We are seeking to appoint an Associate Professor working in the area of the cellular and/or molecular biology of cancer, to be based in Oxford University’s Sir William Dunn School of Pathology. The ro...

Are you an early career researcher interested in the cell or molecular mechanisms underlying disease? Do you have an outstanding record and an innovative research plan?

Are you an early career researcher interested in the cell or molecular mechanisms underlying disease? Do you have an outstanding record and an innovative research plan?

Both researchers are leaders in the rapidly growing field of the human gut microbiome.

Many congratulations to Anjali Hinch and Girish Mali in the Sir William Dunn School of Pathology for this prestigious honour, recognising researchers in the early years of establishing their groups.

Applications are now open to apply for our four year, fully-funded PhD programme in Molecular Cell Biology in Health and Disease.

Many long noncoding RNA–DNA binding peaks detected using common assays arise from technical artifacts.

Schützenhofer et al. show that expression of catalytically impaired PARP1 mutants is toxic to cells, which can be overcome by treatment with saruparib, a PARP1-specific inhibitor that displays a pro-r...

The orphan PARP, PARP4, is shown to play a critical role in the apoptotic response to unresolved DNA interstrand cross-links.

Chloroplasts import thousands of nucleus-encoded proteins via multiprotein translocons. The authors elucidate the assembly and molecular architecture of the outer-membrane TOC translocon (the import “...

Recent studies have shown that ADP-ribose modifications can be further modified by ubiquitin (ADPr-Ub), but there are still major gaps in our knowledge around this modification and its role in the DNA damage response. This study biochemically characterises the amino acid specificity for ADPr-Ub production and its recognition by E3 ubiquitin ligases.

Sorbitol-induced hyperosmotic stress rapidly induces reversible mono(ADP-ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 depend...

Abstract. ADP-ribosylation is a conserved modification that uses NAD+ as a co-substrate to regulate essential cellular processes, such as genome stability

A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields

Abstract. SIRT6, a highly conserved member of the sirtuin family, plays a critical role in diverse cellular processes, including gene regulation, DNA damag

ADP-ribosylation is a versatile post-translational modification that governs fundamental processes, including DNA repair, transcription, and stress ad…

Adenosine diphosphate ribosylated histidine (His-ADPr) is a vital signaling molecule for the bacterial immune system, the antiphage system in particular. In this unique second messenger molecule, the distal nitrogen of the histidine side chain is ribosylated in a β fashion. Here, we describe the synthesis of this bacterial metabolite and its triazole isostere and evaluate the stability of His-ADPr to relevant ribosyl hydrolases.

ADP-ribosylation (ADPr) is a reversible modification of macromolecules critical for the regulation of genome stability, stress responses, and proteost…

imageimageDegradation mechanisms of transcriptionally active aryl hydrocarbon receptor (AHR) are unclear. This work reveals that PARP7 ADP-ribosylates itself and ligand-bound AHR, creating a recogniti...

Nature Structural & Molecular Biology - Baretić and Missoury et al. identify vertebrate proteins FAM118B and FAM118A as sirtuins similar to bacterial antiphage enzymes and show that...

Baretić and Missoury et al. identify vertebrate proteins FAM118B and FAM118A as sirtuins similar to bacterial antiphage enzymes and show that FAM118A/B processing of NAD involves head-to-tail filament...

Abstract. Although poly-(ADP ribose) polymerase 1 (PARP1) and PARylation of histones have been known for over 50 years and have been successfully targeted

Published in EMBO Reports, a new study by the Thurston Group reveals how a small virulence protein from Salmonella called SteE, uses molecular mimicry to reprogramme host kinase specificity.

We highlight primary research and commissioned content that delve into the biology of ubiquitylation and degradation mechanisms.

Append editing of ADP-ribosyl to thymine is used for precise modifications in bacteria and eukaryotes.

Applications are now open to apply for our four year, fully-funded PhD programme in Molecular Cell Biology in Health and Disease.

Nature Structural & Molecular Biology - Post-translational modifications show mechanistic crosstalk, exemplified by the ADP-ribose–ubiquitin hybrid signal, in which one post-translational...

Salary for this Role: From £45,500 with benefits, subject to skills and experience. Job Title: Postdoctoral Fellow - Costa Lab Reports to: Alessandro Costa Closing Date: 03/Aug/2025 23.59 GMT Job Desc...

Help Colin Kleanthous raise money to support Motor Neurone Disease Association

Abstract. Bacteria encode a panoply of defence systems to overcome phage infection. In recent years, over 100 defence systems have been identified, with th

Deltex E3s modify ADP-ribosylated targets with ubiquitin, creating a hybrid modification whose readers remains unknown. Here, the authors synthesise a non-hydrolysable probe that mimics the modificati...

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...