Summary: In silico analysis of complex reaction-diffusion mechanisms reveals fundamental limits on the ability of activator-inhibitor systems to break symmetry in vivo.

The historical order in which mutations appear during evolution determine the evolutionary trajectory of gene regulatory networks and influence how developmental patterns change and diversify over tim...

The authors present a computational framework that leverages mechanical force inference and spatial transcriptomics to enable analyses of the interplay between the transcriptomic and mechanical state.