Changes in the number of chromosomes or their spatial organization within the nucleus have critical consequences for cell fate. Yet capturing the karyotype or three-dimensional architecture of chromat...

Cell-free is a powerful platform to unravel biological complexity. Here, the authors used active learning to optimize buffer composition, boosting mRNA 20-fold, enabling cell-free transcriptomics and ...

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

LinkedIn co-founder Reid Hoffman is stepping down from Microsoft's board after nearly a decade to focus on Manus, his AI drug discovery startup.

A decade on from the launch of an ambitious project, it’s time to revisit the reasons for constructing a human genome from scratch.

Engineered Bacteroides thetaiotaomicron, Btbots, use a genetic AND circuit to sense nitric oxide and deoxycholic acid as inflammatory signal in the gut to release therapeutic molecules, TFF3 and IL-35...

YouTube video by CSHL Leading Strand

A new method to produce strong, biodegradable plastic from bamboo is reported in Nature Communications this week. The bioplastic resembles oil-based plastics in strength, shapability, and thermal stab...

Modular RNA nanostar motifs spontaneously assemble into programmable synthetic condensates in the nucleus and cytoplasm, with RNA design controlling localization, sequence-specific target recruitment ...

The open access movement was bold and promising, but ultimately disappointing. Now is the time to stop and call for a new way to make publishing work…

Ribozymes enable sequence-encoded turnover of RNA droplet material, resulting in transiently active droplets that selectively segregate based on their genotype. This establishes a direct link between...

Solid tumors are sensitized to anti‑PD‑L1 immunotherapy by engineered E. coli to produce nitric oxide.

Peptides are sequenced by converting each amino acid into amplifiable DNA barcodes.

Photopolymerizable BELA hydrogels combine dynamic boronate ester and elastic dithiolane-ene crosslinks to achieve ultrafast stress relaxation and tunable viscoelasticity. By adjusting formulation and ...

Evolutionarily related ‘proto-point’ centromeres providing resolution to the evolutionary origins of point centromeres are identified in yeast, and comparison shows they evolved in an ancestor with re...

In synthetic biology, DNA assembly is a routine process where increasing demands for standardization, high-throughput capacity, and error-free execution are driving the development of accessible, auto...

WASHINGTON—In a firm dismissal of decades of scientific research and real-world data on the organ’s benefits and safety, Health and Human Services Secretary Robert F. Kennedy Jr. publicly questioned t...

Adam Rutherford asks what it might mean if we can build human bodies and minds.

The Canada Impact+ Research Training Awards are a one-time initiative designed to recruit international or returning Canadian students and postdoctoral researchers to Canada. These awards support the recruitment of doctoral students and postdoctoral researchers in priority areas, helping build capacity, strengthen the research ecosystem and enhance Canada’s global competitiveness.

Understanding how cells make decisions over time requires the ability to link past molecular states to future phenotypic outcomes. We present TimeVault, a genetically encoded system that records and s...

The honeybee gut microbiota plays a key role in shaping host health and susceptibility to disease. Yet, the nutrient environment it experiences within the gut remains poorly characterized. In particul...