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Toth-Petroczy lab

@tothpetroczylab.bsky.social
396 followers 196 following 24 posts

Protein evolution, IDRs, bimolecular condensates, phenotypic mutations. Science and fun from the ATPlab.

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HZDR @hzdr.bsky.social · 03/07/2026
Welcome to HZDR, Prof. Ágnes Tóth-Petróczy! Since June 2026, @tothpetroczylab.bsky.social has been a Research Team Leader at the Center for Advanced Systems Understanding (CASUS). Her research focuses on the function and evolution of intrinsically disordered proteins. www.hzdr.de/presse/tothp...
Portrait of Prof. Ágnes Tóth-Petróczy, who has been a professor at CASUS and TU Dresden since June 2026.
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Toth-Petroczy lab @tothpetroczylab.bsky.social · 02/07/2026
I am honored and excited about the opportunity to lead the Department of Systems Biology at the Center for Advanced Systems Understanding (CASUS) at HZDR @casusscience.bsky.social in Görlitz and join as a Professor at BIOTEC/CMCB @biotec-tud.bsky.social. www.casus.science/news-profess...
casus.science
News — Professorship and tenured position: Saxony retains top computational biologist – CASUS – Center for Advanced Systems Understanding
Ágnes Tóth-Petróczy to become third full professor working at CASUS and BIOTEC
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Toth-Petroczy lab @tothpetroczylab.bsky.social · 02/07/2026
I am honored and deeply grateful for the opportunity to continue being part of Dresden’s vibrant and collaborative scientific community as a joint Professor between @casusscience.bsky.social and @biotec-tud.bsky.social. My dream of doing science for life has come true.
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Shevchenko Lab @labshevchenko.bsky.social · 11/06/2026
We are very happy for our colleague Dr. Jonas Pöhls! After defending his Ph.D. in an interlaboratory project between Lab Shevchenko and @tothpetroczylab.bsky.social, Jonas will continue his scientific career as a postdoctoral fellow at the Vienna BioCenter. Stay in touch with @mpi-cbg.de friends!
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Mariotti Genomics Lab @mariottilab.bsky.social · 16/06/2026
This and much more is available in our preprint! Thanks to collaborating labs @tothpetroczylab.bsky.social, Alain Lescure, Irwin Jungreis @manoliskellis.bsky.social, and Diego Garrido, Federica Battistini @biologiaub.bsky.social @geneticsub.bsky.social @molevolub.bsky.social
biorxiv.org
Regulatory landscape of widespread stop codon readthrough in Drosophila
In stop codon readthrough (SCR), ribosomes continue to translate past the stop. While programmed SCR is rare in mammals, it appears remarkably widespread in insects, yet its regulation and biological ...
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Toth-Petroczy lab @tothpetroczylab.bsky.social · 20/05/2026
Girls' Day @mpi-cbg.de
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Toth-Petroczy lab @tothpetroczylab.bsky.social · 20/05/2026
Have you heard of our biomolecular condensate database before? Meet the CD-CODE team at the EMBO Phase Separation Symposium 👇
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CrowDsourcing COndensate Database & Encyclopedia @cdcode.bsky.social · 19/03/2026
CD-CODE v2.2 RELEASE is live🤩 Our #database grew: 💡10 new #condensates 💡639 new #condensate - #protein connections 💡107 new c-mods 💡10 new #condensatopathies 🟣Find your favorite condensate cd-code.org and 👀see more details about the #release: cd-code.org/release #cdcode #IDP #RBP #DatabaseUpdate
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Mihaly Badonyi @mbadonyi.bsky.social · 04/03/2026
Based on this, we introduce Pinc (“probability of interface native contacts”): a simple and interpretable protein-protein interaction score for #alphafold (AF2/AF3) models. Colab + CLI: git.mpi-cbg.de/tothpetroczy... Feedback is appreciated. #rstats
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Toth-Petroczy lab @tothpetroczylab.bsky.social · 04/03/2026
Pinc: a simple probabilistic AlphaFold interaction score. 👇Congratulations to @mbadonyi.bsky.social! 🎉💕
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Toth-Petroczy lab @tothpetroczylab.bsky.social · 01/12/2025
I am honored and proud to work with my amazing group @mpi-cbg.de and @csbdresden.bsky.social 🥰 🧬. Thanks to all my colleagues for the wonderful scientific environment. And thank you @kboes.bsky.social for preparing this superb video! 🤩
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Max Planck Institute of Molecular Cell Biology and Genetics @mpi-cbg.de · 24/10/2025
The new @mpi-cbg.de research group leader Daniela Egas Santander is looking for a Postdoctoral Researcher (m/f/d) in Applied Topology for Biology. Apply until November 16th here: careers.mpi-cbg.de/jobs/6002777...
visual for the job ad with black background
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CrowDsourcing COndensate Database & Encyclopedia @cdcode.bsky.social · 14/11/2025
💡With a #relational structure, programmatic access #API and improved search capabilities, CD-CODE 2.0 easily integrates into #datascience and digital #biology workflows, broadening its versatility and creating connections between condensate biology and #therapeutic development. 🔗 cd-code.org
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CrowDsourcing COndensate Database & Encyclopedia @cdcode.bsky.social · 14/11/2025
CD-CODE is a great example of an interdisciplinary teamwork between computational and experimental biologists and software engineers! #Thankyou to all the authors of @tothpetroczylab.bsky.social, the biomolecular condensate community of @mpi-cbg.de, @hymanlab.bsky.social, and Dewpoint Therapeutics!
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Toth-Petroczy lab @tothpetroczylab.bsky.social · 17/11/2025
Our enhanced knowledge base for condensates is online @narjournal.bsky.social! Congratulations to the first authors @kkuznetsova.bsky.social and @mscheremetjew.bsky.social and all co-authors & curators! What a wonderful team effort to advance condensate research! 🤩 @mpi-cbg.de @hymanlab.bsky.social
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Max Planck Institute of Molecular Cell Biology and Genetics @mpi-cbg.de · 30/09/2025
Schering Young Investigator Award 2025 by the Schering Stiftung for Agnes Toth-Petroczy @tothpetroczylab.bsky.social @mpi-cbg.de @csbdresden.bsky.social. She receives the award for her work on the evolution, diversity, and function of proteins. Congratulations! 🎉 www.mpi-cbg.de/news-outreac...
mpi-cbg.de
New Perspectives on the Hidden World of Proteins
 Schering Young Investigator Award 2025 goes to Agnes Toth-Petroczy
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Elisha Krieg @elishakrieg.bsky.social · 15/09/2025
AI can now generate fake microscopy images that are nearly impossible to detect. A serious threat to scientific integrity—and we’re not prepared for it. Commentary in @natnano.nature.com #nanotechnology
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Human Technopole @humantechnopole.bsky.social · 24/07/2025
🧬 We're excited to host the 13th Symposium on Structural #Proteomics at HT in Milan on 6–8 Oct 25! Join this international meeting with talks on protein structure and interactions by crosslinking MS, HDX-MS, native MS, chemoproteomics & more 👉 ssp2025.squarespace.com ▶️ @ssp2025.bsky.social
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Max Planck Institute of Molecular Cell Biology and Genetics @mpi-cbg.de · 26/06/2025
Novel Research in Biological Artificial Intelligence: Expressions of interest and nominations for a Max Planck Director to lead research in the field of Biological Artificial Intelligence @mpi-cbg.de and @csbdresden.bsky.social. More information: www.mpi-cbg.de/news-outreac...
mpi-cbg.de
Novel Research in Biological Artificial Intelligence
Expressions of interest and nominations for a Max Planck Director to lead research in the field of Biological Artificial Intelligence.
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Nature @nature.com · 03/07/2025
Scientific research is at the heart of Israel’s success and has worldwide benefits. Our work will continue despite adversity, says Alon Chen go.nature.com/40wXMx6
go.nature.com
How we’re rebuilding the Weizmann Institute — and our hopes for a better future
Scientific research is at the heart of Israel’s success and has worldwide benefits. Our work will continue despite adversity.
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Physics of Life Dresden @poldresden.bsky.social · 18/06/2025
Big news 🎉 We are excited to announce the new TUD graduate school "Biomolecular Condensates: From Physics to Biological Functions", with 12 members from PoL! Through this school, we will train a new generation of scientists working on #condensates at the interphase between theory and experiments 🤓⤵️
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CrowDsourcing COndensate Database & Encyclopedia @cdcode.bsky.social · 11/06/2025
The latest release was supported by the #condesathon joined by @mpi-cbg.de condensate community🤩 Big #thankyou to all the participants from @hymanlab.bsky.social, @tothpetroczylab.bsky.social and von Appen labs for your support and enthusiasm!💜
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Max Planck Institute of Molecular Cell Biology and Genetics @mpi-cbg.de · 28/05/2025
Related science sketch video by @marionamec.bsky.social www.youtube.com/watch?v=0REv...
youtube.com
Condensates Inside Condensates—Triggering Disease?
YouTube video by MPI-CBG
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Toth-Petroczy lab @tothpetroczylab.bsky.social · 28/05/2025
Are you looking for homologous sequences but alignments do not seem to work? SHARK is available as a webserver: compare sequences or search against precomputed IDR datasets: bio-shark.org @narjournal.bsky.social @mpi-cbg.de @csbdresden.bsky.social @poldresden.bsky.social doi.org/10.1093/nar/...
doi.org
SHARK: web server for alignment-free homology assessment for intrinsically disordered and unalignable protein regions
Abstract. Whereas alignment has been fundamental to sequence-based assessments of protein homology, it is ineffective for intrinsically disordered regions
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Physics of Life Dresden @poldresden.bsky.social · 21/05/2025
One week left to apply to the Physics of Life MSc this year! Students learn first-class research skills and can also avail of #scholarships to aid their studies. Learn more and apply: physics-of-life.tu-dresden.de/career-educa... #internationalstudents #MSc #EnglishMSc #Physics #studyabroad
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Ksenia Kuznetsova @kkuznetsova.bsky.social · 28/04/2025
Exciting that CD-CODE is now connected to THE go-to resource for everything protein-related! It's a great step forward, directing further developments and outlook for our project @tothpetroczylab.bsky.social @mscheremetjew.bsky.social 🥳
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Toth-Petroczy lab @tothpetroczylab.bsky.social · 16/04/2025
Deep learning tools predict variants in disordered regions with lower sensitivity. Just published by FedericaLuppino, @swlenz.bsky.social and WillisChow @mpi-cbg.de @csbdresden.bsky.social @poldresden.bsky.social bmcgenomics.biomedcentral.com/articles/10....
bmcgenomics.biomedcentral.com
Deep learning tools predict variants in disordered regions with lower sensitivity - BMC Genomics
Background The recent AI breakthrough of AlphaFold2 has revolutionized 3D protein structural modeling, proving crucial for protein design and variant effects prediction. However, intrinsically disorde...
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Max Planck Institute of Molecular Cell Biology and Genetics @mpi-cbg.de · 14/04/2025
New Publication of the @tothpetroczylab.bsky.social: The group found that prediction tools are less sensitive in intrinsically disordered regions of proteins (IDRs). Since they are common & important, new methods tailored to these regions are needed. bmcgenomics.biomedcentral.com/articles/10....
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Max Planck Institute of Molecular Cell Biology and Genetics @mpi-cbg.de · 25/03/2025
The @tothpetroczylab.bsky.social together with the @albertilab-tud.bsky.social developed SHARK-capture to detect recurring patterns (motifs) in intrinsically disordered protein regions (IDRs). Publication in Protein Science. www.mpi-cbg.de/news-outreac...
logo with a shark
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Irina Bezsonova @irinabezsonova.bsky.social · 15/03/2025
You can download my protein structure-inspired artwork from pdb webpage: pdb101.rcsb.org/sci-art/bezs... @rcsbpdb.bsky.social @pdbeurope.bsky.social #sciart
pdb101.rcsb.org
PDB101: Irina Bezsonova Gallery
PDB-101: Training, Outreach, and Education portal of RCSB PDB
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Toth-Petroczy lab @tothpetroczylab.bsky.social · 18/03/2025
Identifying functional motifs in disordered regions is challenging. We gave it a try. Check out SHARK-capture, an alignment-free method to detect SLiMs. Congrats Chi Fung Willis Chow @swlenz.bsky.social et al. @mpi-cbg.de @csbdresden.bsky.social @poldresden.bsky.social doi.org/10.1002/pro....
doi.org
SHARK‐capture identifies functional motifs in intrinsically disordered protein regions
Increasing insights into how sequence motifs in intrinsically disordered regions (IDRs) provide functions underscore the need for systematic motif detection. Contrary to structured regions where moti...
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CrowDsourcing COndensate Database & Encyclopedia @cdcode.bsky.social · 07/03/2025
🍃CD-CODE update v1.09 is here!🍃 👀Check out the new #biomolecular #condensates at cd-code.org 👀We're continuing to update #Protein - #condensate connections and resolve issues! Join us to share your #condensate #expertise as a contributor: cd-code.org/signup #Bioinformatics #DatabaseUpdate #IDR
media.tenor.com
a group of ducklings are running in a field .
ALT: a group of ducklings are running in a field .
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bioRxiv Bioengineering @biorxiv-bioeng.bsky.social · 10/02/2025
Programmable viscoelastic hydrogels uncover mechano-sensing timescales and direct cell polarity www.biorxiv.org/content/10.1101/202…
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Max Planck Institute of Molecular Cell Biology and Genetics @mpi-cbg.de · 30/01/2025
MPI-CBG director Anthony Hyman @hymanlab.bsky.social will deliver the EMBO Lecture at the 49th FEBS Congress in Istanbul in July 2025. Read an interview with him, where he shares some of his inspirations and interests. network.febs.org/posts/anthon...
network.febs.org
Anthony Hyman: "...the realization of phase separation as a critical organizing principle in cellular biology has transformed the field."
From a 1920s book to nanoscopy – Anthony Hyman, who will deliver the EMBO Lecture at the 49th FEBS Congress in Istanbul in July 2025, shares some of his inspirations and interests.
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Toth-Petroczy lab @tothpetroczylab.bsky.social · 29/01/2025
Great opportunity if you are looking for an interdisciplinary postdoctoral position 👇
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Max Planck Institute of Molecular Cell Biology and Genetics @mpi-cbg.de · 13/12/2024
Machine learning algorithm, PICNIC, can predict which proteins are involved in biomolecular condensates, regardless of their structure. Publication in @natureportfolio.bsky.social Communications by the @tothpetroczylab.bsky.social & @hymanlab.bsky.social www.mpi-cbg.de/news-outreac...
Blue logo for PICNIC
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Toth-Petroczy lab @tothpetroczylab.bsky.social · 12/12/2024
Our PICNIC tool predicts condensate-proteins regardless of their structural disorder across organisms @naturecomms.bsky.social. Congratulations to @annaha-poetry-art.bsky.social for developing the algorithm and to Hari @hymanlab.bsky.social for the experiments! www.nature.com/articles/s41...
nature.com
PICNIC accurately predicts condensate-forming proteins regardless of their structural disorder across organisms - Nature Communications
Here the authors report PICNIC (Proteins Involved in CoNdensates In Cells), a machine learning algorithm that predicts approximately 40–60% of proteins form condensates in various organisms, showing n...
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CrowDsourcing COndensate Database & Encyclopedia @cdcode.bsky.social · 09/12/2024
✨Winter CD-CODE update to v1.08!✨ ❄️ New #biomolecular #condensates added (total ⚪: 680) ❄️ #Protein - #condensate connections updated ❄️ Species attributes fixed 🤩 👀Check the current version here: cd-code.org Join us to become a contributor: cd-code.org/signup #DatabaseUpdate #Bioinformatics #IDR
media.tenor.com
a row of penguins are walking in the snow
ALT: a row of penguins are walking in the snow
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Toth-Petroczy lab @tothpetroczylab.bsky.social · 04/12/2024
I am honored and excited to be part of the EMBO YIP!
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