bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 2hStructure-based virtual screening reveals new metabolite interactions and modulators of human glucose-6-phosphate isomerase www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 5hInformatics Methods to Enhance Bacterial Peptide Detection www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 5hStructural basis of coiled-coil domain-mediated inhibition of A. baumannii AbTir NAD+ nucleosidase activity www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 5hFunctional characterization of terpene synthases from Dendrobium nobile provides insights into the biosynthesis of copaborneol, a proposed dendrobine precursor www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 8hThe scaffold nucleoporin Nup188 undergoes liquid-liquid phase separation www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 9hHuman FACT complex coordinates cohesin and transcription on chromatin www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 23hJoining Two Perspectives of the Proteome with the Trypsin+HTA Protease Workflow www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 06/10/2026Peptide frontier-orbital gaps narrow by backbone electrostatics www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 06/10/2026A recombinant heterotrimeric mini-procollagen I reveals new functional and structural roles for the α2(I) chain www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 06/10/2026Mechanistic classification of the AAA superfamily with protein language models www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 06/10/2026The bacterial iron sensor IdeR distinguishes DNA sequences by applying stress to non-cognate DNA www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 06/10/2026A circRNA-derived IRES-like element enables programmable translational activation of the endogenous chaperone HSP90 www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 06/10/2026Tropomodulin and Leiomodin Differentially Nucleate Tropomyosin Assembly on Actin Filaments www.biorxiv.org/content/10.64898/20… 022
bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 06/10/2026Evolution and remodeling of acceptor specificity in the NodZ α-1,6-fucosyltransferase www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 06/10/2026Structural basis of eIF4E recognition of synthetic mRNA 5' cap analogues links cap architecture to affinity and biological activity www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 06/10/2026β-Hairpin Fold Peptide Brush Polymers www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 06/10/2026Tertiary structure of a Nif11-like leader peptide mediates protein-protein interactions with a RiPP biosynthetic enzyme www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 06/10/2026Ambient-Condition Visualization of Metalloenzyme Reactive Intermediates Enabled by the SHINERS Paradigm www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 06/10/2026HNRNPM promotes protein synthesis via an interaction with stem-loop 5 in the SARS-CoV-2 5'-UTR www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 06/10/2026Long-form hibernation-promoting factor coordinates 100S assembly and translational repression www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 06/10/2026C-terminal domain of SARS CoV 2 nucleocapsid protein binds transcriptional regulatory sequence RNA with high affinity and forms higher-order assemblies www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 05/10/2026Mycothiazole enables structural characterization of entire ubiquinone-accessing tunnel in mitochondrial respiratory complex I www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 05/10/2026Coumarin-based blue excitable probe for functional screening of dehalogenase activity www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 05/10/2026Covalent Solvatochromic Membrane Probe for Sensing Lipid Surrounding of Proteins www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 05/10/2026Heterotypic Condensate Formation by Prion Proteins and Pro-Inflammatory S100A9 www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 05/10/2026High-yield expression and purification of the non-phosphorylated form of Human CaMKIIα Kinase www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 02/10/2026KPB82 potently and selectively inhibits ACER2 and protects tumor and primary cells from doxorubicin-induced cytotoxicity www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 02/10/2026Molecular Determinants of G Protein Subtype-Specific Coupling to the Angiotensin II Type 1 Receptor www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 02/10/2026A bacteriophage split DNA polymerase incorporates a sliding clamp-derived processivity subunit www.biorxiv.org/content/10.64898/20… 020
bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 02/10/2026Global Regulatory Functions of the Human CCR4-NOT Complex in mRNA Deadenylation and Decay www.biorxiv.org/content/10.64898/20… 011
bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 02/10/2026Taccalonolide AJ uncouples tubulin GTP hydrolysis from microtubule depolymerization www.biorxiv.org/content/10.64898/20… 011
bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 02/10/2026Proteomics of highly post-translationally modified proteins in kidney tubulointerstitium www.biorxiv.org/content/10.64898/20… 010
bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 02/10/2026Synthetic inhibitors of pregnancy-associated plasma protein-A regulate IGF-1 signaling in vitro and in vivo www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 02/10/2026Mechanism of spike opening in a mammalian gammacoronavirus www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 01/10/2026Beyond RMSD: Deterministic Dlow Matching for Ultrafast and Physically Validated Transition-State Generation www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 01/10/2026The bacterial antiphage protein Tiamat is an ATPase and DNase whose homologs are found across the tree of life www.biorxiv.org/content/10.64898/20… 020
bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 01/10/2026Sequence-specific and programmable catalytic degradation of extracellular microRNAs by membrane-anchored DNA nanomachines www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 01/10/2026Cryo-tides: synthetic peptides for cryo-EM grid preparation of multi-subunit protein complexes sensitive to the air-water interface www.biorxiv.org/content/10.64898/20… 043
bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 30/09/2026Release of the Staphylococcus aureus autoinducing peptide is enabled by active export of the biosynthetic intermediate www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 30/09/2026Native Mass Spectrometry Reveals Distinct Effects of Linker Length and Targeting-Ligand Identity on PROTAC Ternary Complexes www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 30/09/2026Ligand binding remodels the oligomeric state and active site of Klebsiella pneumoniae azoreductase www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 30/09/2026Protoribosomal condensate formation across cationic chemistries www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 30/09/2026A scalable recombinant pipeline for disulphide-stapled peptides www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 30/09/2026Beyond Structure: Protein and Solution Dynamics Shape Ligand-BindingThermodynamics www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 30/09/2026Programmable sequence-resolved in situ profiling of glycoRNA-protein interactomes by GlycoRNA-Map www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 29/09/2026GraPPI: A Self-Supervised Graph Encoder for Transferable Protein--Protein Interaction Modeling www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 29/09/2026MgATP/MgADP-dependent conformational dynamics and intrinsically disordered regions of vascular KATP channels revealed by cryoEM www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 29/09/2026Cytokine-induced nuclear translocation of STAT1 via a non-transferable NLS www.biorxiv.org/content/10.64898/20… 001
bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 29/09/2026Probing the sequence variability tolerance in a de novo α-helical barrel biocatalyst www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 28/09/2026β-arrestin1 directly engages Gαs to sustain endosomal GPCR signaling www.biorxiv.org/content/10.64898/20… 000
