Podcast Episode · Your Undivided Attention · September 17 · 21m

Popular vendors’ catalogs feature more than 18,000 manipulated images

So you think you want to start a biotech company. Read this first.

Data-Rich, Insight-Poor — CLXXVIII Most therapeutic design still runs on a clean cartoon. A receptor sticks out of a bare lipid plane.

Trogocytosis enables the transfer of membrane-bound antigens during pathogenic B-T cell interactions. Here, the authors utilize mouse and human cell models and demonstrate that the B cell marker CD19 ...

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Nature Cancer - In this Review, van Vliet and colleagues provide an overview of aberrant glycosylation as a hallmark of cancer cells, focusing on its impact for cancer immunity and therapeutic...

British Journal of Cancer - Targeting Siglec-engaging immunosuppressive sialoglycans to suppress prostate cancer bone metastasis

Developing therapies and vaccines against integral membrane proteins is hindered by their extensive hydrophobic surfaces, which complicate production and structural analysis. Here, we describe a gener...

HIV-1–driven CD4-to-CD8 T cell conversion results in a distinct cellular reservoir of viral persistence.

What OMB’s Proposed Federal Financial Assistance Rule Means in Practice

Office of Management and Budget Director Russell Vought has poured gas on the foundations of science. Pharma CEOs should demand that President Donald Trump...

We’ve documented more than 100 instances of apparent data manipulation in Thermo’s catalog

Tang, Dai, Qing, Zhang and colleagues describe a role for N-glycosylation in the nucleus: N-glycans modify inner nuclear membrane proteins, and the modification is implicated in the maintenance of H3K...

Microvillar contacts serve as sites of TCR and PD-1 signal integration, modulating T cell activation and tumor control.

Precise control of antigen recognition remains a challenge in engineering cell-cell interactions. Kwon et al. develop extrabody, a split antibody platform that enables optogenetic and chemical control...

He was born before the Great Depression, came of age in WWII, and is still making wildlife documentaries. Brits call David Attenborough a national hero, as he celebrates his 100th birthday.

Discover the world’s best science and medicine | Nature.com

Nature Chemical Biology - A chemoproteomic strategy reveals how posttranslational modifications reshape protein ligandability across the human proteome, uncovering more than 400 state-dependent...

Described is the use of photocatalytic and enzymatic activation of rapid bioorthogonal chemistry for cell surface proximity labeling. Current approaches to proximity labeling rely on the activation of...

The generation of effector CD8+ T cells (TEFF) requires activation of naïve CCR7+ T cells (TN) by dendritic cells (DCs) in lymphoid tissue. How TN-DC interaction duration and signal integration are co...

Cells are coated with glycans that are linked to cellular recognition via sialic acid-binding immunoglobulin-like lectins (Siglecs). Here the authors present a resource characterising human Siglec exp...

A builder and problem solver at heart, she is developing technologies to understand and engineer the roles of cell-surface sugars, called glycans, in the immune system.

Akeke and Zhang defend against the DOJ's investigation into Stanford Medicine and advocate for the importance of diversity consideration in admissions.

Leaked documents show IRGC secretly acquired system and used it to guide strikes during war in March

Macrophages exert antitumorigenic activity through phagocytosis, but phagocytosis-enhancing therapeutics have not improved acute myeloid leukemia (AML) outcomes. To identify phagocytosis regulators, we performed CRISPR knockout screens in human AML cells ...

On with Kara Swisher · Episode

Chen et al. engineer TRANSFER (trogocytosis-inspired receptor transfer and functional effector release), a method to deliver functional cargos from donor to recipient cells in a specific manner via di...

AbstractBackground and aims. While vigorous physical activity (VPA) is known to provide greater health benefits per unit time than moderate activity, the s

Here, the authors suggest that, when major histocompatibility complex class I is downregulated on allogenic or tumor cells, they are more susceptible to CD4+ T cell-mediated ferroptosis.

Here, the authors report metabolic activation as a potential antimicrobial strategy against Mycobacterium tuberculosis. They show that supra-physiological activation of L-histidine biosynthesis r...

Genome-wide analyses identify 13 loci associated with susceptibility to infection with SARS-CoV-2 Omicron variants, including variation in ST6GAL1, previously associated with influenza susceptibility,...

Tertiary lymphoid structures are critical components of tissue immunity, necessitating better understanding of their organization and immune functions. De Lima et al. investigate the spatial and tempo...