Häkkinen et al. show that zebrafish neural crest cells encounter increased tissue-scale confinement along the body axis. Despite nuclear deformation, migrating neural crest cells experience neither nu...

Proteasomal degradation is a fundamental process for all eukaryotic life. A protein destined for degradation is first tagged with a polyubiquitin chain, which is selected by the proteasome. Different ...

Precise spatiotemporal control of protein synthesis is essential during embryogenesis, yet directly measuring translation kinetics in vivo remains challenging in vertebrates. In particular, it remains...

Despite substantial variation in adult size, animals within a species maintain consistent tissue patterns and shapes, a core property known as developmental scaling or size invariance. Developmental s...

Alt: Mad Scientist Working in a Laboratory. A man in a lab coat works on a large cabinet sized device covered in proper dials and levers and blinky lights. We used to be researchers. PROPER researchers.

A key requirement to address fundamental questions in developmental biology is the ability to visualise and manipulate endogenous signalling proteins in vivo. Here we generate such an enabling experim...

Adult neural stem cells (NSCs) in the mouse brain are predominantly quiescent, with activation tightly regulated to balance neurogenesis and stem cell maintenance. Circadian clocks temporally organize...

The lab investigates the molecular mechanisms that control biological timing in mouse and human stem cells (Azzi & Rayon, Curr Opinions 2024; Nakanoh et al., Dev Cell 2026). The central aim of this ex...

Snake embryos coil, but how and why they corkscrew remains unexplored. Weber et al. find that the embryos wind up clockwise via buckling of the rapidly elongating axial body against the slow-growing, ...

High-dimensional data are visualized through representation on tree structures.

Human embryonic development proceeds more slowly than in mice. The segmentation clock offers a tractable model for studying species-specific developme…

Proportional organ growth requires tissue-level control of cell behavior. Yet the cues that adapt growth rates, especially after organ injury, remain unclear. Here, we uncover that developing organs a...

Adult intestinal size plasticity is driven not only by epithelial stem cells but also by remodeling of the surrounding visceral musculature. Sex- and reproduction-dependent muscle remodeling controls ...

Nature Metabolism - Academic careers are shaped by scientific discovery, professional networks, mentorship and the challenges of balancing research with personal and professional responsibilities....

Gastrulation is the morphogenetic process by which the single-layered pluripotent epiblast is reorganised into the three germ layers and the basic bod…

The annual Cryo-EM Symposium is a conference for structural biologists to discuss cutting-edge developments in cryo-Electron Miscroscopy. Held at the Vienna BioCenter.

Lactate dehydrogenase A (LDHA) is a key glycolytic enzyme that commonly exhibits altered expression in human diseases such as cancers and neurodegeneration, making it a valuable disease biomarker and ...

EMBL Hamburg / CSSB The European Molecular Biology Laboratory (EMBL) is Europe’s flagship life sciences organization, with more than 110 independent research groups across Heidelberg, Hamburg, Grenobl...