Sign in

Ross Chapman

@rosschapmanlab.bsky.social
879 followers 275 following 22 posts

DNA damage & repair biologist | Cancer Research UK Senior Fellow | PI at the MRC Weatherall Institute in Oxford | Science, papers, lab news & some personal views & opinions

PostsRepliesMedia
Ross Chapman @rosschapmanlab.bsky.social · 5h
Check out our latest, just out in @MolecularCell! We reveal how common, typically harmless forms of DNA damage synergise with DNA replication defects in ATM-deficient cells to drive tumour-specific responses to PARP inhibitors - We propose that a similar synergy may contribute to A-T pathogenesis.
072
Reposted by Ross Chapman
The Lister Institute of Preventive Medicine @thelisterinstitute.bsky.social · 28/09/2026
How could the same cellular vulnerability help us understand a rare inherited disorder and reveal a weakness in some cancer cells? New Molecular Cell @cellpress.bsky.social paper from Lister Fellow Ross Chapman @rosschapmanlab.bsky.social et al provides an important mechanistic link. 1/6
132
Reposted by Ross Chapman
MRC Weatherall Institute of Molecular Medicine @imm.ox.ac.uk · 9h
🧬New research from the Chapman Group provides insight into why why ATM-deficient cancer cells are particularly vulnerable to PARP inhibitors. The findings may help us better understand how some cancers respond to these drugs.🧪 @rdm.ox.ac.uk @medsci.ox.ac.uk #AcademicSky @rosschapmanlab.bsky.social
imm.ox.ac.uk
034
Ross Chapman @rosschapmanlab.bsky.social · 17/07/2026
Missed it? Our March preprint shows how endogenous oxidative base damage drives the PARPi response in ATM-deficient cells. In working this out we uncovered a role for ATM in safeguarding replication through damaged DNA and discuss what this could mean for Ataxia-Telangiectasia.
2147
Reposted by Ross Chapman
MRC Weatherall Institute of Molecular Medicine @imm.ox.ac.uk · 16/07/2026
#WIMMReads🧪 From the Chapman Group: a new preprint offers a potential explanation for why ATM deficient cancers respond to PARP inhibitors, with implications for cancer treatment and Ataxia Telangiectasia. #CancerResearch #AcademicSky @rdm.ox.ac.uk @medsci.ox.ac.uk @rosschapmanlab.bsky.social 🧬
doi.org
ATM safeguards DNA replication at endogenous base lesions
Poly(ADP-ribose) polymerase inhibitors (PARPi) exploit homologous recombination deficiency (HRD) in BRCA1/2-mutated cancers to induce synthetic lethality[1][1]–[3][2]. PARPi also kill cancer cells lac...
042
Ross Chapman @rosschapmanlab.bsky.social · 25/05/2026
Still contemplating joining us at EMBO-DDR 2026 this October? We have a stellar lineup with slots for short talks (selected from abstracts) still up for grabs. EMBO have extended the registration/abstract deadline until 29 May to accommodate new registration requests! See you (in) Sounio 😎🧬🇬🇷!
0103
Ross Chapman @rosschapmanlab.bsky.social · 18/05/2026
Still contemplating joining us at EMBO-DDR 2026 this October? Many slots for short talks (selected from abstracts) are still up for grabs and EMBO have extended the registration/abstract deadline until 20 May 23:59:59 CET to accommodate some late registration requests- Hope to see many of you there!
141
Reposted by Ross Chapman
Daniel Durocher @durocher1.bsky.social · 01/04/2026
Great conference, great science and great location!
063
Ross Chapman @rosschapmanlab.bsky.social · 31/03/2026
Excited to announce: the EMBO Workshop: DNA damage response in cell physiology & diseases - 12–16 Oct 2026 - in stunning Sounio, Greece - fabulous speaker speaker lineup representing the cutting-edge of genome stability research: Abstract deadline: 17 May meetings.embo.org/event/26-dna... Join us!
0228
Reposted by Ross Chapman
Trevor Graham @trevorgraham.bsky.social · 16/01/2026
Are you fascinated by cancer biology and also ❤️ 💻 ? Feel like this ->😻<- at the thought of exploring oodles of cancer genomes, single cells and spatial multiomics data? Then our core Data Science Team at @icr.ac.uk might be the place for you. Vacancy here: jobs.icr.ac.uk/vacancies/14...
jobs.icr.ac.uk
Data Scientist in Sutton | The Institute of Cancer Research
View details and apply for this Data Scientist vacancy in Sutton. Salary : Salary range £39,805 - £53,500 (Salary appointment dependent on experience ) Reporting to: P...
0108
Reposted by Ross Chapman
Rob Klose @robklose.bsky.social · 11/12/2025
An early Christmas present for those interested in chromatin and transcription! Fantastic work from @au-ho-yu.bsky.social and @aleksszczurek.bsky.social . Thanks to Inge and Michiel for their help. Please repost! www.biorxiv.org/content/10.6...
biorxiv.org
SET1/MLL complexes control transcription independently of H3K4me3
Histone H3 lysine 4 trimethylation (H3K4me3) at gene promoters is thought to play a central role in gene transcription. H3K4 methylation is deposited by the SET1 (A/B) and MLL (1-4) multi-protein comp...
1013465
Reposted by Ross Chapman
Pia Reichl @pia-rei.bsky.social · 02/12/2025
My PhD work is out as a preprint! Have a read 😊👇🏻
0121
Ross Chapman @rosschapmanlab.bsky.social · 01/12/2025
New lab preprint! ERCC6L2 disease is a recessive bone marrow failure syndrome caused by mutations in the putative DNA helicase ERCC6L2. Using mouse genetics, biochemistry and AF3 we uncover ERCC6L2-MRI as a KU-regulatory complex stimulating NHEJ at staggered DSBs: www.biorxiv.org/content/10.1...
biorxiv.org
The ERCC6L2-MRI-KU complex coordinates NHEJ at staggered DNA double-strand breaks
ERCC6L2 disease is a recessive bone marrow failure (BMF) syndrome caused by mutations in the SNF2-like putative DNA helicase ERCC6L2. While implicated in DNA replication, double strand break (DSB) rep...
2388
Ross Chapman @rosschapmanlab.bsky.social · 06/11/2025
When the work of your colleagues really blows your mind 🤯🔥. Congratulations @jojdavies.bsky.social, team and collaborators! 🥂
031
Ross Chapman @rosschapmanlab.bsky.social · 21/06/2025
Thanks Shan Zha for hosting my Social DNA’ing on Thursday. Was a honour to celebrate the 5th anniversary of this epic series. If you didn’t catch it, pls check out the recorded webinar to find out what we’ve been up to with research support from @cruk-ci.bsky.social! fast.wistia.com/embed/channe...
fast.wistia.com
Actual Social DNAing Webinar
Social DNAing Weekly Webinar Serial hosted by Columbia University College for Physicians and Surgerons. The channel host the webinar from preivious week with permission from the speaker.
0120
Ross Chapman @rosschapmanlab.bsky.social · 19/06/2025
Congrats Kelly! 🥂
050
Reposted by Ross Chapman
Zha Lab @zhalab.bsky.social · 17/05/2025
Excited to share our new paper on Nature - how Ku accommodates Alu expansion in primates by binding to dsRNA, providing a clue for both the high levels of Ku and its essentiality in human cells. Thank @chaolinzhang @hchung03 @LenaSteckelberg More to come www.nature.com/articles/s41...
nature.com
Ku limits RNA-induced innate immunity to allow Alu-expansion in primates - Nature
Nature - Ku limits RNA-induced innate immunity to allow Alu-expansion in primates
14925
Reposted by Ross Chapman
Dan Jagger @auditorynerves.bsky.social · 14/05/2025
A new treatment significantly improves survival rates for women with aggressive, inherited breast cancer involving BRCA1 or BRCA2 gene mutations. Giving them the targeted drug olaparib before surgery greatly reduced the chances of the cancer coming back. 🧪🧬💊 #medsky www.bbc.com/news/article...
bbc.com
Breast cancer gene families given hope by drug trial
Treating patients with a drug before surgery greatly reduced the chances of the cancer coming back, a small trial found.
46722
Reposted by Ross Chapman
MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 03/04/2025
Don’t miss the 2025 César Milstein Lecture, by David Pellman from the Dana-Farber Cancer Institute and Harvard University. Join us at 10am (BST) on Thu 24th April to learn about “Mechanisms driving the rapid evolution of genomes” More details: www2.mrc-lmb.cam.ac.uk/news-and-eve... #LMBSeminar
César Milstein Lecture
David Pellman
Dana-Farber Cancer Institute, Harvard University

Mechanisms driving the rapid evolution of genomes

Thursday 24 April at 10 am
Max Perutz Lecture Theatre and Zoom
Details on the LMB website

Sponsored by AstraZeneca
042
Reposted by Ross Chapman
stapleslab.bsky.social @stapleslab.bsky.social · 12/03/2025
Please repost! Post-doc studying novel mechanisms of post-replicative gap-filling available in my lab here in beautiful Snowdonia, between July 2025 to end Nov 2026. Generous travel budget. Lab is full of friendly and supportive colleagues. Link below, or DM me/email c.staples@bangor.ac.uk for info
1715
Reposted by Ross Chapman
Björn Schumacher @bjornschumacher.bsky.social · 02/03/2025
Register and submit your abstract now: The ageing genome: from mechanisms to disease www.embl.org/about/info/c...
embl.org
The ageing genome: from mechanisms to disease
01312
Reposted by Ross Chapman
Sarah Moser @sarahmoser.bsky.social · 03/03/2025
BRCA1 turned 30 🎉 To celebrate, Jos Jonkers and I explored three decades of BRCA1 research - what we’ve learned about its biology, its role in tumorigenesis and future directions to improve the life of BRCA1 mutation carriers. Now out in Cancer Discovery ⬇️: aacrjournals.org/cancerdiscov...
aacrjournals.org
Thirty Years of BRCA1: Mechanistic Insights and Their Impact on Mutation Carriers
Abstract. Thirty years ago, the cloning of the first breast cancer susceptibility gene, BRCA1, marked a milestone in our understanding of hereditary breast and ovarian cancers. This discovery initiate...
16226
Reposted by Ross Chapman
Chris Lord and Andrew Tutt’s Lab Institute of Cancer Research @icrlordlab.bsky.social · 03/03/2025
We show transcriptomic buffering of tumour suppressor loss via syn. lethal genes is not anecdotal but a cancer hallmark. Buffering also seen in BRCAness, predicts penetrant syn leth effects and outcome. @icr.ac.uk @cancerresearchuk.org @breastcancernow.bsky.social www.nature.com/articles/s41...
nature.com
The transcriptomic architecture of common cancers reflects synthetic lethal interactions - Nature Genetics
Tumor cells upregulate compensatory buffering genes following tumor suppressor loss. These genes may represent new synthetic lethal partners that could be harnessed therapeutically.
0159
Reposted by Ross Chapman
Jens Schmidt @jenscs83.bsky.social · 02/01/2025
Really cool work, demonstrating TRF2-RAP1 mediated inhibition of the NHEJ machinery at chromosome ends! www.biorxiv.org/content/10.1...
biorxiv.org
Chromosome end protection by RAP1-mediated inhibition of DNA-PK
During classical non-homologous end joining (cNHEJ), DNA-dependent protein kinase (DNA-PK) encapsulates free DNA ends, forming a recruitment platform for downstream end-joining factors including Ligas...
0143
Ross Chapman @rosschapmanlab.bsky.social · 19/12/2024
Few better ways to end the year with the team than over a few pints (& mini Guinness’s) in the @StarPubOxford
0213
Ross Chapman @rosschapmanlab.bsky.social · 12/12/2024
In our first skeet, check out a very cool postdoc opportunity, in the very cool @susanagodinho.bsky.social lab 👇
262