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Levayer Lab

@levayerr.bsky.social
3.5K followers 503 following 249 posts

Epithelial cell death, cell extrusion, self-organisation, mechanotransduction and many other things

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Levayer Lab @levayerr.bsky.social · 29/09/2026
Not sure how the community will be consulted, but if so this will be really critical and time to be vocal...delegating our peer judgement (admittedly imperfect) to LLM feels like removing the cornerstone of how science works. If this is the way it goes, I'd rather become a teacher or bake bread🤷‍♂️
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Levayer Lab @levayerr.bsky.social · 28/09/2026
Here it is...by delegating decision to non transparent AI models we generate an incentive for grant applicants to use AI writing to tweak system and the vicious/absurd feedback loop is set (which all started by an overload of grant application driven by AI writing). www.science.org/content/arti...
science.org
U.K. funder uses ‘AI triage’ to reject grant proposals—leaving researchers dismayed
The AI-based assessment, which wasn’t explicitly described in the funding call, has raised privacy and fairness concerns
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John Stott @jpsastro.bsky.social · 24/09/2026
Had a UKRI funded grant proposal rejected at the "AI triage stage". "This AI-based triage was used only to identify approximately 50% of the strongest proposals to take forward to full human review." 🧪 #academicsky
I am writing to let you know that, unfortunately, your application was not successful.

Review process

As part of the initial triage of the 179 proposals submitted to this call, each was assessed using an AI-based review. Every proposal was read independently by several different AI models against the same seven criteria used to shape this call (including cyber security relevance, research quality and novelty, importance of the problem addressed, feasibility of the project plan, likely outputs and impact, value for money, and responsible research practice), with each model asked to give a score and a written justification with supporting quotations from the text. To guard against any one model's idiosyncrasies, we also ran a second, independent process in which different AI models debated the merits and weaknesses of each proposal before reaching a judgement, again against the same criteria. Scores from both processes were combined to produce an overall ranking. 

This AI-based triage was used only to identify approximately 50% of the strongest proposals to take forward to full human review.  Projects selected for funding were drawn from those that progressed to the full human review stage. We recognise that AI-assisted assessment is a new and evolving part of the review process, and we are continuing to evaluate how well it aligns with the judgements of human reviewers on this call. We will soon produce a document detailing our method, so that others can build upon it and improve it.

Feedback on your application

Your application was not selected to progress beyond the AI triage stage.  To provide transparency on the outcome of this assessment, we are sharing below the scores (out of 5) from each of the two AI review processes described above, together with the mean score across the two processes.
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Marion Baraban @marionbaraban.bsky.social · 24/09/2026
A funded postdoctoral position is available at the IBPS, Sorbonne University/CNRS/INSERM in Paris, to investigate the formation of the olfactory organ in zebrafish. We are looking for an postdoctoral researcher with expertise in transcriptomics and bioinformatics, (scRNAseq analysis).
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Levayer Lab @levayerr.bsky.social · 24/09/2026
Only one week left to apply ! Check below for more details but the course will be great. Please spread the word 🙏
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Levayer Lab @levayerr.bsky.social · 23/09/2026
Not every cell react the same way to caspase activation. In our recent study (led by @tomcumming.bsky.social and initiated by @avillars.bsky.social ), we tried to better understand what explains this difference and outlined a role of past caspase exposure 👇 www.nature.com/articles/s41...
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Marco MILAN LAB @milanlab.bsky.social · 16/09/2026
Milan Lab is recruiting a new PhD student. Deadline: October 30th. Please, spread the news. www.irbbarcelona.org/en/careers/y...
irbbarcelona.org
IRB Barcelona International PhD Fellowships - Extraordinary call 2026
The following will be offered in this call:Up to 8 FPI positions associated with the “Proyectos de Generación de Conocimiento 2025” Call (funded by the Agencia Estatal de Investigación AEI- MICINN).Ch...
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Terence Tao @teorth.bsky.social · 11/09/2026
A group of 25 Fields Medalists, including myself, have made a joint declaration on Math and AI: mathandai.org . We welcome additional signatories. See also this article in the Economist announcing the declaration: www.economist.com/science-and-...
mathandai.org
Declaration — Math and AI
Read the declaration and add your name.
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Prisca Liberali @priscaliberali.bsky.social · 08/09/2026
What if we stop asking only how cells build tissues and ask how tissues shape cells? That’s what we’ll explore at Modelling Life from Tissues to Cells 🇨🇭 lakeconferences.org/conf/8334d9b...
lakeconferences.org
Conference - Modelling Life from Tissues to Cells: Coordination and Robustness - Lake Conferences
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Levayer Lab @levayerr.bsky.social · 08/09/2026
Institut Curie, Paris, symposium: Where Form Takes Shape October 27-28th 2026 (after the yearly International Developmental Biology course) Registration before October 10th (for free !): docs.google.com/forms/d/e/1F... There will be short talks and posters selected from abstracts.
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Levayer Lab @levayerr.bsky.social · 04/09/2026
📢master or PhD student interested in cell biology ? There are spots left for the Molecular Biology of the Cell course @pasteur.fr. Check the amazing list of lecturers + 1 week practical pocking choano cytokeleton with @thibautbrunet.bsky.social team. Registration 👇 www.pasteur.fr/fr/nous-conn...
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Development @dev-journal.bsky.social · 04/09/2026
The role of geometry in morphogenesis Read this Review from our special issue #DevSIextracellular by Ryan Harrison, Olivier Hamant and @timesaunders.bsky.social. journals.biologists.com/dev/article/...
Role of geometry in shaping tissues. Multiple factors, including cell shape (top left), boundary constraints (top right), topological inputs (bottom left) including from different cell alignment defects (±1/2) and biophysical factors (bottom right) impact how the final tissue form emerges (centre). Centre shows images of a 48 h neuruloid (left; magenta, DAPI; green, actin) and a young Arabidopsis flower (right) treated with oryzalin (depolymerised microtubules) thus showing isotropic growth, but no defect in patterning (organs are still initiated in the right position).
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Levayer Lab @levayerr.bsky.social · 03/09/2026
The last version of our EpiCure tool is now out in @dev-journal.bsky.social, a user friendly Napari plugin for epithelial segmentation curation. A bit thanks to @gaellel.bsky.social for carrying all along this joint department effort (check the details below). Feel free to use it and expand it !
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Thibaut Brunet @thibautbrunet.bsky.social · 02/09/2026
🚨 New preprint alert! 🚨 Choanoflagellates reorganize their global cytoskeletal architecture within seconds to explore confined microspaces. This is the main PhD work of the amazing @maitefreired.bsky.social www.biorxiv.org/content/10.6... A tread 🧵⬇️
biorxiv.org
Rapid repurposing of microvillar content drives a flagellate-to-amoeboid switch in the closest relative of animals
Animal cells extensively remodel their cytoskeleton during differentiation and can notably switch between two major motility modes: flagellum-based swimming and actin-based crawling. We previously sho...
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Cells & Development @cellsdev.bsky.social · 28/08/2026
A very intriguing story by Joao F. Botelho et al shows that in bird, the digit formation (their ✋) is not only governed by apoptosis but also due to changes in the rate of growth extension and cell division between the interdigital zone and the digital zone. So cool! #devbio doi.org/10.1016/j.cd...
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Carolina Rezaval @crezaval.bsky.social · 26/08/2026
We’re recruiting postdocs to join our @wellcometrust.bsky.social , Decoding Competition in the Brain. How does the brain resolve competing needs and prioritise behaviour? 📅 New deadline: 15 September 🔗 Apply: rezavallab.org Please share!
rezavallab.org
Home
​ ​Animals must make crucial behavioural choices on a minute by minute basis to survive in a changing environment. A long-standing enigma is, how are alternative options evaluated in the brain...
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Kate Cavanaugh @katecavanaugh.bsky.social · 25/08/2026
🧵 What if one reason fertility declines with age isn’t just genetic-but mechanical? Thrilled to share our new paper in @NatureCellBio : Elevated contractility drives implantation failure in mouse embryos from aged females… here’s what we found 👇 www.nature.com/articles/s41... 1/11
nature.com
Elevated contractility drives implantation failure in mouse embryos from aged females - Nature Cell Biology
Cavanaugh et al. show that embryos from aged mice have increased contractility and tissue viscosity on embryonic day 4.5, which leads to poor spreading and attachment. Similar age-associated mechanica...
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Delarue Research @delarueresearch.bsky.social · 25/08/2026
Please save the date: The Microphysio Conference is back and will be held in Cargèse from April 25th to April 30th! With a great lineup of speakers, it’s an excellent opportunity to exchange ideas in fields related to organ-on-chip, organoids, bioprinting, mechanobiology, and much more! Stay tuned.
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Stefano Di Talia @ditalialab.bsky.social · 24/08/2026
Happy to see Ashley's paper out @natphys.nature.com www.nature.com/articles/s41...
nature.com
Decaying and expanding Erk gradients process memory of skeletal size during zebrafish fin regeneration
Nature Physics - Zebrafish can regenerate amputated fins back to their original size. It is now shown that gradients in extracellular signal-regulated kinase activity act as rulers during fin bone...
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FlyBase @flybase.bsky.social · 20/08/2026
Treat biological databases as infrastructure, not projects www.nature.com/articles/d41...
nature.com
Treat biological databases as infrastructure, not projects
Letter to the Editor
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Levayer Lab @levayerr.bsky.social · 20/08/2026
So cells do count eventually (still need to check the details but the abstract sounds very appealing) www.nature.com/articles/s41...
nature.com
Intestinal stem cells count self-renewal divisions to switch multipotency - Nature
In Drosophila, cell fate switching in adult intestinal stem cells is determined through an epigenetic mechanism in which these cells count divisions, switching from producing enterocytes to producing ...
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Levayer Lab @levayerr.bsky.social · 20/08/2026
This 👇, and Europe should also have more scheme to finance those essential "infrastructures" (rathen than implementing 10 millions single person grant...) www.nature.com/articles/d41...
nature.com
Treat biological databases as infrastructure, not projects
Letter to the Editor
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Tineke Lenstra @tinekelenstra.bsky.social · 17/08/2026
Sign up now for the EMBO meeting 'quantitative biology to molecular mechanisms'. Fantastic speaker lineup and plenty of speakers slots selected from abstracts. Submit your abstract before Sept 11!
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Böke Lab @bokelab.bsky.social · 12/08/2026
What does an ovary actually look like as it ages—one oocyte at a time? We mapped >85,000 oocytes in >100 intact mouse ovaries, in 3D, across the reproductive lifespan. And the ovary turned out to be much more organized than we expected. 🧵 1/5 www.nature.com/articles/s43...
nature.com
Three-dimensional mapping of intact ovaries reveals the aging dynamics of the ovarian reserve - Nature Aging
The spatiotemporal dynamics of the depletion of the ovarian reserve remain incompletely understood. Combining whole-ovary imaging, AI and modeling, the authors mapped over 85,000 mouse oocytes and fou...
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Journal of Cell Science @jcellsci.bsky.social · 14/08/2026
The CellExIt#1 symposium gathered investigators working on cell extrusion. This report offers a panoramic view of the research teams and ongoing projects of the field. @levayerr.bsky.social @magalisuzanne.bsky.social journals.biologists.com/jcs/article/...
The CellExIt#1 participants. From left to right: Marija Matekcic, Sabrina Vinzens, Xavier Trepat, Saranne J. Mitchell, Yusuke Toyama, Romain Levayer, Lucy Erin O'Brien, Jakub Sedzinski, Jody Rosenblatt, Alpha Yap, Simon de Beco, Cécile Daubech, Benoit Ladoux, Léa Roquin, Naoka Shiratsuchi, Magali Suzanne, Angela K. O. Lwin, Lieke Stockmann, Aline Grata, Jean-François Rupprecht, Yasuyuki Fujita, Sara A. Wickström, Rashmi Priya and Emile Magny.
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David Green @greenbaron.bsky.social · 13/08/2026
Really excited to finally show off our work on the specification of neuroblasts. While it has been a long-standing model for lateral inhibition, we show that Notch does not select the NB, but instead reinforces fate decisions. www.cell.com/current-biol... @currentbiology.bsky.social
cell.com
Positional cues, not Notch, direct neuroblast selection during early neurogenesis in the Drosophila embryo
Using quantitative live imaging, Green et al. show that proneural gene expression is biased by positional cues and that Notch is activated only after neuroblast selection in the Drosophila embryo. Thi...
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Levayer Lab @levayerr.bsky.social · 12/08/2026
A lot of food for thought here. Down the line, many aspects here are based on the hypothesis that we need to have machine readable scientfic results (completly repurposing article from : we write for a "human" community - to - we write for LLM using our results). That opens a lot of questions...
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Irene Miguel-Aliaga @irenemiguel-aliaga.bsky.social · 11/08/2026
Read about our latest work here www.cell.com/cell/fulltex... or let Alessandro tell you all about it (link below)!
cell.com
The sex and reproductive plasticity of intestinal muscles instruct gut size
Adult intestinal size plasticity is driven not only by epithelial stem cells but also by remodeling of the surrounding visceral musculature. Sex- and reproduction-dependent muscle remodeling controls ...
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Levayer Lab @levayerr.bsky.social · 09/08/2026
With a bit of delay, a little report on the great scientific get together we got in April on cell extrusion #CellExit#1. Have look if you want to get a rapid overview of ongoing projects More to come in the near future with a broader meeting hopefully ! journals.biologists.com/jcs/article/...
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Inés Fournon Berodia @inesfournon.bsky.social · 04/08/2026
Very pleased to finally share the main story from my PhD, now published in @natcomms.nature.com ! 🎉 Using a sea anemone we discovered and characterised epithelial cell extrusion as the mechanism underlying starvation-induced cell loss. 🔗 Open-access article: www.nature.com/articles/s41...
nature.com
Epithelial cell extrusion underlies starvation-induced cell loss in a sea anemone - Nature Communications
Epithelial cell extrusion in a sea anemone shares key hallmarks with bilaterians and is dynamically regulated by nutritional status. During starvation-induced body shrinkage, extrusion likely contribu...
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Cornelia Schwayer @cschwayer.bsky.social · 03/08/2026
Looking for a PhD? Applications are now open for PhD positions at the Max Delbrück Center. 🧵 www.mdc-berlin.de/career/jobs/...
mdc-berlin.de
PhD Positions (m/f/d) in Biomedical Research
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Yanlan Mao @yanlanmao.bsky.social · 30/07/2026
This epic paper, which has been a heroic 10 year journey for the lead author, Ricardo Barrientos, is finally out in Cell today! Many thanks to all co-authors, especially Billie Meadowcroft and Andela Saric for their beautiful MD simulations www.cell.com/cell/fulltex...
cell.com
Basement membrane turnover controls cell shape
Basement membranes are scaffolds of proteins, like collagen, that give organs shape. During development, basement membranes must adapt to the growing organ. We infer how fast the basement membrane ada...
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Jean-Yves Tinevez @jytinevez.bsky.social · 09/07/2026
And also, for the story: www.iledefrance-meudon.cnrs.fr/fr/personne/...
iledefrance-meudon.cnrs.fr
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Levayer Lab @levayerr.bsky.social · 09/07/2026
Congratulation @gaellel.bsky.social for the crystal medal ! So well deserved, you've been transformative for the democratisation of image analysis and deep learning. www.insb.cnrs.fr/fr/talents/c...
insb.cnrs.fr
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Benoit Ladoux @bladoux.bsky.social · 08/07/2026
Thrilled to share our new paper on cell extrusion. A beautiful study with a tremendous amount of data, led by the fantastic @fanny-wodrascka.bsky.social ! www.biorxiv.org/content/10.6...
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Thibaut Brunet @thibautbrunet.bsky.social · 09/07/2026
Les nouvelles règles envisagées pour l'ANR sont plus qu'inquiétantes. Elles porteraient un immense coup d'arrêt à la recherche fondamentale en France, surchargeraient les jeunes chercheurs, et n'attendraient sans doute même pas leur objectif (apparent) de réduction du nombre de candidatures
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Margherita Battistara @mbattistara.bsky.social · 08/07/2026
🪲🪰 Our preprint is out! This was a team effort with @wolframponisch.bsky.social, @matthewabenton.bsky.social and Ewa Paluch. We asked whether Drosophila and Tribolium use the same cell behaviours to fold their embryos during gastrulation. 🧵👇 www.biorxiv.org/content/10.6...
biorxiv.org
Morphospace analysis reveals divergent cellular behaviours driving tissue internalisation during insect gastrulation
During gastrulation, embryonic epithelia undergo large-scale remodelling to internalise the mesoderm. Whether the cellular mechanisms underlying these tissue deformations are conserved across species ...
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Levayer Lab @levayerr.bsky.social · 08/07/2026
Si les nouvelles règles de l'éligibilité de l'ANR sont bien réelles, alors je ne comprends pas quelle est la logique sous jacente. Au vu de la pyramide des ages, forcer une collaboration avec chercheurs(ses) <10 ans post thèse va de facto exclure 80% des candidats.
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UCL Faculty of Life Sciences @ucllifesciences.bsky.social · 08/07/2026
New research from @fpichaud.bsky.social and University of Seville researchers found that developing fruit fly retinas behave like metamaterials, folding from flat cellular patterns into precise 3D structures. www.ucl.ac.uk/life-science... #UCLLifeSciences #Biomaterials #Metamaterials
ucl.ac.uk
Fly eyes reveal nature's blueprint for metamaterials
Scientists have discovered that fly eyes develop as natural programmable metamaterials, revealing an "origami" blueprint that could inspire biomaterials, tissue engineering and regenerative medicine.
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Girish Kale @girishkalephd.bsky.social · 07/07/2026
Definitely check out the Preprint by Lerchbaumer et al. Lerchbaumer, G., Simoes, S., Etemadi, E., Zidan, F., Erdemci-Tandogan, G. and Tepass, U. (2026). E-cadherin clustering as a regulator of morphogenesis. bioRxiv. doi.org/10.64898/202...
doi.org
E-cadherin clustering as a regulator of morphogenesis
Cell adhesion enables animal multicellular development. E-cadherin and the cadherin-catenin adhesion complex at adherens junctions are engaged in dynamic interactions with actomyosin generated contrac...
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Zenlabpasteur.bsky.social @zenlabpasteur.bsky.social · 07/07/2026
🚨 New pre-print alert! 🚨 Adult neural stem cell state and fate decisions are hidden within transcriptional heterogeneity. To find out how we decoded these heterogeneities to identify a molecularly encoded quiescence cycle, check out the pre-print on bioRxiv! doi: doi.org/10.64898/202...
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Levayer Lab @levayerr.bsky.social · 06/07/2026
After a quite long process, we are happy to share the last version of our article describing unexpected results regarding the coupling between local cell death and proliferation (heroic revision effort from @ralitzastaneva.bsky.social ) urldefense.com/v3/__https:/...
urldefense.com
A global response contributes to tissue size robustness upon local induction of apoptosis
Tissue resilience requires tight coupling between cell proliferation, growth, and death.1,2,3,4It is assumed to be based on compensatory proliferation…
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Ran Blekhman @blekhman.bsky.social · 27/06/2026
I wanted to like QED's new 1% preprint ranking. I really did. But the more I looked at the data, the more uncomfortable it made me. Here is my full peer review. open.substack.com/pub/blekhman...
open.substack.com
My Peer Review of The 1%
I wanted to like QED's new 1% ranking. I don't.
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Julien Gossa @juliengossa.cpesr.fr · 26/06/2026
[ #VeilleESR #LPPR ] Durcissement des règles d'attribution pour l'appel à projets générique ANR. Notamment : réduction du nombre de dépôts et augmentation du délais de carence. L'argumentaire est : plus les scientifiques ont besoin de l'ANR, moins il faut que les scientifiques sollicitent l'ANR.
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Levayer Lab @levayerr.bsky.social · 26/06/2026
Un pétition du collège des sociétés savantes pour mettre en avant le rôle de la recherche dans la campagne politique à venir et rappeler le sous investissement chronique en France depuis 20 ans. N'hésitez pas à faire ciculer recherche-publique-2027.fr
recherche-publique-2027.fr
Recherche Publique 2027 – Appel des scientifiques pour la place de la recherche dans la société
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Levayer Lab @levayerr.bsky.social · 26/06/2026
Am I in the 1% thinking that after years of debates showing that there is no proper quantitative metrics to quantify article quality and impact, letting AI decides on its own the ranking of research article is a very bad move ? Metrics as usual will be weaponised and used for wrong purpose (see IF)
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Tajbakhsh Lab @tajbakhshlab.bsky.social · 24/06/2026
Our Stem Cell Course #ASCB is back! After 2nd day, @institutpasteur.bsky.social @tajbakhshlab.bsky.social, @zenlabpasteur.bsky.social, Barbara Gayraud-Morel, and great interactive students. Laurence Daheron, Frank Yates, Michel Cohen-Tannoudji covered pluripotency and generating hiPSCs. Great team!
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Levayer Lab @levayerr.bsky.social · 23/06/2026
Congrat for the all awardees (and sorry for those who didn't get it). Very few awardees from France this year (specially in biology), a result of long term under-investment ? (The less you put in...the less you get).
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Levayer Lab @levayerr.bsky.social · 23/06/2026
I missed the chance to meet fly colleagues at the EMBO Crete meeting, but I am also enjoying very much the #Cellmodelinginspaceantime @cshlnews.bsky.social (and the current 21°C...). Exciting modeling and quantitative approches all other the place !
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Levayer Lab @levayerr.bsky.social · 19/06/2026
Studying viola seed sequential balistic popping (driven by dessication) to generate zipping actuator. A nice example of bioinspired design www.science.org/doi/10.1126/...
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