How the complex interplay between multiple nutrients within the microenvironment dictates potential sites of metastatic cancer growth is explored.

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In eukaryotes, DNA-associated protein complexes coevolve with genomic sequences to orchestrate chromatin folding. We investigate the relationship between DNA sequence and the spontaneous loading and a...

Large genome rearrangements in mammalian cells can be generated at scale

We lack tools to edit DNA sequences at scales necessary to study 99% of the human genome that is noncoding. To address this gap, we applied CRISPR prime editing to insert recombination handles into re...