A new method reveals which genetic variants are most important in disease and how cells “buffer” the expression of genes critical for health.

A new web-based program called Delphy assembles viral family trees at unprecedented speed to aid outbreak responses.

In the new method, cells package and export their RNA, enabling researchers to sequence and analyze the RNA without killing the cells.

Paired histopathology and spatial transcriptomics data are advancing our understanding of tissue biology and disease, but modeling both modalities at single-cell resolution while mapping local and dis...

Spatial transcriptomics (ST) encompass technologies that measure gene expression in tissue samples without disrupting their organisation, unlike other single-cell techniques. In imaging-based ST spec...

OptiPrime incorporates prime-editing biochemistry to predict prime-editing outcomes.

The tool, called OptiPrime, helps researchers more easily determine the best guide RNAs for efficient prime editing, avoiding costly, time-consuming steps in the lab.

Broad scientists expand the DepMap by adding cancer organoids and demonstrate the models’ potential to fuel new discoveries.

Directed evolution of proteases induces targeted, multipathway lytic cell death in cancer cells.

AbstractRationale. Yes-associated protein (YAP)-mediated fibroblast mechanoactivation is an important driver of fibrosis in idiopathic pulmonary fibrosis (

The new collaboration aims to develop precision medicines, including base and prime editing, to treat patients with rare diseases, using infrastructure and repeatable practices the center will share w...

Shaped by a tumultuous childhood, Jason Buenrostro pivots from technology development to studying the biology of stress and adversity and finding new ways to boost resilience.

Pediatric Epilepsies & Rare CNS Gene Editing Platform (PERC) accelerates the development of precision genetic medicines for severe childhood neurologic disease.

Twelve organizations spanning gene editing science, clinical medicine, manufacturing, regulatory strategy, and patient advocacy aim to deliver first-in-human trial within three years. div.hero-section...

The Blended Genome Exome approach delivers high-quality, unbiased genetic data at a quarter of the cost of the leading sequencing method.

The $400,000 prize honors five researchers who developed the first medical device to generate a human sense through a direct neural interface, a groundbreaking tool used by more than one million peopl...

The advances in editing efficiency and delivery are important steps toward in vivo therapeutic prime editing.

The Genotype-Tissue Expression (GTEx) project is an ongoing effort to build a comprehensive public resource to study tissue-specific gene expression and regulation. Samples were collected from 53 non-...

The Genotype-Tissue Expression (GTEx) project is an ongoing effort to build a comprehensive public resource to study tissue-specific gene expression and regulation. Samples were collected from 53 non-...

The disordered adapter protein linker for activation of T cells (LAT) propagates T cell receptor signaling. To interrogate how LAT coordinates multiple downstream pathways, we developed a single-cell ...

It’s the first time the potential treatment, a small interfering RNA targeting the prion protein, is being tested in humans.

The next stage of the academic-industrial partnership aims to expand beyond cancer vulnerabilities to investigate cancer resistance, surface targets, and high-dimensional readouts.

The base editing enzyme used in this study is the same one that fixed Baby KJ Muldoon’s disease-causing mutation and saved his life in 2025.

Targeting this protein, called CD43, could offer a new path to treatment for leukemia and other cancers.

Researchers show that Cell Painting, an image-based cell profiling method, can reveal details of how drug candidates and other chemicals may harm cells.

Sequencing of complete genomes of Anopheles darlingi mosquitoes in the Americas finds resistance may make them harder to kill.

Team PROPSECT were funded in 2024 to take on our early-onset cancers challenge. The team is focusing on colorectal cancer, where there is an alarming rise in individuals under 50.

A study in mice suggests that even intestinal cells that appear healthy may hold epigenetic “memories” of earlier bouts of inflammation that can promote colon cancer later in life.

Analysis of some of the most common viruses hiding in the body shows how our genes influence the long-term effects of these viruses on our health.

Joint UCSF and Broad Institute study investigates genetic basis for development of of Aortic Stenosis.