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MichaelMcMurray lab

@mcmurraylab.bsky.social
1K followers 1.1K following 121 posts

Official account of Michael McMurray’s lab in the Dept. Cell and Developmental Biology at the University of Colorado Anschutz Medical Campus. We study septin proteins, folding/assembly of multi subunit protein complexes, & various aspects of yeast biology

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Reposted by MichaelMcMurray lab
Mark Peifer (He, him) @peiferlabunc.bsky.social · 28/09/2026
Are you looking for a postdoc exploring the cell biology of development, defining how cells change shape and move? Do you want to develop a research program & teaching skills preparing you for a position at a college or small University? Our new NIH grant will support those goals 1/n Please share
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Rasmus Jensen @rasmusjensen.bsky.social · 25/09/2026
🎉 Out today in Cell: the paper I've been looking forward to sharing for a long time 🎉 We used cryo-ET to find a molecular machine nobody knew existed on the surface of a minimal bacterium, and worked out what it does. 🧵(1/7) #TeamTomo #cryoET
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Maitreyi Das @daslabpombe.com · 16/09/2026
The Das lab has 1-2 open postdoctoral positions. Our lab investigates the fundamentals of cell-cycle-dependent cell polarity. Boston College has fantastic resources, including a cutting-edge imaging facility with state-of-the-art microscopes. Please apply here: bc.csod.com/ux/ats/caree...
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Andrew Hendry @ecoevoevoeco.bsky.social · 16/09/2026
Maybe you have heard about our Alaska stickleback introduction experiment? You might want to apply for our multi-PI freshwater science postdoctoral position. The video below is of one of our source lakes for the intro. scasscsa.mcjobboard.net/jobs/235865
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Alex Merz 🇺🇸🇨🇦🇺🇦 @merz.bsky.social · 12/09/2026
Good old Coomassie Brilliant Blue G250 can be used as a fluorescent gel stain. And done right, it performs as well as Sypro Ruby, if you have access to an infrared scanner like the LiCor Odyssey.
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Laura Ross @laurarossevo.bsky.social · 10/09/2026
My lab @ Edinburgh university is recruiting a postdoc to work on the weird and wonderful germline-specific chromosomes of flies. elxw.fa.em3.oraclecloud.com/hcmUI/Candid... collaboration with @germline.bsky.social and yukiko yamashita funded by @novonordisk.bsky.social please repost!
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Leonid Schneider @forbetterscience.bsky.social · 10/09/2026
Congratulations to Elsevier on this insanity my colleague found. Is anything in this clinical trial from Spain and UK real? www.cell.com/the-innovati...
cell.com
Quantum evidence of nonlocal consciousness during clinical death
If consciousness can operate under quantum principles, then the boundaries between life, death, and cognition are far more permeable than current science allows. In the first large-scale, randomized, ...
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Magnus Bauer @kinasekid.bsky.social · 06/09/2026
AlphaFold Server’s ligand menu just got a lot bigger and I almost missed it! You can now add any ligand from the wwPDB Chemical Component Dictionary. Just enter its CCD code 🥳
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Michael Feldbrügge @mfeldbruegge.bsky.social · 02/09/2026
Two PhD positions in the Feldbrügge Lab at HHU Düsseldorf within nEXt-RNA: 🔬 DC1: Live-cell imaging of RNA transfer and function 📦 DC10: Mechanisms and applications of RNA delivery RNA biology, fungi, extracellular vesicles and advanced imaging. www.mikrobiologie.hhu.de/en/
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Reese Richardson @reeserichardson.bsky.social · 25/08/2026
A massive update: At least ~15 companies~ are selling scientists antibodies using faked validation data. We've documented 18,000+ manipulated images on 17,000+ products sold by leading laboratory suppliers including Thermo Fisher, Abcam, Santa Cruz Biotechnology, Millipore Sigma and Bio-Techne. 1/🧵
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MichaelMcMurray lab @mcmurraylab.bsky.social · 24/08/2026
Wonderful thread 👇🏽
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Sue Biggins @suebiggins.bsky.social · 18/08/2026
Junior faculty position in Basic Sciences @fredhutch.org! Please repost!
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William Garland @willgarland.bsky.social · 14/08/2026
Postdoc in Nuclear RNA Biology at Aarhus University! Interested in mammalian nuclear RNA production and turnover? Come join Torben Heick Jensen’s team in Aarhus 🇩🇰 www.au.dk/om/stillinge...
au.dk
Postdoc position in Nuclear RNA Biology - Ledig stilling på Aarhus Universitet
Ledig stilling ved RNA-biologi og -innovation, Aarhus Universitet
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MichaelMcMurray lab @mcmurraylab.bsky.social · 14/08/2026
A reminder to budding yeast researchers: if you use the "GAPDH" promoter to drive constitutive expression, please be careful about how you describe this. The gene GPD1 encodes glycerol-3-phosphate dehydrogenase, not Glyceraldehyde-3-phosphate dehydrogenase. The TDH3 promoter is probably what you use
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Rytis Prekeris @prekerislab.bsky.social · 13/08/2026
Looking for a postdoc to join our project studying actin and membrane dynamics during cell migration. If interested, please reach out to me via email: rytis.prekeris@ucdenver.edu
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Alex Guseman @alexguseman.bsky.social · 11/08/2026
Im looking for a postdoc to help with protein engineering efforts. If you know who could be a good fit send them my way! see details below:
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MichaelMcMurray lab @mcmurraylab.bsky.social · 09/08/2026
There's not much to laugh about these days in the research enterprise. A few yrs ago I began performing science-themed parodies at the Annual Retreat of our Molecular Biology PhD Program @molbcu.bsky.social (I am Associate Director). I hope this one from 2024 makes you smile youtu.be/HqPldJ_OIZI
youtu.be
"Wanted": a PCR Parody from the CU Anschutz Molecular Biology PhD Program 2024 Annual Retreat
YouTube video by Michael McMurray
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MichaelMcMurray lab @mcmurraylab.bsky.social · 08/08/2026
One of my favorite parts of this paper full of beautiful experiments is the finding that phosphorylation of a regulatory helix switches the direction of transport. Imagine trying to figure this out using only in vitro reconstitution and recombinant proteins! No chance www.science.org/doi/10.1126/...
science.org
A molecular switch for coordinating kinesin and dynein transport of mitochondrial cargo
The cellular distribution of mitochondria in response to stress and local energy needs is governed by the relative activities of the microtubule-based molecular motors kinesin and dynein. The mechanis...
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Prasad Jallepalli, MD, PhD @prasad.bsky.social · 07/08/2026
looks like “buffer” and “volume” were also mistranslated
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Journal of Cell Science @jcellsci.bsky.social · 06/08/2026
This article includes an abstract in Brazilian Portuguese. It is our first article with an additional language abstract. For more details about this option: journals.biologists.com/jcs/pages/jo...
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Juan Carlos De la Concepcion @delaconcepcionjc.bsky.social · 05/08/2026
PLEASE SHARE! New job openings in my lab @zmbp-tuebingen.bsky.social. We have a broad interest into the mechanistic basis of how molecular complexes are rewired during cellular development in plants and during invasion by pathogens. 🌱🍄🔬 See details below 👇 #PlantSciJobs
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Rebekah Rogers @evolscientist.bsky.social · 04/08/2026
Officially recruiting postdocs at GW. If you are interested in genetic novelty, structural variation, or evo genetics please get in touch! We have data sets on mulitple organisms with large population sizes (Drosophila, Megalonaias nervosa) and species in decline (fireflies, mussels, elephants).
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John F. Rawls @jfrawls.bsky.social · 04/08/2026
The Rawls Lab is hiring! We are seeking a motivated research technician to support cutting-edge studies in gastrointestinal physiology using zebrafish & mice. To learn more about this hands-on & in-person position at Duke University in Durham NC, click here: careers.duke.edu/job/Durham-R...
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Magnus Kjærgaard @proteinmagnus.bsky.social · 03/08/2026
Why do intrinsically disordered proteins behave so weirdly during SDS-PAGE? This is the question we aim to answer in our recent paper: onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
Sequence determinants of the hypomobility of intrinsically disordered proteins in <fc>SDS</fc>‐<fc>PAGE</fc>
Proteins with intrinsically disordered regions (IDRs) migrate at a higher apparent molecular weight in sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis, complicating their analysis and...
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MichaelMcMurray lab @mcmurraylab.bsky.social · 03/08/2026
I asked Google's chatbot, Gemini, to help me install & run an RNA structure/sequence analysis program on my Mac. It asked me to paste the sequence for analysis, and it would make the input file. Output looked a little funny… it had deleted one of the 29 nt from the middle of the pasted sequence!
static.klipy.com
Barack Obama's Confused Reaction
ALT: Barack Obama's Confused Reaction
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Sarah Kendrew @sarahkendrew.bsky.social · 31/07/2026
I heard a story about a detained health researcher the other day and assumed this was it - but no, there‘s a second local scientist, from UMD, who is being held by ICE. On his way home from receiving a “teacher of the year” award. www.wbaltv.com/article/umb-...
wbaltv.com
University of Maryland pharmacy instructor detained in Dallas
Federal officials detained an instructor from the University of Maryland School of Pharmacy last week.
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Eileen Clancy 🧿 @clancyny.bsky.social · 31/07/2026
Ameaka Fatima Nkempu, a Johns Hopkins University researcher in public health, was detained by ICE while boarding a domestic flight. She says she is Cameroonian in a Medium article that she authored. As of Thursday morning, the ICE Online Detainee Locator did not list where she was being held.
Studio photo of a Black African women wearing a beautiful dress in a printed fabric.

Caption:
Ameaka Fatima Nkempu, Johns Hopkins public health
researcher, was detained by immigration agents while
boarding a domestic flight this week. (Johns Hopkins
University)
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Liz Miller @lizmillercu.bsky.social · 31/07/2026
Job alert! I'm recruiting a new post-doc to work on mechanisms of co-translational quality control in the ER. Looking for expertise in ribosome biology and yeast genetics/cell biology. Please reach out to me with any questions. www.dundee.ac.uk/work-for-us/...
dundee.ac.uk
Postdoctoral Research Assistant - UOD2336
Closing date: Thursday 27 August 2026, 23:59
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Sofia Luengo-Woods @sluengo.bsky.social · 30/07/2026
We’re so excited to share our new paper, where we tackle the wealth of structural and functional diversity of anti-phage sensors across bacteria (1/6)
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Stirling Churchman @stirlingchurchman.bsky.social · 28/07/2026
RNA-seq tells us how much RNA is present in the cell. But to understand gene regulation, we need to easily measure the synthesis and decay rates driving this abundance. We introduce AIR-seq: analog intrinsic recoding sequencing. (1/6) www.biorxiv.org/content/10.6...
biorxiv.org
Analog intrinsic recoding measures RNA dynamics without chemical conversion
Steady-state RNA abundance measurements mask the synthesis and decay rates that shape gene expression. Analog intrinsic recoding sequencing (AIR-seq) repurposes the base-pairing properties of N4-hydro...
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American Statistical Association History of Statistics @hos-asa.bsky.social · 21/07/2026
Few statisticians know that Frank Yates, pioneer of experimental design, is responsible for the annoying practice of indicating 3 tiers of statistical significance by stars (*p ≤ 0.05, **p ≤0.01, ***p ≤ 0.001). He soon regretted it and “vehemently opposed its unthinking use”. And here we are.
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Tatiana Moiseeva @tat1anamoiseeva.bsky.social · 15/07/2026
Our lab at Pitt is looking to hire a technician. Ideal candidate would be a recent graduate with some cell biology skills, looking to expand their experience before applying to a PhD program in a couple of years. If you are this person, interested in DNA replication, please email me. moiseevalab.com
moiseevalab.com
Tatiana Moiseeva Lab
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MichaelMcMurray lab @mcmurraylab.bsky.social · 18/07/2026
Any known examples of an RNA localization element in the 5’UTR?
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Rafael Pinilla-Redondo (Rafa) @rafomics.bsky.social · 16/07/2026
1/10 🚨Preprint! One RING to rule them all (phages)👑💍⚔️ Bacteria build giant DNA-scaffolded RNase rings (larger than the ribosome!) to shut down viral infection🧬🧵👇 biorxiv.org/content/10.6...
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Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · 15/07/2026
Join us in a fun, crazy and interesting interdisciplinary research project that combines protein biophysics, evolutionary genomics, biomolecular archaeology, and textile research to resolve species identity and post-translational modifications in the structural proteins collagen and keratin
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Binyam Mogessie ቢንያም ሞገሴ @binyammogessie.bsky.social · 10/07/2026
New paper from the @xionglab.bsky.social and Mogessie labs at Yale! We uncover the molecular architecture of mammalian oocyte cytoplasmic lattices (CPLs), revealing GTP-bound tubulin associated with a degradative protein complex. Read the paper: doi.org/10.1038/s415...
doi.org
Cytoplasmic lattices store developmentally poised degradative and cytoskeletal complexes in mammalian eggs - Nature Structural & Molecular Biology
Li et al. obtain high-resolution, native structures revealing that cytoplasmic lattices in mammalian eggs organize and store degradative and cytoskeletal complexes for early embryonic development.
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MichaelMcMurray lab @mcmurraylab.bsky.social · 10/07/2026
Note septins at play here! www.biorxiv.org/content/10.6...
biorxiv.org
Atonosomes, compartments involved in membrane tension decrease
To ensure survival, cells need to buffer the effects of environmental stress on their plasma membrane, yet the structural mechanisms by which this is acutely achieved remain largely unknown. Here, we ...
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HittingerLab @hittingerlab.bsky.social · 08/07/2026
A tenure-track research position is available for application at the Westerdijk Fungal Biodiversity Institute @westerdijkinst.bsky.social located in Utrecht Science Park in the Netherlands. Please share with colleagues and see the link below for more info: wi.knaw.nl/news/details...
wi.knaw.nl
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MichaelMcMurray lab @mcmurraylab.bsky.social · 07/07/2026
“Flex fuel” helicases 💯 www.nature.com/articles/s41...
nature.com
ATP is dispensable for E. coli DNA replication and eukaryotic helicase activity - Nature Communications
Here the authors show that replicative helicases from bacteria to humans can use dTTP instead of ATP for DNA unwinding, and that the E. coli replisome preferentially uses dTTP during DNA replication, ...
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Craig Kaplan @triggerloop.bsky.social · 29/06/2026
The Kaplan Lab at the University of Pittsburgh has received funds to recruit a postdoctoral fellow to establish a multiplexed assay of variant effect for a disease gene. This relates to our studies on RNA Polymerase II. This project requires experience with human cell lines and genomics 1/
cfopitt.taleo.net
Post Doctoral Associate
Click the link provided to see the complete job description.
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Nikolai Slavov @slavov-n.bsky.social · 24/06/2026
Since the 1960s, the genetic code has been used to predict protein sequences from DNA and mRNA sequences. Our @nature.com article demonstrates that these predictions miss thousands of protein sequences present in human tissues. www.nature.com/articles/s41... 1/
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Yamuna Krishnan @krishnanyamuna.bsky.social · 22/06/2026
1/ Mitochondrial Na⁺ links metabolism, Ca2+ signaling and disease. We know how it gets in, how it gets out, and proteins that use it. But: we've never actually seen Na⁺ in single mitochondria in live cells. We started with an unusual observation, went down a rabbit hole & found some cool biology .
A mitochondrion showing Ca2+ entering through the MCU, exchanged for Na+ by NCLX, Complex I acting as a Na+/H+ exchanger, and various transporters that use Na+ to move their substrates in and out of the mitochondria
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MichaelMcMurray lab @mcmurraylab.bsky.social · 23/06/2026
Our new paper was, by definition, an adventure: stepping outside of our comfort zone, embracing the unknown, and engaging in activities where the outcome is uncertain. Includes discovery of a new species and working with a Native American tribe to name it… 🧵👇 onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
Comparative Analysis of Stress Adaptation in the Yeast Microbiome of Cactus
Yeasts and related fungi isolated from cacti or nearby non-cactus plants were characterized phenotypically and genomically, revealing differences that hint at modes of adaptation to the cactus host.
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MichaelMcMurray lab @mcmurraylab.bsky.social · 20/06/2026
It's great that buffering by chaperones like Hsp90s continues to be studied as "capacitors of evolution". I hope at some point the concept catches on that chaperones can also protect against harmful mutant proteins by kinetically trapping them so they can't poison protein complexes (PMID 25673805)
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Elias Spiliotis @septinlab.bsky.social · 12/06/2026
Our newest review on septins as makers & breakers of membrane contacts in J Neurochem Fun writing with new PhD grad (and FASEB Septin Conference A/V Assistant Extrordinaire) TJ Holt Thanks @mcmurraylab.bsky.social @sergemostowylab.bsky.social for input. onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
Septins in the Middle—Makers and Breakers of Membrane Contact Sites
Septins are a family of GTP-binding proteins that assemble into heteromeric oligomers and polymers, associating with specific membrane domains and organelles according to their subunit composition. G...
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Martin Stoermer @martinstoermer.bsky.social · 09/06/2026
Sad that the university has decided to shut down the 900 MHz NMR in part because Trump’s illegal war has made helium supplies unpredictable and likely unaffordable. Don’t think I’ll ever get a chance to use its ilk again. #ChemSky 🧪
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MichaelMcMurray lab @mcmurraylab.bsky.social · 09/06/2026
Now they want to meet with me in person to discuss... feel free to comment here with talking points I should include!
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EMBO @embo.org · 09/06/2026
Congratulations to Gautam Dey (EMBL) and Omaya Dudin (University of Geneva) for being awarded the EMBO Gold Medal 2026 in recognition of their outstanding contributions to the #LifeSciences in Europe! 🧪 www.embo.org/press-releases/embo-go…
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Christine Mayr @christinemayr.bsky.social · 08/06/2026
Finally out in @Cellcellpress! Proteins with long IDRs are prone to misfolding during protein synthesis. This is prevented by mRNA 3′UTRs that act as mRNA-based IDR chaperones. www.cell.com/cell/fulltex...
cell.com
mRNA 3′ UTRs chaperone intrinsically disordered regions to control protein activity
Highly conserved mRNA 3′ UTRs act as co-translational chaperones for intrinsically disordered regions (IDRs), preventing inter-domain misfolding and enabling biogenesis of fully active proteins.
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