Stress granules (SGs) are multi-component protein–RNA condensates widely viewed as crucibles for fibril formation in neurodegenerative diseases such as amyotrophic lateral sclerosis. Here, we test thi...

Explore biomolecular condensates, phase transitions, and drug discovery in Florida. Hear from experts, attend workshops, and advance your research!

Researchers at Washington University in St. Louis and St. Jude Children’s Research Hospital have found that biomolecular condensates play a role in suppressing the effects of ALS-causing mutations.

Ubiquitin-binding shuttle proteins are important components of stress-induced biomolecular condensates in cells. Yeast Dsk2 scaffolds proteasome-containing condensates via multivalent interactions wit...

Protein responses to environmental stress, particularly temperature fluctuations, have long been a subject of investigation, with a focus on how proteins maintain homeostasis and exhibit thermorespons...

Predicting small-molecule partitioning into biomolecular condensates is key to developing drugs that selectively target aberrant condensates. However, the molecular mechanisms underlying small-molecul...

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