Antibody response variability contributes to differential individual responses and disease outcomes. Here authors show that genetic variation to the IG kappa and IG lambda loci is an important determi...

Ruminant species are vital for agriculture, ecosystems, and conservation and remain vulnerable to infectious and zoonotic diseases. Advances in genome sequencing and genomics now enable high-resolutio...

Abstract. Accurate characterization of adaptive immune receptor repertoires through high-throughput sequencing is critical for understanding immune respons

Abstract. Accurate characterization of adaptive immune receptor repertoires through high-throughput sequencing is critical for understanding immune respons

LifeSciKY’s new lab at the OneNKY Center in Covington welcomed three biotech startups focused on cancer therapy, genomics and fertility.

Genetic variation within immunoglobulin heavy chain constant (IGHC) genes modulates interactions between antibodies and other immune receptors and effector cells, directing cell killing and the cleara...

Abstract. Systemic lupus erythematosus is characterized by activation of many self-reactive B cell clones that produce autoantibodies. This can be modeled

The rise of T cell receptor (TCR) sequencing technologies is driving both new understandings of the immune system and the development of novel clinica…

Neat!

Senate budget bill includes small increase for the health-research agency — but faces a long road before being signed into law.

Since this Sub-Committee has not addressed MHC/HLA nomenclature for several decades, the name of the Sub-Committee has been changed to “T-cell Receptor and Immunoglobulin Nomenclature Sub-Committee”…

For over thirty years, an approach to the nomenclatures of human immunoglobulin (IG) and T cell receptor (TR) genes has operated successfully and has …

Antibodies were at the forefront of protein and gene research in the 1970s and 1980s [1–3]. At that time, every report of a new antibody gene or even a partial antibody gene was eagerly awaited, and s...

Variation in antibody (Ab) responses contributes to disease outcomes and therapeutic responsiveness, the determinants of which remain incompletely understood. This study demonstrates that polymorphism...

The peripheral antibody repertoire is shaped by inherited genetic variation and selection during B cell development. However, how the repertoire changes across developmental stages—and the relative im...

Complete sequences of chromosomes telomere-to-telomere from chimpanzee, bonobo, gorilla, Bornean orangutan, Sumatran orangutan and siamang provide a comprehensive and valuable resource for future evol...

The immunoglobulin heavy chain constant (IGHC) domain of antibodies (Ab) is responsible for a variety of effector functions critical to Ab mediated immunity. In human, this domain is encoded by genes ...

Adaptive immune responses are mediated by the production of adaptive immune receptors, antibodies and T-cell receptors, that bind antigens, thus causing their neutralization. Unlike other proteins, ad...

Research funded by the National Institutes of Health is essential for improving the health of Americans and developing new drugs and treatments for a wide range of diseases.

Sex hormones and chromosomes work in tandem to impact immune responses, with estrogen influencing class-switched memory B cell frequency exclusively in ind

Rhesus macaques (RMs) are a vital model for studying human disease and invaluable to pre-clinical vaccine research, particularly for the study of broadly neutralizing antibody responses. Such studies ...

Competitors will make predictions on previously unpublished TCR-epitope binding data in order to benchmark prediction methods.

The immunoglobulin heavy chain constant (IGHC) domain of antibodies (Ab) is responsible for a variety of effector functions critical to Ab mediated immunity. In human, this domain is encoded by genes ...