Gene-editing techniques could soon allow researchers to replace entire genes and engineer complex cellular circuits — if the systems can be delivered safely into cells.

Cryogenic electron microscopy (cryo-EM) has enabled rapid progress in structural biology throughout the last decade. However, cryo-EM sample preparation still represents a major bottleneck in high-res...

Nature Structural & Molecular Biology, Published online: 30 September 2026; doi:10.1038/s41594-026-01877-6Koenig et al. present a phosphoproteome atlas of 33 human cell lines covering >200,000 phosphosites, advancing cellular kinase activity scoring and drug sensitivity prediction, providing a resource for cell signaling insights and precision oncology.

Ageing reflects progressive decanalization of mammalian cell identity, driven by erosion of a regulatory grammar written during development.

Structural studies support the idea that fibrillized tau protein, a feature of neurodegenerative disorders, acts as a prion-like template to induce misfolding in healthy tau.

ACS Central Science invites authors to share compelling stories that trace research from fundamental insight into real world application.

Scientists are poking holes in established ideas about how cells live and die, and are harnessing these discoveries to fight diseases from cancer to autoimmune conditions.

Increased RNA polymerase III (Pol III) activity and tRNA abundance are widely linked to cancer cell growth, yet the functional requirement for individual Pol III genes and core components remains uncl...

Following on from its success in eradicating malignant B cells in cancer, chimeric antigen receptor (CAR) T cell therapy has been extended to treat autoimmune diseases. This Review discusses the precl...

The CD1 system responds to lipids, not proteins, driving reactions to bee stings, bacteria, and possibly poison ivy

A mechanistic basis for how the hormone salicylic acid promotes transcriptional activation during plant immune responses is described.

How tumors generate a cryptic “dark” proteome absent from healthy tissues, and whether it can be reversibly activated, remains unclear. In Ewing sarcoma, all tumors are driven by EWSR1::ETS fusions, m...

Chinese researchers are testing DREADDs, a gene therapy to turn down neuronal activity, in the clinic

Prime assembly enables RNA-guided integration of medium-to-large DNA sequences in human cells without requiring double-strand breaks or cell cycle progression, and supports exon recoding, transgene insertion and megabase-scale rearrangements.

Coenzyme A (CoA) is an essential metabolic cofactor whose biosynthesis is controlled by pantothenate kinases (PANKs), the rate-limiting enzymes in CoA synthesis. Although CoA production is extensively...

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Single-molecule genomics methods are used to study the activity of regulatory factors on individual DNA molecules genome-wide, thereby enabling quantification of molecular heterogeneity and co-occurre...

CRISPR-Cas provides RNA-mediated adaptive immunity, but how its first RNA-guided effector arose is unclear. In this study, we report the discovery of Viral Interference Programmable Repeat (VIPR) syst...

Researchers detect more than 1,000 overlooked microproteins in human brain tissue, including some that are altered in Alzheimer’s disease.

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An AI system trained on more than 20,000 protein structures from pharmaceutical companies outperforms AlphaFold-like models that use only public data.

SUMOylation is an essential eukaryotic ubiquitin-like post-translational modification that plays a central role in the regulation of various nuclear processes and stress responses. It canonically occu...