Summary: Single cell RNA-sequencing establishes core components of the gene regulatory network that drive Nestin-expressing progenitor to inhibitory neuron differentiation in the developing mouse and ...

Highlighted Article: YAP activation in notochord progenitors of vgll4b mutant zebrafish leads to enhanced progenitor addition to the notochord, compromising the ability of notochord cells to undergo v...

Robust tissue growth control requires long-range communication between the rate of progenitor addition and tissue expansion. However, the regulatory mechanisms that couple these processes are unknown....

Biological systems are never in equilibrium, yet they maintain stability in the face of continuous external disturbances. A prime example of this is organ regeneration, during which organs are reliably rebuilt through controlled cellular proliferation. In this study, we employ a cell-based computati …

The control of animal homeostasis and repair has been studied for decades, mostly from a molecular and biochemical perspective. Recent research shows that biophysical factors, such as mechanical forc…

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Earlier this year, The Company of Biologists celebrated its 100-year anniversary with the Biologists @ 100 conference in Liverpool - bringing together

Regeneration restores a damaged body part to its original size, shape and structure. Research over the last decades identified signaling pathways, cel…

Limb loss remains a significant clinical challenge, but regenerative medicine approaches such as gene therapy offer a promising strategy to trigger endogenous regeneration programs. Optimal vector con...

Our grants support and encourage the sharing of knowledge throughout the community by facilitating international collaboration, event attendance and the organisation of scientific meetings, conference...

Stem cell–derived mesodermal organoids reveal how signaling centers guide cell fate and tissue organization.

Biology Open | The Company of Biologists Fast & Fair peer review A new initiative offering high-quality peer review within 7 working days of submission Biology Open (BiO) has embar...

Nature - Soil compaction traps ethylene around roots, which causes transcriptional upregulation of Auxin Response Factor1, resulting in decreased root cortical cell wall thickness and thereby...

Soil compaction traps ethylene around roots, which causes transcriptional upregulation of Auxin Response Factor1, resulting in decreased root cortical cell wall thickness and thereby promoting root ra...