/09/2025
Exciting news📣: #ProteostasisUK is hiring a network manager to help drive an ambitious, #BBSRC funded initiative connecting and expanding #Proteostasis research across the UK. Position initially for 3 years. Deadline September 28th. More info: tinyurl.com/f83rp673 & proteostasisuk.co.uk Please RT
tinyurl.com
hireful.
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Babraham Institute @babrahaminst.bsky.social · 02/09/2025
Will you be at the @bsrageing.bsky.social ‪#BSRA2025 this week? Look out for Institute contributions: - @martint-babraham.bsky.social: RNA binding proteins in Tregs (Friday) - Rahul Samant: proteostasis strategies, stress resilience & senescence (Friday) - Institute facilities showcase
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