iiinova — where your digital self keeps evolving

Reposted by Mike Spencer Chapman

Wellcome Sanger Institute @sangerinstitute.bsky.social · 10/04/2025

The abnormal gene which causes chronic myeloid leukaemia has a very strong ability to drive rapid growth of the cancer, research has revealed 🧬 Scientists were able to track the evolution of this gene to study the rate at which the cancer cells expand: bit.ly/42riKOk

Image shows chromosome pairs with abnormal, stunted, chromosome 22 which causes chronic myeloid leukaemia. Credit: Nangalia Research Group.

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Mike Spencer Chapman @mikespencerchapman.bsky.social · 02/04/2025

Lovely piece from @s-j-aitken.bsky.social and Claudia Arnedo Pec discussing our recent paper in @nature.com on persistent mutagenic DNA lesions... Love the title! Puts it in the context of their beautiful previous work on lesion segregation

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Reposted by Mike Spencer Chapman

Leif S. Ludwig @leifludwig.bsky.social · 31/01/2025

Interested in 'Mitochondrial single cell-multi-omics for lineage tracing and genetics'? Apply for our free workshop in Berlin following our #ISCO2025 conference! www.isco-conference.eu www.mdc-berlin.de/news/events/...

mdc-berlin.de

Mitochondrial single cell-multi-omics for lineage tracing and genetics

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Reposted by Mike Spencer Chapman

mchasselluhn.bsky.social @mchasselluhn.bsky.social · 31/01/2025

Is hypothesis generation a hindrance to Night Science? @itaiyanai.bsky.social and @stearnslab.bsky.social demonstrated how easy we fall into pattern recognition, missing the “Gorilla” in our own data. Today’s seminar was all about identifying new strategies to stay curious about our own data.

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Mike Spencer Chapman @mikespencerchapman.bsky.social · 16/01/2025

Thanks for sharing! And apologies for the cheap kitten meme..

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Reposted by Mike Spencer Chapman

Trevor Graham @trevorgraham.bsky.social · 15/01/2025

This is a cool paper about the surprisingly long-term persistence of DNA lesions (single stranded DNA errors) in the human body. Exquisitely meticulous work from conception through to execution. Congratulations @mikespencerchapman.bsky.social

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Mike Spencer Chapman @mikespencerchapman.bsky.social · 15/01/2025

Yes! @s-j-aitken.bsky.social your fantastic work on lesion segregation really was the foundation for this.. gave us early confidence that some lesions were able to persist through multiple cell divisions & that our theory was viable

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Mike Spencer Chapman @mikespencerchapman.bsky.social · 15/01/2025

In science, we often see weird blips in the data. The question: is it artefact (usually!), or something new & exciting? We don’t always have time to dig deep. Our paper in @nature.com today came from just such a blip. So don’t ignore the weird stuff. Pull on that thread...

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Mike Spencer Chapman @mikespencerchapman.bsky.social · 14/01/2025

I've made the switch! Looking forward to a more inspiring newsfeed.. 🤞

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