Replication stress drives genomic instability, tumour evolution and therapeutic adaptation, yet also creates exploitable vulnerabilities. In this Review, Chen and Zou discuss how chronic replication stress shapes cancer biology and how emerging therapies are targeting the pathways that enable tumour cells to survive it.

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Data across countries and ages reveal a growing struggle to concentrate, and declining verbal and numerical reasoning

Nature Reviews Cancer, Published online: 28 August 2026; doi:10.1038/s41568-026-00978-0Many advances in cancer treatment depend on discoveries made decades earlier. In this Comment, Murphy et al. discuss the histories of EGFR, HER2, CDK4/6 and RAS, highlighting how long translation can take and how clinical benefit can continue to accumulate as more effective drugs are developed, used in earlier disease settings and combined with existing treatments.

The Annual Conference SciLifeLab Science Summit is a one-day symposium with a new topic each year. The 2026 topic is: Cancer Research: Translating Life Science Discoveries to Clinical Breakthroughs Fo...

Lebrec et al. present a FRET-based cGAS reporter and show that cGAS activation by genotoxic stress is rare and uncoupled from micronuclei. The study implicates R-loop structures and subtypes of chroma...

Segura-Bayona et al. uncover genetically separable ATRX functions that independently safeguard telomeres and genome replication, revealing how CST and 9-1-1 pathways suppress accumulation of toxic sin...

The DNA damage response (DDR) is a complex network of cellular pathways that ensures the faithful maintenance of our genomes upon a wide array of genomic insults. To elucidate the functional architect...

Noboru Mizushima is Professor of Biochemistry and Molecular Biology at the University of Tokyo, Japan, where he runs a laboratory studying the mechanisms and physiological functions of autophagy and o...

Douglas et al. study the E3 ligase HOIL-1, mutated in patients with a type of myopathy. Mutant HOIL-1 influences the sensitivity to disulfidptosis initiated by ZAKα–ATF4 in glucose starvation and inte...

Cystine / Glutathione / NADPH SLC33A1 exports oxidized glutathione to maintain endoplasmic reticulum redox homeostasis Shanshan Liu  (刘珊珊), Mark Gad, Caifan Li  (李采蘩), Kevin Cho, Yuyang Liu  (刘雨洋),…

Schützenhofer et al. show that expression of catalytically impaired PARP1 mutants is toxic to cells, which can be overcome by treatment with saruparib, a PARP1-specific inhibitor that displays a pro-r...

In this Essay, the evolution of life is construed as a ribosomal takeover, whereby the ribosome evolved to consume most of the cell’s resources, while other cellular componentry ensured the…

Ekvik et al. genetically introduced an exogenous ATP-consuming enzyme into human cells in order to study the direct effects of energy stress in vivo. This genetic approach offers flexibility and specificity inaccessible through conventional drug-based models of energy stress. The intervention produced well-established as well as unexplored energy stress responses.

Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors ...

Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors ...

Lisci et al. present a unified model revealing how cells escape glutamine addiction, a metabolic vulnerability of several cancers. Combining systematic genetic and nutrient screens, they show that bio...

SAMHD1 is a deoxyribonucleoside triphosphate (dNTP) hydrolase that controls intracellular dNTP pools and plays diverse roles in human health and disease. Notably, this enzymatic activity also confers ...

SciLifeLab recently decided on 20 Technology Development Projects (TDPs) for funding in the latest TDP call. TDPs are projects aimed at developing new technologies, methods or workflows, often as…

To date, genetic interaction (GI) maps in the context of environmental perturbations have been limited to yeast studies. Herken et al. present five human GI maps that reveal how the landscape of genes...