bioRxiv SysBio @biorxiv-sysbio.bsky.social · 22hA kinetic-aware approach to infer metabolic variations and flux using transcriptomics and metabolomics data www.biorxiv.org/content/10.64898/20… 000
bioRxiv SysBio @biorxiv-sysbio.bsky.social · 02/10/2026Multi-omics profiling identifies a metabolic and energetic signature associated with neuronal dENL/AF9 suppression in aged flies www.biorxiv.org/content/10.64898/20… 000
bioRxiv SysBio @biorxiv-sysbio.bsky.social · 02/10/2026A global signature of microbiome resilience to climate stress www.biorxiv.org/content/10.64898/20… 000
bioRxiv SysBio @biorxiv-sysbio.bsky.social · 02/10/2026Integrating CSF and EV Proteomes Enhances Biomarker Discovery by Capturing Shared Variation Across Compartments www.biorxiv.org/content/10.64898/20… 000
bioRxiv SysBio @biorxiv-sysbio.bsky.social · 02/10/2026Population reweighting and reporter distortion obscure ribosome regulation during translation inhibition www.biorxiv.org/content/10.64898/20… 000
bioRxiv SysBio @biorxiv-sysbio.bsky.social · 01/10/2026Dynamical stability and accuracy of moment closure approximations for bursty gene expression with nonlinear degradation www.biorxiv.org/content/10.64898/20… 000
bioRxiv SysBio @biorxiv-sysbio.bsky.social · 01/10/2026From seven combination hypotheses to one testable interaction: a gated agentic AI QSP workflow applied to healthy ageing interventions www.biorxiv.org/content/10.64898/20… 010
bioRxiv SysBio @biorxiv-sysbio.bsky.social · 30/09/2026The Metabolic Organ Clock: A Computable Framework Linking Cell-Lineage Architecture to Emergent Organ Bioenergetics www.biorxiv.org/content/10.64898/20… 000
bioRxiv SysBio @biorxiv-sysbio.bsky.social · 30/09/2026Stress-recovery dynamics reveal a separatrix in transcriptomic landscapes across organs and aging www.biorxiv.org/content/10.64898/20… 000
bioRxiv SysBio @biorxiv-sysbio.bsky.social · 30/09/2026A mechanistic, mortality-referenced biological age from routine blood tests: construction and temporal validation of IQN-BIOAGE-01 www.biorxiv.org/content/10.64898/20… 000
bioRxiv SysBio @biorxiv-sysbio.bsky.social · 30/09/2026Cyclic uremia without kidney injury drives cardiovascular disease with rapid onset of immunosenescence and heart failure www.biorxiv.org/content/10.64898/20… 000
bioRxiv SysBio @biorxiv-sysbio.bsky.social · 30/09/2026Reducing growth-medium complexity reveals nutrient-responsive programs in a near-minimal bacterium www.biorxiv.org/content/10.64898/20… 000
bioRxiv SysBio @biorxiv-sysbio.bsky.social · 30/09/2026A Reduced Mechanistic Model for Aquatic Decomposition of a Human Body www.biorxiv.org/content/10.64898/20… 000
bioRxiv SysBio @biorxiv-sysbio.bsky.social · 30/09/2026Mapping a genome-scale in vivo knockout screen to a mechanistic network model identifies VAV2, RASA1, and LEPR as regulators of cardiomyocyte hypertrophy www.biorxiv.org/content/10.64898/20… 000
bioRxiv SysBio @biorxiv-sysbio.bsky.social · 29/09/2026Proteomic comparison of Marburg and Kasokero virus infection in natural host Egyptian rousette bat reveals distinct antiviral pathways www.biorxiv.org/content/10.64898/20… 000
bioRxiv SysBio @biorxiv-sysbio.bsky.social · 29/09/2026SpaReg: sparsity-based 3D reconstruction of tissue microenvironments at native resolution across morphological and spatial molecular modalities www.biorxiv.org/content/10.64898/20… 000
bioRxiv SysBio @biorxiv-sysbio.bsky.social · 29/09/2026TxCyto: A machine learning framework for estimating cytokine activity from whole transcriptome www.biorxiv.org/content/10.64898/20… 001
bioRxiv SysBio @biorxiv-sysbio.bsky.social · 29/09/2026Integrative proteomic analysis and molecular dynamics simulations of ANKLE2 reveal mechanisms of microcephaly www.biorxiv.org/content/10.64898/20… 000
bioRxiv SysBio @biorxiv-sysbio.bsky.social · 29/09/2026Interpretable machine learning coupled to gene regulatory networks uncovers subcircuits underlying cell fate decisions www.biorxiv.org/content/10.64898/20… 000
bioRxiv SysBio @biorxiv-sysbio.bsky.social · 29/09/2026Comprehensive in silico analysis reveals candidate regulatory mechanisms underlying selective cerebellar vulnerability in pontocerebellar hypoplasia www.biorxiv.org/content/10.64898/20… 000
bioRxiv SysBio @biorxiv-sysbio.bsky.social · 28/09/2026Quantifying Chemical Fluxes Underlying Gut Microbiota-Host Interactions www.biorxiv.org/content/10.64898/20… 000
bioRxiv SysBio @biorxiv-sysbio.bsky.social · 28/09/2026GEMOT: Towards Mechanistic World Models for Biology www.biorxiv.org/content/10.64898/20… 000
bioRxiv SysBio @biorxiv-sysbio.bsky.social · 28/09/2026Quantitative machine learning of protein interactions reveals the multiscale organization and molecular syntax of signaling networks www.biorxiv.org/content/10.64898/20… 000
bioRxiv SysBio @biorxiv-sysbio.bsky.social · 28/09/2026A thermoregulatory design principle for transitions into hypometabolism www.biorxiv.org/content/10.64898/20… 000
bioRxiv SysBio @biorxiv-sysbio.bsky.social · 28/09/2026Accessing Enzyme Kinetic Data and Prediction Methods at Scale www.biorxiv.org/content/10.64898/20… 000
bioRxiv SysBio @biorxiv-sysbio.bsky.social · 28/09/2026Limit-pushing overexpression reveals constraints on protein abundance www.biorxiv.org/content/10.64898/20… 000
bioRxiv SysBio @biorxiv-sysbio.bsky.social · 25/09/2026Concentration limits and localization of hydrogen peroxide in the extracellular space of solid tissues www.biorxiv.org/content/10.64898/20… 000
bioRxiv SysBio @biorxiv-sysbio.bsky.social · 25/09/2026PyKappa: Rule-based modeling in Python www.biorxiv.org/content/10.64898/20… 000
bioRxiv SysBio @biorxiv-sysbio.bsky.social · 24/09/2026Chaperone isoform and interactome mapping reveals functional diversification of DNAJA2-DNAJA4 complexes via stress-regulated isoforms www.biorxiv.org/content/10.64898/20… 000
bioRxiv SysBio @biorxiv-sysbio.bsky.social · 24/09/2026Age-Related Remodeling of Cross-Tissue Transcriptional Coordination in the Human Motor System www.biorxiv.org/content/10.64898/20… 000
bioRxiv SysBio @biorxiv-sysbio.bsky.social · 24/09/2026LSD-pipeline: Causal Inference of miRNA Network Effects in Alzheimer's Disease www.biorxiv.org/content/10.64898/20… 000
bioRxiv SysBio @biorxiv-sysbio.bsky.social · 23/09/2026Mouse lymph node colonization models predict human tumor metastasis in melanoma www.biorxiv.org/content/10.64898/20… 000
bioRxiv SysBio @biorxiv-sysbio.bsky.social · 23/09/2026Transcription factors read a second regulatory code in chromatin www.biorxiv.org/content/10.64898/20… 000
bioRxiv SysBio @biorxiv-sysbio.bsky.social · 23/09/2026An AI-ready compositional framework for mechanistic aging research and in silico intervention testing www.biorxiv.org/content/10.64898/20… 010
bioRxiv SysBio @biorxiv-sysbio.bsky.social · 23/09/2026Estimation of the transmission dynamics of H5N1 HPAI outbreak in a dairy herd using a modeling approach www.biorxiv.org/content/10.64898/20… 000
bioRxiv SysBio @biorxiv-sysbio.bsky.social · 23/09/2026Speciesformer learns conserved cellular states for cross-species generative virtual cell modeling www.biorxiv.org/content/10.64898/20… 000
bioRxiv SysBio @biorxiv-sysbio.bsky.social · 23/09/2026Combinatorial CRISPR/Cas12a excises targeted loci in the mammalian genome at very low efficiency www.biorxiv.org/content/10.64898/20… 011
bioRxiv SysBio @biorxiv-sysbio.bsky.social · 22/09/2026A Temporal Interactome Atlas across RNA Viruses reveals Convergent Vulnerabilities for Antiviral Repurposing www.biorxiv.org/content/10.64898/20… 000
bioRxiv SysBio @biorxiv-sysbio.bsky.social · 22/09/2026Single residues within the YTHDF intrinsically disordered region control m6A-dependent mRNA decay www.biorxiv.org/content/10.64898/20… 022
bioRxiv SysBio @biorxiv-sysbio.bsky.social · 22/09/2026The Urogenital Lactobacillus Axis Across Menopause: Connections Between the Vagina, Bladder, and Urinary Metabolome www.biorxiv.org/content/10.64898/20… 010
bioRxiv SysBio @biorxiv-sysbio.bsky.social · 22/09/2026mc-ASTRA maps population-level variation to interpretable multicellular tissue organization processes www.biorxiv.org/content/10.64898/20… 000
bioRxiv SysBio @biorxiv-sysbio.bsky.social · 22/09/2026Deciphering the dynamical origin of the Adipogenic commitment during stress-induced disruption of the circadian rhythm www.biorxiv.org/content/10.64898/20… 000
bioRxiv SysBio @biorxiv-sysbio.bsky.social · 22/09/2026Inherited flagellar structures coordinate the onset of swimming among related E. coli cells www.biorxiv.org/content/10.64898/20… 000
bioRxiv SysBio @biorxiv-sysbio.bsky.social · 22/09/2026SPECTRA: predicting cellular perturbation responses with Graph Learning over Gene Regulatory Networks www.biorxiv.org/content/10.64898/20… 000
bioRxiv SysBio @biorxiv-sysbio.bsky.social · 21/09/2026OpenCRS: an open-source regulated human cardiorespiratory model with large-scale calibration and global sensitivity analysis at rest and during exercise www.biorxiv.org/content/10.64898/20… 000
bioRxiv SysBio @biorxiv-sysbio.bsky.social · 18/09/2026Newly identified COPD GWAS protein interactors reveal a potential disease network module www.biorxiv.org/content/10.64898/20… 000
bioRxiv SysBio @biorxiv-sysbio.bsky.social · 18/09/2026Age-related dynamics of DNA co-methylation modules in humans www.biorxiv.org/content/10.64898/20… 000
bioRxiv SysBio @biorxiv-sysbio.bsky.social · 18/09/2026Interpretable spherical geometry of single-cell state transitions from dominant principal components www.biorxiv.org/content/10.64898/20… 000
bioRxiv SysBio @biorxiv-sysbio.bsky.social · 18/09/2026Beyond Steady-State Adaptation: Evaluating the Dynamic Performance of Biological Feedback Control www.biorxiv.org/content/10.64898/20… 001
bioRxiv SysBio @biorxiv-sysbio.bsky.social · 18/09/2026Cell cycle exit is required for differentiation and cell fate diversification but not neoblast specialisation in planarians www.biorxiv.org/content/10.64898/20… 000
