Spatial relationships between tumor neoantigens and cognate T cells are studied.

Polygenic risk scores (PRSs) have generated considerable interest as a means of personalizing prostate cancer (PC) screening by stratifying individual…

This study analyses whole-genome sequencing data of cancer samples from 10,983 patients and explores relationships among mutational signatures, various biomarkers and clinical outcomes.

Blood Cancer Journal - Mendelian randomization of immune cell phenotypes to discover potential drug targets for B-cell malignancy

Screen of minimalistic enhancers in blood progenitor cells demonstrates widespread dual activator-repressor function of transcription factors (TFs) and enables the model-guided design of cell-state-sp...

In a milestone that brings quantum computing tangibly closer to large-scale practical use, scientists at Oxford University’s Department of Physics have demonstrated the first instance of distributed

Nature Biotechnology - Metabolites can be quantified using a combination of aptamers and DNA barcodes.

Studying the functional consequences of structural variants (SVs) in mammalian genomes is challenging because (i) SVs arise much less commonly than single-nucleotide variants or small indels and (ii) ...

Adeno-associated viruses (AAVs) have emerged as the foremost gene therapy delivery vehicles due to their versatility, durability, and safety profile. Here we demonstrate extensive chimerism, manifesti...

We lack tools to edit DNA sequences at scales necessary to study 99% of the human genome that is noncoding. To address this gap, we applied CRISPR prime editing to insert recombination handles into re...

Population-scale single-cell transcriptomic technologies (scRNA-seq) enable characterizing variant effects on gene regulation at the cellular level (e.g., single-cell eQTLs; sc-eQTLs). However, existi...

Lynch’s death inspired tributes from fellow filmmakers, celebrities and past collaborators, who praised his visionary work and singular voice.

Lentivirus-based reporter assays for 680,000 regulatory sequences from three cell lines coupled to machine-learning models lead to insights into the grammar of cis-regulatory elements.

Study identifies a novel mechanism driving osteosarcoma and provides insights to help predict patient outcomes.

Nature Reviews Cancer, Published online: 14 January 2025; doi:10.1038/s41568-024-00784-6Genomic mutations can be translated into modified functional proteins, impacting protein–protein interactions (PPIs) and thus altering cellular functions. In this…

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He was a model ex-president and achieved a great deal in office.

8-oxoG is a common single-base DNA lesion caused by oxidative stress. Here, authors characterize the mutational signature of potassium bromate (KBrO3) exposure, the chromatin structural determinants o...

A new method called polymerase error rate sequencing (PER-seq) can measure the nucleotide misincorporation rate of DNA polymerases. DNA polymerase ε mutants produce an excess of CpG<TpG errors duri...

Following its success for vision and text, the "foundation model" (FM) paradigm -- pretraining large models on massive data, then fine-tuning on target tasks -- has rapidly expanded to domains in the ...

Genetic diversity within the human immunoglobulin heavy chain (IGH) locus influences the expressed antibody repertoire and susceptibility to infectious and autoimmune diseases. However, repetitive seq...

Resting and activated T cell states are established by context-specific regulators and dynamic gene circuits.

News, analysis and comment from the Financial Times, the worldʼs leading global business publication

News, analysis and comment from the Financial Times, the worldʼs leading global business publication

The advent of droplet-based single-cell RNA-sequencing (scRNA-seq) has dramatically increased data throughput, enabling the release of a diverse array of tissue cell atlases to the public. However, we...

Using reported parental disease history to decipher the genetics of Alzheimer’s disease may be promising, but this approach is also susceptible to complex selection and information bias that can misle...

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Improved effectors for CRISPRi/CRISPRa are developed following high-throughput screening of transcriptional domains.

This study aims to characterize the individual-level agreement of polygenic risk scores for coronary heart disease that perform similarly at the population level.