Cell-type-specific eQTL mapping from single-cell pseudobulk expression.

Flexible, scalable, QTL analyses using generalized linear models implemented in JAX - mancusolab/jaxqtl

Abstract. The classic theory of mutation-selection balance predicts the equilibrium frequency of genetic variation under negative selection. The model pred

PhD-level thinking, LLM bias, alignment, AGI, data centers, and AI politics

Nature Genetics - Multi-ancestry GWAS meta-analysis identifies risk loci for severe nausea and vomiting of pregnancy. Downstream analyses explore maternal and fetal contributions of these loci and...

Grammar-first generalized linear modeling in JAX.

More about what it does (maybe more than one line). Continuation lines should be indented.

Contribute to mancusolab/jax_ldsc development by creating an account on GitHub.

Contribute to quattro/jax-numerics-agent development by creating an account on GitHub.

Most current GWAS-eQTL approaches prioritize genes whose mediating effects on complex traits act through cis-regulation, while trans-acting genes remain largely underexplored. Recent perturbational sc...

Ancestral recombination graphs (ARGs) are an attractive means for quantitative genetic analysis of complex traits because they encode the realized genetic relatedness between a sample of individuals i...

Genome-wide association studies and rare-variant burden tests reveal complementary aspects of trait biology.

Genetic association tests prioritize candidate genes based on different criteria.

Genome-wide association studies have revealed that the genetic architectures of complex traits vary widely. This study shows that differences in architectures of highly polygenic traits arise mainly f...

SINGER is a method for creating ancestral recombination graphs to understand the genealogical history of genomes. The method has increased speed, and thus scalability, without sacrificing accuracy.

Our understanding of the dependence of the genetic and environmental architecture of common diseases on age is incomplete. Here, we use longitudinal data to quantify age-dependent genetic and environm...

Samples of millions of genomes provide substantial information about recent demography and mutation, but standard population-genetic methods make assumptions not met in these data. We introduce DR EVI...

How did the chromatin folding mechanisms controlling gene regulation emerge during animal evolution? Kim et al. surveyed chromatin folding at high-resolution in unicellular relatives of animals as wel...

Most genetic variants associated with complex diseases lie in non-coding regions, complicating efforts to identify effector genes and relevant cell types. Here, we map cis-eQTLs across 2.2 million sin...

Statistical Human Genetics course using R

Deep mutational scanning (DMS) experiments interrogate the effect of genetic variants on protein function, often using fluorescence-activated cell sorting (FACS) to quantitatively measure molecular ph...

Abstract. Scaling is a common practice in population genetic simulations to increase computational efficiency. However, few studies systematically examine