Latest collab out in Cell: ~1 mil ribos are embedded per human genome, non-random in distribution. Telomeres are a hotspot with a distinct G-strand rA signature. Watch for future work on how they impact telomere biology! A wonderful collaboration led by the Storici lab. www.cell.com/cell/fulltex...
cell.com
Human nuclear ribomes reveal DNA-embedded ribonucleotides as epigenetic modulators of transcription-associated DNA supercoiling
Human nuclear ribomes reveal that DNA-embedded ribonucleotides accumulate at promoter-associated
regulatory elements and scale with transcriptional activity. RNase H2 and Top1 process
these ribonucleo...