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Devin Schweppe

@dschweppe.bsky.social
1.1K followers 476 following 63 posts

Associate Professor at UW Genome Sciences developing/applying proteomic technologies | he/him/his | Views are my own.

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Reposted by Devin Schweppe
Sergey Ovchinnikov @sokrypton.org · 14/09/2026
Finally a more intuitaive way to learn pLDDT/pAE? 😎 sokrypton.github.io/protein_figh... (Character idea from @hannes-stark.bsky.social & Alex Waldherr)
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Pedro Beltrao @pedrobeltrao.bsky.social · 04/09/2026
Another AI agent swarm cooperation example discovered on a wiki. That these things are not atracting more public discussion is beyond me. collusion.wiki
collusion.wiki
Discovery of a new OpenAI agent message board
A swarm of autonomous AI agents, self-identifying as OpenAI agents, used a small German volunteer wiki to save answers, coordinate live, and share sandbox bypasses. OpenAI noticed and said nothing.
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US HUPO @us-hupo.org · 25/08/2026
🏆 Know someone advancing proteomics? Nominate them for a 2026 US HUPO Association Award! Celebrate outstanding scientists, researchers & innovators shaping the field. 📅 Nominations due Oct. 2, 2026 👉 Learn more & nominate #USHUPO #Proteomics #ScientificAwards #LifeSciences
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US HUPO @us-hupo.org · 10/08/2026
🚨 Tomorrow! Join the US HUPO Spatial Imaging Series: More than Mass Spec to discover how multimodal imaging is advancing biological research. 🎟️ Register now: us02web.zoom.us/webinar/register/WN… #USHUPO #SpatialBiology #Proteomics
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George O'Toole (he/him/his) @geiselbiofilm.bsky.social · 30/06/2026
Pls share: U of Washington has an opening for a tenure-track faculty position at the rank of Assistant Professor. This position is expected to specialize in molecular virology or bacteriology. Here is a link: microbiology.washington.edu/index.php/ne...
microbiology.washington.edu
Micro is Hiring! | UW Microbiology
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Devin Schweppe @dschweppe.bsky.social · 08/07/2026
Really cool collaborative opportunity here for scientific exchange for #teammassspec #proteomics More info here: us-hupo.org/scientist-ex...
us-hupo.org
US HUPO - Scientist Exchange Program Award
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Devin Schweppe @dschweppe.bsky.social · 01/07/2026
Finally got tired enough trying to remember where a bunch of proteomics tools were and had @anthropic.com code a site to digest proteins, estimate isotopic envelopes/protein properties, & just for kicks a "power calculator" and more useful contaminant finder: schweppelab.github.io/for_proteomi...
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ASMS @asms.org · 18/06/2026
Congratulations to the recipients of the 2026 ASMS Postdoctoral Career Development Awards! These awards support the professional growth of postdoctoral fellows in the field of mass spectrometry, helping fund opportunities. #TeamMassSpec #ASMS #MassSpecCommunity #FeMS #ASMS2026
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Nick Riley @nmriley.bsky.social · 02/06/2026
If you are looking for a Tuesday evening #ASMS2026 workshop to attend, consider joining us for fun discussions about real time mass spectrometry.
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Devin Schweppe @dschweppe.bsky.social · 30/05/2026
New work from @csneeze.bsky.social explored how common additives for thermal stability analyses affected protein-drug interaction hit calling. We were surprised to see that buffer and method selection for lysates could recapitulate findings from in cell thermal stability assays!
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Pedro Beltrao @pedrobeltrao.bsky.social · 25/05/2026
new lab preprint - Protein function prediction is a well established problem but proteins exist in different post-translationally modified forms. Here, @julianvangerwen.bsky.social built a ML model to predict the biological process regulated by individual phosphosites www.biorxiv.org/content/10.6...
biorxiv.org
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Patrick S. Mitchell @psmitchej.bsky.social · 25/05/2026
Thrilled to announce that the Department of Microbiology at the University of Washington, School of Medicine is hiring at the Assistant Professor level (tenure-track)! The Pacific Northwest is an awesome place to live and do science 🧪🦠. Join us! apply.interfolio.com/185622 Applications due 8/1.
apply.interfolio.com
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
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Nature Cell Biology @natcellbio.nature.com · 11/05/2026
☕ @riddhiman.bsky.social et al. use experimentally matched mass-spec and RNA-seq to quantify proteins, phosphosites & transcripts across 4 stages of human & mouse gastruloid development. @jshendure.bsky.social @leastarita.bsky.social @nobuhamazaki.bsky.social @dschweppe.bsky.social bit.ly/4dAYyA1
bit.ly
The proteomic landscape and temporal dynamics of human and mouse gastruloid development - Nature Cell Biology
Garge et al. use experimentally matched mass spectrometry and RNA-sequencing to quantify proteins, phosphosites and transcripts across four key stages of human and mouse gastruloid development.
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Devin Schweppe @dschweppe.bsky.social · 06/05/2026
With a few days since it's been out @keribackus.bsky.social @oligopain.bsky.social and I wanted to highlight a few of our favorite aspects of POCA for photocatalytic proximity labeling of DNA, RNA or proteins. (1) POCA builds on standard in situ hybridization and immunofluorescence workflows.
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cpherlihy.bsky.social @cpherlihy.bsky.social · 03/05/2026
Really excited to have lead this work alongside Eli and Lidan! I’d love to chat about applying our platform to your system of interest, the advantages of parallel imaging and proteomics, ability to target DNA, RNA, and protein, or advantages over enzyme-based labeling with anyone who’s interested!
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Devin Schweppe @dschweppe.bsky.social · 03/05/2026
Excited to see this collaborative work with @oligopain.bsky.social and @keribackus.bsky.social out as a preprint now! Took a ton of work from a great team of scientists @uwgenome.bsky.social and #UCLA The imaging coupled with proteomics open our eyes to new aspects of subcellular organization!
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Reposted by Devin Schweppe
Keri Backus @keribackus.bsky.social · 03/05/2026
Super excited to launch POCAxOMAP with @dschweppe.bsky.social and @oligopain.bsky.social and led by Eli Biletch, Conor Herlihy and Lidan Li. If you’ve ever wanted to do proximity labeling on DNA, RNA, or protein without genetic engineering, look no further. www.biorxiv.org/content/10.6...
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Devin Schweppe @dschweppe.bsky.social · 03/05/2026
Excited to see this collaborative work with @oligopain.bsky.social and @keribackus.bsky.social out as a preprint now! Took a ton of work from a great team of scientists @uwgenome.bsky.social and #UCLA The imaging coupled with proteomics open our eyes to new aspects of subcellular organization!
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Devin Schweppe @dschweppe.bsky.social · 28/04/2026
More exciting work from the lab! Along with @maccoss.bsky.social (@uwgenome.bsky.social) and Gary Churchill (@jax.org), Dr. Katarina Vlajic's tour de force multi-omics profiling uncovered molecular signatures of healthy splenic aging! www.biorxiv.org/content/10.6...
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Wyoming Wormboy @wyomingwormboy.bsky.social · 25/04/2026
Please repost! This comes from the good people at ChimeraX, who produce powerful up-to-date software to study protein (etc) structures, which are FREE to the community. 🙏 To stay viable and serve us, they need an experienced structural biologist to assume the leadership role on a funded project.
aprecruit.ucsf.edu
Faculty Position – In-Residence
University of California, San Francisco is hiring. Apply now!
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Reposted by Devin Schweppe
Riddhiman Garge @riddhiman.bsky.social · 25/04/2026
1/ Thrilled to share our latest: an exciting collaboration across the @jshendure.bsky.social, @leastarita.bsky.social, @nobuhamazaki.bsky.social and @dschweppe.bsky.social labs! 🧵 below- #SystemsBiology #SCBEM #MultiOmics #Gastruloids www.nature.com/articles/s41...
nature.com
The proteomic landscape and temporal dynamics of human and mouse gastruloid development - Nature Cell Biology
Garge et al. use experimentally matched mass spectrometry and RNA-sequencing to quantify proteins, phosphosites and transcripts across four key stages of human and mouse gastruloid development.
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Alfonso Martinez Arias @amartinezarias.bsky.social · 25/04/2026
Previously a #preprint, now a peer reviewed @dschweppe.bsky.social work a fine, insightful, useful reference for the growing #gastruloid community . Proteomics, protein-RNA discordances, mouse-human comparison www.nature.com/articles/s41... Insights into human embryos for a growing #SCBEM community
nature.com
The proteomic landscape and temporal dynamics of human and mouse gastruloid development - Nature Cell Biology
Garge et al. use experimentally matched mass spectrometry and RNA-sequencing to quantify proteins, phosphosites and transcripts across four key stages of human and mouse gastruloid development.
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Devin Schweppe @dschweppe.bsky.social · 24/04/2026
Excited to see @riddhiman.bsky.social's gastruloid multiomics paper out now at Nature Cell Bio! Riddhiman used proteomics, phosphoproteomics, and RNAseq to profile stem-cell-derived embryo models to identify protein, complex, and signaling regulators of development. www.nature.com/articles/s41...
nature.com
The proteomic landscape and temporal dynamics of human and mouse gastruloid development - Nature Cell Biology
Garge et al. use experimentally matched mass spectrometry and RNA-sequencing to quantify proteins, phosphosites and transcripts across four key stages of human and mouse gastruloid development.
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US HUPO @us-hupo.org · 24/04/2026
🔬 Meet panelist #3: Parag Mallick, co-founder of NautilusBio and Stanford professor. Hear how he turned a bold proteomics idea into a NASDAQ-listed company and how IP plays a key role. April 27. 📅 Register now: us02web.zoom.us/webinar/register/WN… #USHUPO #Proteomics
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bioRxiv SysBio @biorxiv-sysbio.bsky.social · 21/04/2026
Multimodal analysis of molecular remodeling in aging spleen identified global and cell type specific changes www.biorxiv.org/content/10.64898/20…
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US HUPO @us-hupo.org · 21/04/2026
⚖️ Meet panelist #2: George Fox, VP of IP at SeerBio. IP strategy is a scientific competency, not just a legal one. 💬Hear his take at the US HUPO "Idea to IP" panel, April 27. 📅 Free to attend: us02web.zoom.us/webinar/register/WN… #USHUPO #Proteomics
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Ishmail Abdus-Saboor @ishmailsaboor.bsky.social · 17/04/2026
This program transformed my career! Please apply. @hhmi-science.bsky.social's #FreemanHrabowski Scholars Program offers early career faculty up to $10M over 10 yrs, plus salary & benefits. Postdoc? This year's competition has a program for you too. Applications open 11/3! bit.ly/4vhC0LA
bit.ly
Early Career Faculty Program | Freeman Hrabowski Scholars | HHMI
The Freeman Hrabowski Scholars Program offers comprehensive support to outstanding early career faculty committed to scientific excellence in their own research, and to fostering labs that expand the ...
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UW Genome Sciences @uwgenome.bsky.social · 14/04/2026
Congratulations to Kyra Fetter, Kayla Ly, and Mary Krebs on receiving NSF fellowships and to Katrina Peterson and Ivan Woo on receiving honorable mention!
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cpherlihy.bsky.social @cpherlihy.bsky.social · 08/04/2026
First co-author paper from the first year of my time here at UW is now live! Always happy to chat about it with anyone who is interested ☺️
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US HUPO @us-hupo.org · 07/04/2026
💡 From Idea to IP - Free Webinar Coming April 27: "Idea to IP," a US HUPO panel on turning proteomics research into intellectual property and real-world impact. 📅 Register now us02web.zoom.us/webinar/register/WN… #USHUPO #Proteomics
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Devin Schweppe @dschweppe.bsky.social · 07/04/2026
The next iteration of O-MAP targeting genomic loci is now at eLife!! DNA O-MAP enables proximity labeling at specific DNA loci took a ton of work from many lab members and collaborators, so it's really exciting to wrap up this paper with @oligopain.bsky.social! elifesciences.org/articles/102...
elifesciences.org
DNA O-MAP uncovers the molecular neighborhoods associated with specific genomic loci
DNA O-MAP enables proximity labeling at specific genomic loci in fixed cells using programmable oligonucleotides, revealing locus-proximal proteomes and chromatin interactions without genetic modifica...
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ReSyn Biosciences @resynbio.bsky.social · 07/04/2026
📢 Publication alert🌶️! Congrats to the @maccoss.bsky.social lab who show the use #Mag_Net for enrichment of EV's from #serum to study the effects of monoclonal antibody therapy on the fate and function of T-cells in people with type 1 diabetes! biorxiv.org/content/10.6...
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The Gairdner Foundation @gairdnerawards.bsky.social · 31/03/2026
Congratulations to John R. Yates III, Ruedi Aebersold and Matthias Mann, recipients of the 2026 Canada Gairdner International Award. Prof. Yates: www.gairdner.org/winner/john-... Prof. Aebersold: www.gairdner.org/winner/ruedi... Prof. Mann: www.gairdner.org/winner/matth... #2026GairdnerAwards
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PastelBio @pastelbio.bsky.social · 28/03/2026
News in Proteomics Research blog post | The Proteomics Show is back! Check out chapter one of "All the Parts!" proteomicsnews.blogs... --- #proteomics #prot-other
proteomicsnews.blogspot.com
The Proteomics Show is back! Check out chapter one of "All the Parts!"
  In this US HUPO sponsored season (thank you!) we're being serious scientists who are asking the big questions of bigtime experts of specif...
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Dr Dan Shugar 🇨🇦 @watershedlab.bsky.social · 18/03/2026
In academia, we're good at talking about successes, but sweep unfunded grants & unsuccessful job apps under the rug. It can be a tough road, filled w/ failure* For anyone discouraged about the process, here's my failure CV #AcademicSky 🧪 *None are really failures if you learn from them
A CV of grants that were not funded and jobs applied for but not offeredA CV of grants that were not funded and jobs applied for but not offeredA CV of grants that were not funded and jobs applied for but not offeredA CV of grants that were not funded and jobs applied for but not offered
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Chris Ashwood @cashwood.proteaglyco.com · 04/03/2026
Acquisition news for bottom up and top down proteomics with Thermo acquiring Proteinaceous and MSAID. Proteinaceous was founded in 2016 (possibly earlier) as a spin out from Neil Kelleher’s lab at Northwestern. MSAID was spun out from Mathias Wilhelm and Bernhardt Kuster’s labs in 2019.
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Devin Schweppe @dschweppe.bsky.social · 22/02/2026
@jyates.bsky.social MCing the President’s “Lalapalooza” happening now at #USHUPO2026. Looking forward to learning about alternative methods for proteomics @us-hupo.org
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Matthew Berg @matthewberg22.bsky.social · 29/01/2026
Check out our new work now published in G3! We use proteomics and phosphoproteomics to study how cells cope with tRNA variants that mis-insert amino acids.
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National Academy of Sciences @nasonline.org · 22/01/2026
Congratulations to #NASmember Benjamin F. Cravatt of @scripps.edu, winner of the 2026 NAS Award in Chemical Sciences for providing foundational insights into enzyme function and dysregulation in disease! Learn more about his discoveries: www.nasonline.org/award/nas-aw... #NASaward #chemistry
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PastelBio @pastelbio.bsky.social · 10/01/2026
AutoPELSA: an automated sample preparation system for proteome-wide identification of target proteins of diverse ligands www.biorxiv.org/cont... --- #proteomics #prot-preprint
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Yasset Perez-Riverol @ypriverol.bsky.social · 14/12/2025
Question for the #proteomics community 👇 What should proteomics repositories be doing today (use cases, features, research) that we’re currently missing? Would love your input—RT to reach more voices. #opendata #mass-spectrometry #proteomics
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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 08/12/2025
Congratulations former postdoc @jfhevler.bsky.social (in transit to Roche) and the team on their work using thermal proteome profiling along with glycosylation perturbagens to discover glycan-dependent protein functions at the proteome scale 👏 www.biorxiv.org/content/10.6...
biorxiv.org
Discovering Glycosylation-Dependent Protein Function by Thermal Proteome Profiling
Protein glycosylation regulates essential cellular processes including protein folding, stability, and cell-cell interactions; however, how aberrant glycosylation impacts protein function and interact...
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Nature Biotechnology @natbiotech.nature.com · 03/12/2025
Mapping single-cell diploid chromatin fiber architectures using DAF-seq - @uwgenome.bsky.social @uwdeptmedicine.bsky.social go.nature.com/4rFTAHy
go.nature.com
Mapping single-cell diploid chromatin fiber architectures using DAF-seq - Nature Biotechnology
Single-molecule chromatin fiber sequencing exposes single-cell-level heterogeneity in the chromatin architecture of individual regulatory elements.
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Slavov Laboratory @slavovlab.bsky.social · 03/12/2025
Our latest article is out in Cell ! Together with the Zernicka-Goetz lab, we show that fertilization triggers proteomic asymmetry in mammalian zygotes, giving rise to alpha vs. beta 2-cell blastomeres with distinct developmental potential. cell.com/cell/fulltex...
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Nikolai Slavov @slavov-n.bsky.social · 03/12/2025
I remember fondly how much fun we had with the data analysis, especially when we first identified the consistent proteomic differences between sister blastomeres. Our results exemplify why direct protein analysis is key to discovering and understanding biological mechanisms.
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US HUPO @us-hupo.org · 01/12/2025
We are thrilled to announce our 2026 election results. Olga Vitek has been elected to serve as US HUPO's President-Elect, Devin Schweppe as Secretary, and Sasha Singh and Hanno Steen were elected to serve as Members-At-Large on our Board of Directors. Congratulations to all! 🌟 #USHUPO
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Lindsay K Pino @lindsaykpino.com · 01/12/2025
Woo! Congrats @olgavitek.bsky.social , @dschweppe.bsky.social , Sasha, and Hanno!
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Maitreya Dunham @maitreya.bsky.social · 26/11/2025
Fun new preprint from the lab, headed up by two incredible undergraduate researchers: Using Experimental Evolution to Correct Mother-Daughter Separation Defects in Brewing Yeast. www.biorxiv.org/content/10.1...
biorxiv.org
Using Experimental Evolution to Correct Mother-Daughter Separation Defects in Brewing Yeast
The budding yeast, Saccharomyces cerevisiae, is the workhorse of the brewing industry. Brewers have domesticated a vast array of different strains with traits that complement the beers they wish to br...
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Christopher Rose @cmichaelrose.bsky.social · 25/11/2025
I am looking for a PostDoc to join my group at Genentech to drive the development of proteomics technologies to fuel target and therapeutic discovery and development. Check out the link below! careers.gene.com/us/en/job/20...
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Shawn Fayer @shawnfayer.bsky.social · 22/11/2025
The effects of genetic variants primarily occur in differentiated cells meaning we need to access these cell types to measure variant effects for most disease genes. We developed saturation genome editing in stem cells (iPSC-SGE) to enable phenotyping in diverse genetic and cell contexts at scale!
medrxiv.org
Editing stem cell genomes at scale to measure variant effects in diverse cell and genetic contexts
Multiplexed assays of variant effect (MAVEs) systematically measure variant function but have been limited to cancer cell lines rather than disease-relevant cell types. We developed saturation genome ...
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