A project led by Columbia University scientists has revealed a key weakness in some of the most aggressive and treatment-resistant cancers, including gliomas and pediatric sarcomas.

A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields

The DNA damage response (DDR) is a complex network of cellular pathways that ensures the faithful maintenance of our genomes upon a wide array of genomic insults. To elucidate the functional architect...

Apurinic/apyrimidinic (AP) sites, also known as abasic sites, are among the most frequent DNA lesions, arising spontaneously or as intermediates in base excision repair. Their structural impediment to...

A quiet policy change means the government is making fewer bets on long-term science.

High-fidelity DNA replication is constantly challenged by a diverse range of obstacles, including endogenous lesions and secondary structures in the DNA template, tightly bound protein-DNA complexes, ...

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Join us at the Keystone Symposia on DNA Replication Gaps, Cancer and Disease, April 2025, in Daejeon, with field leaders!

A foundation model learns transcriptional regulatory syntax from chromatin accessibility and sequence data across a range of cell types to predict gene expression and transcription factor interactions...

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