Sign in

Pedro Beltrao

@pedrobeltrao.bsky.social
3K followers 710 following 446 posts

Associate professor at ETH Zurich, studying the cellular consequences of genetic variation. Affiliated with the Swiss Institute of Bioinformatics and a part of the LOOP Zurich.

PostsRepliesMedia
Pedro Beltrao @pedrobeltrao.bsky.social · 01/10/2026
Is it just me ? I don't see the point of adding watermarks to protein designs. www.nature.com/articles/s41...
nature.com
Function-preserving watermarking of AI-generated proteins - Nature
SynthIDBio watermarks AI-generated protein sequences and structures while preserving function, enabling provenance detection and offering a proof-of-concept tool for biosecurity and information integr...
360
Reposted by Pedro Beltrao
Iñaki Ruiz-Trillo @multicellgenome.bsky.social · 28/09/2026
We have a new branch in the family tree of animals: Atreyea- a previously unrecognized lineage among the closest unicell relatives of animals. Led by @konsmitsi.bsky.social & @freejakoba.bsky.social together with a fantastic team of collaborators. 🔗 papers.ssrn.com/sol3/papers.... #protistsOnSky
112251
Pedro Beltrao @pedrobeltrao.bsky.social · 30/09/2026
This is long but worth it. It is perhaps the most emotional I have seen Gates talking about AI risks. After the recent argument that liability should be enough to guarantee safety it is good to see a tech pro business person being so clear about how ridiculously that is. youtu.be/A_156w0aYtU?...
youtu.be
Bill Gates: A.I. ‘Makes Nuclear Weapons Look Like Nothing’ | The Ezra Klein Show
YouTube video by The Ezra Klein Show
261
Reposted by Pedro Beltrao
Colm Ryan @colmr.bsky.social · 30/09/2026
Super cool, structure-function analysis of a whole pathway using CRISPR base editing. www.biorxiv.org/content/10.6...
biorxiv.org
Structure-function analysis of PI3K signalling cascade base editing screens in cancer cells
Knowledge of protein structure and function underpins rational drug discovery, yet many targets lack known selectively druggable sites. Furthermore, the identification of secondary druggable sites off...
021
Reposted by Pedro Beltrao
Nature Structural & Molecular Biology @natsmb.nature.com · 30/09/2026
New online: A phosphoproteome atlas of human cell lines reveals the landscape of kinase activity
dlvr.it
A phosphoproteome atlas of human cell lines reveals the landscape of kinase activity
Nature Structural & Molecular Biology, Published online: 30 September 2026; doi:10.1038/s41594-026-01877-6Koenig et al. present a phosphoproteome atlas of 33 human cell lines covering >200,000 phosphosites, advancing cellular kinase activity scoring and drug sensitivity prediction, providing a resource for cell signaling insights and precision oncology.
01610
Pedro Beltrao @pedrobeltrao.bsky.social · 28/09/2026
There are many low hanging fruit possibilities for creating improved but not verified AI versions of existing bioinformatics models to predict X. They are practically useful but verification is the bottleneck. Shall we make them available with warnings while we verify?
121
Reposted by Pedro Beltrao
Ben Neely @benneely.com · 28/09/2026
So the “breaking containment” stuff is pretty dumb (and hype-y), but also I didn’t appreciate the August openAI hugging face incident. The swarm motivations are still human driven, but their problem solving is cute and terrifying. Music video is chefs kiss. www.reddit.com/r/OpenAI/s/l...
reddit.com
From the OpenAI community on Reddit: POV: you're an OpenAI agent attacking Hugging Face (music video)
Explore this post and more from the OpenAI community
001
Reposted by Pedro Beltrao
Saez-Rodriguez Group @saezlab.bsky.social · 28/09/2026
Introducing mc-ASTRA, an open-source Python framework for studying how tissues vary and remodel across patients, perturbations, time points and other biological contexts. Manuscript: www.biorxiv.org/content/10.6... Package: saezlab.github.io/mc-astra/
1105
Reposted by Pedro Beltrao
Ben de Bivort @debivort.bsky.social · 22/09/2026
Hello friends, the Harvard Life Science departments have banded together to hire a new colleague working at the intersection of Life Sciences and AI. Could be primarily an experimentalist, or could be primarily a compute/theorist. academicpositions.harvard.edu/postings/16773
academicpositions.harvard.edu
Tenure-Track Professor in Life Science and AI
The Life Sciences Departments in Harvard Faculty of Arts and Sciences seek to recruit a tenure-track professor whose research is at the interface of AI and life sciences, from methodological developme...
34053
Reposted by Pedro Beltrao
Tobias Warnecke @tobiaswarnecke.bsky.social · 25/09/2026
Ok, long thread: I think the adoption of such an AI sifting approach builds quite logically on the pernicious foundations that are already in place at UKRI and many other funders, where the deep expertise of panel members and reviewers is regularly sacrificed on the altar of objectivity. 1/n
163
Reposted by Pedro Beltrao
Martin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 24/09/2026
AlphaFold Database is expanding into pandemic preparedness. Together with NVIDIA, DeepMind, EBI et al. we exhaustively predicted ~1.7 million homo- & heterodimers across 2,812 viral proteomes, resulting in 8,028 high-confidence predictions. 📄 research.nvidia.com/labs/dbr/ass... 🌐 alphafold.ebi.ac.uk
28838
Reposted by Pedro Beltrao
Maitreya Dunham @maitreya.bsky.social · 24/09/2026
Exciting news: @uwgenome.bsky.social will be hiring for two tenure-track faculty positions this year, one open rank and one assistant professor. Both are “Genome Sciences” interpreted broadly so we welcome applicants working in a variety of fields and methods. Ad will be out shortly.
1104101
Reposted by Pedro Beltrao
Changyang Linghu @changyanglinghu.bsky.social · 23/06/2026
What if you could record cytosolic activities or archive proteins on an intracellular tape across time? 📼 Introducing: 🔍 CytoSense records protease & kinase signaling activities 📦 CytoCatch archives cytosolic proteins along CytoTape Preprint: doi.org/10.64898/202... 🧵Thread (1/7)
CyTRACE schematic - CytoSense and CytoCatch
195
Reposted by Pedro Beltrao
Saez-Rodriguez Group @saezlab.bsky.social · 21/09/2026
EBI news ➡️ www.embl.org/news/science...
embl.org
Benchmarking: the foundation of reliable AI in biomedicine | EMBL
Establishing shared evaluation standards to ensure AI models in biology are rigorous, reliable, and reproducible.
032
Reposted by Pedro Beltrao
Earth and Planetary Sciences at ETH Zurich @eth-eaps.bsky.social · 22/09/2026
The Department of Earth and Planetary Sciences at ETH Zurich invites applications for the position of Assistant Professor (Tenure Track) of Earth and Planetary Evolution. ethz.ch/en/the-eth-z... Please apply online. The closing date for applications is 15 December 2026.
ethz.ch
Assistant Professor (Tenure Track) of Earth and Planetary Evolution
The Department of Earth and Planetary Sciences (www.eaps.ethz.ch) at ETH Zurich invites applications for the above-mentioned position.
03149
Reposted by Pedro Beltrao
samuel mehr @mehr.nz · 23/09/2026
after some in-depth discussions with my lab and also drawing on conversations on here, we've edited our new policy on AI usage in my lab feel free to adapt or re-use with attribution, or to reply to tell me how awful this policy is lol
1413341
Reposted by Pedro Beltrao
Kevin K. Yang 楊凱筌 @kevinkaichuang.bsky.social · 22/09/2026
Use reward-guided search in a generative model's latent space to design high-affinity protein binders to proteins and carbohydrates. @karstenkreis.bsky.social @pierceogden.bsky.social www.biorxiv.org/content/10.6...
0157
Pedro Beltrao @pedrobeltrao.bsky.social · 22/09/2026
10 whole days between them agreeing on the need to slow down the AI development to releasing new models.
242
Reposted by Pedro Beltrao
Swiss National Science Foundation (SNSF) @snsf.ch · 22/09/2026
🏆 Biochemist Martin Jinek is the winner of the Swiss Science Prize #MarcelBenoist 2026, considered the Swiss #Nobel Prize. He contributed to the development of molecular scissors, namely CRISPR-Cas9 technology. Read more ➡️ sohub.io/3hs4
66321
Reposted by Pedro Beltrao
EMBL @embl.org · 21/09/2026
There is still time to apply for the EMBL International PhD Programme! 📢 Don’t miss this opportunity to receive dedicated mentoring while doing interdisciplinary research. Research groups across EMBL are recruiting now! bit.ly/4x9Edss
01432
Reposted by Pedro Beltrao
Martin Pacesa @martinpacesa.bsky.social · 21/09/2026
ʙɪɴᴅᴄʀᴀꜰᴛ2 is out, and we're not waiting for the paper. The full code drops today, free for academic and industry use. We're releasing it early so you can start designing right now, and bring its full power to the current Adaptyv competition. github.com/PacesaLab/Bi...
4292142
Reposted by Pedro Beltrao
Richard Sever @richardsever.bsky.social · 21/09/2026
"any answer to 'is AI good for science' that neatly fits into a single yes or no is unserious...here is an invitation to join the real discussion" Thoughtful piece by @blekhman.bsky.social on a subject that provokes knee-jerk responses for and against. blekhman.substack.com/p/the-ai-dis...
blekhman.substack.com
The AI Discourse in Academia is Toxic. It Doesn’t have to be.
You are allowed to have a nuanced opinion about AI
3228
Reposted by Pedro Beltrao
Richard Sever @richardsever.bsky.social · 20/09/2026
"All corners of academia will soon be flooded with AI-generated research....Maths and CS go first because their entire output is symbol manipulation...Biology comes later not because biologists are cleverer but because the rate-limiting step is physical" giorgio.gilest.ro/the-weimar-o...
giorgio.gilest.ro
The Weimar of knowledge – la bottega
56641
Reposted by Pedro Beltrao
Arc Institute @arcinstitute.org · 15/09/2026
Want to join Arc? We're hiring experts in disease bio, computational bio, functional genomics, and NGS for our Tech Centers, plus postdocs and research associates in our Core Labs. All roles are based in Palo Alto, and are on-site or hybrid. Learn more or apply here: lnkd.in/gyfgqR3n
arcinstitute.org
Jobs | Arc Institute
Arc Institute is an independent nonprofit research organization headquartered in Palo Alto, California.
045
Pedro Beltrao @pedrobeltrao.bsky.social · 18/09/2026
Anthropic has used Claude to optimise structure prediction and design code to improve speed and memory efficiency. 2-3X speed improvements on AF3, 5X on OF3, 5X on BindCraft low memory modes to model large assemblies. All released as open source www.anthropic.com/research/cla...
anthropic.com
How Claude is uplifting biomolecular modeling
Anthropic is an AI safety and research company that's working to build reliable, interpretable, and steerable AI systems.
55518
Reposted by Pedro Beltrao
Sergey Ovchinnikov @sokrypton.org · 17/09/2026
Introducing highly experimental localfold.org Building on @martinsteinegger.bsky.social af2 webgpu port, @milot.bsky.social optimizations & jax ports of af3-like models by @marielle.bsky.social, Choonghwan Lee, Julia Buhmann. WARNING: runs directly on your 💻, may drain 🪫 & eat data📱 & overheat 🔥💻
26826
Reposted by Pedro Beltrao
Janani Durairaj (Jay) @ninjani.bsky.social · 16/09/2026
The PhD and Postdoc application links are now live! Come join me at UNIL to work on deep learning for protein structure, interactions & design. pickybinders.org#open-positions
career5.successfactors.eu
Career Opportunities: PhD student position in deep learning for enzyme structure & catalysis (22980)
03928
Reposted by Pedro Beltrao
Ethan Mollick @emollick.bsky.social · 16/09/2026
Study from Google about AI use in science, complex impacts: acceleration (7 hours saved per week) along with shifts in the kind of work (more verification) and what research gets done (possibly safer topics). Also a good diagram of the jagged frontier in science right now. ai.google/static/docum...
36618
Reposted by Pedro Beltrao
Tanja Stadler @tanjastadler.bsky.social · 15/09/2026
🚀 Interested in joining our Computational Evolution group at ETH Zürich in Basel @bsse.ethz.ch as a Postdoc? We will be hosting ETH AI Center's Postdoc Fellows on AI x evolution, AI x single cell biology as well as AI x public health. Apply now 👉 ai.ethz.ch/apply Deadline: Oct 27, 2026
ai.ethz.ch
Fellowship Programs
The application portal for the ETH AI Center Fellowship Programs is now closed. The deadline for submitting reference letters is 23:59 CET on November 14, 2025.
01210
Reposted by Pedro Beltrao
Lars Juhl Jensen @larsjuhljensen.bsky.social · 15/09/2026
A video on the STRING version 12.5 update: cleaner functional association network thanks to improved text mining and a new directed regulatory network! youtu.be/tTf_aIE8Wxw #bioinformatics #networkbiology #systemsbiology #textmining
youtu.be
STRING version 12.5: A brief introduction to the quantitative and qualitative changes
YouTube video by Lars Juhl Jensen
0103
Reposted by Pedro Beltrao
Sjors Scheres @sjorsscheres.bsky.social · 15/09/2026
Michel Goedert and myself are looking for two postdocs to work on #cryoEM and #masspec of #alphasynuclein filaments from neurodegenerative disease. Come join our bubbly and friendly team at the @mrclmb.ac.uk in lovely Cambridge, UK. www.nature.com/naturecareer...
nature.com
Postdoctoral Scientist | Neurobiology | Dr Michel Goedert | LMB 2842 - Cambridgeshire job with MRC Laboratory of Molecular Biology | 12864505
Postdoctoral Scientist Salary £42,694 per annum Fixed term, 3 years MRC Laboratory of Molecular Biology, Cambridge, UK To work in the group of Dr M...
01628
Reposted by Pedro Beltrao
Daniel Litt @littmath.bsky.social · 14/09/2026
I've written an essay on how I think the mathematics profession should adapt to highly capable AI systems. It's hosted here on "Proofs and Prompts": proofsandprompts.com/2026/09/14/a... though you should also feel free to complain/comment on my website here: daniellitt.com/blog/2026/9/...
proofsandprompts.com
A beginning for mathematics
Daniel Litt, professor at the University of Toronto Three years ago, AI systems could not reliably add two numbers. A year ago, internal models at OpenAI and DeepMind received the equivalent of a g…
66413
Reposted by Pedro Beltrao
VIB.AI @vibai.bsky.social · 14/09/2026
New group leader recruitment call now open. 📣 Together with KU Leuven, we are looking for two Principal Investigators to join VIB.AI and build ambitious independent research programs on AI in biology. Apply by 15 November 2026 vib.ai/en/join-vibai-group-leader-a…
053
Reposted by Pedro Beltrao
Martin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 13/09/2026
Fold Spacer lets you fly through protein structures (Weekend project #2). It’s my first game: I originally set out to build a racer with structures as the tracks, but was a little too crazy. So it became this instead. You can upload your own structures. 🌐 martin-steinegger.github.io/Fold-Spacer/
215759
Reposted by Pedro Beltrao
Sergey Ovchinnikov @sokrypton.org · 14/09/2026
Finally a more intuitaive way to learn pLDDT/pAE? 😎 sokrypton.github.io/protein_figh... (Character idea from @hannes-stark.bsky.social & Alex Waldherr)
727698
Pedro Beltrao @pedrobeltrao.bsky.social · 14/09/2026
It is outrageous that these companies don't give back this trained model for others to make discoveries on. It is not like their competitive advantage is the model itself since they are willing to share the model among the participating companies. More info here: www.apheris.com/resources/fe...
apheris.com
Apheris
171
Reposted by Pedro Beltrao
EMBL-EBI @ebi.embl.org · 14/09/2026
🚨Two weeks left to apply! There’s still time to apply for the EMBL-EBI-Sanger Postdoctoral (ESPOD) programme. Choose from one of our available projects or propose your own. Deadline: 27 September. www.ebi.ac.uk/research/pos...
01012
Reposted by Pedro Beltrao
Mike Dorrity @mwdorr.bsky.social · 13/09/2026
🧫 We’re hiring a staff/research scientist to develop new experimental approaches that capture cell state dynamics. Join us in Heidelberg, details + application here: embl.wd103.myworkdayjobs.com/EMBL/job/Hei... Closes September 30th
embl.wd103.myworkdayjobs.com
Laboratory Officer
The Dorrity group at EMBL Heidelberg is seeking a motivated and skilled molecular biologist to join as a Laboratory Officer. Our group uses cutting-edge single-cell genomic techniques to study how cel...
11318
Pedro Beltrao @pedrobeltrao.bsky.social · 13/09/2026
There are now 4 USA AI tech companies openly agreeing that slowing things down is a good idea. Let's hope this is a start to broader world wide agreement www.theguardian.com/technology/2...
theguardian.com
‘We must slow the pace’: CEO of Anthropic calls for an AI slowdown
In a social media post, Dario Amodei proposed a plan including third-party evaluations of AI systems
282
Reposted by Pedro Beltrao
Evgeny Kvon @evgenykvon.bsky.social · 24/08/2026
The newly established Department of Systems Biology (systems.bio.uci.edu) @UCIrvine is hiring a tenure-track Assistant Professor in Systems Biology. Great science, incredible faculty support, and beautiful, sunny SoCal weather! ☀️🌴 Details: recruit.ap.uci.edu/JPF10377. Please share.
recruit.ap.uci.edu
12936
Reposted by Pedro Beltrao
Ylva Ivarsson @ivarssonlab.bsky.social · 11/09/2026
Do you want to be my colleague? We are recruiting a tenured #Associate #Professor in #Biochemistry to the Department of Chemistry for Life Sciences at #Uppsala University. Deadline for application November 20. www.uu.se/en/about-uu/...
uu.se
Associate Professor in Biochemistry - Uppsala University
Associate Professor in Biochemistry, Department of Chemistry for life sciences, Uppsala University
01112
Reposted by Pedro Beltrao
Terence Tao @teorth.bsky.social · 11/09/2026
A group of 25 Fields Medalists, including myself, have made a joint declaration on Math and AI: mathandai.org . We welcome additional signatories. See also this article in the Economist announcing the declaration: www.economist.com/science-and-...
mathandai.org
Declaration — Math and AI
Read the declaration and add your name.
422052929
Reposted by Pedro Beltrao
Omaya Dudin 𓂆 ¦🍉¦🦠¦🔬¦ @dudinlab.bsky.social · 11/09/2026
We wanted to share this asap for everyone to use ! This will remain a #preprint for the time being. We are happy to recieve feedback, hear whether or not ot works in your hands and continue to apply it across #eukaryotes as part of #ExÂME You want to know more : www.dudinlab.com/exame
dudinlab.com
Research
ExÂME is the Expansion Microscopy Atlas of Microbial Eukaryotes, a community-driven project uncovering the hidden cellular architectures of protists and microbial eukaryotes. Supported by the Moore Fo...
12513
Reposted by Pedro Beltrao
Alan Brown @alanbrownhms.bsky.social · 10/09/2026
Millions of beating cilia keep airways clean. At the base of each is the transition zone (TZ), a gate that controls which proteins enter and leave. In our paper out today in Science, we used cryo-FIB-ET to image the TZ inside human airway cells www.science.org/doi/10.1126/...
science.org
In situ structure of the human ciliary transition zone links linker defects to primary ciliary dyskinesia
The ciliary transition zone (TZ) regulates ciliary proteome composition, yet its molecular architecture, protein content, and contribution to motile ciliopathies remain poorly defined. We applied in situ cryo-electron tomography and subtomogram averaging ...
211945
Reposted by Pedro Beltrao
Jason Nomburg @jnoms.bsky.social · 10/09/2026
This application closes on Sept 15! If you're interested in a computational postdoc position in my lab, please apply here! Lots of fun science :)
013
Reposted by Pedro Beltrao
Jonathan Frazer @jonnyfrazer.bsky.social · 10/09/2026
Congratulations! Beautiful work. I know Mafalda and @m1quelag.bsky.social found it a pleasure to review.
031
Reposted by Pedro Beltrao
Saez-Rodriguez Group @saezlab.bsky.social · 07/09/2026
🧵 Introducing Karenina, an open-source framework to evaluate LLMs & agents: doi.org/10.64898/202...
1176
Reposted by Pedro Beltrao
Institute of Molecular Systems Biology @imsb-eth.bsky.social · 09/09/2026
Fucoidans from brown algae and diatoms drive marine carbon sequestration partly because they're hard to break down. Sichert et al. show how synergistic interactions between degraders are critical for their degradation, giving insights into ocean carbon cycling www.nature.com/articles/s41...
nature.com
Synergistic degradation of fucoidans in the ocean - Nature
Efficient degradation of fucoidans depends on complementary bacterial guilds that cooperatively break backbone and side-chain sugars, revealing a conserved, globally relevant mechanism that shapes mar...
023
Pedro Beltrao @pedrobeltrao.bsky.social · 09/09/2026
I made a presentation to other faculty about recent progress in general AI, to facilitate the discussion around the impact for research and teaching in biology. It could be that the slides are useful for others trying to do that same. Feel free to re-use. docs.google.com/presentation...
docs.google.com
generalAI_for research_intro.pptx
Recent AI developments and what they mean for us Quick primer on general AI models* State-of-the-art in AI agent capabilities AI agents in biology (examples) Discussion - what does this mean for our r...
79026
Reposted by Pedro Beltrao
EMBL @embl.org · 09/09/2026
Congratulations, Julia Mahamid! The EMBL scientist has been elected to Leopoldina, the German National Academy of Sciences, in recognition of her outstanding contributions to the field of structural cell biology. Learn more: www.embl.org/news/awards-...
010714