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Tyler Weaver

@tmweaver.bsky.social
1.1K followers 1.4K following 15 posts

Assistant Professor, Biochemistry and Molecular Genetics, UVA School of Medicine. Studying mechanisms of chromatin-based DNA repair.

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Reposted by Tyler Weaver
Jens Schmidt @jenscs83.bsky.social · 15/09/2026
We are recruiting a postdoctoral fellow to study DNA damage repair via the homologous recombination pathway using quantitative cell biology approaches. The position will be initially supported for two years by the MSU Research Foundation Postdoctoral Scholars program. Please share! 1/5
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Tyler Weaver @tmweaver.bsky.social · 07/05/2026
My lab is currently hiring at the Research Technician level. This would be a great opportunity for a recent graduate looking to gain additional research experience prior to applying to graduate school! Job ad below: careers.uvahealth.org/us/en/job/R0...
careers.uvahealth.org
Lab Technician 1 or 2 in Biochemistry & Molecular Genetics-Weaver Lab in Charlottesville, Virginia, United States of America | Research at University of Virginia Health System
Apply for Lab Technician 1 or 2 in Biochemistry & Molecular Genetics-Weaver Lab job with University of Virginia Health System in Charlottesville, Virginia, United States of America. Research at Univer...
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Tyler Weaver @tmweaver.bsky.social · 06/04/2026
Excited to share the first work from my new lab describing how LigIIIα catalyzes nick ligation within the nucleosome during the terminal step of BER/SSBR. Hard to believe the lab performed our first experiment just over a year ago! www.biorxiv.org/content/10.6...
biorxiv.org
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Reposted by Tyler Weaver
Ahmad Jomaa @jomaalab.bsky.social · 27/03/2026
Check out the final version of this work, out today! @natcomms.nature.com www.nature.com/articles/s41...
nature.com
A molecular switch in NAC prevents mitochondrial protein mistargeting by SRP - Nature Communications
How ribosome-bound NAC distinguishes mitochondrial precursors from ER clients has remained unclear. Here, authors reveal a molecular switch in NAC that limits SRP access to nascent mitochondrial precu...
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Reposted by Tyler Weaver
ACS BIOL: Division of Biochemistry and Chemical Biology @acsbiol.bsky.social · 09/02/2026
Congratulations and welcome to the newest members of the #ACSBIOL Executive Committee! @freudlab.bsky.social, @doc-jlmeier.bsky.social, @tmweaver.bsky.social, @ebraselmann.bsky.social
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Tyler Weaver @tmweaver.bsky.social · 04/11/2025
Check out the perspective my lab wrote with @freudlab.bsky.social. We provide our perspective on recent work describing the structural basis of chromatin-based base excision repair!
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Reposted by Tyler Weaver
Petr Cejka @cejkalab.bsky.social · 27/10/2025
See our paper “Mechanism of trinucleotide repeat expansion by MutSβ-MutLγ and contraction by FAN1”. Using biochemistry, we show how DNA incisions by the MutLγ nuclease can lead to expansions, and how expansion is prevented by FAN1. Well done Issam and Valentina! www.nature.com/articles/s41...
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Tyler Weaver @tmweaver.bsky.social · 24/03/2025
The final piece of my postdoctoral work in the @freudlab.bsky.social was recently published! Quite amazing what this small little repair polymerase can do to fill 1-nt gaps in chromatin. www.nature.com/articles/s41...
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Reposted by Tyler Weaver
Environmental Mutagenesis and Genomics Society @emgsus.bsky.social · 12/03/2025
🔊There's still time to register for the #EMGS webinar: An Applied Genetic Toxicology Career in the Pharmaceutical Industry with Zhanna Sobol on April 8, 2025 at 12:00 PM EST! Register Now: emgs-us.org/event/AGTCPI...
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Reposted by Tyler Weaver
Yael David @yaeldavidmsk.bsky.social · 21/02/2025
I am extremely proud to see our work about Hepatitis B now published in @cellpress.bsky.social From basic research to identifying the key step of infection & a potential first drug for curing this devastating disease. This has been an incredible journey.🧵 www.cell.com/cell/fulltex...
cell.com
A nucleosome switch primes hepatitis B virus infection
A reconstituted cccDNA platform facilitated the discovery of an early chromatinization event that promotes transcription of the hepatitis B virus (HBV) regulatory X gene. The use of a small-molecule c...
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Tyler Weaver @tmweaver.bsky.social · 10/02/2025
We are still accepting application for the Postdoc position in my lab! We have some exciting projects at the interface of DNA repair and chromatin biology. If interested, please get in touch or apply for the position through the link below! jobs.virginia.edu/us/en/job/R0...
jobs.virginia.edu
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Reposted by Tyler Weaver
Matthew Taliaferro @jmtali.bsky.social · 27/01/2025
Come be our colleague! @cu-bmg.bsky.social is running an open rank search for a structural biologist specializing in cryo-EM/ET. This is a great opportunity in a highly collegial and collaborative department. Apply here: cu.taleo.net/careersectio...
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Tyler Weaver @tmweaver.bsky.social · 27/01/2025
My lab at UVA is looking to hire a Lab Technician to join our team! This position is ideal for someone interested in obtaining research experience prior to graduate and/or medical school. jobs.virginia.edu/us/en/job/UO...
jobs.virginia.edu
Lab Technician 1 or 2 in Biochemistry & Molecular Genetics in Charlottesville, Virginia, United States of America | Research at University of Virginia
Apply for Lab Technician 1 or 2 in Biochemistry & Molecular Genetics job with University of Virginia in Charlottesville, Virginia, United States of America. Research at University of Virginia
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Reposted by Tyler Weaver
Emmanuelle Bignon @emmabignon.bsky.social · 21/01/2025
It is still possible to apply to this postdoc position in my group if you are motivated by using your QM/MM and MD skills to study the fascinating histone post-translational modifications! 🥳 Deadline is the 1st of March #job #compchem #histones #DNA Apply on the CNRS website : lnkd.in/eNxR-TPH
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Reposted by Tyler Weaver
Environmental Mutagenesis and Genomics Society @emgsus.bsky.social · 16/12/2024
The #EMGS is now seeking a new Editor-in-Chief for @EMMjournal! In this pivotal role, the new EIC will influence EMM’s direction and uphold its high scientific standards as the official journal of the EMGS! Learn More: emgs-us.org/news/687716/...
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Tyler Weaver @tmweaver.bsky.social · 16/01/2025
My lab is looking to hire a Postdoc to study mechanisms of DNA repair in chromatin using biochemical, biophysical, and structural biology approaches! Feel free to share with anyone you think may be interested. jobs.virginia.edu/us/en/job/R0...
jobs.virginia.edu
Postdoctoral Research Associate in Biochemistry and Molecular Genetics – Weaver Lab in Charlottesville, Virginia, United States of America | Research at University of Virginia
Apply for Postdoctoral Research Associate in Biochemistry and Molecular Genetics – Weaver Lab job with University of Virginia in Charlottesville, Virginia, United States of America. Research at Univer...
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Reposted by Tyler Weaver
Development @dev-journal.bsky.social · 14/01/2025
Our Pathway to Independence programme aims to support postdocs going on the job market in 2025 with training, mentorship, profile-raising and networking opportunities. Apply by 31 Jan 2025: buff.ly/3VJGgDC #DevBio #StemCells🧪
Pathway to independence: a new initiative supporting postdocs on the job market
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Tyler Weaver @tmweaver.bsky.social · 02/01/2025
The Weaver Lab is officially open today…Let’s see if we can fill up this empty lab space!
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Reposted by Tyler Weaver
Rosana Collepardo @rcollepardo.bsky.social · 24/12/2024
Is chromatin ordered or disordered? It all depends on the linker DNA length. Check our latest work with Mike Rosen and Sy Redding. We explore how changes in linker DNA length (as small as 1 bp) fine-tune chromatin structure, between order and disorder, and the properties of chromatin droplets
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Tyler Weaver @tmweaver.bsky.social · 23/12/2024
Our preprint from earlier this year on the oxidation-induced mutational landscape in human cells was just published! www.nature.com/articles/s41... I’m still amazed how much chromatin structure impacts oxidation-induced mutagenesis. Our cryo-EM contribution in this work provides a glimpse into why!
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Reposted by Tyler Weaver
Christine Cucinotta @chrstne.bsky.social · 13/12/2024
a short and sweet paper in which we use 3D STED and Micro-C analysis to show dramatic changes in large 3D chromatin structures in quiescence. www.biorxiv.org/content/10.1...
biorxiv.org
Sir2 is required for the quiescence-specific condensed three-dimensional chromatin structure of rDNA
Quiescence in Saccharomyces cerevisiae is a reversible G0 crucial for long-term survival under nutrient-deprived conditions. During quiescence, the genome is hypoacetylated and chromatin undergoes sig...
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Reposted by Tyler Weaver
Vijay Ramani @vram142.bsky.social · 06/12/2024
www.biorxiv.org/content/10.1... incredible study from Huabin Zhou and the Villa & Rosen labs -- a blueprint for mapping human chromatin with cryo-ET. The future of chromatin structural analysis in situ has arrived.
biorxiv.org
Quantitative Spatial Analysis of Chromatin Biomolecular Condensates using Cryo-Electron Tomography
Phase separation is an important mechanism to generate certain biomolecular condensates and organize the cell interior. Condensate formation and function remain incompletely understood due to difficul...
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Reposted by Tyler Weaver
Bret Freudenthal @freudlab.bsky.social · 02/12/2024
Today was the last day in lab for @tmweaver.bsky.social. We enjoyed lunch and gave him a 3D print of his first cryo-EM structure. Tyler's era was marked by incredible science, friendship, fun, collabs, and cats! He will do amazing at UVA running his own lab. We will miss you buddy #gogetem 🥹
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Reposted by Tyler Weaver
Jens Schmidt @jenscs83.bsky.social · 23/11/2024
Super excited to share our latest paper led by graduate student Mariia Mikhova! She used single molecule live cell imaging to dissect the kinetics of DNA break repair by non homologous end joining. We estimate the NHEJ pathway can repair up to 1000 breaks per minute! www.nature.com/articles/s41...
nature.com
Single-molecule imaging reveals the kinetics of non-homologous end-joining in living cells - Nature Communications
Non-homologous end joining repairs most double stranded DNA breaks in human cells. Here, the authors apply a single-molecule imaging approach visualizing the recruitment of DNA repair proteins to DNA ...
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Reposted by Tyler Weaver
Ben Van Houten @benvh123.bsky.social · 20/11/2024
Happy to celebrate Brittiani Schnable's PhD work on thymine DNA glycosylase! www.nature.com/articles/s41...
nature.com
Thymine DNA glycosylase combines sliding, hopping, and nucleosome interactions to efficiently search for 5-formylcytosine - Nature Communications
Thymine DNA glycosylase is an essential DNA repair enzyme involved in oxidative demethylation of 5- methylC. In this study the authors have tracked specific and non-specific DNA binding of TDG at the ...
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Reposted by Tyler Weaver
Karolin Luger @nucleosomepolice.bsky.social · 18/11/2024
Our paper on the strange ATP-dependent chromatin remodeler Smarcad1 paper is out and freely accessible. Differential regulation of its many activities by phosphorylation. Congrats to Briana and @nhoitsma.bsky.social 🧪https://www.sciencedirect.com/science/article/pii/S0021925824023950?via%3Dihub
sciencedirect.com
Phosphorylation regulates the chromatin remodeler SMARCAD1 in nucleosome binding, ATP hydrolysis, and histone exchange
Maintaining the dynamic structure of chromatin is critical for regulating the cellular processes that require access to the DNA template, such as DNA …
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Tyler Weaver @tmweaver.bsky.social · 15/11/2024
Time to introduce myself! Incoming Assistant Professor at UVA-SOM. Interested in chromatin structure and DNA repair. Here is some of my final work in the @freudlab.bsky.social, where we determine how 1-nt gaps in the nucleosome are filled during DNA repair. www.biorxiv.org/content/10.1...
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Reposted by Tyler Weaver
Basil Greber @bjgreber.bsky.social · 14/11/2024
New DNA repair/genome stability work by our @icrlondon.bsky.social colleagues, led by Peter Martin in Wojciech Niedzwiedz’ lab. Check it out!
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