A decade on from the launch of an ambitious project, it’s time to revisit the reasons for constructing a human genome from scratch.

Job Description The Department of Genome Sciences has an outstanding opportunity for a Research Scientist Engineer 2 to join the team. About this Opportunity Reporting to the Principal Investigator, t...

The ability to design and engineer mammalian genomes across arbitrary length scales would transform biology and medicine. Such capabilities would enab…

We are working to solve the biggest mysteries in bioscience.

The nuclear lamins are extremely long-lived proteins in most cell types. As a consequence, lamin function cannot be effectively dissected with temporal precision using standard knock-down approaches. ...

Mammalian metabolic engineering is critical to advancing basic biology, bioproduction, and cell therapy. However, as pathway complexity increases, so does the size of both the combinatorial design spa...

The REX element is associated with long-range enhancer–promoter interactions.

A barcoded CRISPR base editing system isolates target clones from complex mammalian, yeast and bacterial populations.

Background Inducible gene expression circuits enable precise control over target gene activation and are widely used in direct reprogramming. However, their usability is often compromised by DNA methy...

We are working to solve the biggest mysteries in bioscience.

June 19-20 2025, Vancouver, BC, Canada

June 19-20 2025, Vancouver, BC, Canada

Large genome rearrangements in mammalian cells can be generated at scale

Studying the functional consequences of structural variants (SVs) in mammalian genomes is challenging because (i) SVs arise much less commonly than single-nucleotide variants or small indels and (ii) ...

ChIP-DIP (ChIP done in parallel) is a highly multiplex assay for protein–DNA binding, scalable to hundreds of proteins including modified histones, chromatin regulators and transcription factors, offe...