Porat et al. develop cell surface ATAC-See, discovering that mitochondrial DNA is a component of the mammalian cell surface. Cell surface DNA (csDNA) on primary human and murine B cells and monocytes ...

British Journal of Cancer - Targeting Siglec-engaging immunosuppressive sialoglycans to suppress prostate cancer bone metastasis

Biomolecular condensates are dynamic, membrane-free compartments that continuously exchange molecules with their surroundings. The dwell time, defined as the time a molecule remains inside a condensat...

EMBO Reports - When experimental controls go wrong, it does not necessarily mean your experiment is flawed. It might well be the first sign of something unexpected.

Precise control of antigen recognition remains a challenge in engineering cell-cell interactions. Kwon et al. develop extrabody, a split antibody platform that enables optogenetic and chemical control...

The disordered adapter protein linker for activation of T cells (LAT) propagates T cell receptor signaling. To interrogate how LAT coordinates multiple downstream pathways, we developed a single-cell ...

Stress granules (SGs) are multi-component protein–RNA condensates widely viewed as crucibles for fibril formation in neurodegenerative diseases such as amyotrophic lateral sclerosis. Here, we test thi...

Heparan sulfate proteoglycans facilitate the assembly of clusters of glycoRNAs and cell surface RNA-binding proteins, which negatively modulate VEGF-A signalling and angiogenesis.

Achieving spatiotemporal gating of signals is desirable for mimicking of biological processes, but is challenging to achieve in synthetic systems. Here, the authors report a multicomponent chemoenzyma...

A new function of glycosylated RNAs has been discovered by Graziano et al. in which the glycosylation of RNA molecules shields acp³U RNA modification from triggering innate immune responses.

Biomolecular condensates are membraneless organelles that compartmentalize biological functions in living cells. Formed by the phase separation of biomolecules, condensates possess a wide range of mec...

The extracellular space is a critical environment for discriminating self versus non-self nucleic acids and initiating the appropriate immune responses through signaling cascades to relay information ...

A chaperone tasked with protein quality control tunes the phase behavior of tau and prevents its pathological phase transitions.

An RNA-binding protein on leukemia cells provides an effective target in mouse models.

Much of our understanding of RNA–protein interactions, and how these interactions shape gene expression and cell state, have come from studies looking…

Celebrating Interdisciplinarity in Soft Robotics The theme for the 8th IEEE-RAS International Conference on Soft Robotics (RoboSoft 2025) centers on “Interdisciplinarity and Widening Horizons”, emphas...

Mammalian cells present RNA-binding proteins on the cell surface that form clustered domains containing glycoRNAs.