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Bret Freudenthal

@freudlab.bsky.social
751 followers 775 following 106 posts

Professor studying the interplay between DNA damage and human health. WY➡️CSU➡️UI➡️NIEHS➡️KU. Personal posts from science to society.

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Bret Freudenthal @freudlab.bsky.social · 01/09/2026
Latest collab out in Cell: ~1 mil ribos are embedded per human genome, non-random in distribution. Telomeres are a hotspot with a distinct G-strand rA signature. Watch for future work on how they impact telomere biology! A wonderful collaboration led by the Storici lab. www.cell.com/cell/fulltex...
cell.com
Human nuclear ribomes reveal DNA-embedded ribonucleotides as epigenetic modulators of transcription-associated DNA supercoiling
Human nuclear ribomes reveal that DNA-embedded ribonucleotides accumulate at promoter-associated regulatory elements and scale with transcriptional activity. RNase H2 and Top1 process these ribonucleo...
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Scott Delaney @scott-delaney.bsky.social · 24/08/2026
Check out our new @grantwitness.org website! 18 months ago, we launched as a humble Google Sheet listing 8 terminated NIH grants. Today, we’ve launched a new site tracking tens of thousands of grants and new awards at several different agencies. THANK YOU to everyone who's made this possible! 🧵
grantwitness.org
Grant Witness
An independent, up-to-date, grant-level record of federal science funding disruptions in the United States.
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Bret Freudenthal @freudlab.bsky.social · 12/08/2026
First day of 6th grade. Go get em boys!
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KU | The University of Kansas @universityofkansas.bsky.social · 06/07/2026
Bret Freudenthal, a professor in KU’s Department of Biochemistry & Molecular Biology, works to develop more effective cancer treatments through DNA repair. 🧬 KU encourages collaborative research to deliver global solutions straight from the heartland. 🔗 bit.ly/3QT7gkC
A blue and red DNA model. Text reads, KU research into DNA repair delivers new cancer treatments. KU professor Bret Freudenthal holds a small piece of equipment while a colleague looks on. Text reads, The research of KU professor Bret Freudenthal into DNA repair mechanisms provides insights for targeting cancer cells and developing more effective chemotherapies. Freudenthal, a professor in the Department of Biochemistry & Molecular Biology, won a 2026 University Scholarly Achievement Award.A portrait of Freudenthal. Text on a blue background reads, Freudenthal is an internationally recognized leader in the field of DNA repair whose work has advanced our understanding of how DNA damage leads to disease.A researcher inspects equipment in a laboratory. Text on a blue background reads, Freudenthal’s research has led to breakthroughs in developing more effective cancer treatments through DNA repair, making a positive difference in people’s lives.
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Bret Freudenthal @freudlab.bsky.social · 11/08/2026
After the World Cup left KC, we squeezed in a few trips to close out the summer. Cape May, Wyoming mountains, and wake surfing in Utah/FoCo. The boys start school tomorrow, so this was the last hurrah.
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Bret Freudenthal @freudlab.bsky.social · 11/08/2026
1/ Latest publication from the Freudenthal lab in Biomolecules: 8oxoG:A base pairs are structurally accommodated in the nucleosome, yet effectively invisible to MUTYH. doi.org/10.3390/biom...
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Bret Freudenthal @freudlab.bsky.social · 12/07/2026
What an incredible game to round out the World Cup in KC!
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Bret Freudenthal @freudlab.bsky.social · 29/06/2026
What a soccer weekend! Kicked things off at KC House, where I heard about exciting things happening in KC, then headed to a wild Algeria vs Austria match with great friends. Beautiful game, even better company. ⚽️🇩🇿
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Barack Obama @barackobama.bsky.social · 18/06/2026
To George and Laura, Bill and Hillary — we're grateful for your friendship, counsel, and devotion to this country. And to Joe and Jill, thank you for being on this journey with us.
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Bret Freudenthal @freudlab.bsky.social · 17/06/2026
Bucket list checked. Arrowhead was fully taken over by Argentina last night and the passion was unreal. We took the boys to watch them beat Algeria 3-0, capped by the first world cup hat trick for Messi. Started at KC FanFest, ended watching history. One we’ll never forget. 🇦🇷⚽️
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Bret Freudenthal @freudlab.bsky.social · 05/06/2026
How does a DNA repair enzyme find a needle in a haystack? 🧬 Our latest paper in NAR, led by the one and only C-trap queen Kaitlin Dehart, uses single-molecule imaging to watch APE1 scan DNA and lock onto AP-sites. @lumicks.bsky.social academic.oup.com/nar/article/...
academic.oup.com
A dynamic search mechanism enables APE1 to identify AP-sites in DNA
Abstract. Apurinic/apyrimidinic (AP) sites are among the most frequent DNA lesions, arising thousands of times per cell each day. These lesions threaten ge
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Bret Freudenthal @freudlab.bsky.social · 03/06/2026
I am honored to receive a 2026 University Scholarly Achievement Award from KU. They say it takes a village. Mine took a village and then some: my lab, my trainees, my family. The award has my name on it, but it is theirs. They do they hard work and make this the best job ever!🙏 youtu.be/o-KcgX3IiP8
youtu.be
Bret Freudenthal, University Scholarly Achievement Award
YouTube video by The University of Kansas
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Bret Freudenthal @freudlab.bsky.social · 01/06/2026
That's a wrap on the 25th Annual Midwest DNA Repair Symposium at the University of Kansas Medical Center. Two days, 175 attendees, 4 keynotes, 22 talks, and 85 posters of genuinely incredible science (also some fun socializing of course). I am still smiling, but a bit tired. 🧬🌻
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Edwin Antony @professorantony.bsky.social · 27/05/2026
www.biorxiv.org/content/10.6... New research space for the group: RNA binding proteins! Been chipping away at this for about 3 years now. But, pretty cool to see how a single PTM in an IDR changes overall configurational states of ordered domains.
biorxiv.org
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Bret Freudenthal @freudlab.bsky.social · 20/05/2026
A season of change in the lab. 🎓 Hooding ceremony for Spencer Thompson who is headed back to the clinic. 🧬 Zach Onyszchuk joins the lab as a graduate student 🔬 Nicholas @nicholaswashton.bsky.social joins the lab as Senior Scientist Excited for what's ahead!!
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Bret Freudenthal @freudlab.bsky.social · 11/05/2026
Action packed Mother’s Day weekend celebrating Jean, cheering on Pierce at his big improv show and watching Grayson’s team bring home tournament gold. This is what great moms do, even on the weekends meant to celebrate them. Grateful for you, Jean. ❤️
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Bret Freudenthal @freudlab.bsky.social · 27/04/2026
We are excited to have Nicholas join the team and see what amazing science we can do together! Also a great connection to the Barnes lab to help with the synergy across our groups.
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Bret Freudenthal @freudlab.bsky.social · 10/04/2026
Big congrats to Spencer Thompson on defending his thesis today! Beautiful @lumicks.bsky.social C-Trap single-molecule work and a major MD/PhD milestone. Proud PI! BioRxiv coming soon.
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Bret Freudenthal @freudlab.bsky.social · 09/04/2026
Abstract deadline approaching (April 15) for the Midwest DNA Repair meeting. Join us for an exciting meeting with outstanding science and valuable networking. Register and share. $100 includes meals, networking, and social events. sites.google.com/view/kumc-mi...
sites.google.com
Midwest DNA Repair
The 25th Annual Midwest DNA Repair Symposium will be held at the University of Kansas Medical Center in Kansas City, Kansas, on May 30–31, 2026. The meeting will take place in the Health Education Bui...
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ACS BIOL: Division of Biochemistry and Chemical Biology @acsbiol.bsky.social · 09/02/2026
Congratulations and welcome to the newest members of the #ACSBIOL Executive Committee! @freudlab.bsky.social, @doc-jlmeier.bsky.social, @tmweaver.bsky.social, @ebraselmann.bsky.social
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Bret Freudenthal @freudlab.bsky.social · 25/03/2026
Great way to wrap up the ski season at Steamboat over spring break last week on a wonderful trip with family and friends. The boys definitely leveled up and are now hitting black diamonds! ⛷️
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Bret Freudenthal @freudlab.bsky.social · 12/03/2026
Great seminar visit to UC Riverside hosted by Linlin Zhao. Excellent discussions with a terrific group of trainees and scientists exploring a wide range of exciting science. Thanks to Linlin for the warm hospitality!
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Bret Freudenthal @freudlab.bsky.social · 04/03/2026
Great first Fusion meeting! 🧬 Presented our telomere/ribonucleotide work. Huge congrats to Abbey Vito for winning Best Poster and Most Engaged 🏆👏 Always great catching up with friends in the field. And the weather didn’t hurt ☀️
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Bret Freudenthal @freudlab.bsky.social · 17/02/2026
Wonderful few days skiing in New Mexico. Every trip the boys get stronger, more controlled, and confident. It is fun to watch the progression in real time. Some fresh snow helped too!
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Kevin M. Kruse @kevinmkruse.bsky.social · 11/02/2026
So, to wrap up today's insanity: President Trump, who is deeply implicated in a pedophilia scandal involving his best friend, the sex trafficker, sent Attorney General Bondi -- who only has that job because Trump's first choice was also implicated in a separate pedophilia scandal -- to the House...
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Rachel Bitecofer @rachelbitecofer.bsky.social · 04/02/2026
“What do you think the odds are that person is a goat fucker?!” Grade A trolling
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Jennie Mason @jenmasonphd.bsky.social · 04/02/2026
Such a great conference for trainees and early career scientists. Going back for the first time last year (since leaving the Midwest) this conference felt like home. Such a wonderful supportive DNA repair community. Awesome science and even better people!!
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Mark Hedglin @hedglinlab.bsky.social · 04/02/2026
This 👇is such a great opportunity for young scientists in the field. I “grew up” on this conference & still hold so many meaningful relationships to this day that I made at these conferences.
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ramsdenlab.bsky.social @ramsdenlab.bsky.social · 03/02/2026
Great conference!!
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Bret Freudenthal @freudlab.bsky.social · 03/02/2026
📣 The 2026 Midwest DNA Repair Symposium is coming to Kansas City (registration is open) 🗓 May 30–31, 2026 ✨ Talks will be selected from abstracts, with a strong focus on trainees and new investigators. Please RT & share with your labs! 🔗 sites.google.com/view/kumc-mi...
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Bret Freudenthal @freudlab.bsky.social · 27/01/2026
🎉Kicking off 2026 with our first paper from the Freudenthal lab in NAR. Ribonucleotides reshape telomeric G4s and are resistant to RNase H2 repair. Congrats to the authors and huge thanks to our collaborator Hui-Ting Lee! academic.oup.com/nar/article/...
academic.oup.com
Effects of ribonucleotides on telomeric G4 formation, dynamics, and initiation of ribonucleotide excision repair by RNase H2
Abstract. Human telomeres are composed of TTAGGG repeats that can fold into G-quadruplexes (G4s). G4s can form several different conformations, including p
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Bret Freudenthal @freudlab.bsky.social · 21/01/2026
Fun filled weekend in San Diego and LA! Really nice to escape the cold and catch up with Mark and Amiel.
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Bret Freudenthal @freudlab.bsky.social · 15/01/2026
I tend to mostly post positive lab outcomes, but not every update is a win. Received my first not discussed grant score of the year. Part of the process and still plenty of year left. 🤞January has been a month. 😞
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Eric Michael Garcia @ericmgarcia.bsky.social · 08/01/2026
Minneapolis public schools canceled classes officials after Roosevelt High School said armed Border Patrol officers came on school property during dismissal Wednesday and began tackling people, handcuffed two staff members and released chemical weapons on bystanders www.mprnews.org/story/2026/0...
mprnews.org
Minneapolis schools cancel classes after Border Patrol clash disrupts dismissal at Roosevelt
Minneapolis schools closed for the week citing safety concerns after an encounter involving armed Border Patrol agents near Roosevelt High School.
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ramsdenlab.bsky.social @ramsdenlab.bsky.social · 16/12/2025
Is NHEJ truly a double-strand break repair pathway...repairing both strands, at the same time?
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Agnel Sfeir @agnelsfeir.bsky.social · 15/12/2025
📢 Telomere community: Registration and abstract submission are now open for the EMBO Workshop “Telomere function and maintenance in health and disease”, May 25–30, 2026, in Lazise, Italy 🇮🇹. Looking forward to an exciting meeting! Please re-post. meetings.embo.org/event/26-tel...
meetings.embo.org
Telomere function and maintenance in health and disease
Telomeres are specialized structures that protect the ends of linear chromosomes in eukaryotes. Research in this area has revealed that telomere maintenance is critical for stem cell function and nor…
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LUMICKS @lumicks.bsky.social · 25/11/2025
Amazing to see the C-Trap in action! We’re proud that the C-Trap plays a part in supporting cancer research in @freudlab.bsky.social lab at @kucancercenter.bsky.social! 🙌
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Bret Freudenthal @freudlab.bsky.social · 22/11/2025
Grateful to host Sen. Moran and NIH Director Jay Bhattacharyya in the lab today. Proud of our trainees, who showcased their work using the @lumicks.bsky.social C-Trap and the KU Cryo-EM Facility. Their dedication shows how federal investment drives cancer research at @kucancercenter.bsky.social.
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Ernst Schmid @ernstschmid.bsky.social · 12/11/2025
Thrilled to share that the final piece of my PhD work is now on bioRxiv! biorxiv.org/content/10.1... With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at predictomes.org/hp
biorxiv.org
Proteome-wide in silico screening for human protein-protein interactions
Protein-protein interactions (PPIs) drive virtually all biological processes, yet most PPIs have not been identified and even more remain structurally unresolved. We developed a two-step computational...
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Dare Obasanjo @carnage4life.bsky.social · 12/11/2025
They’ve laid off so many people that the government is now getting its economic data from DoorDash.
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Tyler Weaver @tmweaver.bsky.social · 04/11/2025
Check out the perspective my lab wrote with @freudlab.bsky.social. We provide our perspective on recent work describing the structural basis of chromatin-based base excision repair!
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Bret Freudenthal @freudlab.bsky.social · 03/11/2025
🎉 Joint paper from the Freudenthal and @tmweaver.bsky.social Labs! Abbey Vito’s first publication discusses a tug-of-war between BER enzymes and chromatin for access to damaged DNA, a battle central to genome stability. Built on Tyler's foundational work! tinyurl.com/ywkt2bt5
tinyurl.com
Base excision repair in chromatin: A tug-of-war for DNA damage
Base excision repair (BER) is a genome surveillance pathway responsible for repairing DNA base lesions distributed throughout the chromatinized eukary…
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Bret Freudenthal @freudlab.bsky.social · 02/11/2025
It was wonderful hosting you for the seminar visit! Also appreciate you being a good sport for having an anglerfish introduce you.🤣
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Bret Freudenthal @freudlab.bsky.social · 31/10/2025
🎃 Happy Halloween from the Freudenthal Lab! 🐟🖤 Anglerfish PI + Emo Researchers = Bioluminescent Despair #Scienceunderpressure
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Bret Freudenthal @freudlab.bsky.social · 29/10/2025
One of my favorite activities of the year is our annual pumpkin carving competition with the Bose Lab. Everyone’s pumpkins were amazing!
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Harmit Singh Malik @harmitmalik.bsky.social · 16/10/2025
I think people adjacent to science (but who now find themselves deciding the fate of US science somehow) undervalue humility, valuing braggadocios hubris instead. Yes it’s true that some scientific discoveries are complete paradigm changers, and we celebrate these. 1/
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Alivia August | HNL | @impressalivia.com · 17/10/2025
By far. Juvenile.
youtube.com
Juvenile: Tiny Desk Concert
YouTube video by NPR Music
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shauna @goldengateblond.bsky.social · 14/10/2025
whoever did this little bit of magnificence, take a bow
satire: a spirit halloween costume that’s a “violent antifa terrorist” and includes:
- inflatable frog suit
- cape
- pepper spray filter
- a thirst for the blood of the innocent
- air pump

batteries and Molotov cocktails not included
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Edwin Antony @professorantony.bsky.social · 08/10/2025
Spread the word if you can. We have an unused stopped flow accessory from Applied Photophysics. We traded in our Chirascan CD instrument so we have no use for this anymore. Reach out if you are interested and can find a home for this setup. Will ofcourse only work with a Chirascan!
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Bret Freudenthal @freudlab.bsky.social · 11/10/2025
The Sangre de Cristo Mountains outside Santa Fe were beautiful today! Wonderful day for a hike.
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