Defense-associated reverse transcriptases (DRTs) are widespread bacterial anti-phage systems that use unconventional mechanisms of polynucleotide synthesis. We show that DRT3, which comprises two dist...

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A new function of glycosylated RNAs has been discovered by Graziano et al. in which the glycosylation of RNA molecules shields acp³U RNA modification from triggering innate immune responses.

N-glycans on glycoRNAs prevent innate immune sensing of endogenous small RNAs, and the natural mechanism they use demonstrates how glycoRNAs exist on the cell surface and in the endosomal network with...

N-glycans on glycoRNAs prevent innate immune sensing of endogenous small RNAs, and the natural mechanism they use demonstrates how glycoRNAs exist on the cell surface and in the endosomal network with...

Karolinska Institutet is a world-leading medical university with a long and proud history of ground-breaking research. We are now recruiting outstanding early-career researchers with particularly exce...

Western University, one of Canada’s leading public research universities, is launching an initiative aimed at luring away PhD students from premier U.S. institutions.

The lawsuit says that NIH has canceled more than 670 research grants, which were due more than $1.1 billion in funding.

In shock move, four institute directors at the US biomedical agency are removed from their posts.

Thousands of CDC employees who worked on things like preventing HIV and lead poisoning have been told they were subject to a reduction in force. Experts say people will die.

In shock move, four institute directors at the US biomedical agency are removed from their posts.

It’s unclear whether the guidance will impact active grants, but it appears to halt opportunities for future studies. One climate health expert said the directive would have a “devastating” impact on ...

OverviewTopic AreasMore InformationOverviewATN is the only multicenter research network in the United States devoted to the health and well-being of adolescents and young adults living with or at risk...

Mammalian cells present RNA-binding proteins on the cell surface that form clustered domains containing glycoRNAs.

Bernaleau et al. show that CCDC134 located in the ER is required for TLR biogenesis by controlling the N-glycosylation, folding, and stabilization of the E

TASL is an adaptor molecule bridging Toll-like receptor signalling and transcription activation by IRF5. Here the authors show that TASL deficiency impacts TLR7/9 responses, and that a TASL paralogue,...

The latest government data shows that cases of a fast-spreading stomach bug are surging in parts of the United States. The most recent numbers from the U.S.

Wang and colleagues show that in skeletal muscle cells and cardiomyocytes, the glucose transporter GLUT4 is a negative regulator of RIG-I-like receptor signaling during viral infection by redistributi...