The extracellular space is a critical environment for discriminating self versus non-self nucleic acids and initiating the appropriate immune responses through signaling cascades to relay information ...

Over recent decades, the glycocalyx, an extracellular organelle composed of a multitude of glycolipids, glycoproteins, proteoglycans, and glycoRNA, has gained considerable interest in cellular biology...

The glycocalyx, the cell’s sugar coat, has key roles in immunology, cancer, viral infections, and more. Visualizing its molecular architecture was impossible until now. Here, we combine metabolic labe...

Nature - Super-resolution technique works with off-the-shelf optical microscopes.

By combining bioorthogonal metabolic labelling and resolution enhancement through sequential imaging of DNA barcodes, the molecular organization of individual sugars in the native glycocalyx has been ...

Super-resolution technique works with off-the-shelf optical microscopes.

Super-resolution technique works with off-the-shelf optical microscopes.

By combining bioorthogonal metabolic labelling and resolution enhancement through sequential imaging of DNA barcodes, the molecular organization of individual sugars in the native glycocalyx has been ...

Researchers have found a readily druggable target on the surface of acute myeloid leukemia (AML) cells — but not normal blood cells.

An RNA-binding protein on leukemia cells provides an effective target in mouse models.

An RNA-binding protein on leukemia cells provides an effective target in mouse models.

Glycobiology is rooted in the study of monosaccharides, Angstrom-sized molecules that are the building blocks of intricate glycosylation patterns. Glycosylated biomolecules form the glycocalyx, a dens...

Fibrosis and persistent inflammation are interconnected processes that inhibit axon regeneration in the mammalian central nervous system (CNS). In zebrafish, by contrast, fibroblast-derived extracellu...