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Roopali Khanna

@roopsiek.bsky.social
27 followers 40 following 0 posts

Integrated Ph.D student @samratmukhopadhyaylab @Iisermohali

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Reposted by Roopali Khanna
Ryan Flynn @raflynn5.bsky.social · 29/06/2026
Taking our first steps towards sequencing the extracellular matrix by “Intact and single-molecule analysis of heparan sulfate” from @phristov.bsky.social in the lab, in collaboration with Miten Jain's lab. "HS-nano-seq" www.biorxiv.org/content/10.6...
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Reposted by Roopali Khanna
Ayusman Sen @ayusmansen.bsky.social · 05/05/2026
Great work by @ektashandilya.bsky.social and @xiaotian-lu.bsky.social. Shifts the paradigm from passive, receptor-based delivery to dynamic, energy-responsive targeting. Chemotaxis of ATPase-Powered Nanoparticles up Extra- and Intracellular ATP Gradients | Nano Letters pubs.acs.org/doi/10.1021/...
pubs.acs.org
Chemotaxis of ATPase-Powered Nanoparticles up Extra- and Intracellular ATP Gradients
Guiding synthetic nanomaterials toward specific cells and subcellular organelles remains a critical challenge for targeted therapeutics. Here, we report that ATPase-functionalized nanoparticles harnes...
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Reposted by Roopali Khanna
Ryan Flynn @raflynn5.bsky.social · 28/01/2026
Science update from my postdoc Peiyuan Chai - his work “glycoRNA complexed with heparan sulfate regulates VEGF-A signaling” is now published @nature.com uncovering a new layer or glycoRNA-regulation of growth factor mediated control physiological processes rdcu.be/e1bBX
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Reposted by Roopali Khanna
Science Magazine @science.org · 22/10/2025
The mice could be used to better understand and treat heavy menstrual bleeding, and study reproductive health conditions such as endometriosis. scim.ag/473mwRw
scim.ag
Lab mice can now have periods like humans
Studies of rodents with a menstrual on/off switch could help people with endometriosis and other disorders
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Reposted by Roopali Khanna
Jerelle Joseph @jerelleaj.bsky.social · 08/10/2025
Is there a way to directly connect microstructural dynamics of condensates to their mechanical response? In his new pre-print, Pablo presents a “condensate Deborah number” that does just that! www.biorxiv.org/content/10.1...
biorxiv.org
Biomolecular condensate viscoelasticity is dictated by the interplay between single-molecule shape memory and mesh reconfigurability
Biomolecular condensates are membraneless organelles that compartmentalize biological functions in living cells. Formed by the phase separation of biomolecules, condensates possess a wide range of mec...
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Reposted by Roopali Khanna
Ryan Flynn @raflynn5.bsky.social · 06/10/2025
Lead by postdoc in the lab Ruiqi Ge and in collaboration with Bob Coffey’s lab, we are happy to share rPAL-seq for rapid and sensitive sequencing based profiling of glycoRNAs @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...
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Reposted by Roopali Khanna
Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · 07/06/2025
Happy to share our latest paper published in Science Advances @aaas.org. Congratulations to my incredible students, Sandeep @sandeeprai.bsky.social, Roopali @roopsiek.bsky.social (co-first author), Anusha @anushasarbahi.bsky.social & Ashish @ashishjoshi.bsky.social. www.science.org/doi/10.1126/...
science.org
Chaperone-mediated heterotypic phase separation regulates liquid-to-solid phase transitions of tau into amyloid fibrils
A chaperone tasked with protein quality control tunes the phase behavior of tau and prevents its pathological phase transitions.
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