STING is a well-known activator of type I interferon (IFN-I) responses. However, it is debated whether STING has an ancestral function independent of interferon responses. Here, by combining evolution...

Speakers Ana Peirò Head of Oncology Medical Affairs, AstraZeneca Biography Antonio Gentinella Group Leader, IDIBELL Assistant Professor, University of Barcelona Biography Website Arkaitz Carracedo Gro...

Glucose metabolism Early-life sugar restriction causally reduces adult cancer incidence and slows biological aging Chen Zhu and Weilong Zhang. PCK2 Inhibition Reverses Cisplatin Resistance of Non‐S…

Caspase inhibitors have repeatedly entered clinical trials but have not reached clinical practice due to toxicity and limited efficacy. Groborz and colleagues now show that gasdermin D pores admit otherwise membrane-impermeable inhibitors into pyroptotic cells, turning poor permeability into a mechanism of cell-state selectivity.

Caspases and FLIP Proteolytic activation of executioner caspase-3 and -7 regulates different physiological processes in mice Noëlle Sieg, Johanna Stachelscheid, Besarta Thaqi, Tanja Schwab, Fabian …

Glucose metabolism Mannose supports lung cancer metabolism during glycolytic limitation Theresa Haitzmann, Niklas B Thompson, Hardik Shah, Katharina Schindlmaier, Joseph Jelwan, Thomas O Eichmann, …

Oncogenesis - Metabolic vulnerabilities in pleural mesothelioma

Oncogenesis - Compartmentalisation of death receptor signalling in cancer

Federal agencies that terminated more than a thousand research grants at the University of California last year admitted that they used keywords related to diversity, gender, vaccine hesitancy and COV...

Diet, systemic metabolism, cachexia A dietary switch promotes sensory neuron–dependent cancer-associated cachexia Michael Cross, Stefan Kotschi, Warren Wu, Fedra Luciano-Mateo, Young-Yon Kwon, Ezeq…

Efferocytosis, extrusion Epithelial cell extrusion underlies starvation-induced cell loss in a sea anemone Inés Fournon-Berodia, Noah Bruderer, Lionel Christiaen and Patrick R. H. Steinmetz. Effero…

Valdivieso, Rozmaric et al. show that wounding rapidly induces a senescent state in skin cells involving p21 protein induction, without the need for new transcription. These senescent cells are benefi...

Harmful algal blooms, the most severe ecological hazards worldwide, terminate abruptly within a few days. In this work, we identified that iron-catalyzed active lipid peroxides predominantly trigger i...

GRP78/BiP/HSPA5 is a widely expressed endoplasmic reticulum (ER) chaperone that also performs the critical role of regulating the unfolded protein response

Mitochondria Mitochondrial lactate venting limits oxidative stress Daniela Rauseo, Yasna Contreras-Baeza, Mildreth Salazar, Abigail J. Galarza, Sebastián Holtheuer-Gallardo, Hugo Faurand, Natali Cá…

Bcl-2 family proteins Pseudo-senescence induced by palbociclib does not sensitise pleural mesothelioma cells to combinations with senolytics Iswarya Sreeram, Sílvia Plans-Marin, Mabel Cruz-Rodrígue…

STING is an evolutionarily conserved key regulator of innate immunity. In the model organism Drosophila melanogaster, STING activates the NF-κB-like transcription factor Relish, initially characterize...

Douglas et al. study the E3 ligase HOIL-1, mutated in patients with a type of myopathy. Mutant HOIL-1 influences the sensitivity to disulfidptosis initiated by ZAKα–ATF4 in glucose starvation and inte...

Cystine / Glutathione / NADPH SLC33A1 exports oxidized glutathione to maintain endoplasmic reticulum redox homeostasis Shanshan Liu  (刘珊珊), Mark Gad, Caifan Li  (李采蘩), Kevin Cho, Yuyang Liu  (刘雨洋),…

TNF Upstream ORFs control TNFR1 abundance and tissue tolerance to TNF Biao Ma, Wenxin Lyu, John Rizk, Xiaoyue Han, Majken Kjær, Vinnycius Pereira Almeida, Malin Jessen, Max Benjamin Sauerland, Caro…

The concept of PANoptosis describes the simultaneous activation of pyroptosis, apoptosis and necroptosis. This Comment discusses the evidence supporting this hypothesis and proposes criteria to valida...

The integrated stress response (ISR) is a major mechanism protecting cells against environmental and physiological stresses. Central to the ISR is a collection of stress-sensing kinases, such as GCN2 ...

Das et al. show that the death mechanism ferroptosis is regulated in cell populations by the parallel induction of necrotic and apoptotic modes of execution. Death propagation, a unique feature of nec...